Skin Cancer
Online ISSN : 1884-3549
Print ISSN : 0915-3535
ISSN-L : 0915-3535
16 巻 , 1 号
選択された号の論文の25件中1~25を表示しています
  • 田矢 洋一
    2001 年 16 巻 1 号 p. 7-12
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    Many acumulating data have suggested that most of signals of oncoproteins and tummor suppressor proteins are transmitted to two basic pathways: the RB pathway and the p53 pathway. In fact, mutations are detected in both of these pathways in almost 100% of cancers.
    Upon DNA damage, p53 protein accumulates rapidly through a posttranscriptional mechanism (s) and is also activated as a transcription factor, which then leads to growth arrest or apoptosis. We have generated antibodies which recognize most of the potential phosphorylation (13 sites) and acetylation sites (3 sites) of p53, and using these antibodies, we have shown that phosphorylation of human p53 at serine 15 and 20 occurs after DNA damage and that this leads to reduced interaction of p53 with its negative regulator, MDM2. Subsequently, we have also shown that ATM protein has intrinsic protein kinase activity and that it phosphorylates Ser15 of p53.
    It is an important question how two different pathways, apoptosis and Gl-arrest, are selected by p53. We have now found that phosphorylation of Ser46 regulates apoptosis-inducing ability of p53. Dr. Yusuke Nakamura's lab. has isolated such a candidate apoptosis-inducing gene which is regulated by phosphorylation of Ser46 of p53. It is p53AIPl (p53-regulated Apoptosis Inducing Protein 1) . It appears that swich between promoters of Gl-arrest and apoptosis genes occurs by Ser46 phosphorylation. This mechanism can be applied for development of a new cancer therapy method without side effects caused by DNA damage in normal cells. [Skin Cancer (Japan) 2001; 16: 7-12]
  • 小口 真司, 斎田 俊明
    2001 年 16 巻 1 号 p. 13-21
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    We investigated the characteristic dermoscopic features of early lesions of malignant melanoma. On dermoscopy, malignant melanoma in situ and the macular portions of invasive malignant melanoma affecting glabrous skin showed accentuated pigmentation on the ridges of the skin markings, which are arranged in parallel. This “parallel ridge pattern” was exclusively found in malignant melanoma in situ and the macular portion of invasive malignant melanoma. In contrast, benign melanocytic nevi on glabrous skin showed, in most cases, one of the following 3 typical dermoscopic patterns: (1) parallel furrow pattern, (2) lattice-like pattern, and (3) fibrillar or filamentous pattern.
    On non-glabrous skin, malignant melanoma in situ and the macular portion of invasive malignant melanoma showed highly irregular pigment network, pseudopods, radial streaming and irregular black dots or brown globules. Other pigmented lesions such as basal cell carcinoma, seborrheic keratosis, solar lentigo and black heel also showed distinctive dermoscopic features, respectively. Because of these characteristic features, we can effectively detect early melanoma using this noninvasive method. [Skin Cancer (Japan) 2001; 16: 13-21]
  • 梅田 晋嗣, 南 祥一郎, 横谷 仁美, 矢野 倫子, 栗木 安弘, 松本 二郎, 伊藤 孝明, 喜多野 征夫
    2001 年 16 巻 1 号 p. 22-26
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    (Case 1) A 2-year-old girl, there was a blackish eruption that rice size on the inside of her left upper arm at birth. She consulted us alteration of its shape and color from two month ago. We diagnosed it MM by extralesional biopsy and removed it.
    (Case 2) A 5-year-old boy, 1 year ago, he noticed blackish eruption on his left sole about 1mm diameter. He consulted us gradually spreading of it. We operated extraction of it, and diagnosed it MM.
