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Volume 62, Issue 4
Displaying 1-7 of 7 articles from this issue
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ORIGINAL ARTICLES
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Yutaka YAMAZAKI, Ken-ichiro SAKATA, Jun SATO, Manabu OOUCHI, Hironobu ...2013 Volume 62 Issue 4 Pages 247-253
Published: 2013
Released on J-STAGE: October 10, 2013
JOURNAL RESTRICTED ACCESSWe performed a retrospective study to elucidate the clinical characteristics of taste disorders in patients attending our dental clinic. Subjects comprised 210 outpatients (54 men, 156 women, mean age 65) that reported taste disorders within the past 4.5 years. Hypogeusia and ageusia were the most common conditions (42%), followed by phantogeusia (39%). The main causes of taste disorders among our patients included idiopathic taste disturbance (27%), oral diseases (26%) and psychogenic taste disturbance (25%). Oral diseases involved oral candidiasis (57%) and oral dryness (25%). Treatment mainly consisted of drug therapy; patients with idiopathic and psychogenic taste disturbance were treated with ethyl loflazepate, and patients with zinc deficiency were treated with polaprezinc. The overall improvement rate of symptoms was 61%. Patients with oral disease showed good response (90% improvement rate) to therapy.
Since this study showed that taste disorders in several patients were caused by various oral diseases, dentists should be aware that oral diseases such as oral candidiasis and oral dryness can lead to taste disorders, most of which respond well to dental management.View full abstractDownload PDF (772K) -
—Clinicopathological study on the effectiveness of cepharanthin—Keiko AOTA, Yoshiko YAMAMURA, Koichi KANI, Hideyuki TAKANO, Katsumi MO ...2013 Volume 62 Issue 4 Pages 254-261
Published: 2013
Released on J-STAGE: October 10, 2013
JOURNAL RESTRICTED ACCESSSjögren's syndrome (SS) is characterized by the eventual total replacement of the acinar structure by marked infiltration of lymphocytes into the salivary and lacrimal glands. We previously demonstrated that tumor necrosis factor-α (TNF-α) induced matrix metalloproteinase-9 (MMP-9) production by the stimulating transcription factor, nuclear factor-κB (NF-κB), in human salivary gland acinar cells and that cepharanthin, a biscoclaurine alkaloid, prevented the activation of TNF-α-induced NF-κB activity. In addition, we have shown that cepharanthin prevented the destruction of acinar tissues in murine SS. Thus, in this study, we investigated the clinicopathological effect of cepharanthin on the patients with SS.
Ten patients with a diagnosis of primary SS were enrolled in this study. They were treated with cepharanthin for three months, followed by the evaluation of salivary production, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-SS-A antibody, anti-SS-B antibody, pathological examination of labial salivary gland biopsy specimens, and the symptom of drymouth.
Average salivary production was 4.25ml/10minutes before the study. This average production increased to 6.46ml/10minutes after the study. There were no remarkable changes in CRP, ESR, anti-SS-A antibody and anti-SS-B antibody. In pathological findings, although the decreases in infiltration of lymphocytes were observed in 5 out of 5 cases, the reduction of destruction of acinar structures was clearly detected in 5 cases. Improvement of symptom of drymouth was detected in 7 out of 10 cases.
These observations suggest that cepharanthin treatment might provide an efficient and useful therapeutic approach for countering the destruction of acinar tissue in salivary glands of patients with SS.View full abstractDownload PDF (1049K) -
—Evaluation by thresholds for sensory tests, subjective symptoms and questionnaires—Akiko KOBAYASHI, Mie MOCHIZUKI, Jyunya AOYAGI, Masashi YAMASHIRO, Teru ...2013 Volume 62 Issue 4 Pages 262-273
Published: 2013
Released on J-STAGE: October 10, 2013
JOURNAL RESTRICTED ACCESSThis study investigated the relationship between sensory thresholds, subjective symptoms and mental state in 166 patients who had sensory disturbances on their unilateral lower lip and chin. The sensory thresholds were determined by nine different testing modalities, which included static light touch, two-point discrimination, warm·cool·heat stimulation, 5-Hz rectangular current stimulation, and current perception thresholds (2000Hz, 250Hz, 5Hz). After each threshold was divided into 5 rank scores (0∼4), the average of them was calculated as the individual score.
To investigate what kind of subjective sensation the patients were experiencing, the McGill Pain Questionnaire-Japanese version (JMPQ) and modified JMPQ were used. The degree of hindrance in daily life, degree of subjective sensory abnormality, and daily duration of sensory disturbance were investigated using visual analog scales. To investigate patient personality and mental state, we used the modified Japanese version of the short-form Eysenck Personality Questionnaire (MS-EPQ) and the Hospital Anxiety and Depression Scale (HADS).
