Journal of The Japanese Stomatological Society
Online ISSN : 2185-0461
Print ISSN : 0029-0297
ISSN-L : 0029-0297
Volume 45, Issue 1
Displaying 1-12 of 12 articles from this issue
  • Differentiation Induced by β-Glycerol Phosphate and Ascorbic Acid
    Yukihiro KATO, Yoshiko BANNO, Shigeru NAKASHIMA, Nobumitsu OKA
    1996 Volume 45 Issue 1 Pages 1-12
    Published: January 10, 1996
    Released on J-STAGE: September 07, 2011
    JOURNAL FREE ACCESS
    The combination of β-glycerol phosphate and ascorbic acid increased alkaline phosphatase (ALP) activity in clonal osteoblast-like cell line MC3T3-E1. The increase was detectable at 24 hours after the addition of these agents to growth medium and reached almost maximum at 5 days of culture, suggesting that differentiation into osteoblasts was induced. Treatment of β-glycerol phosphate and ascorbic acid suppressed phosphoinositide-specific phospholipase C (PI-PLC) and phospholipase D (PLD) activations in response to PGF by 20-30% and 15%, respectively. No significant increase of the intracellular cyclic-AMP levels was observed in treatment with differentiation inducers. Western blotting with antibodies of PI-PLC isozymes revealed that the levels of expr-essions of PLC-β1 and PLC-β3 were decreased to 37% and 67%, respectively, in the cells treated for 5 days with the inducers compared to those of control cells, whereas PLC-γ1 was notaltered. These results indicate that differentiation in osteoblast MC3T3-E1 induced by the combination of β-glycerol phosphate and ascorbic acid supressed signal transduction via PI-PLC and PLD activation mediated by PGF due to the decreases of the levels of PLC-β1 and PLC-β3.
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  • Vessels of the Peroneal Region and Fibula
    Mitsuhiro MATSUURA, Kohsuke OHNO, Ken-ichi MICHI, Kaoru EGAWA, Reiji T ...
    1996 Volume 45 Issue 1 Pages 13-30
    Published: January 10, 1996
    Released on J-STAGE: September 07, 2011
    JOURNAL FREE ACCESS
    The clinical anatomy of the vascularized fibula flap and peroneal vessels was investigated using 41 cadavers.
    The results were as follows:
    1. Results of the morphologic examination: 1) Peroneal nutrient arteries were classified as three types: the facies posterior fibulae type (peroneal nutrient arteries that run from posterior to anterior and enter the facies posterior fibulae) accounted for 83%. 2) Type II (two peronealveins and two posterior tibial veins joined to form two posterior tibial veins) accounted for 98. 1%. 3) Most valves (96.9 %) were bicuspid. 4) Venous valves were found most often at confluences.
    2. Results of morphometric examination: 1) The level of origin of the peroneal artery was 6.8 cm distal to the apex capitis fibulae. 2) The maximal length of peroneal vessels that could be used as bone flap pedicles were 7.8cm for arteries and 7. lcm for veins. 3) The totallength of the fibula was 32. 6cm, and the maximal length that could be used for bone grafts was 21.7 cm. 4) The maximal width of the fibular cross sections was 13.1 mm. 5) The maximal cortical thickness of the fibular cross sections was 4.1 mm.
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  • Yoichiro HOSOKAWA, Keiichi OHMORI, Motoyasu NAKAMURA, Tadashi IIZUKA, ...
    1996 Volume 45 Issue 1 Pages 31-38
    Published: January 10, 1996
    Released on J-STAGE: September 07, 2011
    JOURNAL FREE ACCESS
    For the evaluation of concomitant carboplatin and conventional radiotherapy, forty-four patients with maxillofacial cancer were examined between November 1990 and December 1993. At first, all patients underwent external radiotherapy of up to 40Gy with 4 concomitant weekly courses of carboplatin at a dose of 100-120 mg/m2/week. After 40Gy irradiation, 11 patients, including 2 patients with maxillary sinus carcinoma who underwent debulking surgery at 10-20Gy, have continued radiotherapy while 33 patients underwent surgery.