    (Case 3) A 3-year-old girl, when she was 6 months old, a blackish eruption appeared on the third fingertip of her left hand. We diagnosed it MM by extraction of it. Past 5 years, we experience 20 cases of MM, 3cases of. that is in childhood. [Skin Cancer (Japan) 2001; 16: 22-26]
  • 深津(横尾) 藤子, 富田 靖, 加藤 吉弘, 涌井 玲子, 羽根田 牧, 堀口 大輔
    2001 年 16 巻 1 号 p. 27-32
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    We report a rare case of melanoma of unknown primary origin with visceral and skin metastases. A 24-year-old man noted itchy tumors in the right lower leg and abdomen one month before admission. The tumors were biopsied and diagnosed as metastatic melanoma. Various examinations revealed many metastatic tumors in the lung, the lymph nodes and the skin, but no primary resion. We tried chemotherapy so-called DAV-Feron (DTIC, ACNU, VCR, IFN-β) first, with successful regression of lymph nodes in the axilla. After cutaneous nodules increased, we next tried DAC-Tam (DTIC, ACNU, CDDP, Tamoxifen), and they began to regress two months after starting the chemotherapy. Although the lung metastatic lesions were slowly growing, other metastatic tumors in the lymph nodes and the skin were regressed by the daily administration of tamoxifen for 18 months since his admission.[Skin Cancer (Japan) 2001; 16: 27-32]
  • 澤井 孝宏, 清原 隆広, 熊切 正信, 竹内 章晃, 桑原 宏昌, 浅野 歩, 平井 行一郎
    2001 年 16 巻 1 号 p. 33-36
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    A 76-year-old man presented with a 8×16 mm black plaque on his left ear. The plaque had increased in size for the previous two years. He visited us on March 3, 1999, because of its bleeding. Since the clinical diagnosis was malignant melanoma, the lesion was totally excised with 2mm margin.
    Histopathological findings revealed only one small nest in the papilally dermis in addition to the characterisitics of melanoma in situ. Although the lesion was thought to be within the microinvasive melanoma of pTINOMO stage I, a lymph node metastasis was followed two months after the operation. And he died of multiple metastasis, ten months after the operation.
    It is doubtful whether all microinvasive melanomas are in a radial-growth-phase which is said to have no potential to metastasize. We think that our case corresponded with invasive melanoma with spontaneous regression and histopathologically non-invasive appearance. The diagnosis of microinvasive melanoma should be done carefully. [Skin Cancer (Japan) 2001; 16: 33-36]
  • 森 勝典, 安藤 巌夫, 久木田 淳
    2001 年 16 巻 1 号 p. 37-40
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    A 76-year-old man had a tumor on the right lower leg for a year. It was a diameter 3cm, reddish-brown. There was an ulcer of a diameter 2cm on the center of the tumor and a hyperkeratotic leision around the ulcer. Histopathologically, in the center of the speciman, there were islands of squamoid and basaloid tumor cells with necrosis of central areas, ductal luminas, and direct contination with normal epidermis. It was considered eccrine porocarcinoma. In the peripheral of thespeciman, there was an acanthotic leision with mitosis, keratinocytic atypia, and multinucleation. We considered it was Bowen's disease. Imunohistochemically, eccrine porocarcinoma expressed a cytokeratin pattern which was different from Bowen's disease. We considered our case was Bowen's disease with invasive carcinoma.
    The patient had the examination for internal malignancy, and a colon cancer was discovered. [Skin Cancer (Japan) 2001; 16: 37-40]
  • 岡田 裕之, 鈴木 拓, 金子 博行, 丸石 貴子, 根本 裕次, 本田 実, 渡辺 晋一
    2001 年 16 巻 1 号 p. 41-43
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    We reported a 72-year-old women with Bowen's disease around the right periorbital area involving the conjunctiva. A tumor resected on her right upper eyelid margin at an ophthalmological clinic, 11 years ago. Furthermore, anoperation was performed for blepharoptosis and symblepharon at the Department of Ophthalmology in our hospital. However, symblepharon had recurred, and shedeveloped an erythematous lesion around her right periorbital area. Histopathological examination revealed that it was Bowen's disease (SCC in situ) . Tumor cells invaded to the conjunctival and corneal epithelum, but not to the dermis nor submucosa. We speculated the first operation may be the cause of dissemination of the tumor cells to the conjunctiva, and the development of this eccentric manifestation. [Skin Cancer (Japan) 2001; 16: 41-43]
  • 安齋 眞一
    2001 年 16 巻 1 号 p. 44-46
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    I report a case of 50-year-old male with brain metastasis from genital squamous cell carcinoma of the skin. At his first visit, a giant tumor was seen on his lower abdomen and metastases to para-aortic lymph nodes were already observed as well as to inguinal and external iliac nodes. The tumor had slightly decreased in size by chemotherapy and irradiation. He complaint of loss of power in his both legs five months after his first visit. Multiple metastases to vertebrae, iliac bone and brain were detected by computed tomographic examination. He died of the tumor eight months after his first visit.
