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Nevus sebaceus was discussed on nevoid and precancerous points of view from the results obtained by my own 25 cases and the findings of cases in literatures. The followings were concluded;
1) Clinically, there are few cases with pure nevus sebaceus and some are should be diagnosed as phacomatosis or neurocutaneous syndrome.
2) Basal cell epithelioma, apocrine gland and various tumors of the appendage associated with nevus sebaceus are thought as nevoid in nature.
3) Because of no relationship between the presence of sebaceous cells and the histogenesis of secondary tumors, the term “Carcinogenic Skin Lesion” is proposed by the author as a better entity for nevus sebaceus rather than precancerous skin lesion.

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A 19-year-old man with malignant melanoma was reported, and the findings of melanoma-cell in vitro derived from the patient's lymphnode were described.

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Preliminary reports on topical chemotherapy in tumors of the skin using 5% 5-fluorouracil cream under occlusive dressing were presented. The tumors were two cases of condyloma acuminatum of the genitoanal region, one case of verrucae planae juveniles of the face, one case of Bowen's disease in actinic keratosis of the face, one case of Bowen's disease in arsenical keratosis of the trunk and extremities, two cases of genital Paget's disease and two cases of basal cell epithelioma of the face.
All tumors except for two cases of Paget's disease and one case of basal cell epithelioma disappeared completely with minimum scar formation following the topical chemotherapy. Even in Paget's disease the results were promising.No systemic toxicity was observed.

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1.Molluscum contagiosum nodules were homo genized in a mortar. The homogenate was centrifuged at 2, 000 rpm and the supernate again at 15, 000 rpm. The resulting pellets were resuspended and centrifuged at 2, 000 rpm. The supernate was used as crude molluscum contagiosum extract. The supernatant and Freund's complete adjuvant were injected into rabbit and from which molluscum contagiosum antiserum was prepared. After absorption of the antiserum with human skin and human serum, one precipitin-line remained, which was specific for molluscum contagiosum. Molluscum contagiosum-specific antigen probably reside in the molluscum contagiosum nodules.
2. By using the 20-45% (w/v) sucrose density gradient centrifugation at 15, 000 rpm, the crude molluscum contagiosum extract was divided into two bands. A band of the upper portion was designated “Fract. I”, the lower one was “Fract. II”. In the diffusion gel test, Fract. I produced precipitin-line against antiserum to crude molluscum contagiosum, but Fract. II did not. Virus particles were observed in Fract. II under the electron microscope by means of the negative staining technique. The virus material banded in Fract. II, but host cell component did not.

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