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Volume 47, Issue 1
Displaying 1-24 of 24 articles from this issue
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Modulation of Integrin Ligand-binding Activity in Highly Invasive Oral Squamous Cell Carcinoma CellsKentaro MATSUMOTO, Tokuya TOMIOKA1998 Volume 47 Issue 1 Pages 1-8
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSThe invasive phenotype of two oral squamous cell carcinoma (SCC) cell lines (Ca 9-22 and HSC-3) was examined using our invasion model system. Each cell line showed a unique and distinct invasive phenotype; Ca 9-22 cells invaded poorly into the matrix whereas HSC-3 cells invaded extensively. Cell attachment is one of the key steps during the tumor invasion process, and integrins are considered to play an important role in cell attachment. The expression and function of integrins as well as adhesive property of these cells were examined. Although both cell lines similarly deposited laminin or laminin-like substances, Ca 9-22 cells adhered weakly to laminin whereas HSC-3 cells adhered strongly. A singnificant difference in integrin expression between these cell lines was not detected by FACS analysis. The binding activity of each integrin subunit was examined using blocking antibodies. Anti-β1 antibody totally inhibited attachment of both cell lines to laminin. Anti-α6 integrin antibody blocked attachment of Ca 9-22 cells to laminin, but partially inhibited attachment of HSC-3 cells. When the mixture of anti-α2, α3 and α6 integrin antibodies was used, attachment of HSC-3 cells to laminin was abrogated. From these data, it was suggested that HSC-3 cells adhere to laminin via α2 β1, α3 β1, and α6 β1 integrins whereas Ca9-22 cells adhere via α6 β1 integrin. In conclusion, the rnodulation of integrin ligand-binding activity rather than the change in integrin expression was suggested to contribute to the acquisition of highly invasive phenotype of oral SCCs.View full abstractDownload PDF (989K) -
Hideo KUROKAWA, Tomoyuki MURATA, Yoshihiro YAMASHITA, Keiko MIURA, Shi ...1998 Volume 47 Issue 1 Pages 9-15
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSClinicopathological study was conducted using about 73 patients, having 549 lymph nodes with oral squamous cell carcinoma, who had undergone radical neck dissection in our department from 1978 to 1994.
The results were as follows:
1. Metastasis to the cervical lymph nodes was histologically confirmed in 43 patients (58.9%). In 16 of the cases, late metastasis occurred.
2. Relatively higher frequency of metastasis to the cervical lymph nodes was detected in patients with primary lesions of the gingiva of the lower jaw, gingiva of the upper jaw, buccal mucosa, tongue, and floor of the mouth.
3. As to distribution of involved lymph nodes, the majority were recognized in Level 1 and/or Level 2.
4. The five-year-survival rate was 80.4% for patients without metastasis and 24.7% with metastasis.
5. Metastatic lymph nodes were classified by tumor growth stage into 68.3% of intranodal proliferation and 31.7% of extranodal spread.
6. In the cases of high grade malignancy of primary lesion, the frequency of lymph nodes metastasis and spread of tumor growth stage in the cervical lymph node was higher than in the cases of the other grade of malignancy.
7. The incidence of p 53 protein in primary lesion correlated significantly with cervical lymph node metastasis.View full abstractDownload PDF (4458K) -
Comparative HRP Study on Neurons Supplying Masseter MuscleKouichi YASUDA, Kiyofumi FURUSAWA, Mikiko TANAKA, Daizo OKUDA, Minoru ...1998 Volume 47 Issue 1 Pages 16-23
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSThe morphological characteristics of primary afferents supplying the rat mylohyoid muscle were examined by using the transganglionic transport of horseradish peroxidase conjugated to wheat germ agglutinin (HRP-WGA). In the five rats, HRP-WGA was applied to the mylohyoid branch of the mylohyoid nerve. HRP-labeled cells were observed within the ipsilateral trigeminal mesencephalic nucleus (Vmes) and ventromedial subdivision of the trigeminal motor nucleus. The labeled cells in Vmes were distributed between 0.9 and 1.5mm from the caudal pole of the nucleus. These cells were unipolar with an average somal diameter of 19.5±1.8mm.
