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Volume 19, Issue 1
Displaying 1-20 of 20 articles from this issue
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Hideto SASAKI1978 Volume 19 Issue 1 Pages 1-11
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSAfter dilution of multicomponent mixture consisting of the dyes above with 0.02N ammonium acetate aqueous solution, each component was quantitatively determined by dual-wavelength Spectrophotometry coupled with an ordinary matrix method (Model 356 Hitachi dual-wavelength recording spectrophotometer) without any chromatographic separation. Measurements were made in 0.02N ammonium acetate solution ranging in concentration of these dyes from 1 to 6μg/ml.
Dye contents were satisfactorily recovered, in the case of two kinds of three components mixture (indigo carmine, amaranth and tartrazine; brilliant blue FCF, erythrosine and tartrazine) and of four components mixture (indigo carmine, acid violet 6B, erythrosine and tartrazine: indigo carmine, amaranth, sunset yellow FCF and tartrazine). As the result of Youden testing, relative standard errors from 0.75 to 3.90% were obtained between the concentrations of added dye and those of the dye found by calibration equations for three-components mixture. Also for the four components system, fortunately similar degrees of recovery were obtained.
Four xanthene dyes for food are very similar to one another in their chemical structures and absorption spectra. By this method, each dye in their multicomponent mixtures was also quantitatively determined so that the limitation of the method might be obtained. Among the four three-component mixtures, dye contents were best recovered in a system for acid red, erythrosine and rose bengal. Standard errors from 0.035 to 0.058μg/ml were obained. For other three components system, similar degrees of recoveries were obtained. But in the mixture of acid red, phloxine and rose bengal, it was difficult to establish two wavelengths for quantitative analysis because of much similarity of the spectra among these three dyes. For the mixture of all four xanthene dyes, it was also difficult to determine each component by overlapping of their spectra.
Generally speaking, the application of this method will be limited to three component system for tbese dye mixture.View full abstractDownload PDF (1735K) -
Hideto SASAKI, Hitoshi TANSEI, Minoru MIWA, Mikio ASAKURA, Kazumasa SH ...1978 Volume 19 Issue 1 Pages 12-22
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSOn the standpoint of dual-wavelength spectrophotometry, each component in 156 groups of two-components mixture consisting 11 kinds of food colors and of 2 kinds of similar colors was directly analyzed with ordinary spectrophotometer without chromatography. Measurement for calibration equations was made in the 0.02N ammonium acetate solution ranging in concentration of these dyes from 0 to 10μg/ml.
The reference wavelength (λ1) and measurement wavelength (λ2) chosen were shown in Table 2, and difference absorptivity between λ1 and λ2 were also shown in Table 3. Mean standard deviation between amounts of added dye and those of found dye in monoazomonoazo mixture was 0.03μg/ml (analyte+interfering dye=5μg/ml). In the case of acid red interfered by another dye, 0.099μg/ml was obtained, but the total mean standard deviation was 0.067μg/ml for all mixture groups. Dye contents in commercial dye were quantitatively analyzed by this procedure.View full abstractDownload PDF (1514K) -
Quantitative Analysis of Three-components Dye Mixture for FoodHideto SASAKI1978 Volume 19 Issue 1 Pages 23-33
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSEach dye in three-components mixture for food was quantitatively determined with the absorption multiplier attached to a dual-wavelength spectrophotometer. When there are no isoabsorbance wavelengths on the absorption spectrum of a material in two-components mixture because of their linearity, it may be desirable to take two wavelengths (λm, λr) between which the analyte in the mixture show an appreciable difference absorbance. If the ratio (masking factor=m/r) of the absorbance at wavelengths λm and λr is known, the absorbance error caused by changes in concentrations of that is eliminated electrically by the absorption multiplier. Thus, the apparent difference absorbance of the analyte can be measured between measuring wavelength λm and reference wavelength λr in the presence of the other.
Absorption spectra of two colors in the two-components mixture, may have two points (λm and λr) of intersection on absorbance curves by alternation of their concentrations. Then, the analyte must possess the appreciable absorption between the above points. The apparent absorbance of analyte may be measured after the instrumental masking of other interfering components by multiplication of the absorptivity at λr by the masking factor (m/r). All measurements were made with a Model UV-300 Shimadzu double beam/difference/dual-wavelength recording spectrophotometer on the solutions (0.02N ammonium acetate) ranging in concentration of these dyes from 0 to 20μg/ml.
