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Volume 43, Issue 4
Displaying 1-25 of 25 articles from this issue
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Tetsuya FUKUMORI, Madoka INUI, Yutaka SEKI, Masataka NISHI, Jouji NOMU ...1994 Volume 43 Issue 4 Pages 537-542
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSWe investigated the possibility of liposomes being a drug carrier for cis-diamminedichloroplatinum (II) (CDDP). Liposomes were prepared by sonic dispersion of egg phosphatidylcholine: cholesterol (13: 5 molar ratio) in an aqueous solution containing CDDP. The leakage of entrapped CDDP was examined by means of atomic absorption spectrometry. The release of CDDP from liposomes in RPMI 1640 supplemented with 20% fetal bovine serum at 37°C was rapid and depended on the incubation time. The amount released in 48 hours was about 70%. However, liposomes were stable in PBS (-) at 4°C (about 90% latency after 48 hours). Compared with the activity of free CDDP, CDDP encapsulated in liposomes showed decreased antitumor activity in vitro for a human malignant melanoma cell line and two human osteosarcoma cell lines. These results suggest that the antitumor activity of entrapped CDDP was only due to its release from liposomes bound to cells.View full abstractDownload PDF (2740K) -
For Subjects Over 4-Year Follow-upHiroshi KAWAMURA, Hiroshi NAGASAKA, Shuichi SATO, Katsutoshi MOTEGI, J ...1994 Volume 43 Issue 4 Pages 543-550
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSThis study was an electromyographic investigation of gum chewing in skeletal Class III cases corrected by orthognathic surgery.
Electromyograms revealed that gum chewing patterns of the skeletal Class III cases were obviously different from subjects with normal occlusion.
In gum chewing of Class III patients, duration and cycle time of the temporal muscle on the chewing side were significantly long and duration/cycle time was statistically short in comparison with normal individuals.
All coefficients of variation of duration, interval, cycle time and duration/cycle time were distinctly longer in Class III patients than in controls. Class III patients showed disordered masticating rhythm in gum chewing in comparison with controls. Maximum peak electromyographical frequency of the power spectrum on the chewing side was significantly smaller in both of temporal and masseter muscles in Class III patients than in subjects with normal occlusion.
All of these abnormal findings were corrected, following orthognathic surgeries, to values close to normal.
However, one year follow-up was insufficient to obtain the results and comparatively long-term follow-up was necessary.View full abstractDownload PDF (1191K) -
Mayuko KUNIKATA1994 Volume 43 Issue 4 Pages 551-567
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSChromogranins (CGs) are a family of closely related acidic proteins first detected in secretory granules of adrenal medullary cells. They are co-stored and co-released with catecholamines from storage vesicles and sympathetic nervous system, but the function of CGs are largely unknown. The autonomic innervation of the submandibular gland (SMG) has been an attemptd to study immunohistochemical detectable CGs and their possible function in the rat. The present study was evaluated for immunohistochemical detection of CGs in SMGs of rats including postnatal development (1-98 day), anti-CG antibody-injected, isoproterenol (IPR)-treated and duct-ligated rats. From the first to 14th day of the postnatal stage, proacinar cells and/or acinar cells in SMG indicated a strong positive reaction for CGs, with the strongest reaction on 14th day. Subsequently, the stainability for CGs gradually decreased, and the staining was observed with negative reaction on 28th day specimens. The injection of antibody against CGs into rats, from 7th to 21st day, showed a change in the cytomorphology of SMG cells. In these circumstances, CGs may correlate with the cell proliferation of acinar cells in rat SMG. Chronic administration of IPR leads to several-fold enlargements of the acinar cell in the rat. It showed positive reaction for CG. The duct ligated SMG, 21st day specimens showed a slight regenerative proliferation of acinar cells, it occurred positively with CG. The present study has clearly demonstrated that CGs may play a vital role in acinar cell differentiation.View full abstractDownload PDF (21064K) -
with Special Reference to Tongue Muscles and Salivar GlandsHiroyuki KUMAMOTO, Kiyoshi OOYA1994 Volume 43 Issue 4 Pages 568-571
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSAn 8-year-old girl with mitochondrial encephalomyopathy is presented. This girl had a conscious disturbance with tongue muscles mildly hardened at 5 years of age. Histological examination revealed varied diameters of muscle fibers with increased number, size and area of mitochondria. Salivary glands showed increased consistency. Histological examination revealed the oncocytic change of ductal and acinar cells due to increased mitochondria and the formation of microsialolith in intralobular ducts.View full abstractDownload PDF (5781K) -
Shigeharu NAKAMURA, Toru SHIDA1994 Volume 43 Issue 4 Pages 572-579
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSNeuropeptide Y (NPY), a 36-amino acid peptide, was isolated from porcine brain by its C-terminal tyrosine amide. NPY is believed to have nor adrenergic properties; however, not all NPY-immunoreactive nerve fibers have these properties.