Central projections of the primary afferents of the mylohyoid branch were observed in the ipsilateral medullary and upper cervical dorsal horns of laminae I-III and the adjacent lateral reticular formation. These findings clarified that the mylohyoid nerve branch contains two kinds of primary afferent: muscle spindle and somatosensory afferents.View full abstractDownload PDF (8692K) -
Shinya MAGARA, Takashi YOSHII, Kaoru NAKAO, Keikichi SHIMADA1998 Volume 47 Issue 1 Pages 24-32
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSThe effects of roxithromycin (RXM) on the expression of interleukin (IL)- 6 and IL-1β in experimental osteomyelitis of mouse tibia using S. pyogenes or S. aureus were investigated. The level of IL-6 and IL-1β on day 1, 3, 5, 7, 14, 21, and 28 after inoculation were measured by the immunoassay method. The changes of IL-6 and IL-1β level in osteomyelitis due to S. aureus were estimated after the RXM therapy at a dose of 5mg/kg (p. o.) per day.
The results were as follows: 1) The level of IL-6 peaked in 1 to 3 days after inoculation, whereas the level of IL-1β peaked in 5 to 7 days and was maintained longer than that of IL-6. 2) The level of IL-6 and IL-1β in the S. aureus group was higher than those in the S. pyogenes group, however, the change of the level in both groups was almost the same. 3) The expression of IL-1β was significantly (p<0.05) suppressed in 7 to 14 days by treatment with RXM, but IL-6 expression was only slightly suppressed. 4) Much more sclerotic change of the bone in the group treated by RXM was observed histologically than in the control. These results suggested that RXM acts as an anti-inflammatory agent by suppressing the production of inflammatory cytokine (IL-6, IL-1β) in osteomyelitis.View full abstractDownload PDF (7167K) -
Tetsuji KAWAKAMI, Shouichi MIYAWAKI, Hirohito FUJITA, Katsuhiro HORIUC ...1998 Volume 47 Issue 1 Pages 33-38
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSA studies on the morphological characteristics of teeth and dental arches was conducted. The subjects were 564 Nara Medical University student (433 males, 131 females). Tooth crown sizes, dental arches width, arches length, and cuspal number were determined. Dental arches length and premolar crown sizes were reduced as compared with those of previous subjests. In the group of incomplete eruption or noneruption of mandibular third molar teeth, the value of discrepancy was larger than the group of complete eruption of mandibular third molar teeth.View full abstractDownload PDF (701K) -
Yoshihiro SAWAKI, Hiroko HAGINO, Tomoo ODA, Hideki MIZUTANI, Minoru UE ...1998 Volume 47 Issue 1 Pages 39-43
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSThe purpose of this study was to observe he developing tooth in the area of distraction osteogenesis of the mandible. Five healthy mongrel male dogs with deciduous dentition were used as the experimental subjects. A corticotomy was carefully made around a tooth bud of the permanent first molar. Then the external distractor (Orthofix M-100 (®)) was connected by four screws installed across the corticotomy site. After 10 days for healing of the periosteum, distraction was performed at rate of 0.75mm per day for 10 consecutive days to elongate 7.5mm, and the mandible was held by external fixation to allow ossification of the expanded segment. Then clinical, radiographic, and histological evaluations were performed. As distraction began, the space between the wall of the follicle and the bone expanded. Initially, the open end of the growing root became wider than that of the contralateral first mandibular molar and wavy, and lastly, the apex closed. As a result, the root shape became irregularly, but the first molars erupted normally.View full abstractDownload PDF (9432K) -
Masamichi ITA, Masaki OKAFUJI, Tsukasa KUZUYAMA, Fumihiko SHINOZAKI1998 Volume 47 Issue 1 Pages 44-49
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSIn General, cell death can be classified into two types, necrosis and apoptosis. In this study, whether or not types cepharanthin (CE) induce oral squamous cell carcinoma cell line (KM- 1) was investigated.
The cells were treated with 50 μg/ml of CE. Alive cells were determined by the tripan blue exclusion test. Sub-G1 peak representing DNA fragmentations and DNA strand break were analyzed by flow cytometry using the PC buffer method and TdT-mediated dUTP-digoxigenin nick end labeling (TUNEL) method, respectively. In order to identify the induction of apoptosis, Papanicolaou's stain and agarose gel electrophoresis were performed.