For six kinds of three-components system, calibration equations were obtained between the apparent difference absorbances and the content of an analyte (0-11.5g/ml) in the presence of other interfering components (total 10μg/ml). For six kinds of three-components mixture, each dye was determined by using an artificial mixed solution (each 33.33%) with the recovery of 92-107% (Table 2) and the contents of commercial samples were analyzed by this procedure with. recovery ranging from 86 to 105% for labelled amoutes for seven species (Table 3).
This method may be easily useful for a quantitative analysis of multicomponent mixtures for food.View full abstractDownload PDF (1424K) -
Rapid Analysis of Each Component in Some Two- and Three-components MixtureHideto SASAKI1978 Volume 19 Issue 1 Pages 34-43
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSAbsorption coefficients at characteristic wavelengths on absorption and derivative spectra (1st and 2nd order) were obtained for 11 kinds of food colors and 2 kinds of similar dyes on the 0.02N ammonium acetate solutions ranging in concentration of these dyes from 0 to 20μg/ml. The time derivative method for 1st and 2nd derivative spectrophotometry was introduced and facilitate more the detection of each component in dye mixture for food from the shape of standard derivative spectrum (especially, the spectrum of 2nd-order derivative) than the ordinary derivative method with duochrometer, and also facilitate more accurately the determination of the component even in the case of turbid solution.
Several kinds of synthetic two-components mixture (each: 0-10μg/ml) were simply and rapidly identified and determined with the recoveries of 98-133% by 1st deravative spectrophotometry and of 99-106% by 2nd derivative method. For eight kinds of threecomponents mixture containing equal amounts of dyes (each: 33.3%), each component dye was also identified and determined with the recoveries of 86-112% by 2nd derivative spectra. This method was satisfactorily applied to the rapid analysis of food colors in seven kinds of commercial three-components mixture.View full abstractDownload PDF (1243K) -
Hisanao TAKEUCHI, Hiromichi KATO, Masao FUJIMAKI1978 Volume 19 Issue 1 Pages 44-49
Published: February 05, 1978
Released on J-STAGE: July 27, 2010
JOURNAL FREE ACCESSThe effects of temperature and alkali on the formation of lysinoalanine (LAL) in wheat gluten, L-lysine hydrochloride-added wheat gluten, soybean powder and soybean proteins extracted with water or 0.2N sodium hydroxide solution, and furthermore the degradation of LAL by heating were studied.
1) In wheat gluten, lysine-added wheat gluten and soybean powder exposed to water at room temperature, 100 or 150°C for 60min, and also treated with alkali (0.2N NaOH) at room temperature for 60min, the formation of LAL was not observed. When they were heated at 100 or 150°C for 60min with alkali, LAL was formed and total lysine content was decreased. However, on heating at 180°C for 30min, LAL was not detected in all samples.
2) The amount of formed LAL in lysine-added wheat gluten heated with alkali was greater than that of wheat gluten treated likewise, and the amount of added lysine was decreased.
3) The formation of LAL was not detected in the protein extracted with water from deffated soybean powder at room temperature for 3hr, but LAL was a little formed when the water-extracted protein was heated with alkali. On the other hand, the alkaliextracted protein from the same material at room temperature for 3hr contained the amount of LAL almost to that in the soybean heated with alkali and further the content of LAL was only a little increased by heating the protein with alkali.
4) When LAL fraction was heated at 100, 120 and 130°C with alkali for 20min, the amount of LAL was gradually decreased and that of lysine became little by little greater. Especially at 130°C, LAL was hardly observed, and the yield of LAL reached 69% of the theoretical one.View full abstractDownload PDF (890K) -
Akiko SATO1978 Volume 19 Issue 1 Pages 50-55
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSDrug resistant coliform organisms were isolated from oyster in the winter 1974, and their drug resistance patterns and R plasmids were investigated.