    Brain metastasis from cutaneous squamous cell carcinoma is extremely rare, and to our best of knowledge, no other case has been reported other than direct invasion from squamous cell carcinoma arising on face. [Skin Cancer (Japan) 2001; 16: 44-46]
  • 清水 史明, 渋谷 博美, 加藤 愛子, 浅田 裕司, 寺師 浩人, 藤原 作平, 高安 進
    2001 年 16 巻 1 号 p. 47-50
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    A-75-year-old man developed a rapidly growing tumor followed by swelling of regional lymph nodes, on the left side of his scrotum. Histopathological examination of the tumor revealed a deep invasion of atypical squamous cells associated with embolism of dermal lymphatic vessels by tumor cells, as far as 4cm apart from the tumor. Wide local excision of the tumor including total scrotal skin and bilateral ilioinguinal lymph node dissection was performed. Subsequently five courses of chemotherapy with cisplatin and fluorouracil and radiotherapy were added. In spite of these treatments, he had a recurrence located on the posterior border of the grafted skin of scrotum one year after the operation. [Skin Cancer (Japan) 2001; 16: 47-50]
  • 関 詩穂, 塩原 順子, 市川 健, 小口 真司, 河内 繁雄, 斎田 俊明, 二條 貞子
    2001 年 16 巻 1 号 p. 51-55
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    A 63 year-old man with Merkel cell carcinoma is reported. He noticed an asymptomatic reddish macule on his left lower leg about 8 years previously. The lesion gradually enlarged to a nodule. As the nodule expanded rapidly during past 3 months, he visited our hospital. At his first visit, the lesion was seen as a 70×70mm, indurated reddish plaque accompanied with a dark reddish nodule of 47×45×18mm in size. Biopsy specimen revealed aggregation of atypical small tumor cells, that were immunohistochemically positive for CK20, chromogranine A, and NSE, supporting the diagnosis of Merkel cell carcinoma. We performed wide resection of the primary lesion along with left inguinal lymph node dissection. Inguinal lymph node metastases were confirmed histopathologically. Postoperatively, radiotherapy (50.4Gy XRT) was perfoemed. However, multiple metastases to the liver, pancreas, and distant lymph nodes and local reccurence developed. He was treated with CAV/PE alternating chemotheapy. The metast tic and recurrent lesions reduced, indicating effectiveness of this regimen. After 4 months from the introduction of chemotherapy, the lesions enlarged again. Other regimens of chemotherapy were performed, but he was died due to complication of DIC. [Skin Cancer (Japan) 2001; 16: 51-55]
  • 野間 陽子, 村上 信司, 橋本 公二
    2001 年 16 巻 1 号 p. 56-61
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    We reported a 41-year-old man of primary cutaneous B-cell lymphoma with brain metastasis. He manifestated reddish nodules two times during two years. Radiotherapy and combination chemotherapy resulted in a complete remission each time. But 4 years later, nausea, vomitting and hemiparesis appeared. MRI scan revealed multiple lesions showing hypointensity on T1-weighted and hyperintensity on T2-weigheted images of the brain. Enhancement and edema were not observed, which is rare in intracranial lymphoma by CT and/or MRI examination. It was difficult to distinguish malignant lymphoma from multiple sclerosis based on this findings. Administration of dexamethasone reduced the size of lesions at first. But hemiparesis progressed regardless after use of dexamethasone. Based this finding we started whole-brain irradiation, which resulted in respiratory failure. Finally he died of DIC. Autopsy revealed the presence of atypical lymphocytes in the brain. [Skin Cancer (Japan) 2001; 16: 56-61]
  • 水野 尚, 岡澤 ひろみ, 村上 麻里, 馬場 直子, 石井 則久, 池澤 善郎, 長谷 哲男
    2001 年 16 巻 1 号 p. 62-66
