巻号一覧
44 巻 (1995)
- 4 号 p. 563-
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44 巻, 1 号
選択された号の論文の22件中1～22を表示しています
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湯浅 賢治, 三輪 邦弘, 米津 康一, 田畑 修, 荒木 和之, 吉浦 一紀, 田中 武昌, 中山 英二, 有地 榮一郎, 有地 淑子, ...1995 年 44 巻 1 号 p. 1-6
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーWe evaluated the utility of computed tomography (CT) in diagnosis of 62 major salivary gland tumors (48 parotid gland tumors and 14 submandibular gland tumors). While 91.7% of parotid gland tumors and 50.0% of submandibular gland tumors were detected by plain CT, all tumors in both glands were detected by CT-sialography. Thus CT-sialography was more useful than CT in detection of masses, especially of those in the submandibular gland. For differentiation between malignant and benign tumors, when the standard criterion that a malignant tummor has an ill-defined margin was applied, sensitivity was 0.50. When the criterion that we have developed, i.e., that a malignant tumor has an ill-defined margin and/or large low density area were applied, sensitivity was 0.69.
We conclude that although CT is useful in assessing the extent of salivary gland tumors, its utility in differentiating malignant from benign tumors is limited.抄録全体を表示PDF形式でダウンロード (7229K) -
林 勝彦, 長塚 仁, 井上 正久, 永井 教之1995 年 44 巻 1 号 p. 7-13
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーProliferative potential and cell kinetics of ameloblastoma and malignant ameloblastoma were studied by immunohistochemical staining with monoclonal anti-PCNA antibody (PC10. Novocastra).
In this study, 18 primary, 6 recurrent and 2 malignant ameloblastomas were used. Anti-PCNA antibody was labelled in proliferating cells in all the cases. In primary ameloblastomas, the labelling indices showed no significant difference between follicular (mean 13.1%) and plexiform type (15.9%) of ameloblastomas. However, the distribution pattern of PCNA-positive cells in follicular ameloblastomas was different from that of plexiform type: In the former, only peripheral tumor cells of tumor parenchyma were positive for and-PCNA, but in the latter, PCNA-positive cells were diffusely distributed in tumor parenchyma.
In recurrent ameloblastomas, it was noted that PCNA positive rate was higher (22.2%) than that of primary lesions (13.8%).
Malignant ameloblastomas showed that the growth fractions were remarkably higher (43.3%) than primary ameloblastomas. The results of this study clearly show that recurrent ameloblastomas have high proliferating potential in comparison with primary lesions. Moreover, it is suggested that when it is difficult to distinguish between ameloblastomas and malignant ameloblastomas under light microscopy, PCNA immunostaining is useful to differentiate them.抄録全体を表示PDF形式でダウンロード (8375K) -
生体適合性試験における培養細胞の選択岡田 豊, 朝波 惣一郎, 逢坂 文博, 柴 秀行, 矢郷 香, 川本 義明, 平田 千弥, 田中 陽一1995 年 44 巻 1 号 p. 14-20
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーIn order to determine the in vitro biocompatibility of bioceramics, it is important to select cells appropriate for determination. The biocompatibility of bioceramics was investigated by using the rate of early adhesion of cells and the cell growth rate as indicators in three types (KUSA, C20, C26) of osteoblast-like cells having different characteristics and fibroblast (L929). The experimental materials were various types of bioceramics (HAP, Diopside, α-TCP, β-TCP). ALP activity and DNA contents were determined simultaneously with the rates. On the other hand, an in vivo implant study using bone marrow taken from rabbit femurs was performed and compared with the in vitro study.
The results were as follows.
1) Differences due to materials in the cell growth rate and early cell adhesion rate of osteoblastlike cells exceeded those of fibroblasts.
2) Differences in cell growth rate and early cell adhesion rate among materials were most frequently observed in KUSA cells derived from murine bone marrow showing active cell growth and high ALP activity, compared with other type of osteoblast-like cells (C20, C26) derived from rat calvaria.
3) Under in vivo microscopic study, HAP was surrounded by bone tissue but diopside was surrounded by fibrous tissue.
These results suggest that KUSA cell reflects the in vivo results most exactly on biocompatibility test of bioceramics.抄録全体を表示PDF形式でダウンロード (3070K) -
水沼 秀之1995 年 44 巻 1 号 p. 21-31
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーThe study was performed to conduct histopathological and cytological assessment of the effect of CO2 laser irradiation on the process of experimental carcinogenesis by painting DMBA in the hamster cheek pouch. The following results were obtained.
