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Kazuya KITAMURA, Yoshio HIRANO, Nobuyuki ISHIHAMA, Nobuyuki TANAKA, To ...
1989 Volume 38 Issue 4 Pages
831-839
Published: October 10, 1989
Released on J-STAGE: September 07, 2011
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A (phenylephrine injection) group, light microscopically, morphological changes of granular convoluted tubular (GCT) cells were characterized by duct dilation and degranulation, and GCT cells had few secretory granules (SGs) 120 minutes after phenylephrine injection.
Recovery of SGs had already begun at 12 hr and GCT cells had been full of SGs, but had been not completely finished at 24 hr.
Electron microscopically morphorogical changes of GCT cells were characterized by small SGs near apical cytoplasm and secretory materials in the lumen, but were not observed in any other sites. These results indicated that synthetic site of mEGF couldn't be detected in the process of forming SGs.
There were three kinds of secretory methods to duct of mEGF-eruptocrine secretion, holocrine secretion, and their mixture. In B (isoproterenol injection) and C (pilocarpine injection) groups, morphological changes of GCT cells were not predominantly observed, but those of acinar cells were characterized by duct dilation and vacuolous degeneration.
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Madoka INUI, Toshirou TAGAWA, Yoshio HIRANO, Jyouji YONEDA, Jun MATSUM ...
1989 Volume 38 Issue 4 Pages
840-847
Published: October 10, 1989
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The establishment and the characteristics of five cell lines derived from either hard palate primary or metastatic malignant melanoma have already been reported. In this paper, the relationship between melanization and tyrosinase activity of these five cell lines is reported.
The MMN9 and MMN13 cells remained melanotic and continued to produce melanin granules. The MMN12 cells became amelanotic and developed multipolar neuroblast-like processes. The PMP cells were amelanotic but contained many melanin accumulations. It was suspected that the PMP cells contained pheomelanin. The MAA cells were amelanotic and tyrosinase activity was zero after 6 days of culture. Biochemical and morphological characteristics were strikingly changed by addition of 1% fetal bovine serum (FBS) to the culture medium. This phenomenon appeared to demonstrate the so called “contrary of growth and differentiation”. With GIT and 1% FBS culture medium, the melanin content tended to increase. It was considered that FBS contained some control factors that induce melanin production in culture.
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Comparison between rotational panoramic radiography and computed tomography
Munetaka NAITOH, Masaru SHIOJIMA, Atsushi KIKUCHI, Masahiko FUKAYA, Ts ...
1989 Volume 38 Issue 4 Pages
848-856
Published: October 10, 1989
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W e compared findings obtained by rotational panoramic radiography and computed tomography in postoperative maxillary cyst diagnosed histopathologically. The results were as follows;
1. Twenty two patients (13 males and 9 females) were studied, the average age was 45.8 years and the average period after initial surgery of maxillary sinus was 24.6 years.
2. In the rotational panoramic radiographs, the lesion had well-defined margin in 17 cases, slightly diffuse margin in 4 cases and diffuse margin in 1 case.
In the 21 cases with well-defined and slightly diffuse margin the lesion occupied the maxillary sinus horizontally in 14 cases and the inferior border extended to the alveolar area in 20 cases. The forms of the lesions were classified into four types; round type, partially round type, simular sinus type and unsettled type. The lesion was unilocular in 14 cases.
3. The location of the lesion obtained by different procedures agreed in 18 cases. 70% of lesions grouped round or partially round types in the rotational panormamic radiography were classified into the absorbed type in the computed tomography.
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Natsuki SEGAMI, Ken-Ichiro MURAKAMI, Kazuma FUJIMURA, Masanori MATSUKI ...
1989 Volume 38 Issue 4 Pages
857-869
Published: October 10, 1989
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Arthroscopic examination was performed on 30 joints of 25 patients with closed lock of the temporomandibular joint (TMJ). The subjects consisted of 3 males and 22 females, ranging in age from 17 to 69 years (mean: 43.9 years). Interincisal opening distance was ranging from 10 to 38 mm (mean: 26.0 mm), with moderate to severe TMJ arthralgia. Under local or general anesthesia, the superior joint compartment was punctured employing Wolf telescope® (1.9 mm in diameter), and examined arthroscopically.