Drugs tested were 7 kinds such as tetracycline (TC), chloramphenicol (CP), streptomycin (SM), sulfanilamide (SA), kanamycin (KM), ampicillin (APC) and nalidixic acid (NA), The results were summarized as follows;
1. Of the 90 samples examined, 24 cases (26.6%) included drug resistant coliform isolates. Species of the isolates were Eseherichia coli, Citrebaeter freundii and Klebsiella aerogenes.
2. Eighty-eight percent of these isolates was of multiple drug resistance. The most frequent patterns of the isolates were SM·APC (62.7), SM·SA (10.7%) and TC·CP·SM·SA·APC (6.7%).
3. Of 75 resistant coliform isolates, 10 strains (13.3%) possessed R plasmids capable of conjugal transfer. The resistance patterns of R plasmids were multiple resistance. Especially, the incidence of transferable drug resistance in E. coli strains were much higher than in the other coliforms, and the resistance patterns of the R plasmids were (TC·CP·SM·SA·APC) - and (SM·SA) -resistance.
4. R plasmids derived from drug resistant coliform isolates were transferred to E. coli K-12 ML1410 at the transmission frequency of about 10-2-10-3 per one donor.
5. Drug resistant coliform isolates carried two types of R plasmids, i. e., fi+ R and fi- R plasmid.View full abstractDownload PDF (912K) -
Takashi HAMANO, Yukimasa MITSUHASHI, Yukio MATSUKI1978 Volume 19 Issue 1 Pages 56-61
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSA method was established for determination of Sulfur dioxide in foods which was based on a combination of head space technique with gas chromatography equipped with a flame photometric detector.
Sample (5-20g) was added to 50ml of Sodium mercury tetra chloride solution, then ajusted the pH to 7.0-7.5 with 5% Sodium bicarbonate solution and filled up to 100ml with Sodium mercury tetra chloride solution. After extracted for 4hr at room temperature, 1ml of extract was added to a vial containing 5ml of 50% phosphoric acid and sealed the top with silicon rubber cap and stood for 10min at 30°C. The head space gas (0.5ml) in the vial was analysed by gas chromatography.
This gas chromatographic method was proved to be excellent in reproducibility and minimum limit of quantitative analysis was 2μg as Sulfer dioxide. Other sulfur compounds did not interfere the determination.
Recovery rates conducted on various foods were 95.3-101% at levels of 10-2000ppm.View full abstractDownload PDF (788K) -
Naomichi KUNISAKI, Hiroshi MATSUURA, Makoto HAYASHI1978 Volume 19 Issue 1 Pages 62-67
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSAbsorption and decomposition of N-Nitrosodimethylamine (NDM) in rats were studied in vivo and in vitro. The results obtained were as follows.
1) When NDM was orally administered to rats (50mg/kg), the concentrations of NDM in blood, liver and kidney were maximun at 1hr, then rapidly decreased, and not detected at 4hr after. On the other hand, the amount of NDM excreted in 24-hr urine was only about 1.3% of dose, and increased 2-fold in the rats which were previously administered with NDM.
2) NDM was rapidly absorbed from intestine and slowly from stomach in in vitro experiments.
