日本口腔科学会雑誌
Online ISSN : 2185-0461
Print ISSN : 0029-0297
ISSN-L : 0029-0297
44 巻, 2 号
選択された号の論文の22件中1~22を表示しています
  • 力丸 浩一, 布袋屋 智朗, 藤澤 健司, 中野 孝三郎, 林 英司, 長山 勝
    1995 年 44 巻 2 号 p. 151-159
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    Epidermal growth factor (EGF) is a potent mitogen for a wide variety of cells and its receptor is overexpressed in human squamous cell carcinomas (SCC) including oral cancer. Our previous studies have revealed that the in vitro growth but not the in vivo growth of SCC cells was inhibited by EGF. Recently, EGF was reported to be an inducer of matrix metalloprotenases (MMPs) production by SCC cells. Therefore, there is a possibility that EGF may promote the metastasis of SCC by induction of the MMPs which degrade extracellular matrix such as basement membrane or subendothelial matrix. To address this, we attempted to develop in vivo models of the metastasis and investigated whether EGF promotes metastasis of SCC cells. Out of nine SCC cell lines, which could form tumors on SCID mice, four lines successfully metastasized in the lungs of the animals by injection of cells into the tail vein or the orbital sinus, indicating that metastasis occurs via multiple steps.n the in vivo model, the number of formed metastatic foci was not affected by human EGF.
    These results suggest that EGF administered exogenously does not affect the metastasis of SCC as well as tumor growth in vivo.
  • 小野寺 滋也, 角田 左武郎, 羽鳥 仁志, 岩瀬 正泰, 板橋 勇人, 藤森 伸也, 宮崎 隆, 南雲 正男
    1995 年 44 巻 2 号 p. 160-165
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    The numerous studies on cell attachment or surface interaction between titanium and host cells have been carried out morphologically. However, these techniques require several complicated steps and consume much time. The purpose of this study was to develop a convenient method to evaluate the initial attachment of osteoblastic cells on the titanium plate (TP) by utilizing the marker enzymes of cells.
    In this experiment, UMR- 106 and MC3T3-E1 cells were used as osteoblastic cells, and alkaline phosphatase and lactic dehydrogenase were used as marker enzymes. The results indicated that the enzyme activities were increased with the dependency on incubation times from 30 to 120 min. and number of cells on the titanium plate. When the surface upon initial attachment between smooth TP and rough TP were compared, the enzyme activity was higher in rough TP. Finally, it was concluded that the method introduced in this study was convenient and useful to evaluate the initial attachment of cells on the TP. This method revealed that a rough TP was more efficient than a smooth TP.
  • 植田 栄作, 馬詰 眞, 米田 和典, 山本 哲也, 尾崎 登喜雄
    1995 年 44 巻 2 号 p. 166-178
    発行日: 1995/04/10
    公開日: 2011/11/25
    ジャーナル フリー
    Functions of peripheral blood polymorphonuclear leukocytes (PPMN) and salivary polymorphonuclear leukocytes (SPMN) were investigated in 20 patients with head and neck carcinoma and 20 healthy individuals. In addition, the influence of cancer therapy on salivary suppressive action against candida cell adhesion to HeLa cells and other tumor cell lines was examined periodically. PPMN and SPMN separated from patients generated less superoxide and possessed lower candidacidal activity than those separated from healthy individuals, and these functions were significantly decreased after chemoradiotherapy. Likewise, FMLP-induced chemiluminescence and phagocytosis were significantly suppressed by cancer therapy. Salivary flow rate and concentrations of secretory immunoglobulin A (sIgA), secretory component (SC) and lactoferrin in saliva were decreased with the therapy. Candida cell growth inhibition by saliva was correlated with lactoferrin concentration. Both saliva obtained from patients before treatment and healthy individuals showed near inhibition of candida cell adhesion to the tumor cell lines. However, saliva obtained from patients who received chemoradiotherapy showed a significantly decreased inhibition of candida cell adhesion. The inhibition of candida cell adhesion by saliva was abolished by treatment of saliva with anti-sIgA antibody (Ab), anti-SC Ab, concanavaline A and mannosidase. Like-wise, salivary inhibition of candida cell adhesion was not observed when candida cells or epithelial cells were pretreated with ConA, sIgA or mannose.
