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Volume 53, Issue 1
Displaying 1-6 of 6 articles from this issue
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Masayuki AZUMA2004 Volume 53 Issue 1 Pages 1-8
Published: January 10, 2004
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSThe destruction of acinar structure occurs in patientswith xerostomia caused by various disorders, including Sjögren's syndrome (SS) and aging. Althoughthe precise mechanism involved in this phenomenonremains unknown, accumulated evidence indicates thatcytokines such as TNF-α and IL-1β play an importantrole in the destruction of acinar structure. Thisarticle summarizes our findings obtained by theanalysis of in vitro human salivary gland acinar cellclones, and postulates a possible novel therapy for thepreservation and restoration of acinar structure inpatients with xerostomia. The immortalized humansalivary gland cell clone with acinar phenotype (NSSV-AC) was used. NS-SV-AC produced a large amountof MMP-9 in response to TNF-α, and entered apoptosiswhen cells were cultured on type IV collagen-coateddishes in the presence of TNF-α. However, suppressionof MMP-9 production by the transfection of asuper-repressor form of IκB-α cDNA into NS-SV-AC, via the inhibition of TNF-α-induced NF-κB activity, resulted in the prevention of the destruction ofnormal in vitro morphogenesis. In addition, TNF-α-induce MMP-9 production was effectively suppressedby Cepharanthine through the down-regulation of NF-κB activity. and inhibition of TNF-α-induced MMP-9production restored the aberrant in vitro morphogenesisof NS-SV-AC. Thus, suppression of TNF-α-induced MMP-9 may be a promising strategy for theclinical therapy of patients with xerostomia.View full abstractDownload PDF (2141K) -
Influence on the 5-year survival rateMiyuki KAWAKAMI, Kunio IKEMURA2004 Volume 53 Issue 1 Pages 9-13
Published: January 10, 2004
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSWe studied the extent to which multiple primarycancers affect the 5-year survival rate of patientswith squamous cell carcinoma of the oral cavity.
The 5-year survival rate (disease-specific survivalrate) of 164 patients who had radical therapy was68.2%. The 5-year survival rate of 38 patients withmultiple primary cancers was 46.3%, whereas that of126 patients without multiple primary cancers was73.8%. This difference was statistically significant (P<0.0001). Patients with multiple primary cancershad a 3.065 times higher risk than patients withoutmultiple primary cancers (COX proportional hazardregression model).
When the multiple primary cancer arose only in theoral cavity (n=12), the 5-year survival rate was54.0%. On the other hand, it was 42.5% when themultiple primary cancer was in other organs (n=26).The outcome of these patients showed that 13 pa- tients were still alive, 11 patients died of oral cancer, 12 patients died of second primary cancer and 2patients died of other diseases.
These results revealed that multiple primary cancersaffected the 5-year survival rate of patients withsquamous cell carcinoma of the oral cavity.View full abstractDownload PDF (606K) -
Masato OKAMOTO, Sachiko FURUICHI, Tomoyuki TANO, Hideo YOSHIDA, Mitsun ...2004 Volume 53 Issue 1 Pages 14-21
Published: January 10, 2004
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSDendritic cells (DCs) are professional antigenpresenting cells. Immature DCs (iDCs) present incancer tissues phagocytize the necrotic or apoptotictumor cells. The tumor antigen-bearing DCs followed by adequate maturation migrate to draining lymphnodes (LNs), present the antigens to T cells, and induce cytotoxic T cells (CTLs) and helper T cells. In the current study, we investigated the in vivo antitumor effect of intratumoral administration of syngeneic bone marrow-derived dendritic cells (DCs) after chemotherapy using an oral fluoropyrimidine anti-cancer drug TS-1, followed by immunotherapeutic agent OK-432. In BALB/c mice bearing Meth-A fibrosarcoma, one week of oral administration of TS-1 resulted in a partial eradication of established tumors. Intratumoral injection of DCs and OK-432 once also showed only slight inhibition of the tumor growth. TS-1 administration followed by DCs and OK-432 resulted in marked inhibition in the tumorgrowth, and also contributed to a greater prolongation of survival. Two days after injection of DCs and OK-432, the cytotoxic activities of tumor infiltrating lymphocytes (TILs) and draining LN cells against Meth-A were significantly increased by the combination therapy using TS-1, DCs and OK-432. Furthemore, the increased activities of the CTLs memorizing Meth-A antigen (s) were observed in LN cells derived from the mice administered TS-1, DCs and OK-432 at 23 days after these treatments. The activities were mainly CD8- and MHC class Irestricted. These findings suggest that the DC therapy in combination with TS-1 and OK-432 may bea useful strategy for the treatment of cancer patients.View full abstractDownload PDF (1163K) -
An investigation using chronic blood flow reduction model of rat lower limbsTakahiro NAKAGAWA, Taihiko YAMAGUCHI, Naohira ASADA, Yuji YAMAOKA, Shi ...2004 Volume 53 Issue 1 Pages 22-36
Published: January 10, 2004
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSIt has been pointed out that chronic blood flow reduction may cause exhaustion of masseter muscles, which is known as one of the symptoms of temporomandibular disorders. However, details have not yet been clarified. The present study investigated the influence of chronic blood flow reduction on the skeletal muscle fibers using a chronic blood flow reduction model of rat lower limbs. Soleus muscle (type I fiber-rich muscle) and extensor digitorum longus muscle (type II b fiber-rich muscle) were selected for this study, and changes of muscle fibers were examined enzyme-histochemically and biometrically.
In this model, significant reduction of blood flow had been maintained at least 3 months after ligation of the sinistral external iliac artery. The influence of chronic blood flow reduction was significant in the soleus muscle, appearing as a smaller proportion and attenuation of type I fibers. In contrast, no significant changes were observed in the extensor digitorum longus muscle.
The results suggest that chronic blood flow reduction of the masseter muscle, which is known as type I fiber-rich muscle, may induce the small proportion and attenuation of type I fibers resulting in exhaustion of the masseter muscle.View full abstractDownload PDF (5158K) -
Yoshinari TAKEUCHI, Akiko KOBAYASHI, Tomoaki SHIBUYA, Tadao TACHIBANA, ...2004 Volume 53 Issue 1 Pages 37-40
Published: January 10, 2004
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSA 32-year-old female with peripheral osteoma at the inferior border of the mandible was reported. The chief complaint of the patient was asymmetry of her face and the pressure pain at the inferior border of the left mandible. Although osteomas are often clinically observed in oral and maxillofacial areas, reports of osteomas on the inferior border of the mandible are relatively rare. The tumors on this site are usually resected extraorally under general anesthesia. The osteoma described in the present paper was the largest among intraorally resected cases, and the second largest among all osteomas on the inferior border of the mandible.View full abstractDownload PDF (1241K) -
2004 Volume 53 Issue 1 Pages e1
Published: 2004
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSDownload PDF (28K)
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