In this study, NPY-electropositive innervation of rat submandibular glands was investigated by immunohistochemical techniques.
NPY-like immunoreactive (-LI) nerve fibers which are also immunoreactive for tyrosine hydroxylase (TH) were detected only around the vessels in the lobular area. However, TH-LI nerve nerve fibers were abundant around the acinar cells and ducts, as well as just around the vessels. In the hilus region TH-LI nerve fibers were obseved in large vessels, ducts, nerve bundles and submandibular ganglia were seen. NPY-LI nerve fibers were also detected around the vessels in the hilus region. Nerve bundles immunoreactive for NPY but not for TH were detected in the hilus region. In the superior cervical ganglion (SCG), many cells showed the coexistence of TH with NPY.
Ten days after SCG extirpation, almost all of the NPY/TH-LI nerve fibers had disappeared; however, a few NPY-LI nerve fibers remained. The remaining NPY-LI fibers did not exhibit TH immunoreactivity. In the submandibular ganglia, NPY-LI- cells were detected. Some of these NPYLI cells also showed TH activities. Furthermore, all of the ganglion cells showed AchE activities.
These results suggest that in the rat submandibular gland most NPY-LI nerve fibers exhibiting TH activities are sympathetic and adrenergic originating from the SCG. A few NPY-LI nerve fibers which remained after SCG extirpation and lacked TH-LI were parasympathetic and cholinergic originating from the submandibular ganglion cells.View full abstractDownload PDF (15771K) -
Masayuki AZUMA, Tetsuya TAMATANI, Kazuhiro FUKUI, Tokuyuki YUKI, Mitsu ...1994 Volume 43 Issue 4 Pages 580-585
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSW e examined the status of p53 mutation, a putative tumor suppressor gene, in cultured normal human salivary gland cell clones, which had been immortalized by transfection with origin-defective mutant DNA of SV40. In this study, we employed two anti-p53 antibodies, PAb1801 and PAb240, both of which are murine monoclonal antibodies specifically reactive with p53 products. The characteristics of these antibodies are as follows: PAb1801 detects both wild and mutant forms of human p53, whereas PAb240 is only reactive with humanmutant p53. When expression of p53 was analyzed by both immunocytochemical staining and immunoblot, cell clones were found to express wild-type p53, but not the mutant form of p53. These results, therefore, indicate that normal human salivary gland cell clones transfected with SV40 DNA contain wild-type but not mutant-type p53.View full abstractDownload PDF (3930K) -
Atsushi MORI, Toshiro TAGAWA, Madoka INUI, Jouji NOMURA, Tetsuya FUKUM ...1994 Volume 43 Issue 4 Pages 586-590
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSAn immunohistochemical study was performed on paraffin sections of human malignant fibrous histiocytoma (MFH) grafted into nude mice and original tumor. Original tumor was pleomorphic MFH of the maxilla. Both original and grafted tumor cells expressed vimentin and histiocytic (macrophage) marker CD68 (KP1). A small part of the original tumor reacted with another anti-histiocyte monoclonal antibody (MAb) MAC387, and a few cells expressed HLA-DR. However, the grafted tumor lacked reactivity for these antibodies. Neither the original nor grafted tumor reacted with the anti-leukocyte common antigen MAb. Expression of CD68 suggested that this tumor is histiocytic in origin. However, other immunoreactivity results did not strongly support this hypothesis.View full abstractDownload PDF (9707K) -
Hideaki SAKASHITA, Masaru MIYATA, Hizuru MIYAMOTO, Yuuko MIYAJI, Hiros ...1994 Volume 43 Issue 4 Pages 591-594
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSAdenomatoid hyperplasia of minor salivary glands is an uncommon clinicopathologic entity first described by Giansanti et al. in 1971. It comprises clinical swelling resembling a neoplasm with a histobahologic picture of aggregates of normal-appearing salivary gland tissue in excess of that anticipated for the anatomic site. The significance of this lesion is derived from its clinical resemblance to a neoplesm of salivary gland origin.