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    We describe a 54-year-old man with Sêzary syndrome (SS). He visited our hospital on April 14, 1998. Medical examination showed exfoliative pruritic erythroderma and lymphadenopathy in the neck, axillae and groins. The white blood cell count was 5200/μl with 5% atypical lymphoid cells. The CD4/CD8 ratio was 2.99. The rearrangement study of the peripheral blood with a DNA probe directed against the Cβ 1 gene of the T-cell receptor showed evidence of the presence of a monoclonal T-cell population. A skin biopsy showed a dense band-like upper dermal infiltrate comprising small sized atypical lymphocytes. These atypical cells showed epidermotropism and Pautrier microabscesses were found in the epidermis. Immunohistochemistry revealed these atypicsal cells were CD2+, CD3+, CD4+, CD5+, CD7-, CD8-, CD22-. Biopsy of a lymph node showed infiltration of small atypical cells in the paracortical zones with partial effacement of the lympho node architecture. Flow cytometric analysis of lymph node specimen showed almost same phenotype as sikn infiltrate. The diagnosis of SS was established. Treatments including combination chemotherapies, interferon and predonisone were not effective, but the disease was indolent. On August, 2000, he was treated with methotrexate and erythroderma was slightly improved. [Skin Cancer (Japan) 2001; 16: 62-66]
  • 信原 聡美, 小西 洋平, 高橋 健造, 田中 俊宏, 宮地 良樹, 和田 康夫, 白神 悟史, 谷口 政寿
    2001 年 16 巻 1 号 p. 67-71
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    We reported a case of cutaneous NK cell lymphoma. A 63 year-old woman had a solitary tumor on the right side of her back two years ago. Gradually the tumor developed. The biopsy showed dense infiltration of abnormal lymphocytes in the dermis and subcutaneous tissue. Those abnormal lymphocytes are large and had atypical nuclei and mitosis. Destructive infiltration to blood vessels was not observed. The immunophenotype was positive for CD56 and negative for other T cell and B cell histiocytic markers. The immunogenotype showed germline configurations for immunoglobulin heavy chain gene and T cell receptor gene. In situ hybridization using the anti-sense EBER RNA probe revealed negative. She received radiation and chemotherapy. After these treatments, the tumor sized down and disappered. [Skin Cancer (Japan) 2001; 16: 67-71]
  • 長谷川 洋一, 永岡 徹也, 近藤 美幾, 谷内 克成, 森 俊典, 坂井 秀彰, 高田 実, 竹原 和彦, 大溝 由香里, 福井 米正, ...
    2001 年 16 巻 1 号 p. 72-76
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    We report two cases of synovial type of clear cell sarcoma arising from the subcutaneous tissue of the back. The patients were 13-year-old girl and 47-year-old man, who presented with subcutaneous nodules on the back. Histologically, both tumors were composed of round or polygonal cells with clear cytoplasm and vesicular nuclei. Immunohistochemistry were negative for S-100 protein and HMB45. RTPCR analysis did not show the expression of hybrid EWS/ATF-1 transcript. One of the patient developed local recurrence, and the other developed multiple lung metastasis after the wide local excision of primary tumors. Combined chemotherapy with adriacin, cisplatin and caffeine were effective for these recurrent tumors. [Skin Cancer (Japan) 2001; 16: 72-76]
  • 渋谷 博美, 浅田 裕司, 寺師 浩人, 山口 都美子, 安西 三郎, 波多 野豊, 高安 進, 森 照明, 横山 繁生
    2001 年 16 巻 1 号 p. 77-82
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    A 22-year-old Japanese man visited our hospital with a large tumor on his occipital region. He first noted a nodule on his scalp when he was 14-years-old in 1986. Although the tumor was excised in 1987, he noticed recurrence one year later. Since then, surgical excision of recurrent tumors had been performed six times. In 1994, he complained of frequent headaches, walking disturbance and visual disorder. Physical examination revealed several large nodules located on the anterior border of the previously grafted skin. Magnetic resonance imaging showed the scalp mass invading the cerebral parenchyma. The recurrent tumors were further resected five times. In spite of the radiotherapy and chemotherapy, the tumor progressively disseminated into spinal cord, and he died of respiratory failure in January, 2000. [Skin Cancer (Japan) 2001; 16: 77-82]
  • 梶 ひろみ, 梶 彰吾, 伊木 秀郎
    2001 年 16 巻 1 号 p. 83-88
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    Sebaceous gland carcinoma is one of the most malignant tumor in the eye lid. High rate of recurrence have been reported due to inadequate excision of tumor because that the eye lid is the area especially needs functional and cosmetic repairing. We report focusing about the tumor excision and one-stage reconstruction of 5 cases of sebaceous gland carcinoma of the eyelid, using the palatal mucosal graft for conjunctival repair in combination with local skin flaps. As so far, tumor recurrence have not been observed with good cosmetic and good functional result.
