Skin Cancer
Online ISSN : 1884-3549
Print ISSN : 0915-3535
ISSN-L : 0915-3535
16 巻 , 3 号
選択された号の論文の21件中1~21を表示しています
  • 石原 和之, 斎田 俊明, 山本 明史
    2001 年 16 巻 3 号 p. 281-288
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    A statistical investigation was conducted of Japanese angiosarcoma patients who had been registered by the Prognosis and Statistical Investigation Committee of the Japanese Skin Cancer Society. Data were obtained from 44 major medical institutions in Japan during the period from 1985 to 1995, and 162 patients were registered.
    The data analyzed included the age, sex, anatomical distribution, clinical features, immunohistochemical staining patterns and treatment of the primary lesions. The survival rate was assessed by the Kaplan-Meier method and the log-rank test.
    The commonest sites for angiosarcoma in both sexes were the head and face, and the prognosis was worse than that of tumors at other sites.
    To improve the prognosis, treatment including rIL-2 seems superior to treatment without rIL-2 at the present time. [Skin Cancer (Japan) 2001; 16: 281-288]
  • 石原 剛, 小野 友道
    2001 年 16 巻 3 号 p. 289-294
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    We report two cases of a malignant Schwannoma without NF-1. The first case was a 78-year-old female who presented with an elastic-hard, subcutaneous tumor on her left back area. In 1992, when she was 73 years old, the first resection was performed. In 1996, forty months after the first resection, it recurred locally without distant metastasis when she was 76 years old. After the second surgery, the tumor's origin was the accessory nerve based on surgical findings and post-operative clinical symptoms. In 1998, when she was 78 years old, lung metastasis was recognized.
    The second case was a 59-year-old male who presented with an elastic-hard tumor on his left thigh area. When he was 48 years old, he developed a bruise on his left leg. The tumor's origin was the lateral femoral cutaneous nerve based on surgical findings. Long-term follow-up is necessary for patients with malignant schwannoma with or without NF-1. [Skin Cancer (Japan) 2001; 16: 289-294]
  • 赤木 竜也, 出来尾 哲, 梶 彰吾, 林 忍
    2001 年 16 巻 3 号 p. 295-298
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    A 58-year-old Japanese male had developed an ulcerated skin tumor on the burn scar of the right foot. He had been burned on the hearth 55 years previously. The histopathological examination of the tumor revealed that it was squamous cell carcinoma, i.e., burn scar carcinoma. He was treated with amputation of the right foot and dissection of lymphnodes of the right inguinal area. [Skin Cancer (Japan) 2001; 16: 295-298]
  • 石原 剛
    2001 年 16 巻 3 号 p. 299-304
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    The location of sentinel lymph nodes was evaluated about the head and neck, and the axilla area using blue dye. In the axilla area, sentinel lymph nodes were mainly located in the central and lateral lymph nodes, because the lateral and central lymph nodes were draining mainly the deep lymph channels of the upper extremity. However, the case with metastasis in several lymph nodes has a lower detection rate in the original sentinel lymph nodes because of the change in lymph flow, and the evaluation of the cubital lymph node is a study assignment. In the head and neck area, the location of sentinel lymph nodes was almost in accord with anatomical lymph flows ; sentinel lymph nodes were recognized in submandibular lymph nodes which originated in cheek skin tumors, submental lymph nodes which originated in underlip skin tumors, pre-auricular lymph nodes which originated in temporal skin tumors, and occipital lymph nodes which originated in occipital skin tumors. The lymph vessels of the head and neck area were s ort, and both afferent lymph vessels and efferent lymph vessels were dyed. [Skin Cancer (Japan) 2001; 16: 299-304]
  • 高橋 義雄, 難波 祐三郎, 光嶋 勲, 安藤 陽夫, 清水 信義
    2001 年 16 巻 3 号 p. 305-309
