巻号一覧
49 巻 (2000)
- 6 号 p. 313-
- 5 号 p. 271-
- 4 号 p. 219-
- 3 号 p. 157-
- 2 号 p. 57-
- 1 号 p. 1-
49 巻, 4 号
選択された号の論文の6件中1～6を表示しています
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梅原 一成2000 年 49 巻 4 号 p. 219-229
発行日: 2000/07/10
公開日: 2011/09/07
ジャーナル フリーIL-12 has various effects on T cells and natural killer cells including the stimulation of lymphokine production, especially of IFN-γ. IL-12-mediated antitumor effect requires T cell infiltration into tumor masses. However, it remains to be examined whether IL-12 affects the expression of VLA-4/LFA-1 on T cells or modulates the capacity of these adhesion molecules.
In the present study, the expression levels of VLA-4 and LFA-1 on T cells present in lymphoid organs and tumor masses from tumor-bearing mice were analyzed with and without IL-12 treatment in various (two IL-12-curable and two incurable) tumor models. The results showed that significantly enhanced expression of both VLA-4 and LFA-1 (VLA-4intLFA-1int) was observed in some T cells from spleens of IL-12- untreated tumor-bearing mice only in IL-12-curable models. In these models, IL-12 treatment increased the number of VLA-4intLFA-1int T cells in splenic populations as well as the number of tumorinfiltrating T cells. In IL-12-incurable models, VLA- 4intLFA-1int T cells were not generated in spleens, and tumor-infiltrating T cells were hardly harvested even after IL-12 treatment. The inhibition of the VLA-4-VCAM-1 and LFA-1-ICAM-1 interactions with anti-VCAM-1 and anti-ICAM-1 monoclonal antibodies resulted in the prevention of T cell migration, and tumor regression was induced following IL-12 treatment. The results suggested that the capacity of IL-12 to promote T cell migration correlates with the induction of VLA-4intLFA-1int T cells prior to IL-12 treatment.抄録全体を表示PDF形式でダウンロード (1710K) -
井口 新, 梅田 正博, 寺延 治, 古森 孝英2000 年 49 巻 4 号 p. 230-238
発行日: 2000/07/10
公開日: 2011/09/07
ジャーナル フリーThe purpose of this study was to investigate the process of bone formation by combined graft of HA granules and pedicle tibula periosteum into the abdominal subcutaneous tissue in rats.
Thirty rats were divided into 3 groups 1) HAperiosteum group, 2) HA-muscle group, and 3) periosteum group (control group). Histologic examination was done 3 days and 1, 2, 4, and 8 weeks after grafting.
The results were as follows:
1) New bone was formed with endochondral ossification in both the HA-periosteum and the periosteum groups. The results indicated that the periosteum had osteoinduction activity.
2) Both in the HA-periosteum and periosteum groups, cartilage formation was observed 3 days, followed by active ossification 1 week and formation of mature circular bone 4 to 8 weeks after grafting. The extent of hard tissue of the HA-periosteum group was better than that of the periosteum group.
3) In the HA-muscle group, cartilage and bone formation was not seen during the experimental period, which indicated that HA had no osteoinductivity.