The number of alive cells were notably decreased at 12 hours after treatment, and sub-G1 peak was clearly detected at 36 hours. After 48 hours, about 15% of cells showed DNA strand breaks. However, not only did Papanicolaou's stain not show apoptotic cells, but agarose gel electrophoresis did not demonstrate ladder fomation. These results suggested that CE could induce necrosis accompanied by DNA single-strands breaks.View full abstractDownload PDF (5319K) -
Norio SHIBAKI, Kenji YUASA, Shigenobu KANDA1998 Volume 47 Issue 1 Pages 50-55
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSClassification of facial images was done using the eigen-faces method, which is based on a method known as the principal component analysis.
The average face images of 30 young females aged from 18 to 19 years were prepared, and individual face images were classified into 30 eigen-faces. Then 30 cropped faces of each subject were reconstructed using some of the 30 eigen-faces and the average face. The reconstructed facial images were evaluated as to whether or not they were similar to original facial images by 19 observers.
As a result, estimation scores by observers correlated linearly with the number of eigen-faces. It was considered that the individual face was identified to the cropped face with at least 7 eigen-faces. Furthermore, subjects were classified into 5 groups by cluster analysis with eigen-faces.View full abstractDownload PDF (6696K) -
Report of 5 Case sShigetoshi YOKOYA, Yukihiko KINOSHITA, Takeshi KUZUHARA, Yoshiro HONMA ...1998 Volume 47 Issue 1 Pages 56-60
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSCheilitis granulomatosa (CG) is a rare disease characterized clinically by chronic enlargement of the lips and histologically by nonspecific inflammation and local granulomas with hyperplasia of eptitheloid cells. In this report, five cases with CG, four male and one female, aged between 19 and 47 yrs, with mean age of 30.2 years were presented. Lesions were revealed in the upper lip of two cases and the lower lip of three cases. One of five cases was found to be suffering from Melkersson-Rosenthal syndrome with fissured tongue and oral mucosal swelling, but no peripheral facial nerve palsy. All of the cases had poor oral hygiene, decayed teeth, and periodontitis.
Histological examination revealed edematous change and granulomas of nodularly formed epitheloid cells and proliferation of collagen fibers in the submucosal and muscle layers.
Local treatment was performed by oral hygience, periodontitis therapy, extraction of severely decayed teeth, and apicoectomy. General treatment was performed by the administration of steroids, antiallergic drugs, and antibiotics. As the treatment progressed, the size of lip returned to near normal without recurrence in three cases. In the other two cases, surgical reduction cheiloplasty was performed due to persistent lip swelling and the result was considered to be satisfactory.View full abstractDownload PDF (8172K) -
Hideo KUROKAWA, Kentaro YAMASAKI, Yoshihiro YAMASHITA, Minoru KAJIYAMA1998 Volume 47 Issue 1 Pages 61-67
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSIn this paper, a clinical and histopathological investigation of 113 patients with oral leukoplakia, some with multiple lesion, was presented.
The results were as follows:
1. The lesions were classified by clinical appearance. The white-spotted type was the most prevalent, especially on the tongue, gingiva, and oral floor. The erosive type was found mainly on the tongue, and the verrucous type was found on the tongue, gingiva, and buccal mucosa.
2. As for epithelial dysplasia, there were 38 cases of mild dysplasia, 51 of moderate dysplasia, and 25 of severe dysplasia. Severe epithelial dysplasia was observed mainly on the tongue (84.4%). There was a close correlation between the clinical appearance and the degree of epithelial dysplasia. The verrucous type was the most frequent (87.5%).
3. Recurrence of the lesions was observed in 10 of 128 cases (7.8%). Recurrence was observed between 1 month and 6 years 10 months after treatment; the mean was 2 years 3 months.
4. Malignant progression was observed in 4 of 128 cases (3.1%). Malignant transformation occurred between 7 months and 13 years after treatment ; the mean was 4 years 6 months. Each of these 4 cases had severe epithelial dysplasia before primary treatment.View full abstractDownload PDF (824K) -
Treatment by Impacting Tooth RootKeiko MATSUI, Seishi ECHIGO, Satoshi KIMIZUKA, Masatake ITO1998 Volume 47 Issue 1 Pages 68-75
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSA Case of “ multiple idiopathic root resorption” of all of 26 remaining teeth was reported. This was the first case of root resorption beginning at the cementoenamel juction in Japan. This patient was a 31-year-old male who was healthy according to examination of the endocrine system and osteopathy in general condition. There were no peculiar bacteria in saliva and sordes on the teeth.
