巻号一覧
51 巻 (2002)
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51 巻, 5 号
選択された号の論文の5件中1～5を表示しています
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大林 由美子, 三宅 実, 岩崎 昭憲, 今川 尚子, 西山 佳宏, 山本 由佳, 小川 尊明, 谷崎 明弘, 長畠 駿一郎2002 年 51 巻 5 号 p. 315-323
発行日: 2002/09/10
公開日: 2011/09/07
ジャーナル フリーOral malignant melanoma was treated with a local injection of interferon-β, as immunotherapy. Inter feron-β has a direct local and a systemic effect through an immunological mechanism. In our study, we monitored immunologic parameters (distribution of T-cells and B-cells, CD4/CD8 ratio, natural killer cell activity, antibody-dependent cell-mediated cytotoxicity activity, and lymphocyte blastoid transformation) in three oral malignant melanoma patients treated with interferon-β. The CD4/CD8 ratio went up, in from one to three months after IFN-beta medication was initiated, suggesting a successful response. At the time of tumor progress, T-lymph cell malfunction during progress was observed as a result of the CD4/CD8 ratio at two to three months previously. The immunologic parameters show that cellular immunity based on interferon-β may be reflected in the patient's clinical course in oral malignant melanoma.抄録全体を表示PDF形式でダウンロード (4037K) -
横矢 重俊, 木下 靭彦, 福岡 真一, 水沼 秀之, 小園 知, 田畑 泰彦, 筏 義人2002 年 51 巻 5 号 p. 324-334
発行日: 2002/09/10
公開日: 2011/09/07
ジャーナル フリーThe aim of this study was to evaluate the efficacy of bFGF-incorporated gelatin microspheres (bFGFGMs) for regeneration of experimental mandibular defects. Biodegradable microspheres were prepared from gelatin with an isoelectric point of 4.9, and their water contents were fixed at 75, 85, 90, and 95%. The freerse-dried microspheres were impregnated with PB solution of bFGF, to obtain bFGFGMs. They were implanted in defects made in the base of mandibles of 13 adult beagle dogs. As controls, GMs without bFGF were implanted in the defects, or nothing was implanted. The animals were sacrcificed at 4 and 12 weeks after implantation, and regeneration of the bone defects was studied by histological examination and soft X-ray images.
The area of bone formation was larger in the experimental animals than in the controls, and active bone formation was observed around the bFGF-GMs. GMs with water contents of 95 and 90% were absorbed at 4 and 12 weeks after implantation, respectively. However, those with water contents of 75 and 85% remained, being surrounded by osteoid or bone tissue, at 12 weeks after implanation. It was concluded that the favorable water content of bFGFGMs for bone regeneration in the mandible is 90 to 95%.抄録全体を表示PDF形式でダウンロード (6157K) -
中野 真祐, 鬼澤 浩司郎, 生井 友農, 山縣 憲司, 白土 貴之, 吉田 廣2002 年 51 巻 5 号 p. 335-339
発行日: 2002/09/10
公開日: 2011/09/07
ジャーナル フリーLong-term corticosteroid administration induces secondary adrenal insufficiency and an increased susceptibility to infection. Surgical intervention in patients receiving steroid medication should be performed with consideration to preventing adrenal crisis, delayed wound healing, and infection. To securely manage tooth extraction in patients receiving steroid medication, 50 patients taking predonisolone (PSL) were retrospectively investigated. The mean dosage of PSL in the patients was 14.2mg/day, and the mean duration of the treatment was 7 years and 3 months. Forty-nine of the 50 patients were treated under local anesthesia, and the number of teeth concurrently removed was from 1 to 4. Preoperative supplemental steroid administration was applied to only two patients: one treated under general anesthesia, and the other during a period of reducing steroid dosage. Penicillin was commonly selected as the antibiotic to prevent infection, and it was administered preoperatively and postoperatively, for a mean duration of 4.1 days. As complications, infection occurred in 2 cases, and dry socket and discomfort in 1 case for each, in whom PSL had been taken for more than 12 years. These results suggested that removal of teeth in patients taking steroid medication can be securely performed without supplemental steroid by using effective administration of antibiotics.抄録全体を表示PDF形式でダウンロード (674K) -
癌免疫療法剤OK-432の分子標的岡本 正人, 田野 智之, 大江 剛, 古市 幸子, 西川 英知, 吉田 秀夫, 佐藤 光信2002 年 51 巻 5 号 p. 340-348
発行日: 2002/09/10
公開日: 2011/09/07
ジャーナル フリーThere are few reports describing the molecular mechanism of the anti-cancer effect of OK-432, a streptococcal agent. A useful methodology for discrimination between responding and nonresponding patients to OK-432-based immunotherapy has not been established. Toll-like receptors (TLRs) and their cofactors: MD-2 and CD14, are significant receptors to recognize becterial components. In the current study, we examined whether expression of mRNAs for TLRs and cofactors may be associated with responsiveness to OK-432 in head and neck cancer patients. IFN-γ was analyzed as an index of OK-432 responsiveness. The treatment of peripheral blood mononuclear cells (PBMC), derived from the patients in vitro, with OK-432 resulted in an increased expression of IFN-γ mRNA, irrespective of expression of genes for TLR2, TLR4, TLR9, MD-2, and CD14. When PBMC were stimulated in vitro with OK-PSA: a certain effective molecule of OK-432 prepared in our laboratory, the increase of IFN-γ mRNA expression was almost dependent on expression of TLR4 and MD-2. In contrast, amounts of IFN-γ in sera from the patients administered OK-432 were greatly correlated with expression of TLR4 and MD-2. MD-2 is physically associated with TLR4 on the cell surface and plays an essential role for TLR4 signaling. Activation of immune cells by OK-432, irrespective of TLR4/MD-2 signaling, may be insufficient to induce IFN-γ in vivo but not in vitro. These findings strongly suggest that TLR4 and MD-2 may be certain molecular targets for OK-432 therapy, and that expression of these genes may be a useful marker to discriminate between responders and nonresponders to OK-432.抄録全体を表示PDF形式でダウンロード (2167K) -
吉田 誠孝, 西川 哲成2002 年 51 巻 5 号 p. 349-358
発行日: 2002/09/10
公開日: 2011/09/07
ジャーナル フリーTo investigate the red blood cell destruction that seems to be one cause of anemia accompanying malignant tumors, we examined the enhanced destruction of heat-damaged red blood cells, and the transaction and excretory function to urine of the destroyed cells. Rats with experimentally-induced oral carcinomas were injected with 51Cr-labeled heat-damaged red blood cells. The disappearance of 51Cr from the blood cells, the uptake of 51Cr in the rats' reticuloendothelial system, especially their spleens and in tumor tissues, and excretion of 51Cr in the rats' urine, were examined over time. Their spleens and tumor tissues were observed histopathologically.
Compared with controls, rats with carcinoma showed the following results. The time for disappear-ance of 51Cr from the blood cells, and the time for excretion of 51 Cr in urine, were both prolonged. Although the uptake of 51Cr decreased in the liver, spleen, and bone marrow, it increased in the tumor tissues. In the spleen, there was a decrease in the number of macrophages phagocytizing hemosiderin at the marginal sinus and red pulp. There was increased deposition of hemosiderin in the stroma, and in some cancer pearls of the tumor tissues.
These results suggest that there is a decrease in the destruction of red blood cells in the spleen and excretion of 51Cr to urine, and bleeding is seen in tumor tissue in rats with oral carcinomas.抄録全体を表示PDF形式でダウンロード (3851K)
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