Ten primary cases of malignant lymphoma in the oral and maxillofacial region, which were treated in our department between 1985 and 1997, were examined clinically and histopathologically. The results were as follows:
1) The patients consisted of 4 males and 6 females. Their mean age was 61.9 years.
2) The chief complaints were tumor formation in 5 cases, swelling in 4, and spontaneous pain in 1.
3) The presumed primary site of the tumor was the submandibular lymph nodes in 2 cases, the submental lymph nodes in 1, the upper gingiva in 3, the lower gingiva in 1, the hard palate in 1, the oral floor in 1, and the mandibular bone in 1.
4) The initial clinical diagnoses were malignant lymphoma in 4 cases, malignant tumor in 2, benign tumor in 3, and inflammation in 1.
5) Laboratory examination indicated a high LDH level in 5 cases and anti-HTLV-I antibody was positive in 4 cases.
6) Non-Hodgkin's malignant lymphoma was diagnosed in all cases. Histopathological classification was applied according to the LSG classification. In the cases of nodal lymphoma, the tumor cell type was diffuse large in 1 case, diffuse pleomorphic in 1, and follicular medium-sized in 1. In the cases of extranodal lymphoma, the tumor cell type was diffuse large in 2 cases, diffuse mixed in 2, diffuse pleomorphic in 2, diffuse lymphoblastic in 1, and follicular mixed in 1. Immunophenotypic analysis of surface markers revealed that 2 of 3 cases of nodal lymphoma were T-cell type, and 3 of 7 cases of extranodal lymphoma were T-cell type.
7) According to the Ann Arbor staging classification, 4 cases were in stage I, and 6 cases were in stage IV.
8) For treatment, radiotherapy alone was performed in 1 case, both radiotherapy and chemotherapy were performed in 1, and chemotherapy alone was performed in 8 cases.
9) Five patients were alive and 5 patients had died as of May 1997. The overall 5-year survival rate was 29.2 %.
View full abstract