We encountered a 45-year-old male who had a mass in the left retromolar area. Under local anesthesia, the mass was excised and diagnosed histopathlogically as adenomatoid hyperplasia of the minor salivary gland.
Very few reports of this lesion appear in literature, and the total number of well-documented cases is 65 (including this case). Especially, this report was the 7th in Japan and clinical and histopathologic features are analyzed. The exact nature of this lesion is not clear.View full abstractDownload PDF (3155K) -
Wataru KOBAYASHI, Waka HIROTA, Mitsugu SUZUKI, Makoto KOBAYASI1994 Volume 43 Issue 4 Pages 595-599
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSRecently serious odontogenic infections have decreased because of improved chemotherapy. A case of thrombocytopenia induced by antibiotics is reported. A 77-year old man with swelling in the right cheek and neck was referred to our hospital. Authors diagnosed him as having parapharyngeal abcess and osteomyelitis, which was treated by antibacterial therapy. The platelet count decreased abruptly. Therefore antibiotics were changed, which improved thrombocytopenia quickly. By clinical course, we diagnosed this case as thrombocytopenia induced by antibiotics.View full abstractDownload PDF (3593K) -
Jitsuo NISHIHARA, Shunichiro NAGAHATA, Keishi TSURUTA, Hiroaki TANIZAK ...1994 Volume 43 Issue 4 Pages 600-603
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSW e encountered a patient who had partial ossification of the styloid ligament adjacent to lesser horn of the hyoid bone. This patient was a 65-year-old man who visited our hospital with chief complaints of pharyngeal and swallowing pain. The symptom did not disappear though he had received the treatment for TMJ arthrosis at another hospital.
No findings were observed through the oral examination of the right tonsillar fossa, but X-ray examination revealed the existence of a radio-opaque lesion from the right mandibular angle to the hyoid bone. According to the clinical diagnosis of the fracture of the styloid process on the right side, the fragment was removed by the intra-extraoral approach.
This removed fragment was shown to be partially ossified tissue of the styloid ligament by operating and pathological findings. It was a bone tissue with normal bone marrow and the formation of new bone was seen on both sides of the removed fragment.
Within a week after operation, the symptom disappeared. At present, about a year after operation, the patient is symptomless.View full abstractDownload PDF (5820K) -
Minoru UEDA, Hideharu HIBI, Atsushi NIIMI, Yoshihiro SAWAKI, Toshio KA ...1994 Volume 43 Issue 4 Pages 604-608
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSIn this report two cases who had recieved segmental mandibulectomy were treated by free scapular osteocutaneous flap and osseointegrated implant.
Patients were 41-and 42-year-old males and their primary diseases were intraosseous neurofibroma and ameloblastoma of the mandible.
The fixtures installed in the grafted bone integrated completely and fixed implant bridges were placed.
