Previous report (Aiso et al, 1962) dealt with macroscopic examination of rats fed 2- (2-furyl) -3- (5-nitro-2-furyl) acryl amide and nitrofurazone. In the present study we have observed their liver, kindney, heart, spleen and testis histologically.
Degenerative changes, atrophy, hydropic degeneration, pyknosis, and fatty metamorphosis of the hepatic cells, were observed in all groups of the rats fed nitrofurazone, but the extend of disorders was mild in general, and the degree of changes was more intensive when the rate of chemical concentration in the diet was increased. Cirrhotic changes were not recognized.
On th contrary, the tendency of hypertrophy of the hepatic cells was noted in the rats fed 2- (2-furyl) -3- (5-nitro-2-furyl) acryl amide, especially at the 0.02% and 0.2% level. Degenerative changes were markedly observed in only a group of rats fed the diet at the level of 0.2% for one year, and their growth was retarded. Cirrhotic changes were also not recognized.
There was nothing of the neoplastic changes in hepatic cells of all the rats fed both derivatives.
Remarkable toxic effect in the kidney, heart, spleen and testis was not observed in all groups fed both compounds.
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