悪性黒色腫患者の手術療法に併用した予防的DAV療法の効果を検討した。治療後5年以上経過した患者を対象とし, DAV加療群Stage II 10例, Stage III 22例, DAV非加療群Stage II 12例, Stage III 10例の生存率をStage別に比較した。5年生存率ではStage IIの両群に差はなく, Stage III DAV加療群は生存率が有意に高かった。 Stage II DAV非加療群では遅発転移による死亡が多い。DAV加療群の遅発転移の有無によりDAV予防投与の効果の有無はさらに明らかになるであろう。
The patient was a 37-year-old housewife, with no reported family history or personal history. Twenty years previously, she found dark-brown pigmentation on her lower eyelids. One year prior to its excision in June, 1985, the lesion exhibited partial elevation and darkening. It was subsequently diagnosed as nodular melanoma. In April of 1989, she had bloody sputum and an examination of her head and neck revealed a hemorrhagic mass on the epipharynx. Abdominal CT scanning revealed metastasis in the form of intraabdominal lymph nodes. In June of 1989, 80mg/m2 of CPT-11 in 500ml of 5% glucose was infused intravenously. One course of the treatment consisted of one infusion a week for approximately 4 weeks. A total of 5 courses were administered. During the second course, the size of the mass was reduced. A partial response was obtained after the fourth course, and by the fifth course the lesion nearly disappeared. As of December 1991, the patient has been in good health and there has been no recurrence of the mass. Her only complaint was of mild nausea and vomiting 5-6 hours after infusion. Hematological finding revealed no abnormalities.