Painting the hamster cheek pouch with 0.5 percent DMBA acetone solution 3 times a week for 5 weeks and waiting 4 weeks resulted in the formation of leukoplakia lesions and small mass lesions closely resembling human precancerous lesions.
No malignant transformation was detected in the group in which leukoplakia lesions were laser irradiated. No significant difference was detected between the malignant transformation rates in the laser irradiated small mass lesions group and the unirradiated group ; however, rapid enlargement of the masses, inward growth of cancer and diffuse tumor cell invasion were observed in the former. PCNA positive rate and the intranuclear mean Ag-NORs number count was increased in cancer of the irradiated group.抄録全体を表示PDF形式でダウンロード (17041K) -
中島 潤子1995 年 44 巻 1 号 p. 32-46
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーCancer cachexia is frequently accompanied by hyperlipidemia. To identify the mechanism underlying these changes in lipid metabolism, serum triglyceride (TG) alterations in hamster cheek pouch carcinogenesis were determined. TG concentration in tumor-bearing hamsters showed a significant increase from an early stage in comparison with other lipids, while the activity of lipoprotein lipase (LPL), the key enzyme of TG metabolism, was drastically reduced. As for the origin of tumor necrosis factor-α(TNF-α), TNF-α was found to be present in both the sera and the extract of tumor from tumor-bearing banisters. Depending upon the concentration of TNF-α added to preincubation, the result was a significant inhibition of LPL activity. Therefore, TNF-α increase in vivo caused the increase of TG in DMBA induced carcinoma bearing hamsters. In this investigation, a study on other serum lipid alterations in hamster cheek pouch carcinogenesis was also conducted.抄録全体を表示PDF形式でダウンロード (7013K) -
林 英司, 力丸 浩一, 里村 一人, 中野 孝三郎, 布袋屋 智朗, 倉郷 貴敏, 長山 勝1995 年 44 巻 1 号 p. 47-54
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーIn the present study, we tried to establish cell lines from 16 patients with squamous cell carcinoma of the oral cavity and maxillary sinus by a modified primary culture method. Finally, four novel cell lines were established, of which HOC 512 was from primary lesion of the maxillary sinus carcinoma, and HOC 1119 and HOC 1-19, and HOC 519 were from neck lymph-node metastases of tongue cancers and of cancer of oral floor, respectively. These cell lines have been cultivated more than one year and are in good condition. Moreover, we tested whether or not these cells could grow in a proteinfree medium of PF 86-1. Consequently, two cell lines were able to propagate serially in a protein-free condition and they were named HOC 519 PF and HOC 1-19 PF. It was also investigated whether or not these cells carry an amplified gene for epidermal growth factor receptor (EGFR) by the Southern hybridization technique using its complimentary DNA, pE7 instert, as a probe. Then, it was revealed that HOC 512 had an obviously amplified gene for EGFR when compared with that of normal human gingival cells. These results suggest that these cell lines are useful to investigate the biological features of oral cancer.抄録全体を表示PDF形式でダウンロード (8836K) -
主観的評価法と客観的評価法による検討山下 夕香里, 大野 康亮, 今井 智子, 松井 義郎, 高橋 浩二, 道脇 幸博, 道 健一1995 年 44 巻 1 号 p. 55-65
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーThe purpose of this study was to assess the postoperative function of oral cancer patients reconstructed with free radial forearm flap using objective assessment and interview.
Forty-three normal individuals and twenty-seven patients served as subjects. Reconstructed patients were categorized into three groups: in the first group, the tongue and floor of the mouth were resected; in the second group, the soft palate and lateral wall of the oropharynx were resected ; and in the third group, the mandible was resected. Subjective asessment was carried out by interview. Objective assessment was carried out by three different methods: the spectrophtometric examination of mastication using ATP particle, the swallowing examination of swallowing using 30m1 water, and the oral feeding examination of ingestion using jelly, grule and cracker.