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    A-68-year-old man had a tumor on the thoracic wall for two years. It had a diameter of 10cm, and was elastically hard. Histopathological findings showed fibrous tissue made of compact and mature fibroblasts and collagen fibers. Fbbroblasts are small, slender nuclei with rare mitotic figures. We diagnosed that tumor as a desmoid tumor. Tumor resection was performed; a large defect (20×20cm) in the trunk had to be reconstructed. We showed a new strategy of repairing soft-tissue defects in the thoracic wall. We utilized two flaps, which are both pedicled latissimus dorsi muscle perforator flaps. One is perforated from the circumflex scapular artery, which we call a scapular flap, and the other is perforated from the intercostal artery. We propose these flaps latissimus dorsi perforator flaps and demonstrated some points of technique for the repairing of soft-tissue defects in the thoracic wall and rising musculocutaneous flaps. [Skin Cancer (Japan) 2001; 16: 305-309]
  • 大畑 千佳, 河原 邦光
    2001 年 16 巻 3 号 p. 310-313
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    A-28-year-old Japanese woman presented with a black papule 3×5mm in size on the left buttock that had developed within the preceding 2 years. The lesion was excised under local anesthesia. Light microscopic examination revealed an increased number of melanocytes arranged as solitary units and in nests situated at the dermo-epidermal junction and above it. The melanocytes had abundunt cytoplasms and large nuclei with prominent nucleoli. However, the lesion was symmetrical and well-circumscribed. It was diagnosed as Spitz's nevus and did not recur during a 1 year of follow-up. [Skin Cancer (Japan) 2001; 16: 310-313]
  • 雄山 瑞栄, 山村 真弘, 清島 真理子, 小林 英敏
    2001 年 16 巻 3 号 p. 314-318
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    We report a case of malignant melanoma of a 44-year-old female. The patient developed a subcutaneous nodule on her scalp during the past 3 months. It was diagnosed as maligmant melanoma by biopsy of the subcutaneous nodule, and she was treated with combination chemotherapy with dacarbazine (DTIC), ACNU, vincristine (VCR) and interferon (IFN) β after the operative excision of the nodule with a 3 cm margin around the lesion. After 3 years, lung metastasis was found and combination chemotherapy with DTIC, ACNU, cisplatin (CDDP) and tamoxifen (TAM) and a combination of IFN α and DTIC were performed, but they were not effective. Recently, metastases to the left coxa, right tibia and right femur occurred and the bone metastases caused intolerable pain which necessitated the administration of morphine sulfate. Radiotherapy (70Gy, 60Gy and 35Gy) was performed for these bone metastases, respectively. The pain disappeared, although the sizes of the lesions did not change. [Skin Cancer (Japan) 2001; 16: 314-318]
  • 寺師 浩人, 松尾 由紀, 竹尾 直子, 多田 英行, 浅田 裕司, 園田 広典, 高下 光弘, 澁谷 博美, 藤原 作平, 高安 進, 横 ...
    2001 年 16 巻 3 号 p. 319-323
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    We reported a 42-year-old female patient with a malignant peripheral nerve sheath tumor (MPNST) arising within the radial nerve in her left axilla. She had noticed a subcutaneous mass in this area in 1988. The tumor had grown slowly. We performed partial excision of the tumor in 1997, which was histologically diagnosed as a plexiform neurofibroma. Since then, it increased in size more rapidly, became harder, and was complicated with pain. In August 2000, we performed a second partial excision and confirmed the malignant change. The tumor was totally excised and radical dissection of the lymph nodes of the left axilla was performed. Resulting radial nerve palsy was relieved by tendon transfers which were done one month later. She returned to work as a nurse two months after the last surgery. [Skin Cancer (Japan) 2001; 16: 319-323]
  • 岩田 浩明, 山崎 隆治, 荒木 麻里, 前田 学, 神谷 秀喜, 北島 康雄, 坂 昌範
    2001 年 16 巻 3 号 p. 324-327
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    Dermatofibrosarcoma protuberans (DFSP) is a fibrohistiocytic tumor, which grows slowly and tends to relapse locally after inadequate removal. DFSP is frequently difficult to distinguish from other fibrohistiocytic tumors; however, anti-CD34 staining is useful for differential diagnosis.