The obtained results were satisfactory both aesthetically and functionaly.View full abstractDownload PDF (3270K) -
Etsuko KAYANUMA, Michitoki KINEHARA, Hujio ATSUTA, Hideki TANZAWA, Ken ...1994 Volume 43 Issue 4 Pages 609-614
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSAgnathia literally means absence or severe dysplasia of the mandible. It is a rare expression of first branchial arch malformation therefore, only 100 case have been reported so far. Some of these cases were syndromic, occurring with patterns of associated anomalies. The fetus of our case had been in polyhydramnios, and proved to have mandibular dysplasia with prenatal ultrasound diagnosis at 31 weeks of gestation. Ninety minutes after delivery, this female infant died due to severe respiratory failure. The facial features included agnathia, severe microstomia, low set ears and bird face. The mandible was absent with ordinary X-ray and computed tomography. Chromosomal examination revealed normal karyotype (46XX). The autopsy findings were microglossia, cleft palate, hypoplasia of the cerebellum and congestion of the lung. There are many reports about complicated variation of holoprosencephalyagnathia. In our case, since the separation-formation of telencephalon was normally recognized with X-ray CT, we diagnosed it as agnathia not associated with holoprosencephaly-agnathia.View full abstractDownload PDF (1451K) -
Satoshi ISHIDA, Tomoko SEKI, Norimasa KUROSAKI, Takashi FUJIBAYASHI, H ...1994 Volume 43 Issue 4 Pages 615-619
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSTwo cases of subcutaneous emphysema associated with the use of the air turbine hand-piece in dental treatment of the lower right third molar of a 26-year male and of a 32-year old female are reported. In the process, where sectioning had to be performed, there was sudden swelling of the right side of the face. The cause and probable course of subcutaneous emphysema were explained to the patient by the attending dentist, and the patient's consent for the medical treatment was obt ained. Every dentist should be aware of the possible occurrence of emphysema and its management. This is a report of 2 cases of emphysema occurring after tooth extraction and includes a review of the literature.View full abstractDownload PDF (5749K) -
Yoshiyuki MORIYA, Ken-Ichiro MURAKAMI, Ryo KAKEI, Mitsuo NISHIDA, Tada ...1994 Volume 43 Issue 4 Pages 620-624
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSFacial nerve palsy following sagittal split osteotomy of the mandibular ramus, which is a rare but serious complication, is reported.
A 24-year-old man underwent sagittal split osteotomy performed by the Obwegeser technique for correction of mandibular prognathism. The intraoperative course was uneventful. The mandible was set back 6 mm. Right facial palsy appeared on the first postoperative day. A steroid was given immediately after surgery for about one month, but recovery of the palsy was not obtained. It was postulated that the facial nerve was injured at the trunk of the stylomastoid foramen. According to CT findings, a spicule of the mandible could have compressed the trunk of the facial nerve against the mastoid process. Facial palsy might have arisen from ischemic change of the nerve which was caused by hemorrhage, edema and compression of a spicule of the mandible.
Facial nerve decompression surgery was performed 52 days after sagittal split osteotomy. Facial palsy was completely recovered two months after the decompression.View full abstractDownload PDF (4184K) -
Ken-ichi KOMATSU, Wataru KOBAYASHI, Tohru OGAWA, Hiroto KIMURA, Hisash ...1994 Volume 43 Issue 4 Pages 625-629
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSA case of DIC (disseminated intravascular coagulation) in a patient with carcinoma of the buccal mucosa under preoperative care was reported.
The patient was a 53-year-old man who had been administered an anti-neoplastic agent internally before the first visit to our clinic.
The patient received one course of chemotherapy (450mg carboplatin and 30mg peplomysin). One week later, during preoperative radiotherapy, severe myelosuppresion, such as sudden leucopenia and thrombocytopenia, occurred which is considered to be a relatively risk of chemotherapy. Hematologically DIC was diagnosed, and FOY and platelets were administered immediately. But 10 days after the onset of DIC, the patient died of heart failure.
DIC is one of the most serious complications of head and neck carcinoma, and the importance of careful observation for various symptoms in DIC was emphasized.
Carboplatin was noted to be less nephrotoxic, but more myelosuppresive than cisplatin in the clinical study, and whene combined with other anti-neoplastic agents and/or radiation, adverse reaction tended to be augmented. Therefore, extremely careful and supportive treatment is necessary during administration of this agent.View full abstractDownload PDF (4039K) -
Yasushi HIRATA, Yukou IZUMI, Shigeaki SHIOIRI, Hidemi YOSHIMASU, Norih ...1994 Volume 43 Issue 4 Pages 630-635
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSOsteosarcoma is a very frequent and malignant osteogenic tumor with extremely destructive potential. Osteosarcoma is said to occur more frequently in the mandible than in the maxilla, and in the posterior region than in the anterior region of the jaw. Prognosis is thought to be poorer when occuring in the maxilla than in the mandible. We experienced a case of osteosarcoma occuring in the maxillary canine region.