Twenty teeth that had spontaneous pain or fracture due to gradual root resorption were extracted.
As for the remaining 6 -teeth with slight resorption, the roots in the alveolar bone were impacted with the mucoperiosteum. Six years after this operation, one root disappeared due to root resorption, but 5 roots remained in the alveolar bone and the condition of the 5 roots did not change as compaired with the condition at the time of operation. The shape of the alveolar ridge was maintained by impacting tooth roots and it was useful for stabilization of the full denture.
According to presented literature concerning “idiopathic root resorption”, the teeth of all cases were extracted. It is thought that impacting roots is suitable for restraint of root resorption beginning at the cementoenamel junction.View full abstractDownload PDF (12637K) -
Tomohiro OHWADA, Kazuyuki TSUNODA, Hiroshi IWABUCHI, Katsuhiro ONIZAWA ...1998 Volume 47 Issue 1 Pages 76-79
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSA Case of complete atrioventricular block was experienced during operation under general anesthesia. The patient was a 60-year-old male who had oral floor cancer and a past history of unstable angina but the clinical course was under a sufficient observation. 100 mg of thiopental sodium and 7mg of Vb were used for induction therapy and 4:2 nitrous oxide, 0.5% of isoflurane, 0.4mg of fentanyl citrate, and 10mg of droperidol were used for the maintenance therapy. Immediately after the operation was initiated, the blood pressure and pulse dropped to the level of 50/30mm Hg and 30 beats/minute, respectively. On the ECG, total atrioventricular block was seen. When intravenous injection of 1mg of atropine sulfate, 40mg of ephedrine hydrochloride, and 3mg of epinephrine as well as heart massage were initiated, total atrioventricular block disappeared along with the increase in the blood pressure and pulse; nevertheless, the operation was discontinued for fear of recurrence.
As for the cause, it was thought that something induced the spasm of the right coronary artery which lead to ischemia of the atrioventricular nodule and subsequent complete atrioventricular block.View full abstractDownload PDF (472K) -
Tomoaki SANO, Takaaki HORIKAWA, Megumi FUKUDA, Takashi OHNISHI, Yoichi ...1998 Volume 47 Issue 1 Pages 80-83
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSA case of geminated tooth erupting in the third molar region of the right maxilla was presented. The patient was a 23-year-old female who was referred to our department by her dentisy. Panoramic radiograph showed an extramely large fused tooth. The lesion was extracted and underwent optical, microradiographic, and histologic examinations. The optical appearance and the X-ray image obtained from the extracted tooth showed an extra large crown, being fused to that of the normal portion of third molar. The root apex was not completed. Low magnification microradiograph of a ground section showed a well-organized dental structure. The large magnification microradiograph clearly showed dentinal tubules which were radially spread from the pulp cavity. Small globe-shaped radiopacities, showing a layerlike structure, were found along the cavity surface. The histologic images also revealed those small globe-shaped radiopacities, as well as those obtained by microradiography. More of those globe shaped radiopacities were found in these structures rather than in the normal portion.View full abstractDownload PDF (6769K) -
An Immunohistochemical Study on Expression of PCNA, p53 Protein, and CD44v6Yoshiaki KAYADA, Koji YOSHIGA, Ikuko OGAWA, Hiroshi ITO1998 Volume 47 Issue 1 Pages 84-88
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSAn extensive erythroplakia was reported with the results of an immunohistochemical examination for PCNA, p53 protein, and CD44v6. A 69-year-old female was referred to the Hiroshima University Dental Hospital for a progressively enlarging red lesion with tenderness of the oral mucosa. Clinical examination revealed extensive red plaque involving the left hard palatal, buccal, and upper alveolar vestibular mucosae. Histological diagnosis of epithelial dysplasia (moderate) was made on the biopsy specimen. Surgical extirpation of the red lesion was performed as three separate operations. The mucosal epithelium in the surgical specimens showed a various degree of epithelial dysplasia. The frequency of PCNA-positive cells in the dysplastic epithelium was significantly higher than that in the adjacent normal epithelium. The expression of p53 protein was only observed in the dysplastic epithelial cells. In the severe dysplastic areas, p53 positive cells were numerous and widely distributed from the basal to superficial layers. On the other hand, the expression of CD44v6 on the cytomembrane was decreased and became heterogeneous in the dvsplastic epithelium.View full abstractDownload PDF (6481K) -
Yasuyoshi HANADA, Masahiro UMEDA, Toru NAKATANI, Shin-iti SUGIOKA, Yas ...1998 Volume 47 Issue 1 Pages 89-94
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSGas producing phlegmon (gas gangrene) rarely occurs in the head and neck region, and the prognosis is poor. Two patients with non-Clostrigium gas gangrene caused by dental infection were reported.