    In two patients, only 3 courses were possible due to renal toxicity. In the other forty-two patients, toxicities were self-limiting and no patient required interruption of carboplatin administration. As compared with historical control receiving radiotherapy alone, intensity of mucositis was not found.
    In forty-two patients, except for maxillary sinus carcinoma, CR+PR was 42.9%, obtained at 40Gy. The actual survival rate and local control rate of 44 patients at 2 years were 72.5% and 74.6% with a mean follow-up period of 27.8 months. These data were similar to the previous data of historical controls receiving radiotherapy alone, and the efficiency of using concomitant carboplatin was not found. Those cases with planned operation were inconclusive by clinical parameters alone although the histopathological findings were estimated at 40Gy.
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  • Toshimi MUROKI, Kiyomasa NAKAGAWA, Etsuhide YAMAMOTO, Shinichi NAKAMUR ...
    1996 Volume 45 Issue 1 Pages 39-45
    Published: January 10, 1996
    Released on J-STAGE: September 07, 2011
    JOURNAL FREE ACCESS
    A 39-year-old woman was reported who recently had buccal phlegmon caused by secondary infection of the 2 radicular cyst with isolated Bacteroides fragilis. She was came to the emergency department because of general fatigue and swelling of face and upper lip. She underwent antibiotic (FOM, CFT) therapy for three days, but this therapy was ineffective. Bacteroides fragilis was isolated as a result of bacteriological examination of dark yellow pus obtained from a closed abscess. Susceptibility of Bacteroides fragilis to 7 antibiotics was tested by bioassay. Susceptible antibiotics were ofloxacin, clindamycin, imipenem, minocycline, and nonsusceptible ones were ampicillin, piperacilin, and lomefloxacine. Surgical drainage, cyst extirpation and tooth extraction was perfomed. It was suggested that the infectious route was endogenous rather than exogenous. Therefore, local proliferation of invading Bacteroides frogilis becomes.
    Critical and spreads throughout the body.
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  • Toshimi MUROKI, Kiyomasa NAKAGAWA, Masayoshi NARINOBOU, Etsuhide YAMAM ...
    1996 Volume 45 Issue 1 Pages 46-50
    Published: January 10, 1996
    Released on J-STAGE: September 07, 2011
    JOURNAL FREE ACCESS
    Traumatic herniation of the buccal fat pad is rare. Recently, a 3-year-and 5-month-old boy visited our clinic ; he had fallen with a toothbrush in his mouth and struck the buccal mocosa with the brush tip.
    His complaints were intraoral bleeding and buccal mass three days after injury.
    Intraoral examination revealed a yellowish-red, smooth mass with pedicle attached to the left buccal mucosa.
    The clinical diagnosis was traumatic herniation of the buccal fat pad.
    The patient was admitted, the mass was surgically excised at the pedicle, and the wound was closed with suture. Pathological examination revealed a mixture of adipose tissue and fibrous connective tissue under inflammatory cellular invasion due to bacterial infection.
    Healing was rapid and uneventful. No recurrence was noted when the patient was seen in April 1995.
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  • Yoshiaki TAKE, Masahiro UMEDA, Naohisa OKU, Satoshi YOKOO, Hironari KA ...
    1996 Volume 45 Issue 1 Pages 51-56
    Published: January 10, 1996
    Released on J-STAGE: September 07, 2011
    JOURNAL FREE ACCESS
    Correlation between the method of mandibular resection and local recurrence was studied in 41 patients with squamous cell carcinoma of the lower gingiva who underwent surgery from 1980 to 1991. The results were as follow:
    1. Marginal mandibulectomy was performed in 18 patients, segmental mandibulectomy in 17, and hemimandibulectomy in 6.
    2. Local recurrence occurred in 6 out of 41 patients. The rate of recurrence was 4/25 (16.0%) in T1·T2 patients and 2/16 (12.5%) in T3·T4, while it was 3/18 (16.7%) in patients who underwent marginal mandibulectomy and 3/23 (13.0%) in those who underwent segmental or hemimandibulectomy.