A 34-year-old female was referred to our hospital, complaining of a separation between the left upper canine and premolar teeth, and swelling of the palate in the same region.
The dental X-ray film showed a radiopaque mass at the apex of the teeth.
CT findings showed the mass to be of the same density as the soft and hard tissues around it. Bone scintigram revealed abnormal uptake in the left maxilla. Chest X-ray film showed no metastasis. Periphery and biochemical blood examination values were all within the normal range.
Diagnosing the case as maxillary tumor, we removed a mass en-bloc for biopsy.
Histopathological examinations of the first resected specimen indicated osteochondroma. During the follow-up period the swelling appeared in the same region again. The second biopsy specimen indicated signs of osteosarcoma or chondrosarcoma. Partial maxillectomy was performed, and since then, there has been no recurrence and no metastasis for more than 3 years.
We reviewed 29 cases of osteosarcoma from 19 Japanese literatures published between 1981 and 1990. Twenty of the 29 cases of osteosarcoma were in the mandible and 9 in the maxilla. Only four case's were diagnosed as osteosarcoma in the initial clinical diagnosis. Twenty cases were diagnosed as osteosarcoma by biopsy, but other lesions such as osteochondroma, fibroma, fibrosarcoma, fibrous dysplasia, inflammatory granulation tissue, malignant fibrous histiocytoma and chondroblastoma were found through pathological diagnosis.
It is occasionally difficult to diagnose osteosarcoma in clinical and pathological findings. Therefore, careful follow-up observations over a long period of time are essential.View full abstractDownload PDF (6768K) -
Atsushi SHINOHARA, Shiro YAMADA, Yoshiaki KAZAOKA, Noriaki KAWAI, Tugu ...1994 Volume 43 Issue 4 Pages 636-644
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSThe patient of Temporomandibular arthrosis often have overlapping symptoms such as trismus, TMJ pain and muscles mastication. Especially, abnormal tonus and a vicious cycle of tonus are related to pain. For such pain and tonus, medication, physiotherapy and exercise cure are done. Tizanidine, a centraly acting muscle relaxant, has not only a muscle relaxation effect but also an analgetic effect. Tizanidine was independently administered to 40 patients with TMJ syndrome, to evaluate its utility. The patients were given Tizanidine from 2 to 4 weeks as a fundmental rule.
Results:
(1) The efficacy rate of all subjects was: effective in 67.5%, and slightly effective in 92.5%.
(2) For 1 week medication, TMJ pain, muscles of mastication, oppressive pain of TMJ and muscles, maximal mouth opening were significant improved. On the other hand, TMJ clicking and crepitation were not improved.
(3) The effect of classified temporomandibular arthrosis for types I and II were highly improved, but type DI and closed lock type did not have good prognosis. Unrelated to the above classificatives, muscle pain and TMJ pain were improved. Especially, the efficacy rate of muscle pain was increased with the passage of time. However the effect was not favorable in patients with symptoms related to deformity and malposition of the disk.
(4) Side effects were observed in 11 cases (24.4%), such as sleepiness in 7 cases, and one case each of languor in body, edema in hands and legs, abnomal feeling in submandibular region and vomitting.View full abstractDownload PDF (1050K) -
Hizuru MIYAMOTO, Hideaki SAKASHITA, Masaru MIYATA, Yuuko MIYAJI, Kenic ...1994 Volume 43 Issue 4 Pages 645-648
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSA case with the primary symptoms of rheumatoid arthrosis at the temporomandibular joint (TMJ) is reported.
A 19-year-old female was referred to our department complaining of a disturbance of the mouth opening. Upon examination, the maximum opening measured 23mm with pain of the right TMJ. Radiological examination showed “hallawing-out erosion” of the top of the right condyle. Nuclear medicine examination with 99mTc scintigraphy showed the accumulation at the right TMJ and the right elbow. The diagnosis was definite rheumatoid arthrosis according to diagnostic criteria for the classification of America Rheumatism Association. The patient was treated with a non-steroidal anti-inflammatory drug.