3) NDM was enzymatically decomposed by liver slice and the decomposition was also decreased in NDM treated animals.View full abstractDownload PDF (873K) -
Investigation about the Lipids and their Unsaponifiable MattersYukuho NAKAYAMA, Nobuko KAWAI, Toshitaka MORI, Sadao MATSUOKA, Hachiro ...1978 Volume 19 Issue 1 Pages 68-72
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSThe muscle of rudder fish (one of the deep-sea fishes, Centrolophus niger: Stromateidae) contained a large amount of lipid which showed an extremely higher value for unsaponifiable matter contents and lower saponification value than of other fishes. Moreover the lipid showed very low triglyceride contents. The trimethylsilyl derivatives of unsaponifiable matters were analyzed by the methods of gas-liquid chromatography and mass spectrometry. These results assured that the unsaponifiable matters had the 1, 2-diol structure, and were presumed to be glyceryl ethers. We also investigated about the muscle lipids of some deep-sea fishes (silver king fish: Rexea solandri, silver fish: Sriollela punctata, Black cod: Anopiopoma fimbria). The triglyceride was the major constituent of their muscle lipids. Among them, silver king fish had the lowest saponification value and the highest contents for unsaponifiable matters which showed the same properties as that of rudder fish.View full abstractDownload PDF (746K) -
Identification of Glyceryl Ethers in the Unsaponifiable MattersNobuko KAWAI, Yukuho NAKAYAMA, Hachiro AKEHASHI1978 Volume 19 Issue 1 Pages 73-77
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSIn the previous paper, it was assumed that the unsaponifiable matters of rudder fish and silver king fish had the 1, 2-diol structure. This paper showed the existence of the C-O-C bond (ether bond) by means of infrared spectroscopy and hydrogen iodide degradation. Therefore the unsaponifiable matters were presumed to be glyceryl ethers and the molecular weights were measured by the mass spectroscopy of their isopropyridene derivatives. The glyceryl ethers bind two carboxylic acids and exist as diacyl glyceryl ethers in the lipids. It may be that the low eyolution, the inhabitation of deep-sea and the function of the body were considered as the cause of the existence of diacyl glyceryl ethers. It is suspected that diacyl glyceryl ethers in rudder fish may cause diarrhea for somebody.View full abstractDownload PDF (718K) -
Investigation on Polychlorodibenzofuran FormationHideaki MIYATA, Takashi KASHIMOTO1978 Volume 19 Issue 1 Pages 78-84
Published: February 05, 1978
Released on J-STAGE: July 27, 2010
JOURNAL FREE ACCESSThe concentrations of polychlorodibenzofuran (PCDF) in two KC-400s which were used as thermotransfer medium was 8.4 (277ppm) and 15.5 (510ppm) times higher than that in original KC-400 preparation. These PCDFs were mainly composed of tetra-, penta- and hexa-chlorodibenzofuran. The component ratio of higher chlorinated PCDFs increased in thermotransfer medium which was used for long period under high temperature. The PCDF components in thermotransfer media were similar to that of Kanemi Rice Oils which caused “Kanemi Yusho, ” but the ratios of PCDF versus PCB concentration in thermotransfer media were lower one to two order in comparison with that of the Kanemi Rice Oils.
On the other hand, when KC-400 sealed in glass ampules was heated at 180 to 300°C, a little PCDF was genetated from PCB. When heating temperature was rised to 360°C, PCDF formed clearly, and its concentration became 2 to 2.8 times in comparison with that of non heating KC-400. Stainless steal acted catalytically on the PCDF formation. It became clear that water also accelerated the PCDF formation. However, PCDFs in heated KC-400 were mainly composed tri- to penta-chlorodibenzofuran, and the component was different from that of PCDF in Kanemi Rice Oils.View full abstractDownload PDF (819K) -
Ayako SAKAI, Kunie YOSHIKAWA, Hiroshi KURATA, Akio TANIMURA1978 Volume 19 Issue 1 Pages 85-90
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSThe nitrosation of methyl N-methylanthranilate (MMA), which is permitted to be used to foods as flavor in Japan, with equimolar nitrite was measured at 37°C at the concentrations of 10-1-10mM of both reactants. MMA was nitrosated very easily, and when 0.1mM of MMA was reacted with equimolar sodium nitrite at pH 2.0 fbr 5min and at pH 3.0 for 20min, the yields of methyl N-methyl-N-nitrosoanthranilate (NO-MMA) were 89.5% and 82.6%, respectively. The rate of nitrosation was found to be dependent on the acidity of reaction mixture and the highest yields of NO-MMA was obtained below pH 2.0 at the MMA concentration of 0.2mM for 5min. A mutation test of NO-MMA was carried out, but NO-MMA was non-mutagenic to Salmonella typhimurium tester strain TA 100 and TA 98 in the presence and absence of the metabolic activation system (S9 mix).View full abstractDownload PDF (856K) -
Salivary Secretion and Urinary Excretion of Nitrosatable Compounds in ManHajimu ISHIWATA, Hiroko MIZUSHIRO, Akio TANIMURA, Toshiro MURATA1978 Volume 19 Issue 1 Pages 91-97
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSLevels of nitrosatable compounds in saliva and urine were determined. The mean value, which was calculated as equivalent to dimethylamine (DMA) in 25 human saliva samples cellected from 11 subjects was 0.3±0.2ppm. When a subject ingested the foods containing low levels of volatile nitrosatable compounds the concentration of nitrosatable compounds in saliva was less than 0.2ppm over the day, but increased to 1.0ppm 1hr after the ingestion of 100mg of DMA·HCl with 100ml of water. DMA remaining in the oral cavity after the ingestion of DMA·HCl disappeared within 20min. No changc in the concentration of nitrosatable compounds was observed when the saliva collected 1hr after the ingestien of DMA·HCl was incubated a t 37°C for 2hr. DMA was identified as the main nitrosatable compound in saliva, which was cellected after the ingestion of DMA·HCl, by thin-layer chromategraphy and gas liquid chromatography. The pattern of the time course of urinary excretion of nitrosatable compounds after the ingestion of DMA·HCl was almost similar to that of the salivaly secretion. About 95% of DMA ingested was presumcd to be excreted as nitresatable compounds into 24-hr urine.