Case 1, an 82-year-old female, consulted our hospital with painful swelling of the buccal and temporal regions after extraction of the mandibular first molar. Case 2, a 33-year-old female, consulted our hospital with painful swelling of the submandibular region after root canal treatment of the mandibular third molar. CT scan of these two patients showed phlegmon with a gas product. They underwent surgery under general anesthesia on the first examination day, and the prognosis was good.View full abstractDownload PDF (6555K) -
Kazuo SANO, Masataka UEHARA, Hidenori NINOMIYA, Hiroyo DOTSU, Hiroaki ...1998 Volume 47 Issue 1 Pages 95-100
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSThe osteotomy technique of the zygoma and zygomatic arch in the Crockett's operation was modified to approach the pterygopalatine region, and this technique was applied to a patient with carcinoma of the maxillary gingiva and a patient with hard palate cancer. The osteotomy and fixation technique as well as the clinical course were presented.View full abstractDownload PDF (1545K) -
Yutaka KOBAYASHI, Koji KINO, Hirokazu MANITA, Riri SATOU, Kiyoshi KIKU ...1998 Volume 47 Issue 1 Pages 101-107
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSFrom April 1964 to March 1995, 1597 cases of cysts in the soft tissue were diagnosed histopathologically in our department.
1. Of all the soft tissue cysts, 100 (6.2%) of the cases were diagnosed either dermoid or epidermoid cyst. Among those 39 cases were dermoid cysts and 61 cases were epidermoid cysts.
2. Among 39 cases of dermoid cysts, the most frequently observed skin appendage was the sebaceous gland (24 cases, 61.4%), followed by sebaceous gland and hair follicles (6 cases, 15.4 %), only hair (2 cases, 5. 1%), and sebaceous glands, hair follicles, and sudoriferous glands (2cases).
3. As for the sex, the male to female ratio was 1.2: 1 for the dermoid cyst and 3.1: 1 for the epidermoid cyst.
4. As for the age, 41.3% of the patients with the dermoid cyst were between 10 and 20 years, while 52.4% of those with the epidermoid cyst were between 20 and 30 years.
5. Twenty-nine dermoid cyst (74.4%) were located in the floor of the mouth, while the epidermoid cyst were located in the submandibular and upper cervical region (27.9%), the cheek (7.9%), and the floor of the mouth (26.2%).
6. While about 80% of all dermoid cysts were distributed between 1cm and 5cm in diameter, about 80% of all epidermoid cysts were 3 cm or less in size.View full abstractDownload PDF (838K) -
Keiichirou OKAMOTO, Takeshi WADA, Tetsuji OOMATA, Nobuo MORITA, Tadayu ...1998 Volume 47 Issue 1 Pages 108-114
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSFrom 1986 to 1996, 6 patients who suffered from leukemia were found by oral manifestation in our department. Their initial symptoms and clinical courses were investigated. The results were as follows:
1) Gingival bleeding was the initial symptom in 3 patients with a diagnosis of chronic marginal periodontitis by the referring dentist. The diagnosis for one patient was oral candidiasis, and that for the other 2 patients was pericoronitis of lower third molar and suspect of odontogenic infection, respectively. Two patients had been treated surgically by scaling and incision.
2) The period from onset of symptoms until the first visit to our outpatient clinic was relatively short, with an average of 10 days.