    We reported a 67-year-old male with a DFSP on his right cheek. He had noticed a subcutaneous tumor on the right side of his mouth for 20 years. The tumor had formely grown slowly, but it grew rapidly in 1999. We then performed wide excision including facial muscles and skin grafting. Histopathologicaly the tumor was composed of uniform spindle-shaped and mild atypical fibroblast-like cells. Most parts of the tumor formed a storiform pattern. Spindle-shaped cells were showed positive with anti-CD34 staining. We diagnosed this case as a giant DFSP on the cheek. [Skin Cancer (Japan) 2001; 16: 324-327]
  • 山田 瑞貴, 大原 國章, 鄭 憲
    2001 年 16 巻 3 号 p. 328-331
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    Giant Cell Fibroblastoma is a rare mesenchymal tumor. It has been considered as a juvenile variant of dermatofibrosarcoma protuberans.
    We reported a case of congenital giant cell fibroblastoma occuring in the buttocks. The patient was a 2-year-old boy. Histologically, the tumor was characterized by a mixed proliferation of fibroblastic cells and multinucleated giant cells and sinusoid like spaces. Immunohistochemical studies were positive for CD34 and Vimentin. [Skin Cancer (Japan) 2001; 16: 328-331]
  • 植原 政子, 土田 幸英, 三浦 洋靖, 若松 慶太, 井上 義治, 原科 孝雄, 伊崎 誠一
    2001 年 16 巻 3 号 p. 332-335
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    A 51-year-old male was referred to us with resection of liposarcoma of the upper back region. The patient underwent wide resection of the primary lesion including partially the trapezius muscles, and skin graft. Histological examination revealed no residual lesion of liposarcoma and two lipomas of the lumbar region. The patient is alive without local recurrence and distant metastasis at twenty months postoperatively. [Skin Cancer (Japan) 2001; 16: 332-335]
  • 服部 友保, 高橋 亜由美, 田村 敦志, 石川 治
    2001 年 16 巻 3 号 p. 336-339
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    Cutaneous leiomyosarcoma arises from the arrector pili muscles of the hair follicle, and is a rare tumor. We report the clinico-pathological features of a 42-year-old man suffering from a nodule of the right hip. Histological appearance of the tumor corresponded to cutaneous leiomyosarcoma, showing spindle-shaped atypical myomatous cells arranged in interlacing fascicles that merged into collagenous stroma. Immunohistochemical studies demonstrated positivity of the tumor cells for vimentin, α-smooth muscle actin and desmin. The lesion was completely excised with wide margins. He has been free from recurrence or metastasis for seven months. [Skin Cancer (Japan) 2001; 16: 336-339]
  • 川浦 菊美, 王生 淳子, 大槻 匠, 玉田 康彦, 松本 義也, 横井 太紀雄, 原 一夫, 佐賀 信介
    2001 年 16 巻 3 号 p. 340-344
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    Three years before presenting at our hospital at the age of 57, this male patient was examined by a local doctor for sudden elevations in part of an erosive plaque located on the lower right leg. At the time of presentation, there was a 6 cm plaque from dark brown to pink in color on the right lower leg, in the central to somewhat lower part of which was a 3 cm tumor. Histologically, this presented an image of Bowen's disease, and in the tumorous portion there were mixed eosinophilic-stained tumor cells and poorly differentiated basophilic-stained tumor cells. From the clinical picture and histological findings, the diagnosis was squamous cell carcinoma that hadprogressed from Bowen's disease. The tumor was excised. Metastasis to the right inguinal lymph nodes was discovered about 1 year after this excision, and soonmetastases were discovered in organs throughout the body. The course was rapid, and the patient died 1 year later.
