巻号一覧
54 巻 (2005)
- 4 号 p. 401-
- 3 号 p. 309-
- 2 号 p. 199-
- 1 号 p. 1-
54 巻, 4 号
選択された号の論文の5件中1～5を表示しています
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Interleukin-1とそのレセプター, ケモカインの発現について小倉 直美, 戸邊 真希子, 酒巻 裕之, 秋葉 正一, 安孫子 宜光, 近藤 壽郎2005 年 54 巻 4 号 p. 401-409
発行日: 2005/09/10
公開日: 2011/01/31
ジャーナル フリーInterleukin (IL)-1β responsible gene expressions in sy novialcells obtained from the human temporomandibular joint (TMJ) were analyzed using GeneChips. Synovial cells (TMJ1 and TMJ2) were obtained from synovial tis sueof two patients who underwent arthrotomy of TMJ using a method of out-growth. The synovial cells were stimulated with IL-1β for 4 hours, and then total RNA was extracted using RNeasy kit. Gene expression profil ingwas analyzed using the Affymetrix Human Genome Focus Array. The analysis of the hybridization data was performed using GeneSpring software. TMJ1 and TMJ2 expressed vimentin, prolyl 4-hydroxylase and type I col lagen, which are markers for fibroblasts. In contrast, the expression of HLA class II antigens were not detected. Among 8, 763 genes in the microarray, 192 genes, 154 up regulatedand 38 down-regulated genes, showed intensity greater than a 2-fold difference between with and with outIL-1β-treatment in both of TMJ1 and TMJ2. The genes whose levels were significantly altered by IL-1β could be classified into categories of enzyme and signal transducer. TMJ1 and TMJ2 constitutively express genes of IL-1 receptor type I and its associated mol ecules.Gene expression of IL-1β was stimulated by IL-1β. In contrast, IL-1α gene expression was not detected. The most significantly up-regulated gene was CCL20 (MIP-3α), which is a member of the chemokine super family. Gene expression of 12 chemokines was increased more than 2-fold by IL-1, 3-treatment in both of TMJ1 and TMJ2. In conclusion, IL-1β may cause abnormalities associated with intracapsular pathologic conditions of the TMJ through enhancement of gene expression for IL-1β and chemokines in synovial cells.抄録全体を表示PDF形式でダウンロード (1357K) -
レチクルを組み込んだファイバースコープ井上 公秀, 舘林 茂, 青木 久美子, 山川 延宏, 川上 正良, 今井 裕一郎, 桐田 忠昭2005 年 54 巻 4 号 p. 410-415
発行日: 2005/09/10
公開日: 2011/01/31
ジャーナル フリーFiberoptic endoscopic evaluation of swallowing is currentlyused for diagnosis of dysphagia. The endoscope is, however, not reliable for measuring the pharyngeal amplitude. We developed a new method of pharyngeal measurement using a fiberscope with built-in reticle.
The ENF-P4 fiberscope (Olympus Co. Ltd., Japan), with a built-in reticle with check patterns to rectify radialdistortion by a lens, was used in this study. In order to know the inserting length of the fiberscope, we mea suredthe length of the airway from the nasal edge to the epiglottis on lateral cephalograms with the subjects including 14 males and 24 females (mean age 22.1 years). Single regression analysis between stature and airway length was performed. We examined twice the sizes of 10 epiglottises with the fiberscope through digital video pictures.
The average of the airway length was 141.1mm for males and 130.0mm for females. A significant correlation was found between height and airway length (r=0.693, p<0.01). Comparing between the first and second ob servations, the use of the reticle improved a reliability of projective analysis of the pharynx area.
The fiberscope with built-in reticle may be used for relative analysis of the pharyngeal amplitude. Our de viceappeares to be useful for evaluation of laryngopha ryngeal structure.抄録全体を表示PDF形式でダウンロード (2816K) -
山下 佳雄, 檀上 敦, 奥村 晃, 重松 正仁, 後藤 昌昭2005 年 54 巻 4 号 p. 416-423
発行日: 2005/09/10
公開日: 2011/01/31
ジャーナル フリーTooth loss due to periodontal disease, trauma, tumor, or genetic disorders may significantly impair quality of life. A regenerated tooth for replacing a lost tooth would provide a useful alternative to available clinical treat mentswith dentures or dental implants. Despite ex tensiveknowledge of tooth development, little is known about the characteristics and properties of the dental stem cells in the postnatal organism.
To assess the ability of human dental pulp cells to re generatedental hard tissue, we used a method that had been previously developed for tooth transplantation into NOD/scid mice. We present histologically-characterized dental hard tissue generated by pulp organ or dissoci ated pulp cells seeded onto collagen membranes. Our results revealed that postnatal dental pulp contains stem cells that are capable of regenerating dental hard tissue.
On the other hand, tooth development is the cumula tiveresult of reiterative signaling of growth factors. We also examined the role of IGF-I (insulin-like growth factor-I) for tooth regeneration with the same strategy. Our results demonstrated that IGF-I serves as one of the important regulators of dentin and bone formation during tooth development.抄録全体を表示PDF形式でダウンロード (2978K) -
舌痛症と自律神経渡貫 圭2005 年 54 巻 4 号 p. 424-429
発行日: 2005/09/10
公開日: 2011/01/31
ジャーナル フリーWe hypothesized that glossodynia represents an autonomicdysfunction resulting from chronic stress, and examined the autonomic nervous system in patients with glossodynia through a compilation of their com plaints.Subjects were 100 patients with glossodynia and 70 healthy controls. Surveys were performed using a complaint questionnaire formulated by the authors and colleagues. The results of the questionnaires were as follows. First, systemic complaints, complaints concern ingthe oral/head and neck, and complaints concerning the gastrointestinal systems were presented significantly more often by the glossodynia group than the control group. Second, 15 specific symptoms occurred signifi cantlymore often in the glossodynia group. From these results, we suggest that either the functional level of the sympathetic nervous system was elevated or that of the parasympathetic nervous system was depressed in patients with glossodynia. In addition, our results sug gestthat glossodynia is one complaint arising from an impaired state of the autonomic nervous system.抄録全体を表示PDF形式でダウンロード (935K) -
春日 聡子, 白土 雄司, 長田 哲次2005 年 54 巻 4 号 p. 430-433
発行日: 2005/09/10
公開日: 2011/01/31
ジャーナル フリーPeripheral facial nerve paralysis (PFNP) is often used synonymously with the term “Bell's palsy”. Approxi mately 80% of patients with all of the facial nerve paralysisare Bell's palsy. However, the majority of cases remain without an identified etiology and eventually are diagnosed as idiopathic peripheral facial palsy, or Bell's palsy. This paper reports on the analysis of 13 cases of PFNP after dental treatment. Thirteen out of 28 cases of Bell's palsy, treated in the First Department of Oral & Maxillofacial Surgery, Kyushu University Dental Hospital over the past 15 years between 1988 to 2003, had an epi sodewith dental treatment including 3 cases of resin filling, 2 of pulpectomy, cementation, root canal treatment, and 1 of tooth extraction, scaling, denture adjustment, disinfection, respectively. We discuss the possible asso ciationbetween PFNP and dental treatment.抄録全体を表示PDF形式でダウンロード (938K)
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