    From these results, oral candidiasis complicated with cancer therapy seems to be induced by suppression of neutrophil functions, decrease of salivation and salivary proteins which inhibit candida cell adhesion and growth. In addition, it was clarified that inhibition of candida cell adhesion by saliva depends on mannose residues of sIgA and SC.
  • 玉井 学, 林 解平, 森廣 宏則, 石井 保雄, 小室 裕冉, 指江 浩之, 東村 享治
    1995 年 44 巻 2 号 p. 179-188
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    Single energy quantitative computed tomography (SEQCT) is useful in evaluating vertebral bone mineral content (BMC), and it can segregate cortical bone and trabecular bone in vertebral bodies.
    BMC in the mandible was investigated by SEQCT. The accuracy and reproducibility of this method were examined using the mandible. W e propose using an indefinite region of interest (ROI) when measuring BMC in the mandible and evaluating the replication of results.
    Test results demonstrated good correlation between the BMC and the CaCO
    3 density of the phantom rods as well as good replication. The results of clinical tests demonstrated good replication using the indefinite ROI in the mandible and that repositioning error was slight.
    In conclusion, with the single energy technique, accurate quantitative measurement of BMC was possible.
  • 着色歯のビリルビン分析
    柴田 敏之, 渡辺 一史, 小田 浩範, 加藤 元康, 永易 裕樹, 有末 眞, 村瀬 博文
    1995 年 44 巻 2 号 p. 189-195
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    It is known that the LEC (Long-Evans Cinnamon) rat, an inbred strain of a mutant rat isolated from Long-Evans rats, has spontaneously developed acute hepatitis accompanied with severe jaundice about 4 months after birth, and that the copper metabolism in the LEC rat is abnormal, its clinical signs resemble W ilson's disease. The green-pigmented incisors in LEC rat erupted 3 weeks after hereditary hepatitis, and the pigmentation might be caused by bilirubin from histopathological analysis was reported. In this study, to elucidate the cause of pigmentation, the copper and bilirubin concentration in the pigmented teeth was examined using energy dispersive x-ray analysis (EDX), atomic absorption analysis, and determination of light absorption analysis. In the pigmented area, the peak of copper was not recognized with point analysis using EDX. As a result of atomic absorption copper analysis, LEC rat pigmented teeth contained 6.833±2.353 (ppm) and normal LEA (Long-Evans Agouti) rat teeth contained 2.884±1.183 (ppm). Copper concentration of both teeth were minimal. Bilirubin analysis indicated that in LEA normal teeth bilirubin was not detected but that in LEC pigmentedteeth bilirubin was detected as in LEA artificial pigmented teeth caused by bile duct ligature and bilirubin administration. These results indicated that the pigmentation in LEC rat was caused by bilirubin. Thus LEC rat seems to be a very useful animal model for analysis of the pigmented teeth caused by bilirubin.
  • 第1報 病理組織学的検討
    佐々木 江美, 宇佐美 雄司, 江幡 晃治, 上田 実
    1995 年 44 巻 2 号 p. 196-201
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    Injection of lymphocytes into healthy semiallogeneic hosts or immunocompromised allogeneic recipients results in graft versus host disease (GVHD). The course of GVHD can be acute or chronic, depending on genetic and environmental factors.
    In the oral region, chronic GVHD presents mucous lichen planus and xerostomia caused by the fibrous change of the salivary glands. These symptoms are diagnosed pathologically, but histological changes are not investigated sufficiently.
    Injection of lymphocytes derived from P1 mice into (P1×P2) P1 mice causes the appearance of antibodies to dsDNA consequent chronic form of GVHD. In accordance with Gleichmann's method, the chronic form of GVHD model was made using C57/B6, DBA/2 mouse and their P1 (B6D2P1) mouse in order to investigate the histological and the immunohistological variation of the salivary gland.
    The mice were sacrificed at weeks 4, 6, 8, 10, .12, 20 post transplantation and submitted for histological and immunohistological examination.