In the results, synovitis of moderate to severe degree existed in 23 joints, predilected on the posterior and anterior recess. In 25 joints, fibrillation of the fibrocartilage located throughout the compartment in various degree, which was identified as an initial change of the eminence in the joint with 2 to 3 months' locking duration. Fibrous adhesion was observed in 23 joints, located from the anterior recess to medial capsule in the joints with 3 to 9 months' locking duration. In 11 joints with long-term closed locking over 10 months, extensive synovitis, fibrillation and adhesion were observed, combined with discal perforation in 4 joints. These results indicated that the intracapsular pathosis was clealy detected through the arthroscopy, and which enabled significant progress in diagnosis and treatment for closed lock TMJ patients.
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Kikuo TAKAHASHI, Yukihiro AKIYAMA, Harusachi KANAZAWA, Ken-ichi SATO
1989 Volume 38 Issue 4 Pages
870-888
Published: October 10, 1989
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A cell line from a F344 rat osteosarcoma induced by serial injections of
32p was established. This cell line, designated MSK, has been maintained for many passages for over 4 years. In the present experiment we investigated a variety of biological properties of the cultured cells.
MSK culture cells had a logarithmic doubling time of 18 h, and exhibited a plating efficiency of 15.7 % even after being cultured for 3 years. The modal chromosome number of the MSK cell line was 56 in the 9 th and 53 in the 45 th and 107 th passages.
Morphologically, the cultured cells had fusiform or polygonal features with multiple cytoplasmal projections in the growing state, and became smaller, more epithelioid when crowded against each other without contact inhibition.
By transmission electron microscopy, the fine structure of MSK cells showed an elliptoid or flattened shape with large nuclei. Prominent cytoplasmic structures with well-developed mitochondoria, and both rough and smooth endoplasmic reticula were observed, but a dilated rough endoplasmic reticulum was rarely seen. Numerous cross-banding typical collagen fibrils and matrix vesicle-like structures were frequently seen among the culture cells. Energy dispersion X-ray analysis of these vesicles revealed peaks for calcium and phosphorus.
MSK culture cells possessed high alkaline phosphatase activities, as much as 10 times more than Hela S3 cells, and these activities have been retained through many passages. The culture cells also showed the accumulation of cyclic AMP upon the addition of parathyroid hormone (PTH 1-84 human) to the culture medium; the production of cyclic AMP was dependent on concentrations of h-PTH ranging between 10-9 and 10-7M.
MSK cells were tumorigenic when transplanted into F344 inbred rats. Histologically, the induced tumors showed characteristic features of osteosarcoma, producing extensive areas of calcification. The ability of the culture cells to calcify in tumors has not decreased throughout the long-term repeated passages.
These results suggest that the MSK cell line is a useful tool not only for the investigation of the characteristics of osteosarcoma, but also for attaining a clearer understanding of the role of the osteoblast on bone metabolism.
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Yasuharu TEJIMA, Shuichiroh NAGAOSA, Masayuki YOKOMIZO, Yoshihiko TAKA ...
1989 Volume 38 Issue 4 Pages
889-897
Published: October 10, 1989
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To investigate the extent of oral diseases in the aged, a dental examination was conducted in combination with medical examinations of elderly inhabitants of Miyako district, Okinawa pref.
Abnormal oral findings were noted in 1, 655 (29.19 %) of 5, 670 examinees. The incidence of oral disease tended to increase with age. Among the oral disease detected, oral mucosal diseases showed the highest frequency. Suspected malignant tumors were found in 0.14%, benign tumors in 4.36 %, leukoplakia in 1.29 % and diseases presumably due to insufficient oral care by dentists or patients in 8.77 % of the examinees. Evaluation of the state of disease revealed that a higher proportion of systemic diseases were under medical treatment as compared with oral diseases. Further detailed examination was indicated in 50 (0.88 %) examinees with oral diseases.
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Kazuya WATATANI, Kanemitsu SHIRASUNA, Hideyuki FURUSAWA, Munehisa SAKA ...
1989 Volume 38 Issue 4 Pages
898-904
Published: October 10, 1989
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Three adenoid cystic carcinoma cell lines were isolated from different patients. In the three lines, the cultures contained two types of cells during early passages; one type was small epithelial cells and the other was large flattened cells. Further passages resulted in a slowing of growth and conversion of the epithelial cells into large flattened cells, suggesting that both types of cells had the same origin. The large flattened cells being similar to myoepithelial cells tended to form a pseudocyst, which is a specific architecture of adenoid cystic carcinoma. These cells were able to display. the potential for production of an extracellular matrix including basal lamina and collagen like filaments.