    Complete tumor excision followed by one-stage anatomical and functional reconstruction should improve the prognosis and quality of life of patients. [Skin Cancer (Japan) 2001; 16: 83-88]
  • 西口 健, 磯田 憲一, 水谷 仁
    2001 年 16 巻 1 号 p. 89-92
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    Extraocular sebaceous carcinoma of the skin is uncommon neoplasm. We report a case of sebaceous carcinoma with gastric diffuse large B cell Lymphoma. A 76year old man had a ulcerated tumor measuring 15×15mm in size on his cheek. He was pointed out gastric diffuse large B cell Lymphoma at the same time. Two times of local excision had been performed, but he had a local recurrence. We tried radiotherapy that resulted in a complete remission of the skin region. [Skin Cancer (Japan) 2001; 16: 89-92]
  • 榎本 詩子, 西村 拓也, 幾井 宣行, 草壁 秀成, 清金 公裕
    2001 年 16 巻 1 号 p. 93-98
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    A 82-year old man was referred to our hospital for the treatment of the angiosarcoma of the scalp. Multiple collections of erythematous nodules and paples up to lcm in diameter were visible. We performed a wide surgical excision. Postoperatively, the patient started the intra-arterial injection of recombinant interleukin-2, but it was impossible to continue the treatment because of the side effect of the first administration, the paraplasia, the urinary incontinence and the enesthopathia. The cause of these side effects are unclear. Instead he received electron beam therapy of the scalp. He remained in good condition, and was discharged from the hospital. However, pulmonaly metastasis developed 8 months after the surgical excision. A chest x-ray and CT revealed reticulonodular shadow in the lower lung field. The patient then underwent the high-energy x-ray therapy for a total of 40 Gy. The hemopytis stopped and the manifest improvements of the shadow in the chest radiography and the CT were observed. This patient has had no evidence of recurrence 3 months after completion of radiation therapy. Highenergy X-ray may represent an effective treatment for lung metastases of angiosarcoma. [Skin Cancer (Japan) 2001; 16: 93-98]
  • 渡辺 洋, 橋本 彰, 高橋 和宏, 飯澤 理, 加藤 泰三
    2001 年 16 巻 1 号 p. 99-103
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    We reported two cases of angiosarcoma of the scalp (case 1: 71 years-old male, case 2: 68 years-old female) . Both patients showed recurrence of the skin after chemotherapy (carboplatin, ifosfamide, vindecine), and IL-2 therapy. Therefore we perfomed intravenous chemotherapy of docetaxel (40mg/body, once a week), that resulted in complete remission of the skin lesion (Case 1) and partial remission of cervical lymphnode (Case 2).
    In our cases, docetaxel was administrated in multi-therapy resistant patient, and it was effective. We suggest that docetaxel would be helpful for angiosarcoma of the scalp that resisted for the other therapy.[Skin Cancer (Japan) 2001; 16: 99-103]
  • 宮本 秀明, 石川 照子, 小野田 雅仁
    2001 年 16 巻 1 号 p. 104-109
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    We report a typical case of nevoid basal cell carcinoma syndrome (NBCCS) . The patient, a 71-year-old woman, visited us because of deformation of the lower eyelid due to ulcerated black lesions on the cheek. She had undergone surgery on thelower jawbone at the age of 38, and four black nodules on the face had been removed surgically at the age of 48. Her family history was non-contributory. At presentation, she had a large tumor measuring 60×56×25mm on the scalp and more than 80 black tumors on the head, trunk, buttocks, genitals and thigh. We resected 34 of the tumors, which were shown microscopically to be basal cell carcinoma. As well as the multiple basal cell carcinomas, the patient showed calcification of the falx, palmar pits, mandibular cysts, hypertelorism, frontal and temporal bossing and mild mandibular prognathism. The NBCCS tumors showed no aggressive malignancy. We intend to treat the remaining small tumors with liquid nitrogen and the large tumors by surgery. [Skin Cancer (Japan) 2001; 16: 104-109]
  • 月永 一郎, 吉田 哲憲
    2001 年 16 巻 1 号 p. 110-113
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    A 70 years old female first visited our hospital because of the tumor of her scalp in April 1997. She had had a operation of some skin adnexal tumor resected by plastic surgeon in 1990. Afterwards it was silent for years, but 3 years ago, it became ulcerated. On the occipital area, there were 2cm tumor atrophic epidermis with granular appearance. Histological findings revealed solid tumor consisted of basaloid cells. There were scar formation near the tumor islands, suture thread and granulation tissue with giant cells.[Skin Cancer (Japan) 2001; 16: 110-113]