The results indicated that:(1) in mastication, the functional recovery was obtained by Group 2, Group 3, and Group 1 in that order ;(2) in deglutition and ingestion, it obtained by Group 3, Group 2, and Group 1 in that order. The findings seem to indicate that composite assessment methods (interview and objective examination) are needed in assessment of postoperative oral function.抄録全体を表示PDF形式でダウンロード (1391K) -
由良 義明, 近藤 康夫, 原田 耕志, 辻本 仁志, 日下 淳, 吉田 秀夫, 佐藤 光信1995 年 44 巻 1 号 p. 66-76
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーGenistein and prunetin, inhibitors of protein-tyrosine kinase, inhibited the replication of herpes simplex virus typt 1 (HSV-1) at concentrations of more than 25μM, where as the related compounds, daidzein and genistin, which do not inhibit protein-tyrosine kinase, did not affect the replication of HSV-1. In the presence of genistein, the phosphorylation of tyrosine residues in specific viral proteins, including ICP 19 and 25, was markedly reduced, but the effect of genistein on HSV-1 protein synthesis was marginal. These results indicate that the phosphorylation of tyrosine residues in viral proteins may be essential for the replication of HSV-1.抄録全体を表示PDF形式でダウンロード (10787K) -
小谷 久也, 小林 身哉, 光藤 健司, 渡部 真法, 藤内 祝, 上田 実, 星野 洸1995 年 44 巻 1 号 p. 77-82
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーThe presence of Langerhans cell in the developing mucosal epithelium of mice was investigated by ATPase histochemistry and by electron microscopy. In the stratified squamous epithelium of the tongue and forestomach, a few ATPase-positive Langerhans cells could be recognized at 1 or 2 weeks after birth. They increased in number by 3 weeks of age, but the density was lower than that in epidermis. The ATPase-positive cell in the mucosal epithelium had longer (18-22μm) dendritic processes ; each cell thus occupied a large space. The mucosal Langerhans cell with elongated dendritic processes may well be responsible for the surveillance of a wide area in the defense system of the mucous membrane. The cell has a clear cytoplasm among keratinocytes in the basal cell layer and, under electron microscopy, showed characteristics similar to those of the epidermal Langerhans cells. Birbeck granules were also recognizable in the cytoplasm.抄録全体を表示PDF形式でダウンロード (11517K) -
寺井 陽彦, 島原 政司1995 年 44 巻 1 号 p. 83-87
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーThe effect of artificial palate on palatography were investigated using two different thickness plates (0.7 mm and 1.5 mm), made of thermal plastic resin, in five adult men with normal occlusion. The plates were set for two hours a day respectively, subjective or objective articulatory disorders and palatograms were observed three times, at onset, one week later, and two weeks later.
The results were as follows:
1) The sudjective or objective articulatory disorder were improved two weeks later in patients using the 0.7 mm thickness plate, but a few disorders remained in patients using the 1.5 mm thickness plate.
2) Palatograms of sound [sa] were improved to the normal pattern as time elapsed, but palatograms of sound [ci] were unchanged.
3) These results indicated that sffficient time for practicing with the artificial palate was required before palatography.抄録全体を表示PDF形式でダウンロード (2272K) -
岩瀬 正泰, 杉森 正英, 佐藤 篤, 桜田 重世, 倉地 洋一, 南雲 正男1995 年 44 巻 1 号 p. 88-92
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーThis study was designed to examine the changes of the serum levels of lipid peroxide (LPO) and ceruloplasmin (CP), and the production of reactive oxygen species (ROS) of polymorphonuclear leukocytes (PMN) in postoperative inflammation. In this study, peripheral blood was obtained from thirteen patients with mandibular prognathism preoperatively and on day 1 and day 5 postoperatively and serum LPO, serum CP and luminol dependent chemiluminescence (CL) of PMN were measured, respectively. The results showed that CP concentration and CL significantly increased with the concomitant increase of PMN count on day 1 postoperatively. These parameters have showed a tendency to decrease on day 5 of postoperatively. However, the level of LPO in serum was not altered during observation. Furthermore, these parameters did not show any correlation with each other. These results indicate that, in noninfectious inflammation, LPO would not be accumulated because the host may not need to produce ROS. However, the host may keep the activate state of PMN to maintain homeostasis.抄録全体を表示PDF形式でダウンロード (677K) -
ATP顆粒剤法と食品アンケート法笠井 唯克, 中山 敏, 松浦 秀博, 村松 泰徳1995 年 44 巻 1 号 p. 93-100
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーThe purpose of this study was to evaluate the masticatory function of the patients who under went surgery for tongue carcinoma at Aichi Cancer Center Hospital.
The patients (n=23) were divided into 4 groups as follows ; A. partial glossectomy (n=13), B. oral hemi-glossectomy (n=4), C. hemi-glossectomy (n=3) and D. subtotal glossectomy (n=3).
