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Volume 55, Issue 2
Displaying 1-12 of 12 articles from this issue
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Hiroshi KURITA2006 Volume 55 Issue 2 Pages 73-84
Published: March 10, 2006
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSInternal derangement (ID) of the temporomandibular joint (TMJ) relates to a mechanical and anatomical disturbance interfering with the smooth joint function. The ID usually develops in a benign and self-limiting fashion and does not always lead to progressing disorders. Radiographically visible degenerative changes occur with advancement of ID. It is thought that most of these changes closely correlate with the self-limiting nature of ID. In this report, a variety of radiographically visible degenerative changes were shown to develop with advancing ID. These changes, including a total and more anterior displacement of the TMJ disk, deviations in configuration of the TMJ disk, resorption of lateral pole of TMJ condyle, regression in horizontal size of the TMJ condyle, and flattening of the articular eminence, developed reflecting each other and might play an important role in an improvement of clinical signs and symptoms in the long run. It is also suggested that most of the acute and destructive radiographically visible degenerative changes were arrested or slowed in those patients whose symptoms and signs were successfully resolved or reduced.View full abstractDownload PDF (2302K) -
Kanemitsu SHIRASUNA, Yoshiaki YURA2006 Volume 55 Issue 2 Pages 85
Published: March 10, 2006
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSA number of clinicians and researchers in many fields have been engaged in research projects to cure cancer patients with chemotherapy. For this purpose, powerful and selective agents will be required. One of the most promising approaches is the application of molecular targeting therapy for cancer patients. The targets of this therapy include oncogene products, growth factor receptors, signal transduction pathways, angiogenetic factors and cell adhesion molecules. To determine the overexpression of target genes, the construction of a reliable gene-screening system is essential. In the following articles, authors will describe the latest results of molecular targeting therapy and gene screening methods for oral cancer. We hope they help improve the treatment of oral cancer in the near future.View full abstractDownload PDF (161K) -
Satoru SHINTANI, Hiroyuki HAMAKAWA2006 Volume 55 Issue 2 Pages 86-89
Published: March 10, 2006
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSRadiation therapy remains a major treatment modality for oral cancers. Molecular targeting therapy has been developed as a new molecular approach based on the recent improved understanding of cancer biology. A better understanding of cancer biology and in particular of tumor radiation resistance mechanisms has led to the identification of new molecular targets that could be used to increase the therapeutic ratio of radiation therapy. These approaches attempt to increase specifically tumor radiation response with little impact on normal tissue response. We describe the current approach of combined radiation with molecular targeting agents relevant for the treatment of oral cancer. Molecular targeting agents (inhibitors of EGFR, COX-2, CDK, and angiogenesis) enhanced the response of tumors to radiation. Because of tumor heterogeneity and the multiple radiation-resistance pathways, the responses of tumors varied. These results suggested that the selection of relevant molecular targeting agents based on molecular biological information will be necessary for improvement of radiation therapy.View full abstractDownload PDF (579K) -
Masayasu IWASE, Masao NAGUMO2006 Volume 55 Issue 2 Pages 90-94
Published: March 10, 2006
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSIn general, oral squamous cell carcinoma (OSCC) cells are relatively resistant to death receptor-mediated apoptosis. Here, we studied the role of target molecules for cancer such as phosphatidylinositol 3-kinase (PI 3-K)/Akt and epidermal growth factor receptor (EGFR) in death receptor-mediated apoptosis. We found that both PI 3-K inhibitors and EGFR inhibitors markedly suppressed phosphorylation of Akt, and accelerated Fas- and TRAIL-mediated apoptosis in OSCC cells. It was also found that caspase-3 and -8 inhibitors reduced the accelerative effect of PI 3-K inhibitors on the death receptormediated apoptosis in OSCC cells, but not caspase-9 inhibitor. Although PI 3-K inhibitors did not affect the expression of death receptors in OSCC cells, these inhibitors remarkably reduced cellular FLICE-inhibitory protein (c-FLIP) levels. Moreover, transfection of antisense oligonucleotide of c-FLIP confirmed that down-regulation of c-FLIP enhanced sensitization to death receptor-mediated apoptosis in OSCC cells. These results suggest that PI 3-K/Akt and EGF signaling pathways may, in part, regulate death receptor-mediated apoptosis in OSCC cells through c-FLIP expression.View full abstractDownload PDF (683K) -