  • 町田 秀樹, 中西 幸浩, 山本 明史, 山崎 直也, 野呂 佐知子, 石川 雅士, 石原 和之
    2001 年 16 巻 1 号 p. 114-119
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    Forty-five patients with extramammary Paget's disease (thirty-five male and tenfemale) treated at National Cancer Center Hospital between August 1975 and August 1999 were reviewed. The median age was 65 years (range 42 to 99 years) . The median follow-up was 62months (range 6 to 232 months) . Twenty-one patients had lesions on the scrotum, four on the penis, ten on the scrotum and penis, nine on the vulva, and one on the perianal region. Twenty-nine patients underwent clinical excision with >3cm macroscopic clearance of the surgical margins, nine underwent pathological excision with microscopic clearance of the surgical margins, and seven underwent conservative excision to preserve excretional and sexual function. The patients were divided into four groups according to histopathologic findings; 1. intraepithelial lesion (IE) : histologic findings of Paget cells within the epidermis and the adnexal epithelium, 2. minimally dermal invasion (MDI) : invasion of papillary dermis, 3. dermal invasion (DI) : invasion of reticular dermis, 4. subcutaneous invasion (SI) : invasion of subcutaneous fat tissue. Twelve patients were diagnosed with IE, twenty-four with MDI, five with DI, and four with SI. At the first surgery, four patients with SI and two with DI had lymph node metastasis, and three with SI had distant metastasis. The 5-year survival rate was 0% in SI patients, 80% in DI, 100% in MDI, and 100% in IE. The prognosis was related to the depth of invasion, not to the method of operation. [Skin Cancer (Japan) 2001; 16: 114-119]
  • 小澤 麻紀, 高橋 和宏, 加藤 泰三
    2001 年 16 巻 1 号 p. 120-123
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    We reported a 61-year old male patient with a huge solid tumor, which surface was reddish and granular, on his right axilla. The tumor had rapidly grown during one month.
    Histologically, nest of tumor cells was observed in dermis to subcutaneous tissue, and tumor cells had eosinophilic cytoplasm and atypical nuclei. Immunohisto-chemical examination showed that tumor cells were positive for cytokeratin, PAS (with diastase-resistance), and GCDFP-15, but not for vimentin and S-100 protein. A diagnosis of poor-differentiated sweat gland carcinoma was made.
    MRI examination revealed that the tumor extended to around right apical nodes. No obvious metastatic lesion was detected.
    In treatment, the selective intraarterial administration of cisplatin and systemic administration of adriamycin were combined with local X-ray irradiation. These combination therapy led to remarkable clinical resolution. [Skin Cancer (Japan) 2001; 16: 120-123]
  • 飛澤 慎一, 高橋 英俊, 山本 明美, 橋本 喜夫, 飯塚 一
    2001 年 16 巻 1 号 p. 124-127
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    We report a case of verrucous carcinoma of the glans penis. A 71-year-old man visited our hospital because of erythematous slightly infiltrated plaque on the glans penis. Histopathology disclosed that he had erythroplasia of Queyrat and the lesion was resected with 5mm margin. Three years later, he noticed 8mm×5mm-sized verrucous nodule on the excised area. Histopathology showed marked hyperkeratosis, irregular acanthosis and individual keratinization, but minimal cellular atypia. Immunohistochemical analysis for HPV was negative. He was treated by wide excision with skin graft, and no evidence for recurrence or metastasis has been detected so far. [Skin Cancer (Japan) 2001; 16 :124-127]
  • 前田 学, 澤田 陽子, 佐藤 美貴, 周 園, 岩田 仁, 笹岡 郁乎
    2001 年 16 巻 1 号 p. 128-131
    発行日: 2001/04/20
    公開日: 2010/08/05
    ジャーナル フリー
    Leiomyosarcomas, occurre in middle age and most common on the extremities, develop as solitary painful or tender intra-or subcutaneous nodules showing a relatively benign biologic course. We reported a 39-y-old female with intracutaneous leiomyosarcoma seen in the left inguinal region. She was in good health. First total resection was done under the diagnosis of infectious atheroma because of painful subcutaneous nodule, but histopathological feature showed that tumor nest consist of a poorly delineated proliferation of spindle-shaped atypical myomatous cells arranged in interlacing fascicle with positive smooth muscle actin stain. Wide local excision was carried out after the diagnosis. No recurrence was noted one year after the excision. [Skin Cancer (Japan) 2001; 16: 128-131]
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