Since the primary symptoms of the rheumatoid arthrosis rarely appear in the TMJ, it is difficult to make the diagnosis during the early phase of rheumatoid arthrosis. A team-approach with other medical departments should be considered for its treatment because this disease advances gradually to other joints.View full abstractDownload PDF (5993K) -
Syuya NISHIMAKI, Tomoko SUZUKI, Hisashi KANNO, Tateharu KAWASAKI1994 Volume 43 Issue 4 Pages 649-652
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSWe encountered an 18-year-old male, who had three supernumerary teeth in the lower premolar region. Two of them erupted lingually between the first and second premolars, one in the right quadrant and one in the left quadrant. The third one appeared close to the apex of the left second premolar as a impacted tooth with cyst formation. Morphologically, both the right and left supernumerary teeth resembled a regular upper first premolar, and the impacted supernumerary tooth resembled a regular lower second premolar.View full abstractDownload PDF (5582K) -
Shigeru SUZUKI, Kazuo IOROI, Seiichirou OOTSURU, Masashi SUGISAKI, Har ...1994 Volume 43 Issue 4 Pages 653-656
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSA case of a 69-year-old female with synchronous multiple primary carcinomas on the bilateral maxillary gingiva and the right margin of the tongue was presented. The patient had appeared systemic lupus erythematosus and chronic renal failure for two years. Histopathological examination of the biopsy spacemens revealed anaplapstic carcinoma (bilateral maxillary gingiva) and squamous cell carcinoma (tongue). After 22Gy external irradiation, three cancerous lesions disappeared. However, her physical condition worsened and she died of sepsis and disseminated intravascular coagulation 8 months after radiotherapy.View full abstractDownload PDF (7088K) -
Hideaki SAKASHITA, Masaru MIYATA, Hizuru MIYAMOTO, Yuuko MIYAJI, Hiros ...1994 Volume 43 Issue 4 Pages 657-660
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSOsteoma is a benign tumor and rarely arises peripherally on the mandible. A case of peripheral osteoma arising on the left coronoid process of the mandible was reported.
A 65-year-old woman was referred to our department. Her chief complaint was swelling of the left cheek. Radiological examination revealed a well-defined, round radiopaque mass (about 2cm in diameter) on the left coronoid process of the mandible. Clinically, a peripheral osteoma was suspected. Under general anesthesia, the tumor was resected by the intraoral approach. This histopathological examination revealed compact osteoma.View full abstractDownload PDF (6306K) -
Kazue KASAHARA, Ichizo KOBAYASHI, Toshikatsu FUJIWARA, Satoshi NISHIKA ...1994 Volume 43 Issue 4 Pages 661-671
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESS252 cases of odontogenic tumors treated for 21 years, from September 1970 to December 1992, at the Department of Oral Maxillofacial Surgery, Hokkaido University School of Dentistry were clinically analyzed on the basis of the 1992 WHO classification.
1) The tumors were classified as ameloblastoma (52.4%), compound odontoma (18.6%) and complex odontoma (13.4%). The remaining 16% consisted of 5 cases of malignant tumors and 7 rare benign odontogenic tumors.
2) Histopathologically, the ameloblastomas were classified as the follicular type in 49 cases (37%) and plexiform type in 75 cases (57%).
3) Of the 252 cases, 161 were males and 91 were females, a 1.8: 1 sex ratio.
4) The age at the first visit was generally between 10 and 30 years.
5) 189 cases (75%) developed in the mandible and 63 cases (25%) in the maxilla. In most of the mandibular ameloblastomas, the lesions were very extensive, usually extending from the molar to the ramus region.
6) 60% of the chief complains was swelling.
7) Impacted teeth were found in 139 cases (55%).
8) The surgical treatments employed for ameloblastoma were the “Dredging Method”, a conservative procedure, in 77 cases (58%), enucleation in 12 cases (9%), block resection in 10 cases (8%) and hemimandibulectomy in 5 cases (4%). Fifteen cases of ameloblastoma were recurrent.
The surgical treatment usually employed for the other benign odontogenic tumors was enucleation. The “ Dredging Method” was employed in 5 cases where benign tumors, other than ameloblastoma, caused extensive destruction of the mandible. No sign of recurrence had been noted.