These findings suggest that the isolated cell lines are essential cells for tumor formation consisting of peculiar stroma.
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Hiroshi NAGASAKA, Hiroshi KAWAMURA, Shuichi SATOU, Yoshio TAKAHASHI, K ...
1989 Volume 38 Issue 4 Pages
905-914
Published: October 10, 1989
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This study examined the condylar positions of mandibular prognathism patients in centric occlusion radiographically. 40 patients were selected as mandibular prognathism group, who complained of severe anterior cross bite without facial asymmetry. Control group consisted of 20 volunteers with normal occlusion and asymptomatic TMJs. Lateral oblique transcranial radiographs were made of bilateral TMJs in centric occlusion on each subject. The films were traced and measured using a modified Blaschke and coworker's method to assess the condyle-fossa relationships along the postero-anterior axis of the TMJ. The two groups were compared and the results are as follows:
1) Normal occlusion group showed that of the condyles were in the anterior position near the center.
2) In the mandibular prognathism group, the average condylar position was anterior near the center same as the normal occlusion group. However, the dispersion of individual condylar positions around the average was greater in the mandibular prognathism group as compared to the normal occlusion group. Consequently the mandibular prognathism group showed that many of the condyles were in variable positions relatively far from center.
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Koji EBATA, Minoru UEDA, Toshio KANEDA
1989 Volume 38 Issue 4 Pages
915-928
Published: October 10, 1989
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Since skin grafted into the oral cavity does not turn into mucosa, its original characteristics remain unchanged. This may cause discomfort to patients treated with such grafted skin on account of hair follicles and keratinization. This phenomenon is induced by subepithelial connective tissue, and is thus refered to as “Epithelio-Mesenchymal Interaction”, which concept has been well known in the field of the developmental biology. The grafting of mucosa itself would be preferable, but this is severely limited due to its scarcity.
Accordingly, we have recently prepared artificial mucosa in vitro, using fibroblasts and epithelial cells derived from rabbit oral mucosa and collagen gel, and transplanted it to donor animals. The grafted artificial mucosa survived and was analized clinically and histologically. At 1 week after grafting, artificial mucosa survived completely, some part of epithelial cells remained. Epithelial cells grew out from the epithelial segment and covered a part of the artificial lamina propria. Small capillaries (φ5-10 pm) invaded into the graft and completed the vascular structure as the mucosal tissue. More a week the graft matured and epithelial layer thickened for 7-8 layers. Basement membrane was observed on the PAS stain specimen on the 21 st day. On the 28 th day, the graft contracted into 80 % of original size. No hair regrowth or keratinization of the graft were observed. Histologically, the inflammatory reactions induced by immunologeail rejection were not seen during the whole period of grafting.These findings suggested its possibility for clinical use.
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Yuichi NAKAI, Koichi OKABE, Kiyomasa NAKAGAWA, Etsuhide YAMAMOTO
1989 Volume 38 Issue 4 Pages
929-939
Published: October 10, 1989
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With a view to analyzing bacterial flora of dental calculus and examining its relationship with oral infections and bacteremia, bacterial isolation from dental calculus was performed and susceptibitity of these isolates to antibiotics was examined. On the basis of the experimental results with bacterial isolation method, bacterial isolation from dental calculus was performed by 48 hr-enrichment culture of sample in Tamai-Fukuda (TF) medium.
The results of bacterial examination of 203 cases of dental calculus revealed that only aerobes were isolated in 21 cases and both aerobes and anaerobes in the remaining 182 cases. A total of 741 isolates were obtained ; the number of aerobes and anaerobes were 393 (53.0%) and 348 (47.0 %), respectively. Bacterial genera isolated with high frequency were Lactobacillus (123 strains), Streptococcus (77 strains), Corynebacterium (57 strains), Staphylococcus (34 strains) in aerobes, and Veillonella (72 strains), Eubacterium (59 strains), Bacteroides (57 strains), and Peptococcus (50 strains) in the anaerobes; these bacterial general represented more than 70 % of all isolates, suggesting that they are main bacteria in the dental calculus. A total of 735 strains, 386 aerobes and 349 anaerobes, were tested, by three concentration-disc method, for susceptibility to 8 antibiotics, penicillin G (PCG), ampicillin (ABPC), cephaloridine (CER), tetracycline (TC), erythromycin (EM), clindamycin (CLDM), gentamicin (GM), and polymixin (PL). More than 90 % of strains of the aerobes and more than 95 % of those of the anaerobes were susceptible to CER, TC and CLDM, and to PCG, ABPC, CER, TC and CLDM, respetively.