The mean value of the amounts of nitrosatable compounds excreted in the 24hr urine collected from 9 subjects was 21.1±9.3mg and that of volatile nitrosatable compounds contained in the foods and beverages ingested for the experimental period was 10.4±6.9mg.View full abstractDownload PDF (1049K) -
Takeshi TERAYAMA, Masao SHINGAKI, Sumio YAMADA, Hiroshi USHIODA, Hideo ...1978 Volume 19 Issue 1 Pages 98-104
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSDuring the period from July 1975 through October 1976, a total of 3, 551 samples of commercial food, consisting of 730 soybean curd (Tofu), 698 sandwiches and salad, 698 European type of cake, 485 boiled Japanese noodle, 259 Japanese cake, and 681 miscellaneous foods in Tokyo, was subjected for the presence of Bacillus cereus. Of them, 398 (54.5%) of soybean curd, 79 (11.3%) of sandwiches and salad, 74 (10.6%) of European type of cake, 44 (9.1%) of boiled Japanese noodle, 15 (5.8%) of Japanese cake, and 57 (8.4%) of miscellaneous foods were found to be contaminated with B. cereus. The most highly contaminated food was soybean curd with a maximum amounts of 106/g of the organisms, while other foods were found to be contaminated with 102-104/g of the organisms.
When 667 B. cereus isolates were typed by their flagella antigens by the method described by Taylor and Gilbert, 150 (22.5%) isolates were typed into their 1-18 serotypes and 276 (41.4%) were typed into the additional our own T1-T12 serotypes, while the rest of 241 (36.1%) were untypable. Of the typed isolates, 88 were typed as T11, 48 as type 1, 31 as type 4, 30 as T8, and the rest of the isolates as various serotypes except types 2 and 6. Most of the T11 strains were the ones isolated from soybean curd.View full abstractDownload PDF (1159K) -
Masahiko UYETA, Sakae TAUE, Koshi CHIKASAWA, Masanori MAZAKI1978 Volume 19 Issue 1 Pages 105-111
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSA great number of papers have been published on mercury residues in rice grains and mercury contents in Japanese human hair. In those papers, however, little attention has been given to the relationship between the mercury contamination in human hair and in rice grains. In this paper it was described that mercury residues in polished and in unpolished rice grains decreased rapidly since 1968 when the use of mercury pesticide was prohibited in rice fields, and were reduced to the back ground levels (0.01-0.02ppm) in 1972. Whereas mercury contents in Japanese human hair showed almost no decrease during the period of twelve years from 1965 to 1976.
Although it is reported that mercury contents in human hair is an indicator of mercury contamination in food, the correlation between the mercury contents in hair and the amounts of daily intakes of mercury was not found In this work. This might be an indication that we should reconsider the toxicological significance of mercury residues in human hair.View full abstractDownload PDF (907K) -
Hitoshi HONDA, Miyuki ISHIKAWA, Hideaki YAMANAKA, Takeaki KIKUCHI, Kei ...1978 Volume 19 Issue 1 Pages 112-116
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSThree different series of rearing experiments were conducted using sea bream (Chrysophrys major) and sea bass (Lateolabrax japonicus) to observe the accumulation of mercury in major tissues of the fish via gill or skin and feeding materials.
