Journal of the Society of Powder Technology, Japan
Online ISSN : 1883-7239
Print ISSN : 0386-6157
ISSN-L : 0386-6157
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Volume 41, Issue 12
Displaying 1-6 of 6 articles from this issue
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  • Surface Modification of Silica Particles with Calixarene
    Shuhei Shioji, Masashi Hanada, Yasuhiro Hayashi, Kenjiro Tokami, Hideo ...
    2004 Volume 41 Issue 12 Pages 852-859
    Published: December 10, 2004
    Released on J-STAGE: April 30, 2010
    DOIhttps://doi.org/10.4164/sptj.41.852
    JOURNAL FREE ACCESS
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    Calixarene was applied to surface modification of silica particles. Calix [4] arene with two alcoholic hydroxyl groups in the molecule (referred to as CADOL) was synthesized as a modification reagent. The surface of silica particles was modified by alkoxylation reaction with CADOL in xylene solution. The immobilized CADOL introduced the micro or ultramicro holes on the surface without changing the over-all pore size distribution of the material particles. The fundamental properties of the surface modification reaction with CADOL were examined in comparison to the alkoxylation reaction by aromatic alcohols.
    The modified particles were characterized by gas chromatograph and TPD measurement for chloroform. For the modified particles, the retention time of chloroform became longer and the separation factor of chloroform for the other molecules increased. The infrared spectra of desorbed gas showed the existence of strongly adsorbed chloroform on the modified surface. The introduced holes served as molecular cavities to enhance the interaction between the particle surface and chloroform molecules.
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  • Influence of Particle Hardness on the Discharge through Orifices
    Hiroyuki Asou, Katsuya Funatsu, Yuji Tomita
    2004 Volume 41 Issue 12 Pages 860-866
    Published: December 10, 2004
    Released on J-STAGE: April 30, 2010
    DOIhttps://doi.org/10.4164/sptj.41.860
    JOURNAL FREE ACCESS
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    Eleven types of polyethylene particles are used to examine the influence of particle properties on the gravity flow through an orifice located on a flat bottom of a vessel. The density of particles is varied from 825 to 945kg/m3 and four of them are mixed with a slipping agent to improve the surface properties. Orifice size is changed from 20 to 27mm with an increment of one mm. As a result, when Duro-hardness becomes small, the mass flow rate of particles decrease whereas the wall friction coefficient against an acrylic plate and the angle of repose increase. Although the contraction coefficient increases with a decrease in Duro-hardness, the flow coefficient of the Beverloos' correlation equation is lowered. The particles with slipping agent show a decrease in the wall friction coefficient.
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  • Percutaneous Absorption Study of Biodegradable PLGA Nano-spheres via Human Skin Biopsies
    Hiroyuki Tsujimoto, Kaori Hara, Toyokazu Yokoyama, Hiromitsu Yamamoto, ...
    2004 Volume 41 Issue 12 Pages 867-875
    Published: December 10, 2004
    Released on J-STAGE: April 30, 2010
    DOIhttps://doi.org/10.4164/sptj.41.867
    JOURNAL FREE ACCESS
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    The objective of this research was to demonstrate the applicability of PLGA nano-spheres for transdermal drug deliveries. By applying spherical crystallization with emulsion solvent diffusion method in an aqueous PVA solution, the pro-vitamin C loaded and the coumarin-6 loaded PLGA nano-spheres with an average particle size of 215nm were prepared and tested via the human skin biopsies in a modified Bronaugh diffusion chamber. The coumarin-6 loaded PLGA nano-spheres showed excellent capability of passing through skin pores and had a superior cutaneous penetrability to deep-epidermis, both in speed and quantity compared to the coumarin-6 dispersion liquid at a much higher concentration.
    The pro-vitamin C loaded PLGA nano-spheres were also found to be much more effective in supplying reduced vitamin C to deep-skin than pro-vitamin C emulsion. In addition, the PLGA nano-spheres could prolong the retention of reduced vitamin C for better skin care results. Furthermore, inhibitory effects of pro-vitamin C loaded PLGA nano-spheres on DNA double-strand breaks by UV-A and UV-B irradiations were confirmed.
    The PLGA nano-sphere was proven to be a viable vehicle for transdermal drug delivery application.
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  • Orderd Nanospace Materials as Stages of Integration
    Tatsuya Okubo
    2004 Volume 41 Issue 12 Pages 876-880
    Published: December 10, 2004
    Released on J-STAGE: April 30, 2010
    DOIhttps://doi.org/10.4164/sptj.41.876
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  • [title in Japanese]
    Ryusei Ito
    2004 Volume 41 Issue 12 Pages 893
    Published: December 10, 2004
    Released on J-STAGE: April 30, 2010
    DOIhttps://doi.org/10.4164/sptj.41.893
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  • [title in Japanese]
    Noritaka Iida
    2004 Volume 41 Issue 12 Pages 894
    Published: December 10, 2004
    Released on J-STAGE: April 30, 2010
    DOIhttps://doi.org/10.4164/sptj.41.894
    JOURNAL FREE ACCESS
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