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Michi-ichiro ITOH
1989 Volume 38 Issue 4 Pages
940-959
Published: October 10, 1989
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Representation of hypoglossal nerve branches and tongue muscles was examined in the hypoglossal nucleus of the house musk shrew (
Suncus murinus) by the horseradish peroxidase method, and furthermore in the rat, rabbit and dog in order to find out the general organization of the hypoglossal nucleus in mammalian species. In the shrew, the nucleus was roughly divided cytoarchitectonically into dorsal and ventral divisions. The former was further divided into the dorsomedial and dorsolateral subnuclei, and the latter into the ventromedial, intermediate, ventrolateral and ventral subnuclei. The dorsal division mainly supplied the lateral branch of the hypoglossal nerve, and the ventral division the medial branch. The styloglossus and hyoglossus motoneurons were located in the lateral aspect of the dorsolateral subnucleus. The genioglossus and geniohyoid motoneurons were distributed in the dorsolateral aspect of the ventrolateral subnucleus, and in the ventral subnucleus, respectively. Patterns of the representation in the rat, rabbit and dog resembled that in the shrew.
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Masayuki KANEKO, Tomoaki SANO, Touei KAKU, Tomoko NISHI, Hajime INAGAK ...
1989 Volume 38 Issue 4 Pages
960-967
Published: October 10, 1989
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Three cases of epulis osteoplastica were examined by soft X-ray radiography and microradiography. Extructed tissues pathologically diagnosed epulis fibrosa osteoplastica were offered to this examination.
The soft X-ray radiograms showed a so-called cotton wool appearance in case 1, well defined trabecular structures in case 2, and a bony mass with small particles in case 3.
The microradiograms obtained from cases 1 and 2 revealed the same bone structures as were observed in the healing process of bone fractures, but those obtained from case 3 demonstrated the same bone structures as were shown in the flat bones.
Histological examinations supported these findings.
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Koichi SHIBASAKI, Makoto TSUCHIMOCHI, Izumi MATAGA, Kohzo TSUCHIKAWA, ...
1989 Volume 38 Issue 4 Pages
968-973
Published: October 10, 1989
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HB virus associated antigen-antibody in dental students as examined in order to find out of HB virus infections occurring.
In order to prevent HB virus infections, the students were inoculated with HB vaccine only if they had previously showed negative HBs antibodies before their clinical training.
1. Among 581 dental students, 6 (1.0%) showed positive HBs antigen, and 27 (4.6%) showed positive antibody. The total cases of HB virus infection, which were positive with HBs antigen and/or and HBs, were 33 (5.7%).
2. During the past 4 years, 506 dental students had clinical dental training. In that period, one student changed to HBs antigen positive, two changed to and HBs positive and 6 changed to and HBc positive. Consequently, 6 students were infected with HB virus. However, these 6 students showed transient and latent infections with no jaundice or other clinical symptoms.
3. Seventy-five students had been inoculated with HB vaccine 3 times. Fifty-nine students (78.7%) showed anti HBs positive. Those who were still negative anti HBs had inoculations a 4 th and 5 th time. Consequently the and HBs positive students increased to 85.3% after the 4 th time, and 89.3% after the 5 th time. The results showed that additional inoculations were effective.
4. Each company's human plasma derived HB vaccine showed different values or effectiveness of and HBs acquisition.
5. After 3 inoculations, the rates of and HBs were 75.0%(45/60) in males, and 93.3%(14/15) in females. Also females had a high titre of and HBs.
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Hidemori MIZUTANI
1989 Volume 38 Issue 4 Pages
974-990
Published: October 10, 1989
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The effect of anticancer therapy on the incidence of sister chromatid exchanges (SCE's) of the peripheral lymphocytes was studied in 13 patients with oral cancer. For comparison, the influence of three anticancer agents to SCE's of cultured lymphocytes from healthy adults was also examined. SCE's were detected by Hoechst-Giemsa technique, following incubation of the cells in the presence of 5-bromodeoxyuridine.
The baseline SCE frequency in normal subjects was 7.68±3.70 per metaphase. SCE level was elevated moderately when the cells were treated
in vitro with peplomycin (PEP), but was not affected by bleomycin (BLM) nor 5-fluorouracil (5-FU). Mitotic activity was suppressed markedly by 5-FU, and in lesser degree by PEP.