    In immunohistological examination, the following monoclonal antibodies were used: antibodies against Thy 1.2, CD 45 R, CD 4, CD 8, H-2 Db, and H-2 Dd.
    Histologically, lymphocytic infiltration into the salivary gland was found at the 4th week after transplantation. These lymphocytes increased with time and atrophic change was observed in the same area. These histological variation were similar to those of Sjögren syndrome.
    By the immunological analysis, CD 4 and H-2 Dd positive T lymphocytes were the majority in lymphocytic infiltration.
    These results suggested that T lymphocytes derived from the donor mainly infiltrate the submandibular gland, and atrophy of adenocytes and damage to the submandibular gland are induced
  • 桐山 健, 吉賀 浩二
    1995 年 44 巻 2 号 p. 202-206
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    Clinico-statistical analysis was performed on 71 cases of maxillofacial fractures in the Department of Oral and Maxillofacial Surgery, Hiroshima Prefectural Hospital from 1986 to 1993.
    The results were as follows:
    1) The majority of the patients were aged 10 to 40 years, with the peak incidence occurring in the 20-year-old group. The male/female ratio was 2.2: 1.
    2) The most common causes of injury were traffic accidents (54.9%).
    3) Forty-five (63.4 %) cases visited our clinic within 3 days after injury.
    4) The majority of the patients were referred to our clinic from the departments of neurological surgery or othopedics.
    5) The most common fractures were midface factures (64.8 %). The fractures of the mandible alone were found in olny 25 cases (35.2 %).
    6) Thirty-eight (53.5 %) cases were treated by open reduction.
  • 中井 英貴, 林 康司, 光藤 健司, 藤内 祝, 上田 実
    1995 年 44 巻 2 号 p. 207-211
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    In this paper, a case of locally advanced and unresectable osteosarcoma of the cheek region, which was treated with combination therapy using hyperthermia, irradiation and chemotherapy, is reported. The patient was a 51-year-old female with recurrent osteosarcoma in cheek region which was 60×70×80 mm. She received a total of 50 Gy 60 Co irradiation. 2 Gy each day for five days a week. Simultaneously, four-time RF-hyperthermia was performed once a week.
    Afterward, she received chemotherapy using high-dose Methotrexate and THP-adriamycin. The effects of the above combined therapy was CR, with no recurrence of the tumor.
  • 下顎枝矢状分割法のために
    秋葉 正一, 酒巻 裕之, 鯨岡 裕晃, 関 睦弘, 青木 秀史, 秋葉 和実, 山口 福光, 追川 哲雄
    1995 年 44 巻 2 号 p. 212-215
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    Raspatories were newly developed for sagittal split osteotomy of the mandible to achieve protective dissection of the periosteum around the ascending ramus, especially at its posterior portion, where dissection was very difficult. Four raspatories make one set, and their distinguishing marks are as follows:
    1. Each raspatory has an overall length of 235 mm and is bent 10 degrees to the rear at the narron shaft, making the edge always visible during dissection.
    2. Each head of the four raspatories has a gradually different curvature. Their use by turns enables easy and safe dissection of the periosteum from the inner surface over the posterior margin of the ramus.
    3. Each raspatory was specifically designed to have a very thick head, which applies adequate pressure to and tension of the periosteal membrane, hence dissection can be performed without damaging the membrane.
  • 高木 伸二, 大矢 亮一, 池村 邦男
    1995 年 44 巻 2 号 p. 216-219
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    A case of a cementifying fibroma of the mandibular bone is reported. A 28-year-old male patient visited our hospital with swelling of the mandibular body on the right side. The biopsy specimen showed a cementifying fibroma and this lesion was treated by extirpation under general anesthesia. No recurrence has been noted for about 9 months after the operation.
    Cementifying fibroma is one of the rare tumors of the jaws. In 33 cases of odontogenic tumors which we experienced between 1988 and 1992 at our department, this cementifying fibroma case was the only one (3.0 %). The plain x-ray showed the radiolucent lesion with no evidence of internal radiopacities, despite the tumor reaching the inferior border of the mandible and being remarkably expanded on the buccolingual side. This means the tumor was clinicopathologically in the late stage. We reviewed 37 cases of cementifying fibroma in Japan reported between 1988 and 1992, only two cases (6.7 %) presented x-ray and clinicopathological features similar to our case.