Evaluating masticatory efficiency by the spectrophotometric method using ATP-G (Adenosine Triphosphate Granules), the absorption values of groups A, B, C and D were 1.55±0.60 (mean±S.D.), 1.42±0.24, 0.97±0.49 and 0.74±0.30, respectively.
These results show that the wider extent of the resection becomes, the more disturbance of mastication becomes.
Ingestive function was evaluated by questionnaire with a listing of 31 different types of foods and classified into grades from 1 to 6. The rates of the grade 6 (best one) patients in group A, B, C and D were 11/13, 3/4, 1/3 and 1/3, respectively.
In all patients, the correlation between ATP absorption values and questionnaire results were recognized. Therefore, this indicated that ATP-G absorption method is useful to evaluate the masticatory function objectively.抄録全体を表示PDF形式でダウンロード (1040K) -
米田 和典, 山本 哲也, 山本 一彦, 尾崎 登喜雄1995 年 44 巻 1 号 p. 101-107
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーThree malignant melanomas accompanying oral melanosis are presented in this article. In case 1 (49-year-old male), pigmentation which started from the palatal gingiva of the right premolars has finally spreaded to the entire palate. At 2 years after the first recognition, the pigmentation revealed microscopical appearances similar to lentigo maligna. The soft palate was swollen slightly 7 years after the start of pigmentation, and malignant change was microscopically ascertained. Metastasis to the upper cervical lymph node occurred 10 months after removal of the primary lesion. No sequelae had been noted after the localized soft palate resection and neck dissection.
In case 2 (30-year-old male), the palatal gingiva of 23 was pigmented and swollen accompaning melanine pigmentation in the marginal gingiva of 55and the hard palate mucosa corresponding to 35 Microscopic examination revealed malignant tumor cells possessing melanine granules in the swollen gingiva, but no malignant findings were observed elsewhere. The pigmented tissues with alveolar bone and positive cervical lymph nodes were resected.
In case 3 (70-year-old male), the gingiva corresponding to 87, 43, and 34 were swollen with pigmentation and necrosis. Other parts of the upper jaw gingiva and palatal mucosawere entirely pigmented, but not swollen. Microscopically, malignant findings were observed in only the swollen gingiva. Partial maxilloectomy and neck dissection of the enlarged lymph nodes were performed. In a short time after surgery, the patient had complications of lethal liver abscess and disseminated intravascular coagulation.
In all cases, both the oral cavity and neck have been controlled. These clinical and histopathological appearances seem to indicate that oral malignant melanoma differs from dermalmelanoma in clinical manifestation, that malignant change of oral melanosis occurs via multistage-transformation from melanosis, and that, after microscopic examination, the pigmented but not swollen tissues should be removed without a wide surgical safe margin.抄録全体を表示PDF形式でダウンロード (13201K) -
伊藤 直子, 奥田 孝, 安岡 忠, 兵東 巌, 中田 隆明, 中島 正人, 土井田 誠1995 年 44 巻 1 号 p. 108-111
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーW e report a case of ameloblastic fibro-odontoma and the literaturein Japan is also reviewed.
An 8-year-old boy was referred to us because of delayed eruption of the right mandibular first molar. On the roentgenogram, radiopaque masses surrounded by radiolucency were recognized at the distal root apex of the right mandibular second deciduous molar. Its clinical diagnosis was odontoma, and the lesion was extirpated under local anesthesia. Radiopaque masses were recognized as tooth-like calcified bodies. Histopathology showed the proliferation of both fibrous tissue andameloblast-like epithelial cells, which resembled dental papillae and enamel organ. Pathological diagnosis was ameloblastic fibro-odontoma.
19 cases (including our own case) were used for clinical evaluation. More than half of the patients were under ten years old. 11 patients were male and 8 were female. The tumor mostfrequently occurred in the mandibular molar region. Histopathology revealed that the tooth-like hard mass showed various developmental stages and resembled immature odontoma.
W e considered this tumor as an odontoma in the early stage because of the similarity in clinical and histopathological appearances.抄録全体を表示PDF形式でダウンロード (5510K) -
河原 健司, 木下 靱彦, 本間 義郎, 小園 知, 志村 介三1995 年 44 巻 1 号 p. 112-115
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーThe discovery of one case of focal epithelial hyperplasia was reported.
