Currently, few studies have been conducted on the effects of physiological factors during exposure to mild hyperbaric oxygen (MHBO) environment on infertile. Thirteen healthy women and seven infertile women undergoing in vitro fertilization (IVF) were exposed to MHBO environment using an oxygen room. The specific physiological data collected during the study were analyzed. Exposure to MHBO increases blood oxygen saturation and may enhance metabolism, potentially improving the chances of pregnancy in infertile women by improving the outcome of implantation. Heart rate variability (HRV) analysis showed that women in the infertile group exhibited slightly less parasympathetic nerve activity than those in the healthy group after exposure to MHBO. These findings suggest that the blood supply to the reproductive organs in infertile women may not yet be sufficient. We hypothesized that further enhancement of blood flow through exposure could improve implantation success in women with infertile. Furthermore, decreased parasympathetic activity in infertile women may be one of the causes of infertile, as increased sympathetic activity prevents mental relaxation. This study is a key step in investigating the mechanisms underlying infertile.

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A 73-year-old woman was diagnosed with severe mitral stenosis five years ago but had not been to a hospital since then. Last year, she was referred to our cardiology department due to dyspnea on exertion caused by heart failure.
An echocardiogram showed a mitral valve area of 0.37cm² and TR-PG of 86.2mmHg, and she was diagnosed with severe mitral stenosis. Because of the extremely small left ventricular diameter (LVDd 29.8mm, LVDs 20.9mm) we scheduled the patient for mitral valve replacement after performing PTMC and confirming that the left ventricular diameter had expanded.
Three months after PTMC, echocardiography confirmed left ventricular diameter enlargement (LVDd 43.7mm, LVDs 28.2mm, TR-PG). Six months after PTMC, the patient underwent mitral valve replacement with favorable results. We have reported the results in a literature review.

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