    3. Marginal mandibulectomy was shown to be a very useful method of mandibular resection, but it was shown that wide resection of the soft tissue surrounding the mandible was important.
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  • Histopathological Study on Section of Discectomy in Human Adult Temporomandibular Joint
    Hiroaki YOSHIDA, Shigeyuki FUJITA, Masaki FURUHARA, Kazuya YOSHIDA, Ke ...
    1996 Volume 45 Issue 1 Pages 57-61
    Published: January 10, 1996
    Released on J-STAGE: September 07, 2011
    JOURNAL FREE ACCESS
    Recently, a patient was encountered who had a perforated disc in the temporomandibular joint.
    MR images showed an anterior disc displacement on the right side.
    Discectomy and condyle head plasty were performed. Histological examination of the extracted disc by hematoxylin and eosin stain, as well as toluidine blue stain, revealed hyperplastic synovial membrane and osteochondroid metaplasia.
    Immunohistological examination of the extracted disc by antigen of type IV collagen and factor-Vlfrelated antigen revealed specific new growth of lymphatic duct in the hyperplastic synovial membrane.
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  • Shinya TAGAWA, Madoka INUI, Atsushi MORI, Yutaka SEKI, Akira GOTO, Tos ...
    1996 Volume 45 Issue 1 Pages 62-66
    Published: January 10, 1996
    Released on J-STAGE: September 07, 2011
    JOURNAL FREE ACCESS
    A case of peripheral ameloblastoma arising in the left retromolar region is described. The patient, a 59-year-old man, was hospitalized with a mass in the left mandibular gingiva. The hard mass was 25×20 ×15 mm in size, and the surface mucosa was normal except for erosion due to denture. The tumor, surrounding gingiva, and adjacent bone were excised by an intraoral procedure. Pathologic examination of the tumor revealed an ameloblastoma of the acanthomatous type. After surgery, no evidence of recurrence was observed.
    The literature on peripheral ameloblastoma in Japan was reviewed. Sixty-three cases were reported in the past 27 years. The age of the patients ranged from 9 to 89 years, with a mean age of 50.7 years. Of 49 cases, there were 35 men and 14 women. The premolar region of the mandible was affected most frequently. Our case was the first one to occur in the retromolar region. Most of the lesions were 1 to 3 cm in size. In almost all cases, various methods of simple excision, local excision with curretage or wide excision with en bloc resection were selected. There was no recurrence in most cases, however, recurrence was found in two cases treated with simple excision.
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  • Seiji IIDA, Kanemitsu SHIRASUNA, Tadafumi ADACHI, Takafumi OGURA, Miki ...
    1996 Volume 45 Issue 1 Pages 67-71
    Published: January 10, 1996
    Released on J-STAGE: September 07, 2011
    JOURNAL FREE ACCESS
    The purpose of this paper was to clarify the evaluation of nutritional estimation during induction chemotherapy of oral cancer. Twenty-four untreated patients with oral squamous cell carcinoma, who received induction chemotherapy with PEP, VCR, MMC and CDDP in our department, were analyzed. For estimation of the nutritional status, the prognostic nutritional index (PNI) proposed by Onodera was used and this index was calculated by the following formula.
    PNI = 0.005 × Lymphocyte count +10 × serum albumin (g/l)
    There was no significant difference between the PNI value of effective cases and that of ineffective cases before chemotherapy. In all cases, the PNI value decreased during chemotherapy, but the value of effective cases was slightly higher than that of ineffective cases throughout the therapy. The rate of decrease in effective cases was lower than that in ineffective cases, and 4 of 6 cases, which showed increase of PNI during 1 course of chemotherapy, were effective cases. According to these results, it was surmised that there is a relationship between the PNI and the effect of induction chemotherapy.