4) These findings suggested that combined graft of HA granules and pedicle periosteum could formed the bone into the soft tissue.抄録全体を表示PDF形式でダウンロード (8073K) -
野口 忠秀, 神部 芳則, 内藤 浩美, 赤坂 庸子, 矢尾板 英夫2000 年 49 巻 4 号 p. 239-245
発行日: 2000/07/10
公開日: 2011/09/07
ジャーナル フリーICAM-1は, 上皮細胞と活性化T細胞の接着過程において重要な役割を果たす接着分子の一つである。
今回われわれは, 口腔粘膜と表皮上皮細胞におけるICAM-1の発現状態の違いを解析する目的で, ヒト歯肉ならびに皮膚由来培養上皮細胞を用い, ICAM-1の発現についてIFN-γの影響を観察した。
材料と方法: 検体となる歯肉ならびに皮膚は手術の際に採取し, 1～2週間培養後, 培地にIFN-γを加え5～48時間後に免疫組織化学的ならびにフローサイトメトリーにてICAM-1の発現を観察した。
結果: 免疫組織化学的観察において, 歯肉ではIFN-γ103U/ml添加24時問後でICAM-1の発現を認めたが, 102U/mlでは発現は認めなかった。一方, 皮膚では, 102U/mlで発現を認めた。フローサイトメトリーでの解析では, 10, 102U/ml添加12, 24, 48時間後と103U/ml添加12時間後において, 皮膚に比べ歯肉はICAM-1の発現量が統計学的に有意に低い結果であった。
われわれの結果は, 口腔粘膜と皮膚上皮細胞ではICAM-1発現におけるIFN-γの感受性に違いがあることを示唆した。抄録全体を表示PDF形式でダウンロード (2952K) -
古土井 春吾, 吉位 尚, 林 徹, 宮井 大介, 吉川 朋宏, 古森 孝英2000 年 49 巻 4 号 p. 246-249
発行日: 2000/07/10
公開日: 2011/09/07
ジャーナル フリーTwenty-seven previously untreated patients with oral cancer (Stage III, IV) were analyzed in regard to the relationship of nutritional status to postoperative infections.
The prognostic nutritional index (PNI) proposed by Onodera was used to estimate the preoperative nutritional status. PNI was calculated by the following formula:
PNI=10×serum albumin (g/dl)
+0.005×lymphocyte counts (/mm3)
There was no correlation between PNI value and sex, age, primary site, size and stages of tumor. The number of cases who had infection postoperatively was 6 (22.2%) out of 27 cases. They showed lower PNI (41.0±6.2) than those (46.9±3.4) of noninfection cases (p<0.01). From the results, it is considered that PNI could be beneficial to know the risk of postoperative complications in oral cancer, and the cases who showed lower PNI should be provided a positive countermeasure to improve the nutritional status up to at least 41 in PNI before surgery.抄録全体を表示PDF形式でダウンロード (555K) -
深田 健治, 桑沢 隆補, 西原 昇, 岡本 俊宏, 金子 裕之, 扇内 秀樹2000 年 49 巻 4 号 p. 250-255
発行日: 2000/07/10
公開日: 2011/09/07
ジャーナル フリーA 24-year-old female visited our hospital with chief complaints of high fever, swelling, and marked tenderness of the left cervical region. A clinical diagnosis of cervical lymphadenitis was given. Administration of antibiotics and non-steroidal anti-inflammatory analgesics reduced the fever and alleviated the swelling and tenderness of the cervical region; but swelling of the lymph nodes persisted. On the 31st day, a biopsy was conducted on the lymph nodes. Pathological diagnosis based on the biopsy material was subacute necrotizing lymphadenitis (SNL). By the 5th day following the biopsy, the residual swelling of the lymph nodes had been eliminated. Based on histologic and immunohistologic findings the main pathologic characteristics of SNL is that at first, the T lymphocytes proliferate and undergo apoptosis, and histiocytes phagocytose the apoptotic bodies, and second, the necrotic lesion form.抄録全体を表示PDF形式でダウンロード (4312K) -
小田 有紀子, 宇佐美 雄司, 各務 秀明, 新美 直哉, 重冨 俊雄, 上田 実2000 年 49 巻 4 号 p. 256-259
発行日: 2000/07/10
公開日: 2011/09/07
ジャーナル フリーDental extractions of a patient with idiopathic thrombocytopenic purpura (ITP) sometimes requires platelet concentrate transfusion or local hemostatic management. However, such statistical report is rare. In this report, clinical analysis of 18 patients with ITP who had required dental extraction in our hospital from 1989 by 1999 was reported.
The results were as follows:
1. It was possible to obtain hemostatic after ordinary dental extraction without platelet concentrate transfusion if platelet counts were above 2.5×104/μl.
2. It was possible to obtain hemostasis after impacted tooth extraction if platelet counts were about 5×104/μl.
3. Local hemostasis management was important for ITP patients to decrease in platelet concentrate transfusion.
4. Oral surgeons should consult physicians when planing dental extraction of a patient with ITP.抄録全体を表示PDF形式でダウンロード (627K)
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