It was found upon examination of the gingiva of a 43-year-old female patient and thought to have been caused by infection of human papilloma virus.
Observation of the gingiva of the upper and lower jaws confirmed the presence of small papules 2-3 mm in diameter, growing gregariously ; the papules were milky white in color.
Histopathological observation of the papulous area revealed slight parakeratosis and acantholysis ; observation also confirmed numerous large-scale cells with light cytoplasm (so-called “Koilocytotic atypia”) in the region extending from the polocyte stratum to the cortex.
Immunohistological references confirmed the existence of positive cells of human papilloma virus in the epithelium. Further, observation with a transmission electron microscope confirmed that virions 50 nm in diameter were present in the nuclei and in the bodies of the epithelial cells.
A part of the change to morbid state was transpired with CO2 laser, and no recurrence was confirmed.抄録全体を表示PDF形式でダウンロード (6411K) -
高齢者での文献的検討乾 真登可, 中川 俊幸, 田川 新也, 村田 琢, 後藤 亮, 田川 俊郎1995 年 44 巻 1 号 p. 116-119
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーAn 83-year-old man with a calcifying odontogenic cyst (COC) on the mandible is reported. The Japanese literature describing such cases in the elderly is also reviewed
An elderly man complained that his denture did not fit. Roentogenographic examination indicated a large multiple cystic lesion of the mandible, but there were no radiopaque findings. The lesion was extirpated surgically and was pathologically diagnosed as odontogenic keratocyst. Ghost cells and calcified tissues were found in the epithelium of the keratocyst. Daughter cysts were also found.
Our case is the oldest reported patient with COC, but nine cases above 60 years of age, including our case, have been reported in Japan. Four patients were in their 60 s, 3 in thier 70 s and 2 in thier 80s. Four lesions occurred in the maxilla and 6 in the mandible (two lesions were found in one case). Among patients over 70 years of age (5 cases), large cysts were predominant. Therefore, fenestration was performed in 2 cases.抄録全体を表示PDF形式でダウンロード (3160K) -
金村 成智, 奥田 正人, 福島 淳夫, 築谷 康二, 堀 亘孝, 石田 武1995 年 44 巻 1 号 p. 120-124
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーA case of nonfamilial localized gingival fibromatosis that occurred in a 3-year-old Japanese boy is reported. The segmented swelling with elastic hard and smooth surfacewas localized unilaterally at the gingiva of both upper and lower jaws. Systematic disorders of the endocrine and skeleton were not found upon careful systemic examination by a pediatric doctor at our hospital. The lesion was clinically diagnosed as gingival fibromatosis and was excised under general anesthesia. Histopathologically, the rete ridges were irregularly elongated into the proliferated fibrous tissue and inflammatory cells were not observed. The histopathological diagnosis was the same as the clinical diagnosis. The postoperative course has been good without any evidence of recurrence. Moreover, nonfamilial localized gingival fibromatosis in Japanese literatures was reviewed.抄録全体を表示PDF形式でダウンロード (7085K) -
AgNORs法による検討熊本 裕行, 大家 清, 川村 仁1995 年 44 巻 1 号 p. 125-129
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーAcinar and ductal cells of one case of sialadenosis and three control parotid glands were investigated by argyrophilic nucleolar organizer regions (AgNORs) technique. Sialadenosis was characterized by an increase in size, but not the number of AgNORs in acinar cells. The parotid swelling in sialadenosis is caused by an enlargement of acinar cells with an increased number of secretory granules.抄録全体を表示PDF形式でダウンロード (7077K) -
橋本 孝, 藤田 訓也, 重松 久夫, 早乙女 均, 斎藤 一彦, 朱 春溪, 鈴木 正二1995 年 44 巻 1 号 p. 130-135
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーBenign cementoblastoma is an uncommon neoplasm and is classified as true neoplasms related to the odontogenic apparatus.