The mean SCE score in the untreated oral cancer patients was slightly higher (9.08±2.98) than the control level. Chemotherapy with BLM elevated SCE score a slight degree (11.28±2.28). During the course of chemoradiotherapy, SCE frequency was markedly increased (21.35±6.27), when the patients had been exposed to 10 to 12 Gy of radiation doses. Inhibition of mitoses progressed in parallel with the incidence of the SCE level in a few patients under chemo- or chemoradiotherapy.
As increased SCE's of the peripheral lymphocytes are considered to reflect damages to DNA of non-tumorous cells, it is suggested thet SCE analysis could be a useful tool for monitoring unfavorable side effects caused by anticancer agents.
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Keise TAKEDA
1989 Volume 38 Issue 4 Pages
991-1006
Published: October 10, 1989
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The phagocytic activity and bactericidal capacity of polymorphonuclear leukocytes (PMNL) from 12 healthy volunteers were examined in Hanks' balanced solution (HBSS) with 10% heat inactivated fetal calf serum. Bacteria harvested from early log phase culture were used.
The phagocitic activity and bactericidal capacity of PMNL were higher for
Staphylococcus aureus and
Streptococcus pyogenes than for
S. salivarius, S. mutans, S. mitis, S. sanguis, Actinomyces viscosus, S. faecalis, S. faecium, Haemophilus actinomycetemcomitans, and
Capnocytophaga ochracea. H. actinomycetemcomitans and
C. ochracea, particularly, were little ingested. The number of bacteria phagocytosed and killed increased with exposure time. This suggests that the phagocytic and killing activity of PMNL may be involved in the establishment of oral infectious diseases.
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Hiroyuki KIHIRA, Toshirou TAGAWA, Madoka INUI, Hiroshi NAKAMURA, Atsus ...
1989 Volume 38 Issue 4 Pages
1007-1012
Published: October 10, 1989
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The establishment of a cell line derived from a human osteosarcoma after transplantation into nude mice is reported. Many of the cells were of the fibroblastic type (fusiform type), and the doubling time was 30.75 hours. These cells interdigitated with each other and showed loss of contact inhibition. Blue granules were seen in the cytoplasm following the use of Jacobson's stain. On electron microscopy the cells showed microfilaments in the cytoplasm. Alkaline phosphatase was weakly positive and acid phosphatase was moderately positive. Chromosomal analysis showed a human pattern. This cell line should provide a useful model for investigation of human osteosarcoma.
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Nobuyuki ISHIHAMA, Yoshio HIRANO, Madoka INUI, Toshiro TAGAWA
1989 Volume 38 Issue 4 Pages
1013-1022
Published: October 10, 1989
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Two submandibular salivary calculi were studied with scanning electron microscope and X-ray microanalyzer.
In the scanning electron microscope finding of the surface of one calculi, a structure consisted of concentric layers surrounding one central core and line structures were observed.
In another calculi, most amorphic structure, porous and line structures were showed.
By using the X-ray microanalyzer, Ca, P, S, K, Si, Al, Mg, Na, Cl were detected as component elements of two salivary calculi.
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On cases with mandibular prognathism treated by sagittal split osteotomy
Lianq-Horng CHEN
1989 Volume 38 Issue 4 Pages
1023-1036
Published: October 10, 1989
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Moiré topography was employed to evaluate pre- and post-facial contour changes in 42 cases of mandibular prognathism treated by sagittal split osteotomy. The relation between bony changes and related soft-tissue change induced by surgery was also studied.
In the mandibular prognathism without asymmetry group:
1) Marked retraction was noticed in the chin region ; i. e. aproximately 1: 1 correlation with underlying bony change was observed, and this decreased progressively upward and backward.
2) The upper lip was slightly reduced by the osteotomy. No direct effect, however, was observed in the buccal region.
3) Soft tissue chages in the lower third of the face were strongly correlated to the movement of the underlying skeletal structure. The degree of mandibular set-back and mandibular counterclockwise rotation correlated highly with soft-tissue changes around the chin.
In the mandibular prognathism with asymmetry group:
1) No definite changes were noticed in the lower soft-tissue around the chin area.
2) In addition to backward movement and counterclockwise rotation, lateral rotation of the mandible also played a role in post-operative facial soft-tissue changes. Precise pre-operative prediction proved difficult.