Hideki TANZAWA, Hiroki BUKAWA, Hidetaka YOKOE, Katsuhiro UZAWA2006 Volume 55 Issue 2 Pages 95-99
Published: March 10, 2006
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSRecently, comprehensive studies of gene expression in cancer have been made possible by the micro-array technique. However, such studies have not always yielded a comprehensive understanding of genetic phenomena in cancer and too much data may confuse researchers, In searching for the genes responsible for tumor metastasis and/or cisplatin resistance, we have demonstrated micro-array analysis combined with gene cluster analysis. During our studies, we faced difficulties such as the precise amplification of micro-scale mRNA, quality check of mRNA, and control of the labeling difference between Cy3- and Cy5-dUTP. In order to solve these problems, we checked RNA by electrophoresis, optical meters, and Affymetrix Test ChipTM, and confirmed the array data by quantitative real-time PCR. In the cluster analysis, contamination of poor data and hidden common characters among the samples were critical problems. Pathway analysis and evaluation of the gene function using clinical cases and/or transformation were useful to help detect candidate gene clusters.View full abstractDownload PDF (1523K) -
Tsuyoshi SUGIURA, Kanemitsu SHIRASUNA2006 Volume 55 Issue 2 Pages 100-103
Published: March 10, 2006
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSTetraspanins are a family of widely expressed four transmembrane domain proteins and also reported to suppress metastasis. The tetraspanins are associated with adhesion receptors of the integrin family and regulate integrin dependent cell invasion by reducing matrix metalloprotease (MMP)-2 production or reducing receptor bound urokinase plasminogen activator (uPA). In addition to the suppressive effect on integrin dependent cell invasion, the tetraspanins are associated with growth factor receptors and regulate the receptor signaling. As a result of the regulation of receptor signaling by tetraspanin, cell migration is significantly inhibited.
Taken together, the tetraspanins are multi-functional regulators of cell surface receptor dependent cell invasion. The tetraspanins may be a new therapeutic tool for molecular targeting therapy of cancer.View full abstractDownload PDF (608K) -
Yoshiaki YURA, Masakazu HAMADA, Soichi IWAI2006 Volume 55 Issue 2 Pages 104-107
Published: March 10, 2006
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSCertain protein kinase C (PKC) isoforms expressed in cancer must play important roles in tumor promotion, tumor invasion and resistance to cytotoxic anti-tumor drugs. A variety of PKC inhibitors have been designed and their anti-tumor activities examined in many cancers. Safingol, a PKC a-selective inhibitor, induces endonuclease G-mediated apoptosis of human oral squamous cell carcinoma cells in a caspase-independent manner. Studies of the mechanisms of PKC inhibitors should contribute to the development of molecular targeting therapy for oral cancer.View full abstractDownload PDF (630K) -
Hiroki SUGIURA, Akira YAMAGUCHI, Koichi SHIBASA2006 Volume 55 Issue 2 Pages 108-112
Published: March 10, 2006
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSIntroduction: Helicobacter pylori (H. pylori) DNA has been detected at a high prevalence in saliva. The aim of this study was to clarify the prevalence and the risk of intrafamilial transmission of H. pylori infection by detecting H. pylori DNA in saliva of Japanese children and their parents.
Materials & Methods: Saliva was collected from 92 children and their parents, and nested PCR and PCRRFLP were used to detect and analyze H. pylori DNA. Subtyping by PCR-RFLP is considered to be useful in order to clarify the mode of transmission.
Results: The detection rate of H. pylori DNA in saliva was 12.0%(11/92) in Japanese children, however, all of the children aged less than 6 years old were negative. All of the H.pylori infected children had H.pylori positive parents (both or only one), and in 7 out of 11 cases, children and their parents were infected with the sam e strain. Especially, in 6 cases, the subtype of both the child and the mother was the same.
Conclusion: H. pylori DNA in saliva was detected in 12.0%, and parents-to-child, especially mother-to-child, transmission is the most likely route of intrafamilial infection of H. pylori.View full abstractDownload PDF (1561K) -
Motoko OZAWA, Yukihiro MICHIWAKI, Hiroto SAITO, Mayu SAITO, Tatsuya KI ...2006 Volume 55 Issue 2 Pages 113-119
Published: March 10, 2006
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSThe swallowing movement is a rapid, continuous and invisible movement constructed in the mouth, pharynx and larynx. Therefore, 2D images cannot achieve suitable resolution of the swallowing mechanism. This paper reports our successful visualization of the swallowing movement using 4D-MRI.