    We conducted a clinical and histological investigation of the risk factors for metastasis in cases of skin squamous cell carcinoma. [Skin Cancer (Japan) 2001; 16: 340-344]
  • 金児 みわ子, 松原 麻貴, 小口 真司, 宇原 久, 斎田 俊明, 石川 雅世, 日高 恵以子, 吉澤 明彦, 中島 広聖, 中曽根 潤
    2001 年 16 巻 3 号 p. 345-348
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    We report a case of clear cell sarcoma. A 42-year-old Japanese man noticed a solitary subcutaneous nodule on the left side of his foot 5 years previously. After incomplete removal of the nodule by an orthopedician, he was referred to our clinic.At his first visit, metastases to the left inguinal lymph nodes were already observed together with the residual nodule on the foot. Histological examination of the nodule on the foot revealed nests of round cells with clear cytoplasm separated by fibrous septa. Immunohistochemically, turnor cells were positive for S-100 protein and HMB-45. Translocation t (12; 22) (q13; q13) and other chromosomal abnormalities were detected by chromosomal analysis. We performed the amputation of his left leg and left inguinal lymph node dissection followed by adjuvant chemotherapy. However, multiple bone metastases developed a month after the surgery and he died of the disseminated disease. [Skin Cancer (Japan) 2001; 16: 345-348]
  • 石澤 俊幸, 斎藤 寛幸, 川口 雅一, 片方 陽太郎, 穂積 豊, 三橋 善比古, 近藤 慈夫, 大類 広
    2001 年 16 巻 3 号 p. 349-352
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    We reported a case of clear cell sarcoma. A 67-year-old man presented with a subcutaneous tumor on the left poples which had been first noticed 4 years before. He decided to visit our hospital, because recently the tumor suddenly increased in size. Physical examination revealed a large and firm subcutaneous tumor about 6 cm in diameter in the left poples. The tumor was excised with wide dissection of the overlying skin and with left inguinal lymphnodes. Histologically, the tumor wascomposed of round or polygonal cells with clear cytoplasm and vesicular nuclei. Immunohistochemically, the tumor was positive for S-100, HMB-45, NSE, vimentin and Leu-7, but negative for EMA and polykeratin. RT-PCR analysis did not show the expression of hybrid EWS/AFT-1 transcript. In electron microscopy, some melanosomes were found in the tumor cells. Although it is difficult to distinguish between clear cell sarcoma and malignant melanoma with the unknown primary site, we diagnosed this tumor as clear cell sarcoma in clinical and histological respects. [Skin Cancer (Japan) 2001; 16: 349-352]
  • 久保 宜明, 浦野 芳夫, 松本 和也, 荒瀬 誠治
    2001 年 16 巻 3 号 p. 353-356
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    Squamous cell carcinomas (SCCs) are supposed to develop through the multistep process that involves activation of proto-oncogenes and/or inactivation of tumor suppressor genes in the human epidermis. To elucidate the multistep process, we screened mutations in H-Ras, p53, PTEN, and the INK4a locus in 21 SCCs by meansof PCR-SSCP analysis. One, 3, and 7 SCCs were detected mutations in H-Ras, INK4a, and p53, respectively. No mutation was detected in PTEN in any SCC. Nine SCCs in total were shown to have mutations at least in one gene. Among them, we detected both mutations of H-Ras and INK4a in one SCC, and both mutations of p53 and INK4a in another SCC. In particular, activation of H-Ras and inactivation of both of p16INK4a and p14ARF were supposed in the former SCC. This finding indicates the possibility that the combination of mutations might contribute to the cacinogenesis in the SCC. [Skin Cancer (Japan) 2001; 16: 353-356]
  • 野本 重敏, 山田 聰, 伊藤 雅章, 岩渕 三哉
    2001 年 16 巻 3 号 p. 357-360
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    An 80-year-old man presented with a purpuric macule on his right cheek.
    The histological examination showed proliferated and dilated small vessels in the dermis and subcutis. Atypical cell was not recognized in the specimen. The lesion developed rapidly to the scalp and neck, and hematological examination showed decreased platelet counts. There was no sign of intracranial invasion. Abdominal CT and MRI showed multiple hemangiomas in the spleen.
