A clinicopathological analysis was made on 43 cases of squamous cell carcinoma of the tongue, which were treated at the First Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry from 1984 to 1995. The clinical stages of these cases were defined as follows: 10 cases were classified as stage I, 13 cases as stage II, 11 cases as stage III, and 9 cases as stage IV. Their five-year cumulative survival rates were 100 %, 72.7 %, 62.5 %, and 40 %, respectively.
These cases were classified into degrees of histological malignancy according to the Anneroth classification, and the relationship of the degree of histological malignancy with the prognosis was examined. The material was analyzed by 6 parameters: degree of keratinization, nuclear polymorphism, number of mitoses, pattern of invasion, stage of invasion, and lympho-plasmocytic infiltration. Each parameter was classified into 4 grades according to morphology.
Total score for each parameter ranged from 8 to 17, and the average score was 11.5. The materials were classified into three groups according to the total score: low malignancy group, moderate malignancy group, and high malignancy group. Their five-year cumulative survival rates were 83.3 %, 76.5 %, and 0 %, respectively.
A close correlation was found between the prognosis and the following parameters: pattern of invasion, stage of invasion and lympho-plasmocytic infiltration. However, no statistical significance was found between the prognosis and the following parameters: degree of keratinization, nuclear polymorphism and number of mitoses.
View full abstract