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  • Ken OMURA, Shyujiro MAKINO, Mitsunobu ONO, Shigehito WADA
    1996 Volume 45 Issue 1 Pages 72-79
    Published: January 10, 1996
    Released on J-STAGE: September 07, 2011
    JOURNAL FREE ACCESS
    Reconstruction of the surgical defect of the soft palate and lateral oropharyngeal wall is complicated and frequently results in velopharyngeal dysfunction. In this paper, a simple and reliable reconstructive method of the soft palate and lateral oropharyngeal wall is described and the postoperative function of the patients who underwent reconstruction is evaluated.
    The soft palate is reconstructed by developing a plane between the prevertebral fascia and superior pharyngeal constrictor in the oropharyngeal resection margin. The pharyngeal myomucosal flap is mobilized and sutured to the posterior edge of the hard palate and remaining soft palate, resulting in reconstruction of a smaller velopharyngeal space. Then the faucial arch is narrowed by suturing the edge of posterior pharyngeal wall to the tongue base. Lastly, the exposed muscle of the pharyngeal constrictor and other surgical defects are covered with a forearm flap or myocutaneous flap.
    During the past 15 years, we performed this reconstructive procedure on 15 patients with carcinoma of the oral cavity or oropharynx. All of these patients had the surgical defect of one- to two-thirds of the soft palate combined with the lateral oropharyngeal wall.
    After reconstruction, 14 patients had normal nasal air and swallowing without aspiration. Slight nasal regurgitation of liquids with swallowing developed in 4 patients. Postoperative articulatory dysfunction resulting from velopharyngeal insufficiency was within the acceptable range.
    This reconstructive procedure is easy to carry out and preserves the important function of the soft nalate.
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  • Goro KAWASAKI, Yoshihiro KUGA, Yuko KONDO, Michio TOKUHISA, Akio MIZUN ...
    1996 Volume 45 Issue 1 Pages 80-85
    Published: January 10, 1996
    Released on J-STAGE: September 07, 2011
    JOURNAL FREE ACCESS
    In this report, special reference was placed on epulis osteoplastica and clinico-histopathological analysis was carried out on 40 cases of epulis examined in the First Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, from 1984 to 1993.
    The results were as follows:
    1. The y were classified as 14 cases of epulis granulomatosa (35.0 %), 13 cases of epulis fibrosa (32.5 %), 7 cases of epulis osteoplastica (17.5 %), and 6 cases of epulis hemangiomatosa, according to Ishikawa's classification.
    2. The majority of the patients with epulis was in their fifties to sixties and was females. The majority of the patients with epulis osteoplastica was in their fifties to seventies.
    3. The size of the lesion of epulis osteoplastica was larger than that of other types of epulis.
    4. The site of 27 cases (67.5 %) of epulis was in the upper alveolar region, and the site of the majority of 7 cases with epulis osteoplastica was in the maxillary region.
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  • Tomoko EGASHIRA, Tadamitsu KAMEYAMA, Shinichiro TERASAKI, Yoshifumi KO ...
    1996 Volume 45 Issue 1 Pages 86-90
    Published: January 10, 1996
    Released on J-STAGE: September 07, 2011
    JOURNAL FREE ACCESS
    Herpes simplex virus (HSV) was isolated from the saliva of 7 patients with zoster of the trigeminal nerve to determine the possibility of simultaneous reactivation of varicella zoster virus (VZV) and HSV.
    Saliva specimens for inoculation were collected from the floor of the oral cavity, and the virus was isolated using human embryonic lung (HEL) cells. The saliva specimens were collected daily from inpatients during hospitalization, as well as when these patients visited our hospital for follow-up. HSV was isolated in five of the seven patients. The viruses were isolated only at the time of initial examination in four, but in one patient the virus was isolated several times during hospitalization.
    A lesion of type HSV-1 was found to coexist with HSV in one of the five patients.
    In two patients, HSV was not isolated though one ramus was found to be morbid.
    These results suggest that simultaneous reactivation of type HSV-1 is very common in patients suffering from zoster of the trigeminal nerve.
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