More detailed three dimentional facial evaluation using Moiré topography may be obtained as compaired with the previous reports by using sagittal plane analysis of the lateral cephalogram.
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Tooru EGUCHI, Syuichi NINOMIYA, Hiroshi TAKASE, Shinichi WADA, Nobuyas ...
1989 Volume 38 Issue 4 Pages
1037-1042
Published: October 10, 1989
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Incoordination is a disk movement anomaly in the temporomandibular joint (TMJ) in which the condyle is displaced anterior to the anterior band of the disk at maximum opening and difficulty in closing mouth occurs clinically. This disorder has been previously reported in only 9 cases.
Recently we encountered a case of incoordination in a 43-yaer-old woman. The chef complaint was difficulty in mouth opening and closing. The clinical symptoms observed were intermediate clicking in her left TMJ and overbite.
Conventional radiographic findings of bilateral TMJs showed few changes in hard tissue, therefore, osteoarthrosis was denied.
We thought that the cause of difficulty in mouth opening and closing existed in the soft tissue of the left TMJ, and therefore performed double contrast arthrotomography in the left one. Double contrast arthrotomograms showed anterior disk displacement at hibitual occlusal position and reduction of the disk at 30 mm of opening. Furthermore, the condyle was displaced anterior to the anterior band of the disk at maximum opening (incisal edge clearance is 39 mm). Internal derangement with incoordination in the left TMJ was diagnosed on the double contrast arthrotomography.
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Tae TANAKA, Takahide KOMORI, Humihide YANAGI, Motohiro OHKOSHI, Tetsuy ...
1989 Volume 38 Issue 4 Pages
1043-1048
Published: October 10, 1989
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Schwannoma occuring in the neck is rare. This report presents a case of Schwannoma occuring in the neck. A 17 year-old female was first examined on March 25 th, 1988, with a several month history of slowly growing nodule in the right upper neck region. The mass was found to have smooth surface on palpation. There was no sign of metastasis to the lymph nodes of the neck or other regions. Preoperative needle aspiration biopsy showed Antoni A type schwannoma. Surgery was performed under intubated general anesthesia on Aug. 17 th, 1988. The tumor was extirpated with the capsule. The tumor measured nbout 5×4×2.5cm. During surgery, the nerve of origin of the tumor couldn of be found. The vagus nerve was assumed to be the origin of the tumor as hoarseness occured after surgery.
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Naoki SUGIURA, Ikuko KUBO, Tatsuko AOYAMA, Kinko KAKEHI, Takaaki TSUJI ...
1989 Volume 38 Issue 4 Pages
1049-1057
Published: October 10, 1989
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A Japanese female, 9 years of age with juvenile periodontitis, presented at our hospital complaining of mobility of the upper and lower incisors and first molars and gingival bleeding. She had no marked medical history. Oral and medical examinations were as follows:
1. Dental radiographs revealed moderate bone loss, especially in the regions of incisors and first molars.
2. Immunological examinations showed positive antinuclear antibodies, increased IgM.
3. Increased thyroid activity was noted, and showed antithyroglobulin and antimicrozome. We suspected a Hashimoto-like asymptomatic autoimmune disease.
4. Bacteriological examination of pus from the blind sac showed mainly gram positive Gemella haemolizans, but no Actinobaciilus actinomycetcomitans or Capnocytophaga.
This case was treated with general oral care and penicillin according to testing the oral bacteria.
Her present oral condition is healthy, normal gingival color and improved alveolar bones.
This study suggests that cases of juvenile periodontitis should be examined to determine if it is a nonsymptomatic disease, and further studies on the relationship between autoimmune disease and juvenile periodontitis should be done.
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Hiroshi KURITA, Kenji KURASHINA, Minoru TAMURA, Tadashi OGISO, Makoto ...
1989 Volume 38 Issue 4 Pages
1058-1066
Published: October 10, 1989
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Apert syndrome is a rare craniosynostotic syndrome characterized by acroce - phaly and syndactyly of the hands and feet. The authors report two cases of Apert syndrome with review of literature regarding oral and maxillofacial findings.
First case; A 26-year-old man visited the left molar area of his mandible caused by a cystic lesion. The patient showed some features peculiar to Apert syndrome ; acrocephaly, maxillary hypoplasia, mandibular prognathism, hypertelorism, exophtalmus and so on, and further examinations led to a diagnosis of atypical Apert syndrome.