The synchronized sampling method was applied for 4D-MRI. Each of 9 slices of 4D-MRI had 35 images with the frame rate of 66 msec. The subject was a normal volunteer who swallowed 2 ml of liquid 128 times.
Though any section in the X, Y, Z directions could be used in 4D-MRI, we selected images of the sagittal section of the whole, and axial section of the velopharyngeal and glottic plane, and coronal section of the laryngeal plane. These images were useful to depict the complicated movement of organs during a swallow.
The results proved that adduction of vocal cords and laryngeal elevation started immediately after the liquid was infused into the subject's mouth, and then 198 msec after the infusion the pharyngeal lateral walls moved inward and the soft plate elevated. The velopharynx closed 132 msec after the elevation of the soft palate, and then its closure continued for 594 msec. Both the glottis and the larynx closed 66 msec after the velopharyngeal closure. After the time that the esophagus opened, the velopharynx gradually started to open. The esophagus opened for 198 msec, while the larynx continued to close for 462 msec. The glottis continued to close for 594 msec.
This first study of 4D-MRI for the swallowing movement simultaneously visualized the closure of the velopharynx, larynx and the glottis as well as opening of the esophagus. The 4D-MRI yielded detailed images of a normal swallow, which will help to clarify the mechanism of swallowing movement.View full abstractDownload PDF (2608K) -
Motoo SUEMATSU, Mitsunobu KISHINO, Noritami TAKEUCHI, Toshiyuki TAKASE ...2006 Volume 55 Issue 2 Pages 120-124
Published: March 10, 2006
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSWe describe a case of giant lymphoproliferative disorder in the submandibular region. A 52-year-old male had a unicentric, unusually large, slow growing, asymptomatic mass which involved aggregation of plural lymph nodes. A pre-operative definite diagnosis was difficult as routine investigations, ultrasound sonography, CT, MRI, and RI scintigraphy were inconclusive. A biopsy specimen was characterized by only reactive follicular hyperplasia of lymph nodes without hyalinized and hypervascular germinal centers or plasma cell aggregates that are common features of Castleman's disease. Surgical removal of lymph nodes was performed and there have been no signs of recurrence.View full abstractDownload PDF (2816K) -
Shuuichi FUKUNAGA, Kazumasa MORI, Atsushi IDEO, Masahiro SASAKI, Kaoru ...2006 Volume 55 Issue 2 Pages 125-129
Published: March 10, 2006
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSWe report a case of salivary duct carcinoma that occurred in the submandibular gland and review the relevant literature.
A 68-year-old male was referred with a chief complaint of a left submandibular mass. Physical examination revealed a 45× 51 mm, hard, barely movable and nontender mass. Pantomography, CT sialography, and MRI showed a solid mass in the anterior part of the enlarged left submandibular gland. Excision of the left submandibular gland was performed under general anesthesia after clinical diagnosis of a benign tumor of the gland. However, the pathological diagnosis was salivary duct carcinoma showing solid, papillary, or cribriform patterns with comedonecrosis. Several months later, metastatic lesions appeared in the left submandibular lymph nodes and right lung. Therefore, left radical neck dissection and resection of the tumor under thoracoscopy were perfomed. Surgical specimens of them corresponded to the salivary duct carcinoma. Although the patient remained free of the disease for 15 months, metastatic lesions occurred in the left cervical lymph nodes and left lung again. Consequently resection of metastatic cervical lymph nodes and resection of tumor under thoracoscopy were performed. About 8 months later multiple metastatic lesions arose from bilateral cervical lymph nodes and lungs. Though the patient underwent chemotherapy 4 times, he died of the disease 3 years and 4 months after the first examination.View full abstractDownload PDF (3605K) -
a case report and problemsJae Seong BOO, Hidetaka NAKAI, Minoru UEDA2006 Volume 55 Issue 2 Pages 130-133
Published: March 10, 2006
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSThere have been some reports on the use of KTP laser for sublimis and small hemangioma in the oral region. In the case reported in this paper, a relatively large and deep-seated hemangioma of the retromolar and buccal region was treated with photo-coagulation by KTP laser.
The KTP laser is a pure green light in the visible portion (532 nm) of the electromagnetic spectrum. It has unique characteristics such as high absorption by hemoglobin, negligible absorption by water and a relatively shallow depth of penetration, which are ideal for the photo-coagulation of hemangioma. In this case, the tumor disappeared by performing photo-coagulation one time and bleeding was not encountered during the operation. The results suggested that KTP laser is effective for the treatment of relatively large and deep-seated hemangioma.View full abstractDownload PDF (1623K)
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