3) The initial clinical diagnosis at our outpatient clinic was that 3 patients had leukemia and the other 3 patients had oral candidiasis, perimandibular abscess, malignant tumor, respectively. The patient with leukemia showed a remarkable bleeding tendency and general symptoms such as gingival bleeding, subcutaneous petechiae, paleness, severe general fatigue, fever and appetite loss. For gingival and mucosal bleeding, suture, compression, and gingival bandage were attempted, but local hemostasis was difficult. The diagnosis of leukemia could not be made for 3 patients because they did not show typical oral and general symptoms of leukemia.
4) Attention must be paid to some cases without typical oral and general symptons to diagnose leukemia as early as possible.View full abstractDownload PDF (7531K) -
Yasushi HARIYA, Takashi SEKIGUCHI, Makoto NOGUCHI, Tatsuru SUYAMA, Nor ...1998 Volume 47 Issue 1 Pages 115-119
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSPolymorphous low grade adenocarcinoma (PLGA) is a neoplasm, which predominantly involves minor oral salivary glands, occurring almost exclusively in the palate. An extremely rare case of PLGA in the oral floor was reported.
A 78-year-old female was referred to our clinic with the chief complaint of a painless swelling of the right oral floor. Physical examination revealed a relatively well-demarcated tumor with mucosal ulceration, 50×25mm in size. The cervical lymph nodes were not palpable.
Clinical diagnosis of the tumor of the oral floor was made, and en block resection, including the right upper neck region, was performed.
Macroscopically, necrosis and hemorrhage were found in the tumor.
Histopathologically, the tumor growth pattern was variable, including tubular, solid, trabecular, and papillary-cystic patterns.
Immunohistochemically, keratin was partially positive in the solid, tubular, and papillarycystic patterns. Vimentin and S-100 protein were constantly positive in all growth patterns. Actin was positive in the peripheral cells of the solid pattern, but only slightly positive or not positive in the other patterns. From these findings, it was suggested that the origin of the tumor might be the myoepithelial cells of the intercalated duct.View full abstractDownload PDF (7826K) -
Part 1 Cases of CondylotomyMichiko WATANABE, Hideki MIZUTANI, Katsuhiro SENGA, Yuriko IZUMI, Mino ...1998 Volume 47 Issue 1 Pages 120-126
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSIn this report, condylotomy and intraoral vertical ramus osteotomy (IVRO) were performed on 5 cases of internal derangement of the temporomandibular joint.
The cases were all females and satisfied the following conditions: 1. Painful and/or audible click, 2. Click disappeared under protruded position of the mandible and anterior cross -bite, 3. Maximal opening of mouth of more than 30mm, 4. The personal normal occlusion, 5. No severe deformed condyle on X-ray film and 6. Confirmed mobility of articular disc on manipulation and Magnetic Resonance Imaging (MRI). Six months after operation, the clinical condition was estimated by using mandibular kinesiograph (MKG), MRI and standardized X-ray of the temporomandibular joint. In all cases, the postoperative condition was improved. It was confirmed that condylotomy is useful for internal derangement of the tempo -romandibular joint if appropriate criterior is extablished.View full abstractDownload PDF (2007K) -
Goro KAWASAKI, Masato NAKAI, Mikiko TAKANO, Nobuyuki BABA, Shigeru YAM ...1998 Volume 47 Issue 1 Pages 127-134
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSA clinicohistopathological study was conducted on 38 cases of squamous cell carcinoma of the gingiva, which were treated at the First Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry from 1984 to 1995. The clinical stages of these cases were defined as follows: 4 cases were classified as stage I, 9 cases as stage II, 5 cases as stage III, and 20 cases as stage IV. The five-year cumulative survival rates were 100%, 80%, 60%, and 58%.