  • 吉田 博昭, 別所 和久, 藤田 茂之, 瀬上 夏樹, 西田 光男, 村上 賢一郎, 飯塚 忠彦
    1995 年 44 巻 2 号 p. 220-223
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    The positive state of infectious disease among surgical patients in our outpatient clinic was investigated for two years.
    The positive rate of infectious disease by medical interview was 33.3 % for TPHA·VDRL, 50.0 % for HBs antigen, and 63.5 % for HCV antibody, respectively.
    Each prevalence rate of the positive of infectious disease by blood examination was 1.76 % for TPHA, 0.92 % for VDRL, 1.26 % for HBs antigen, 4.0 % for HCV antibody, respectively.
  • 吉田 雅司, 杉原 一正, 山口 孝二郎, 内山 秀樹, 上川 善昭, 山下 佐英
    1995 年 44 巻 2 号 p. 224-230
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    The efficacy of nonionic iron supplementation in autologous blood transfusion for orthognathic surgery was evaluated hematologically. During the two-week preoperative period, when 2 units of blood were donated, oral nonionic iron preparation with 2.4 g of sodium ferrous citrate (200 mg Fe2+) per day was administered repeatedly to mandibular prognathism patients. Iron supplementation induced the advancement of the serum erythropoietin levels during the period of donation significantly (p<0.05), and the other data indicated that the recovery process of postoperative anemia in the Fe-supplement group was better than that in the control group without Fe-supplement. Our results indicated that repeated administrations of nonionic iron preparation during autologous blood transfusion are quite effective to accelerate erythropoietic activity during the perioperative period and can reduce the physiological burden of the patients.
  • 美馬 孝至, 白砂 兼光, 綿谷 和也, 小倉 孝文, 福田 康夫, 松矢 篤三
    1995 年 44 巻 2 号 p. 231-235
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    Basal cell adenoma is a rare benign salivary gland tumor which is placed in a distinctive group of adenomas, in the W orld Health Organization Classification 1991. In this article, a case of basal cell adenoma arising in the left parotid gland of a 50-year-old woman is reported. A well-defined painless tumor in the superficial lobe of the parotid gland was excised surgically and diagnosed as benign parotid tumor. The excised tumor was 20×20 mm, and the cut surface revealed a solid mass with a partial cystic space containing serous liquid.
    Histopathologically, the tumor was well circumscribed by a fibrous connective tissue and mainly composed of monomorphic basoloid cells, forming both solid and trabecular patterns. An ultrastructural study revealed the presence of basal lamina around the tumor cell nests. In the immunohistochemical study, laminin and type IV collagen were strongly positive at the stroma around the tumor cell nests.
  • 歯科技工士のB型肝炎ウイルスならびにC型肝炎ウイルスの抗体保有率
    木原 俊之, 関 直子, 亀山 忠光
    1995 年 44 巻 2 号 p. 236-239
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    We have presented a series of reports referring to the particularity of dental employees. Here is a report dealing with HBV and HCV antibodies in dental technicians.
    The subjects were 40 male dental technicians, whose age distribution ranged from 22 to 62 (mean 40.7) years old and who had been practicing for 2 to 47 (mean 19.9) years.
    The assessment was performed using RPHA method for HBs antigen, EIA method for HBc antibody and PHA method for HCV antibody.
    The results showed HBc antibody in 15 testees (37.5 %) and HCV antibody in one (2.5 %) respectively. The evidence of dental technicians having more HBc antibody than common people did, as expected in view of their higher risk to be exposed to infectious sources, which is less than dentists, required the established sterilization method and thoroughgoing performance of it in the treatmentroom.
  • 三輪 邦弘, 湯浅 賢治, 米津 康一, 神田 重信, 樋口 勝規, 篠原 正徳
    1995 年 44 巻 2 号 p. 240-244
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    Fifty-five patients with parotid gland tumors and fourteen with submandibular gland tumors were evaluated by high-resolution real time linear scanners using transducer frequencies of 7.5 MHz. The results were compared with clinical, surgical and pathological data.
