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Volume 56, Issue 2
Displaying 1-4 of 4 articles from this issue
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Tetsuya YAMAMOTO2007 Volume 56 Issue 2 Pages 215-225
Published: March 10, 2007
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSReactive oxygen species (ROS) are well known to play a dual role as both deleterious and beneficial species. In cancer cells, ROS could contribute to carcinogenesis and progression, however, ROS can also induce cell injury and apoptosis. Despite the negative impacts of increased ROS in cancer cells, it is possible to exploit this biochemical feature and develop novel therapeutic strategies to kill cancer cells through ROS-mediated mechanisms. This article describes (i) the role of ROS in apoptosis of oral squamous cell carcinoma (OSC) cells induced by ionizing radiation and chemotherapeutic drugs; (ii) DNA damage by ROS; (iii) nitric oxide (NO) and apoptosis; (iv) the role of ROS in apoptosis induced by lymphokine-activated killer (LAK) cells; (v) hypoxia-inducible factor-1α (HIF-1α) and ROS. Anticancer agents such as chemotherapeutic drugs, ionizing radiation and LAK cells exerted their apoptosis-inducing effects on OSC cells by the production of ROS leading to the up-regulation of proapoptotic Bcl-2 family proteins and oxidative damage of nuclear and mitochondrial DNA. Manganese-superoxide dismutase (Mn-SOD) activity of OSC cells was negatively correlated with their susceptibility to anticancer agents and the transfection of Mn-SOD antisense into OSC cells enhanced their susceptibility. Functions of cytochrome c and procaspase-3 were not impaired even though anticancer agents induced the up-regulation of intracellular NO levels and tyrosine nitration of these molecules. ROS was also involved in the anticancer agent-induced expression of HIF-1α that is associated with chemo/radio-resistance. These results suggest new therapeutic strategies that down-regulate Mn-SOD activity in cancer cells are needed to enhance the therapeutic efficacy of anticancer agents.View full abstractDownload PDF (2346K) -
Atsushi TAKADA, Taito OKAMURA, Mitsuaki MORIMOTO, Shin-ichi TAKAHASHI, ...2007 Volume 56 Issue 2 Pages 226-233
Published: March 10, 2007
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSThere have been a number of case reports on oral mucosa disorders or skin disorders caused by metal allergy. Patch tests are performed for the diagnosis of such disorders, but it is difficult to objectively evaluate patch tests.
In order to establish an objective evaluation of patch tests, we examined the usefulness of the erythema index (E. I.) and the quantity of corneous moisture (Q. C. M.), using the ear swelling rate determined in delayed type hypersensitivity (DTH) model mice by the mouse ear swelling test (MEST). We measured E. I. and Q. C. M. using a MEXAMETER MX18 (R)(MX18) and a CORNEOMETER CM825® (CM825) respectively.
The E. I. was significantly higher in the test ear than in the control ear, but the difference in the Q. C. M. between the test and control ears was not significant. The ear swelling rate was significantly correlated with the EI (p<0.001, r=0.841), but not with the Q. C. M.(r=0.015).
These findings suggested that measurement using a MX18 can be applied to the evaluation of DTH reactions.View full abstractDownload PDF (2166K) -
Shigehiro TAMAKI, Kazuhiko YAMAMOTO, Satoshi FUKUTSUJI, Jun-ichi ISHID ...2007 Volume 56 Issue 2 Pages 234-240
Published: March 10, 2007
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSThe relationship between moisture of the oral mucosa and salivary flow rate was clinically investigated. Fifty patients complaining of dry mouth, 19 males and 31 females, with the average age of 60.4±17.1 years old, were the subjects of this study.
The subjects included 23 patients diagnosed as xerostomia with salivary flow rate of lower than 10ml/10 min and 27 healthy patients with salivary flow rate of higher than 10ml/10min. We measured the moisture of the oral mucosa at four sites: tongue dorsum, buccal mucosa, and upper and lower lips.
The moisture of the oral mucosa in the patients with xerostomia was lower at all measured sites, compared with the healthy patients. In addition, the moisture of the oral mucosa decreased the salivary flow rate in the patients with xerostomia.
In conclusion, the moisture meter is considered to be useful for diagnosis of xerostomia.View full abstractDownload PDF (1870K) -
Yumi MOCHIZUKI, Ken OMURA, Norihiko OKADA, Kei SAKAMOTO2007 Volume 56 Issue 2 Pages 241-246
Published: March 10, 2007
Released on J-STAGE: January 31, 2011
JOURNAL FREE ACCESSPolymorphous low-grade adenocarcinoma (PLGA) is rare in the Japanese population and it shows low-grade malignancy.
We report a case of PLGA arising in the cheek.
The patient was a 48-year-old female, who noticed a painless tumor of the right side of the cheek in 1985. She was referred to our clinic and presented in August 2001.
The tumor was elastic soft, well-demarcated, measuring 2.0×1.7 cm, and a mucosal ulcer was recognized in the central portion of the tumor. Biopsy was performed and the histopathological diagnosis was pleomorphic adenoma (PA). The tumor grew during three years without follow-up. In November 2004, we performed surgical excision with 0.5cm wide margins through an intraoral approach and reconstructed the surgical defects using full-thickness skin grafts from the groin.
Non-encapsulated and infiltrative growth of the tumor was observed by examination of the whole specimen and a definitive diagnosis of PLGA was made.
There have been no signs of recurrence or metastasis in the follow-up.
Because of histopathological similarities among PLGA, PA and adenoid cystic carcinoma, it is necessary to diagnose these tumors carefully.
The first choice of treatment for PLGA is wide surgical excision.View full abstractDownload PDF (3579K)
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