These cases were also classified for degree of histological malignancy according to Anneroth's classification. The material was analyzed by 6 parameters such as tumor cell population, degree of keratinization, nuclear polymorphism and number of mitoses, as well as tumor-host relationship, degree of pattern of invasion, stage of invasion and lymphoplasmocytic infiltration. Each parameter was classified into 4 grades accordind to the morphology. The materials were classified into three groups according to the total score: low malignancy group, moderate malignancy group and high malignancy group. Their five-year cumulative survival rates were 66.7%, 78.3%, and 35.7%. Furthermore, the materials were classified into three groups according to the score of 3 parameters of tumor cell population and the score of 3 parameters of tumor-host relationship: low malignancy group, moderate malignancy group and high malignancy group. Their cumulative survival rates by tumor cell population were 100%, 65.7%, and 40%, and those by tumor-host relationship were 40%, 76. 5%, and 50%.View full abstractDownload PDF (712K) -
Hirohito FUJITA, Tetsuji KAWAKAMI, Masashi TSUZUKI, Ken-Ichi TAKAYAMA, ...1998 Volume 47 Issue 1 Pages 135-140
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSThe efficacy of the pumping-manipulation technique in combination with sodium hyaluronate for internal derangement of the temporomandibular joint of 139 patients, 161 joints, was evaluated. The patients were 16 males and 123 females. The age of the patients ranged from 13 to 73 years (mean age of 27.3 years).
This technique was followed by pumping of the upper compartment to distend the joint space after local anesthesia. Maximal mouth opening, joint pain level, and daily activity level were evaluated.
The results suggested that the pumping-manipulation technique is an effecitive method for treating patients with interanal derangemet of the temporomandibular joint and can be performed under local anesthesia in the outpatient clinic.View full abstractDownload PDF (2880K) -
Akinori OHIRA, Yoshiki SUGIYAMA, Saburo SEKIYAMA, Masanori SHOZUSHIMA, ...1998 Volume 47 Issue 1 Pages 141-146
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSRecently, with the development of antibiotics, detection of the pathogenic microorganisms in actinomycosis has become difficult, and the number of patients with typical symptoms has decreased. In this report, a case of actinomycosis showing bone absorption in the coronoid process was presented.
The patient was a 59-year-old male with the chief complaint of swelling in the right cheek. He was first examined June 19, 1996. Five years ago, swelling occurred in the right cheek after extraction of the lower right second molar, but it was left untreated. The swelling in the right cheek increased 3 weeks after extraction of the lower right first molar in May 1996, and the patient showed trismus. Then the patient was referred to our hospital. The anamnesis included liver cirrhosis and esophageal varices. As for extraoral observation, a diffuse inelastic swelling measuring about 50 mm in diameter was observed in the region corresponding to the right parotid gland. The opening width of the mouth was 18 mm. As for intraoral observation, exudation of pus was noted in the region corresponding to the lower right first molar. The clinical diagnosis at the first examination was possible tumor in the right parotid gland. Radiography and CT revealed bone absorption in the right side of the head and ramus of mandible. A hyperintense area was found by MRI and T 2 -weighted imaging from the masseter to the parotid gland. Gallium-67 scin-tigraphy showed accumulation in the temporomandibular joint, and Technetium-99m-MDP scin-tigraphy showed accumulation in the right body to head of mandible. Blood flow was measured by the color and power doppler methods. As for treatment and clinical course, the swelling was reduced and localized by chemotherapy using PIPC and AMPC, and a sample was excised. His course has been good without recurrence. The pathohistological diagnosis was actionmycosis.View full abstractDownload PDF (11255K) -
Akira KITAMURA, Narihiro KAMASAKI, Yuji NARIMATSU, Tsugio INOKUCHI1998 Volume 47 Issue 1 Pages 147-150
Published: January 10, 1998
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSTitanium oxide is known to be biocompatible and corrosion resistant. However, there have been some reports of an elevated titanium level due to passive dissolution, wear or fretting of implants. In this experiment, the peak of titamium was detected in the soft tissue surrounding titanium plate by X-ray microanalyser (XMA). The case was gum cancer and bone fixed by titanium plate after tumorectomy and mandibular osteotomy. The specimens were removed from the patient because infection was suspected one year after the operation.
The inspection was carried out by transfer electron microscope (TEM) and X-ray microanalysis. There were two types of small monotone particle, one was nontypical and the other was crystal-like. Titanium was detected at the crystal-like particle.
According to recent findings, dissolution behavior of titanium is associated with a change in the surface oxide or biological effects of the structure from mixed oxides to a more stable structure in the body. Long-term observation could be necessary for the biological relevance of these release effects because titanium is known to be nontoxic and well-tolerated.View full abstractDownload PDF (6379K)
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