    A comparative study of ultrasonography was carried out to assess respective roles in the investigation of salivary gland tumors and to determine if equivalent or complementary information can be obtained.
    In the cases of salivary gland tumors, the detectability of ultrasonography was 100%. The three signs, that were acoustic shadows, echogenic spots and coarseness in the ultrasonographic images of tumors, were used to decide whether a lesion was benign or malignant were selected. As a result the sensitivity and the specificity of ultrasonography was found to be 88% and 98% respectively.
    It should be noted that ultrasonography was useful for the evaluation of salivary gland tumors and that a benign tumor could be distinguished from a malignant tumor by ultrasound.
  • 保存療法と外科療法の治療成績について
    太田 嘉幸, 額田 純一郎, 加納 康行, 浄徳 佳之, 松本 理基, 藤代 博巳, 上房 健裕, 足立 実, 作田 正義
    1995 年 44 巻 2 号 p. 245-249
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    Six cases each of unilateral mandibular subcondylar fractures with slight displacements treated conservatively and with severe displacements treated surgically from November 1986 to August 1993 at our department were reviewed and evaluated clinically. The results were as follows: 1. As for the average period of maxillomandibular fixation, there were 27 days of conservative procedures and 8 days postoperation of surgical procedure.
    2. At 6 months after removal of maxillomandibular fixations: 1) The maximum mouth opening and the occlusion were obtained with good results of both conservative and surgical procedures. W hen surgical procedures were compared with conservative procedures, limitations of laterotrusion toward the unfractured side, jaw deviations at mouth opening, and signs of temporomandibular joint disfunction were not found.
    2) In X-Ray findings of surgical procedure cases, good bone healing and good morphological recovery were obtained.
    The above results indicated that surgical procedures for mandibular subcondylar fractures with severe displacements of bone fragments should be successful.
  • 佐藤 美樹, 田中 信幸, 佐藤 孝幸, 三村 将文, 天笠 光雄
    1995 年 44 巻 2 号 p. 250-256
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    A clinical study was carried out on 144 tumors in children which was diagnosed by pathological examination among 8, 103 pediatric patients under the age of 15 years old in The First Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tokyo Medical and Dental University between 1978 and 1992. The ratio of boys to girls was 1: 1. Of all the cases, 132 were benign tumor cases and 12 were malignant tumor cases. 60 tumors were shown in the soft tissue and 72 tumors in the jaw bone. The most common tumors were hemangioma in the soft tissue and odontoma of the jaw bone. There were 6 cases of malignant lymphoma which accounted for 50% of all the malignant tumor cases in this study. The most common tumor site in soft tissue was the tongue followed by the lip and buccal mucous membrane and that of the jaw bone was the mandible. The 6-11 years old group was common ; numerous jaw tumors were found at the age of at least 6 years. Lymphoangioma was the most frequent tumor in all the age groups. Enucleation was mainly performed for the benign tumor and surgical therapy was performed for the malignant tumor. In general, the prognosis of the cases of children with tumors was good, however, 4 of 6 patients with malignant lymphoma died.
  • 内山 秀樹, 杉原 一正, 向井 洋, 新屋 俊明, 浜田 邦朗, 山下 佐英
    1995 年 44 巻 2 号 p. 257-260
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    Forty-three cases of pleomorphic adenoma treated in our department from April 1980 to March 1993 were clinico-statistically studied.
    The results were as follows:
    1. Of the 43 cases of pleomorphic adenoma studied, there were 16 males (37.2%) and 27 females (62.8%), and the male to female ratio was 1: 1.69.