In the first group, fish were fed with commercial pellet feed in the sea water containing mercuric chloride at a level of 0.1ppm of Hg. The second group of fish were fed with the pellets containing methyl mercury at a level of 0.85ppm of Hg. The pellets were prepared from a species naturally contaminated by methylmerculry. In the third series, fish were fed with the pellets added by mercuric chloride at a level of 1ppm of Hg.
In the first group, mercury moved into the tissues very rapidly, in particular, accumulation was large in kidney and spleen, whereby a retarded accumulation was shown in the second group. In the last group of fish, only a minor accumulation was seen in the different tissues of the two species of test fish. Less than 5% of mercury was absorbed through intestine of the fish when mercuric chloride was given as the adjunct of pellet feed.
Since no appreciable increase was observed in the level of methylmercury in the groups fed by mercuric chloride or reared in mercuric chloride-added sea water, methylation of mereury may hardly takes place in the living tissues of fish.
Consequently, the presence of methylmercury in the tissues of fish should mainly depend upon their food chain rather than direct absorption from sea water.View full abstractDownload PDF (693K) -
Yataro KOKUBO, Shigeru MATSUSHITA, Akemi KAI, Mitsuru YAMADA, Hirotaka ...1978 Volume 19 Issue 1 Pages 117-121
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSDuring the period from October 1976 through March 1977, a total of 405 raw oyster samples mainly obtained at Tokyo Central Wholesale Market were subjected for the presence of Escherichia coli. Enumeration of E. coli in the specimens was made by a standard simplified multiple tube technique with EC broth.
Of the specimens tested, 229 (56.5%) were found to be contaminated with E. coli, and 39 of the positive samples, accounting for 9.6% of the total samples tested, had harbored greater than 230/100g of the organisms. Among the specimens tested, those originated from Hiroshima Prefecture tended to show more heavy and frequent contamination with E. coli than those from the other areas. In addition to this fact, the increase of E. coli contamination was observed on oyster samples obtained in December.
Among the 138 isolates tested for their producibility of the enterotoxin, 4 (2.9%) strains were found to be the enterotoxin producers. Of these, strains 1 strain isolated from the oyster originated from Hiroshima Prefecture was a producer of sole heat-labile enterotoxin (LT, ) while the other 3 strains isolated from the oyster originated from Iwate and Mie Prefectures were the producers of sole heat-stable enterotoxin (ST). Two ST-producing strains were identified as their serotypes of 025: H42 and 020: H-, but the other 1 strain of H- was remained 0 untypable. One LT-producing strain was 0 untypable and H2.View full abstractDownload PDF (929K) -
Mutagenicity of N-Nitroso Derivatives of 3-Methylphenyl N-Methylcarbamate, 3, 4-Dimethylphenyl N-Methylcarbamate and Naphthyl N-MethylcarbamateAyako SAKAI, Kunie YOSHIKAWA, Hiroshi KURATA, Akio TANIMURA1978 Volume 19 Issue 1 Pages 122-125
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSN-Methylcarbamate insecticides, 3-methylphenyl N-methylcarbamate, 3, 4-dimethylphenyl N-methylcarbamate and naphthyl N-methylcarbamate, and their N-nitroso derivatives were tested for mutagenic activity to Salmonella typhimurium TA 98 and TA 100 in the presence and absence of metabolic activation system (rat liver microsomal preparation, “S-9 mix”). The nitroso derivatives were mutagenic for strain TA 100 without S-9 mix but not for strain TA 98, indicating that the nitroso derivatives were potent base-change mutagens. The mutagenic activity of nitroso derivatives for strain TA 100 was found to disappeared in the presence of S-9 mix. Neither strain TA 100 nor strain TA 98 responded to N-methylcarbamate insecticides with or without S-9 mix.View full abstractDownload PDF (495K) -
Hideaki MIYATA, Takashi KASHIMOTO, Nobuharu KUMTA1978 Volume 19 Issue 1 Pages 126-127
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSDownload PDF (257K) -
Yuichi WADA, Mitsumasa KAWABATA, Juyu KIYOTANI, Keiko KOBAYASHI, Tetsu ...1978 Volume 19 Issue 1 Pages 128-132
Published: February 05, 1978
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESS
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