Second case; A 13-year-old girl consulted us about a phonetic problem. She had an unsuccessfully treated cleft palate and showed cranio-facial anomalies, symmetric syndactylia, club foot, anomalies in teeth position and mental deficiency. A diagnosis of Apert syndrome was made, but her parents refused any treatment except teeth extraction
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Kohzo TSUCHIKAWA, Joji KATO, Izumi MATAGA, Makoto TSUCHIMOCHI, Kazuhis ...
1989 Volume 38 Issue 4 Pages
1067-1078
Published: October 10, 1989
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This paper describes the clinical and histopathological investigation of 10 cases of oral papillomatous lesions. Clinically the majority of cases occurred in older patients. The areas involved were the cheek mucosa, lower gingiva, palatal mucosa, tongue, and floor of the mouth. Tumour size was the most important clinical differention factor. Verrucous carcinomas tended to show a reddish thinge. Bony invasion was principally observed in verrucous carcinomas.
Histopathologically, 6 cases showed epithelial dysplastic changes identified as verrucous carcinoma. Those not showing epithelial dysplastic change included 3 cases of squamous cell papilloma and 1 case of leukoplakia verrucosa. The verrucous carcinomas showed not only epithelial dysplastic changes existing in the basal portion of the epithelium, such as increased number of mitotic figures, loss of polarity of the basal cells, the presence of more than a layer of cells having a basiloid appearance, but keratinization of single cells or cell groups in the prickle layer. Although they were strongly suspected to be carcinomas, their histopathologic findings were not so aggressive. The case of leukoplakia verrucosa was indistinguishable from a squamous cell papilloma associated with a leukoplakia.
Cases suitable for surgical excision showed a good clinical course. Malignant transformation was seen in 4 cases. Simultaneous squamous cell carcinoma at a second oral site was seen in 2 of 3 cases who died. 5 cases were complicated by hypertension which hampered effective surgical treatment.
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Hikoemon INAMURA, Kazuo RYOKE, Noriyuki OZAKI, Junji FUKUMOTO, Arifumi ...
1989 Volume 38 Issue 4 Pages
1079-1085
Published: October 10, 1989
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Cases of oral cancer with pulmonary tuberculosis have rarely been reported. Recently we encountered a case of a 71-year-old man who was referred to our department for treatment of the floor mouth cancer with pulmonary tuberculosis under treatment. The patient was treated with radical neck dissection and tumor extirpation. Antimicrobial drugs were administered intravenously before and after operation. We performed inhalation therapy positively as respiratory cleanings and attempted shortening of the operation time.
The anesthetist was careful not to raise the endotracheal pressure in order to prevent mycobacterium tuberculosis from spreading to the intact pulmonary area.
Respiratory complications were not observed and the patient has been in good condition with no recurrence for 1 year and four months after removal of tumor.
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Jingo KUSUKAWA, Shunichi TANAKA, Yoshiaki NAKAMURA, Teruo HIEDA, Tadam ...
1989 Volume 38 Issue 4 Pages
1086-1090
Published: October 10, 1989
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Benign cementoblastoma is a very rare odontogenic tumor. W e experienced a case of benign cementoblastoma with the lesion at the 6 root in a 17-year-old female.
It was treated by enucleation and has an excellent prognosis.
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Hitoshi SASAKURA, Takanobu OHKIBA, Tomoyuki IWASAKI, Yuuko ABE, Kooji ...
1989 Volume 38 Issue 4 Pages
1091-1098
Published: October 10, 1989
Released on J-STAGE: September 07, 2011
JOURNAL
FREE ACCESS
The purpose of this paper is to show one of the best ways to correct the cases in which central incisor is to be extracted in early stage. Three cases with extraction of the central incisor were reported here. In each case upper canine and lateral incisor were transpositioned successfully. After canine erupted in the position of central incisor, orthodontic appliances were placed to align the upper arch. First premolor in the opposite side was extracted in order to correct the midline deviation and to retract the anterior segment. After the alignment of arches, only canine was reshaped as central incisor prothodontically.
The prevalence of the transposition of canine and lateral incisor depends on the relative position of crown of canine to root of the lateral incisor in the bone. W e suggest, therefore, abnormality of the central incisor must be found at as early stage as possible in order to set the treatment planning including the transposition of before-mentioned teeth.
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1989 Volume 38 Issue 4 Pages
e1
Published: 1989
Released on J-STAGE: September 07, 2011
JOURNAL
FREE ACCESS