    2. With respect to the primary site, 16 cases (37.2%) occurred in the palate.
    3. The sixth decade of life was the age at which 10 patients (23.3%) were affected.
    4. As fnr the size of the tumor. walnut-sized tumors were found in 12 cases (27.9%).
  • 里村 一人, 力丸 浩一, 林 英司, 野沢 孝行, 宮本 洋二, 長山 勝
    1995 年 44 巻 2 号 p. 261-264
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    The cumulative cases of ranula which had been treated from April 1983 to March 1993 in our clinic were reported. Thirty-nine cumulative cases consisted of 13 male and 26 female patients. The youngest patient was 2 years old, and the oldest was 66. Nineteen cases (48.7 %) were below the age of 20. These 39 cases were 87.2 % sublingual type, 5.1 % sublingual-submandibular type and 7.7 % plunging type.
    As for the treatment, marsupialization or extirpation was performed for the sublingual type. Marsupialization was performed for the sublingual-submandibular type. Further, for the treatment of the plunging type of ranula, extirpation or marsupialization combined with extirpation of the sublingual gland was carried out.
    The rates of recurrence were 16.7 % in the sublingual type, 33.3 % in the plunging type, 27.3 after marsupialization, and 12.5 % after extirpation, respectively. Most of the recurrent cases were within four months.
    Moreover, the availability of marsupialization combined with extirpation of sublingual gland and compression in the submandibular region for treatment by the plunging type of ranula was confirmed.
  • 川崎 一慶, 領家 和男, 片岡 聡, 加納 聡, 岡本 和己, 濱田 驍
    1995 年 44 巻 2 号 p. 265-269
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    An analyses of intraoral anomaly and cephalogram for a case of Lowe's syndrome present with open bite and gingival hypertrophy are reported.
    1. The cause that occurred most hypertrophy of gingival in anterior palatal region was not clearly defined, but open bite was considered as one of the causes.
    2. Pulp cavity was enlarged in deciduous and permanent teeth, but the form and the number of teeth was normal in this patient.
    3. As for analysis of the cephalogram, this patient had bimaxillary prognathism and open bite.
  • 木村 幸紀, 代田 達夫, 関 健次, 大野 康亮, 道 健一, 岡野 友宏
    1995 年 44 巻 2 号 p. 270-274
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    A case of double cancer of thyroid papillary carcinoma and squamous cell carcinoma of the lower gingiva is presented. Squamous cell carcinoma (T2N1M0) was diagnosed in a 64-year-old female patient, and tumor excision and radical neck dissection were performed. Histological examination revealed late metastasis from the thyroid papillary carcinoma, which was excised 10 years ago, to the cervical lymph nodes. In addition, it was suspected that thyroid carcinoma, metastasized to the lateral retropharyngeal node, because a low density mass in the retropharyngeal space was detected on CT at the initial examination. Thus a fine-needle aspiration biopsy under the guidance of CT was performed, showing no metastasis to the node. After the aspiration, CT examinations showed the mass had a tendency to disappear. Finally, at the second operation for reconstruction of the mandible, no mass was palpated. Hence the lesion detected at the initial CT examination was retrospectively diagnosed as lymphadenitis with cystic degeneration of the lateral retropharyngeal node
  • 加來 慶久, 河野 憲司, 水城 春美, 柳澤 繁孝, 清水 正嗣
    1995 年 44 巻 2 号 p. 275-281
    発行日: 1995/04/10
    公開日: 2011/09/07
    ジャーナル フリー
    Eight cases of epulis with hard tissue formation were studied clinico-pathologically. The age of patients was from 14 to 59 years with the average of 34.4 years. Four patients were male ; 4 were female. Five cases occurred in the maxilla (3 in the incisor-canine area and 2 in the premolar- molar area), whereas 3 occurred in the mandible (2 in the premolar-molar area and 1 in the incisor-canine area).
    Three types of mineralized tissues were observed histologically: dystrophic calcification, bone and cement-like material. Three cases contained only one type of them, and five other cases showed two or three types. Four cases with dystrophic calcification were noted exclusively in the incisor-canine area of the gingiva. In 7 out of 8 cases, the proliferation of mesenchymal cells, which were characterized by oval or spindle nuclei, was accompanied with hard tissues. It was suggested that these mesenchymal cells were associated with the formation of bone and cement-like materials. Since large amounts of oxytalan fibers were detected in the area with proliferating mesenchymal cells, it was likely that these mesenchymal cells were of periodontal membrane origin.
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