9) Two patients with malignant ameloblastoma underwent surgical therapy. One died of uncontrolled tumor, and the other patient has survived for 20 years since surgery without recurrence. A pa-tient with primary intraosseous carcinoma that received surgical and radiation therapy has survived for 14 years since surgery without recurrence. A patient with ameloblastic fibrosarcoma has survived for 7 years since surgery without recurrence, but a patient with an unclassified malignant odontogenic tumor died of uncontrolled tumor after surgery.View full abstractDownload PDF (1402K) -
Shinichi OHASHI, Yuji OGAWA, Makoto AKIYAMA, Hitoshi KAMATA, Junichi S ...1994 Volume 43 Issue 4 Pages 672-675
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSPrader-Willi syndrome is a very rare disease that was first reported by Prader et al. in 1956. Its primary symptoms are hypotonia, mental refardation, hypogonadism, and obesity.
We experienced a case of this syndrome with Ameloblastoma. A 15-year-old female visited our hospital with the chief complaint of painless swelling of the right mandibular gingiva. She had been diagnosed as Prader-W illi syndrome by pediatricians of Jikei University Hospital, and she was short and obese and had other symptoms of the syndrome. Oral examination revealed diffuse swelling of the distal gingiva of the mandibular first molar without fluctuation. X-ray findings showed a hen's egg-sized discrete radiolucent lesion with the impacted right mandibular second and third molars.
Pathological examination of the biopsy revealed an ameloblastoma. Extirpatations were repeated four times under local anesthesia, due to her anxiety about her general condition.
The prognosis was good, and there have been no signs of recurrence.View full abstractDownload PDF (6285K) -
The Patterns of Initial Metastasis and the Application of Supraomohyoid Neck DissectionSatoshi YOKOO, Masahiro UMEDA, Yoshiaki TAKE, Akiteru OHMORI, Osamu TE ...1994 Volume 43 Issue 4 Pages 676-684
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSA clinicopathological study was made of 39 patients with squamous cell carcinoma of the oral cavity who had histologically proven to be neck metastasis at the initial therapy with special reference to the location there of.
The prevalence of neck metastasis was not related to the primary site or T-stage. However, apparent correlation between histologic grade of malignancy and the location of metastasis was found. Patients with histologic malignancy of grade I-II exhibited limited neck metastasis in the submental, submandibular and the upper jugular region. On the other hand, grade III-IV patients often had extended neck metastasis beyond the midjugular region regardless of T-stage.
These results suggested the following: 1) Supraomohyoid neck dissection can be adapted to N1 patients whose histologic grade of malignancy is grade I (well-differentiated squamous cell carcinoma with a well-defined border), 2) N1 patients with histologic grade of malignancy of grade III-IV and N2-3 patients who should undergo radical neck dissection.
In this paper, we advocate that the application of supraomohyoid neck dissection should be considered in view of histologic grade of malignancy as well as the clinical findings.View full abstractDownload PDF (1271K) -
1. Histopathological Metastasis to the Cervical Lymph Node at the Initial TreatmentTomoji MORIYAMA, Mitsuhiro NAKAZAWA, Kayoko AMINO, Tetsuro SUMI, Itsur ...1994 Volume 43 Issue 4 Pages 685-690
Published: October 10, 1994
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSA clinicostatistical investigation was carried out 349 patients with oral squamous cell carcinoma at the Second Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Osaka University from January 1978 to December 1992. Metastasis to the cervical lymph nodes there of at the initial treatment was histologically confirmed in 66 patients (18.9%).
The most significant factors, influencing the frequency of metastasis to the cervical lymph nodes, were primary site, T-stage, histological malignancy points (Jakobsson's) and clinical findings of the primary tumor.
The floor of the mouth had the highest frequency of metastasis (29.7%), and the maxillary sinus had the lowest frequency (10.0%). The tongue was the most common site of primary lesions (40.0%), which metastatic rate of cervical lymph nodes was 14.8%.
The majority of the involved nodes were submandibular lymph nodes (76% in patients with metastasis) and superior internal jugular nodes. But in some patients with tongue carcinoma, metastasis was found at lower cervical lymph nodes.View full abstractDownload PDF (760K)
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