    32 Gy of electon beam radiotherapy for the skin lesion had significant local effect, but disseminated intravascular coagulation was not improved. The patient died of pulmonary failure 8 months after the initial observation. Autopsy and pathological examination revealed multiple hemangiomas of the spleen and liver, showing no signof malignancy.[Skin Cancer (Japan) 2001; 16: 357-360]
  • 町田 秀樹, 山本 明史, 山崎 直也, 野呂 佐知子, 藤沢 康弘, 石原 和之
    2001 年 16 巻 3 号 p. 361-366
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    Twenty patients with angiosarcoma (six male and fourteen female) treated at National Cancer Center Hospital between April 1982 and December 2000 were reviewed. The median age was 66 years (range 32 to 87 years) . The median followup was 13 months (range 2 to 112 months) . Ten patients had developed regional lymph node metastases. Seventeen patients had developed distant metastases. The 5-year survival rate was 20%. Fourteen patients underwent surgery, seventeen underwent radiotherapy, nine underwent chemotherapy, thirteen underwent IL-2 therapy and two underwent IFN therapy. Compared with the patients who didn't undergo wide excision, the patients who underwent wide excision showed a statistically significant increase in survival rate (p=0.029). Compared with the patients who didn't undergo adjuvant radiotherapy, the patients who underwent adjuvant radiotherapy showed a statistically significant decrease in recurrence rate (p=0.018) . [Skin Cancer (Japan) 2001; 16: 361-366]
  • 八代 浩, 臼田 俊和, 小寺 雅也, 木村 多美, 柳田 邦治, 落合 賢一, 山雄 久美, 村上 榮, 中村 栄男
    2001 年 16 巻 3 号 p. 367-371
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    A 58-year-old woman visited our hospital because of an indurated erythematous nodule on her right forearm. Histological findings revealed that atypical large lymphoid cells had massively infiltrated the middle and lower dermis. Immunohistochemically, the atypical cells were stained CD2, CD4, CD30, CD43, TCR α β, but ALK (anaplastic lymphoma kinase) was negative. This patient was then diagnosed as suffering from primary cutaneous anaplastic large cell lymphoma (ALCL). ALCL is widely recognized with its broad morphologic and phenotypic spectrum causing controversy in the diagnosis of this peculiar neoplasm. We experienced and reported the case as “aggressive type” ALCL. [Skin Cancer (Japan) 2001; 16: 367-371]
  • 貴志 知生, 山本 有紀, 上出 康二, 古川 福実, 岸 和史, 辻岡 馨
    2001 年 16 巻 3 号 p. 372-375
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    A 59-year-old male noticed an eczematous lesion on his genital region in January, 2000. Skin biopsy revealed genital Paget's disease. Computed tomography showed inguinal and paraaortic lymphnodes swelling. CEA level in the serum was 827ng/ml. Histopathologically, the inguinal lymphnodes were replaced with the tumor cells. The patient received combination therapies including an operation, radiation, chemotherapy, immunotherapy and hyper thermia therapy. After these therapies the size of the swelled lymphnodes decreased, but serum CEA continued increasing. He died from lymphangitis of the lung metastasis in November, 2000. [Skin Cancer (Japan) 2001; 16: 372-375]
  • 宮本 秀明
    2001 年 16 巻 3 号 p. 376-381
    発行日: 2001/12/28
    公開日: 2010/08/05
    ジャーナル フリー
    We report a case of extramammary Paget's disease in which metastatic skin lesions were treated successfully with low-dose Etoposide administered orally over a 12-week period. The patient, an 84-year-old male, visited us because of a tumor and erythema of the scrotum in June 2000. At presentation, he had a tumor measuring 56×30mm on the scrotum and erythema measuring 12×7cm around the tumor. ACT scan revealed swollen lymph nodes in the bilateral groin. Surgery and lymph node biopsy were carried out in July 2000. Infiltration of tumor cells was revealed microscopically in the bilateral inguinal lymph nodes. Metastatic skin lesions developed on the abdomen two months after the operation, but the tumors regressed gradually and disappeared seven weeks after the introduction of oral low-dose Etoposide (25mg/day) in October 2000. The serum level of carcinoembryonic antigen (CEA) decreased and was normalized 12 weeks after the start of administration. Because of the onset of interstitial pneumonia, administration of Etoposide was stopped in December 2000.
    Although Etretinate was introduced after the pneumonia was resolved by steroid pulse therapy, metastatic skin lesions gradually developed and the patient died 11 months after the operation. Although Etoposide caused interstitial pneumonia in this patient, we conclude that its oral long-term use at a low dose is worth considering in patients with advanced extramammary Paget's disease. [Skin Cancer (Japan) 2001; 16: 376-381]
feedback
Top