In this paper, a new case of cementoblastoma with findings by electron probe X-ray microanalyzer (CMA: Computer-aided Micro Analyzer) is reported. A 20-year-old male was referred to our clinic in March 1990, complaining of swelling and spontaneous pain with over 6 months duration in the lower right molar region. Family and medical histories were not contributory. Extraoral examination showed no evidence of abnomality nor any lymphadenopathy in the region. Intraorally, there was a bone-hard swelling in the right molar region of the mandible. Radiographically, there was a wellcircumscribed radiopaque area (approximately 1.5 cm in diameter) in the lesion, and apparent contiguity between the tumor and the roots of the involved tooth. Clinicoradiographically, it was diagnosed as cementoma. The tumor was enucleated and the involved tooth was extracted under local anesthesia. The patient followeed at satisfactory postoperative course. The gross specimen was 13 × 10 × 13 mm in size, bone-hard, and gray-white in color. Histological diagnosis of benign cementoblastoma was obtained. The findings of CMA showed that large percentages of Ca and P as well as small amounts of Mg, Na, K, and S were contained in the specimen.抄録全体を表示PDF形式でダウンロード (8047K) -
村上 賢一郎, 宮木 克明, 森家 祥行, 藤村 和麿, 別所 和久, 瀬上 夏樹, 西田 光男, 飯塚 忠彦1995 年 44 巻 1 号 p. 136-141
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーOver six years, a long-term follow-up study after disk repositioning surgery was carried out in nine patients with 10 temporomandibular joints (TMJ). The patients consisted of three males and six females aged: 8 to 56 years when they had surgery. The surgical procedure was full thickness disk plication surgery performed on six right and two left unilateral and one bilateral TMJ. The preoperative jaw opening degree was 21.5 mm in average. The follow-up period ranged from six years and one month to seven years and four months. The follow-up study was composed of a questionnaire for evaluation of pain and TMJ dysfunction, clinical examination, and radiographic observation. In three patients, MRI follow-up study was carried out.
As a result, the conditions of eight patients were judged to be excellont, one patient was judged to be good, and no patient was judged to be poor. All patients showed sufficient range of jaw motion, and no pain nor occasional mild pain.
Few patients disclosed inability of mastication of hard food but improved as compared to that condition in the preoperative status. The study disclosed the postoperative long-term stable condition after TMJ disk repositioning surgery.抄録全体を表示PDF形式でダウンロード (6837K) -
Tegafurが舌癌に著効を示した1例松田 耕策, 小枝 浩幸, 山口 泰, 越後 成志, 手島 貞一1995 年 44 巻 1 号 p. 142-146
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーSince the diagnostic technique for cancer has been progressing and the cancer therapy has been increasing the survival rate, the incidence of multiple primary malignancies has been recently increasing.
This report presents an 80-year-old male case of three primary malignancies.
The initial malignancy was a diffuse type malignant lymphoma originating in the lower abdominal skin, the pelvic and the paraaortic regions, the second a well-differentiated tubular adenocarcinoma in the stomach, and the third a squamous cell carcinoma in the left margin of the tongue.
The interval between the first and second malignancies was 7 years and 2 months; the interval between the second and third malignancies was 2 years and 4 months.
Since the second malignancy of the gastric cancer was detected 7 years after irradiation therapy for the initial malignancy of malignant lymphoma, the stomach was involved in the irradiation field. Since the origin and histological type of each of the two malignancies were different, the second malignancy of gastric cancer was suspected to be a radiation-induced cancer.
The tongue cancer (T 2 N 0 M 0) remarkably reacted to oral administration chemotherapy of Tegafur only (600 mg/day), and the tumor completely responded to additional radiation therapy (28 Gy).
Malignant lymphoma relapsed in the right supraclavicular region 9 years after the initial irradiation and chemotherapy, but the tumor was cured by irradiation therapy (60 Gy).
This patient died of other disease 2 years after therapy of the tongue cancer, without recurrence and or metastasis of each malignancy.抄録全体を表示PDF形式でダウンロード (6460K) -
中村 英司, 小野 貢伸, 船岡 孝誠, 戸塚 靖則, 飯塚 正, 雨宮 璋1995 年 44 巻 1 号 p. 147-150
発行日: 1995/01/10
公開日: 2011/09/07
ジャーナル フリーW e recently experienced a case of large epulis fibroosteomatosa. A 35-year-old woman was referred to our hospital in September 1992 because of sudden growth of a lesion on the right upper gingiva. Clinical examination revealed a hen's egg-sized, hard, elastic and nodular mass on the gingiva behind 7|. Its surface was partially ulcerated. Radiographs showed radioopacity in the mass and bone destruction of the alveolar and maxillary bone. Biopsied material was diagonosed as granulation tissue. The lesion was removed. A decayed tooth root was found in the surrounding tissue of the alveoli.
The histologic findings of the lesion showed multiple trabecular bone formations in fibrous tissue and was diagnosed as epulis fibroosteomatosa.抄録全体を表示PDF形式でダウンロード (6711K)
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