Although infection of
Porphyromonas gingivalis (
P. gingivalis) is closely correlated with progress of vascular inflammatory diseases, distinctive pathogenesis induced by
P. gingivalis is still elusive. We investigated the impact of
P. gingivalis lipopolysaccharide (
P. gingivalis-LPS) on gene expression in endothelial cells with comparison to
Escherichia coli lipopolysaccharide (
E. coli-LPS) and zymosan. Here, we showed that the expressions of interleukin-6 and tumor necrosis factor-α mRNA induced by
P. gingivalis-LPS are much lower than those by
E. coli-LPS, and that the expressions of interleukin-8 and hypoxia inducible factor-2α are also lower than those by zymosan. These effects of
P. gingivalis-LPS-mediated alterations of gene expression were cancelled in the absence of fetal bovine serum in culture medium. Of note,
P. gingivalis-LPS treatment reduced the gene expressions of tissue factor and plasminogen activating inhibitor-1 as opposed to either
E. coli-LPS or zymosan treatment. Our finding suggests that alterations of gene expression pattern in endothelial cells mediated by
P. gingivalis-LPS may contribute to the pathogenesis of vascular inflammatory diseases.
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