There were correlations between each score determined by static light touch, two-point discrimination, warm, cool, 5-Hz rectangular current stimulation, and all VASs or the number of word descriptors chosen on the JMPQ. Both anxiety and depression scores on HADS correlated with the VAS for hindrance in daily life or the number of word descriptors chosen on the JMPQ, although they did not correlate with the other 2 VASs. The anxiety and depression scores correlated with the neurosis score on MS-EPQ. The highest average score group (3.5∼4) patients chose the words “Numb”, “Sore”, “Dull”, “Troublesome”, “Wretched” in the modified JMPQ, which consisted of 80 words, more than the other score groups patients.View full abstractDownload PDF (504K) -
Kimie MORI, Yukari YAMASHITA, Yoshiko TAKEI, Kazuko HASEGAWA, Yuka NAK ...2013 Volume 62 Issue 4 Pages 274-280
Published: 2013
Released on J-STAGE: October 10, 2013
JOURNAL RESTRICTED ACCESSThis study was designed to investigate the articulatory tongue movements for the five Japanese vowels in normal subjects. Ultrasonography was used to three-dimensionally examine the tongue shape and position of the tongue tip in 30 healthy individuals (14 males and 16 females). The tongue shapes were classified into five types: convex type which forms a high-domed shape toward the palate (C type), flat type which shows a flat-shaped tongue (F type), groove type which forms a deep depression at the center of the tongue (G type), and intermediate shapes of these types (flat-convex type (FC) and flat-groove type (FG)). The position of the tongue tip was examined by comparing the tongue tip during vowel production with that in the rest position, and was classified into three positions: ‘anterior’ in which the tongue moved forward during articulation, ‘middle’ in which the tongue stayed in nearly the same position, and ‘posterior’.
As a result, frequent patterns were F type-posterior and FG typec-posterior for vowel /a/, G type-anterior for vowel /i/, G type-anterior for vowel /e/, and F type-posterior for vowel /o/. The patterns varied for vowel /u/ and the tongue movements of subjects who did not show these specific patterns. C type was not seen for any vowel by any subject. Also, an intersubject analysis of tongue movement patterns revealed that very few subjects showed agreement for all five vowels.
These results reveal the complexity of tongue movement during production of the five vowels in normal subjects.View full abstractDownload PDF (685K)
CASE REPORTS
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Shigeaki TORATANI, Ryouji TANI, Yasuto FUKUI, Taku KANDA, Takashi TAKA ...2013 Volume 62 Issue 4 Pages 281-285
Published: 2013
Released on J-STAGE: October 10, 2013
JOURNAL RESTRICTED ACCESSThe squamous odontogenic tumor (SOT) represents one of the extremely rare odontogenic epithelial neoplasms originating probably from the rests of Malassez in the periodontal ligament. The common site of this tumor is the alveolar process in close proximity to the roots of permanent teeth. We reported a case of relatively large SOT involving the body of the mandible in a 54-year-old female. Radiographically, a well-defined multilocular lesion was revealed in the median alveolar to the mandible. Through a histological examination of a biopsy specimen, it was seen that the lesion consisted of varied sizes of islands of well-differentiated squamous epithelium embedded in a fibrous connective stroma and was diagnosed as SOT. As a result of immunohistochemical analysis of cytokeratins (CKs), the tumor cells were mostly stained by AE1/AE3 (pan-keratin), although they were negative for CAM5.2 (CK8) and CK19. This expression pattern of CKs suggested that the tumor cells differentiated into squamous epithelium. The tumor was intraorally extirpated under general anesthesia. There was no recurrence after seven years of follow up.View full abstractDownload PDF (656K) -
Seibu MATSUMOTO, Toru FUJISAWA, Tomoko KIRISAWA, Keiichi MORIOKA, Yosh ...2013 Volume 62 Issue 4 Pages 286-292
Published: 2013
Released on J-STAGE: October 10, 2013
JOURNAL RESTRICTED ACCESSWe report a case of mediastinal emphysema and pneumothorax following intraoral vertical ramus and Le Fort I osteotomies. A 19-year-old man was presented at our hospital with anterior cross-bite. We diagnosed open bite, retromaxillism and skeletal class III malocclusion and, following preoperative orthodontics, he was admitted for surgery in March 2011. Intraoral vertical ramus and Le Fort I osteotomies were performed under general anesthesia. However, bilateral nasal obstruction and labored breathing appeared after the operation. Moreover, he felt something wrong in the precordium and neck on the day following the operation. He had difficulty in breathing and fine crackle was heard in the supraclavicular space and sternum region on postoperative day five. Lucencies were acknowledged by computed tomographic scanning in the right pterygomandibular space, both sides of the prestyloid and retrostyloid parapharyngeal space, retropharyngeal space, anterior tracheal wall, upper mediastinal space, and left thoracic cavity. The lower lobe of the left lung had shrunk. He was diagnosed with subcutaneous emphysema from the neck to the mediastinum, and left pneumothorax. His breathing normalized after removal of the surgical splint. Twelve days after onset a chest X-ray showed his mediastinal emphysema and pneumothorax had improved, and he was discharged on postoperative day 14.View full abstractDownload PDF (694K) -
Daisuke NAKAMURA, Takeshi WAKITA, Takao IMAI, Atsushi ABE, Yoshihiko S ...2013 Volume 62 Issue 4 Pages 293-298
Published: 2013
Released on J-STAGE: October 10, 2013
JOURNAL RESTRICTED ACCESSSpindle cell carcinoma is characterized by multiplication of polygonal cells, which mainly comprise tumor cells, and is classified as a type of squamous cell carcinoma. The frequency of spindle cell carcinoma in the oral area is low, particularly in the floor of the mouth. Since spindle cell carcinoma shows a sarcomatoid structure in deep parts; diagnosis requires both clinical and immuno-histological confirmation. We report the case of a patient presenting spindle cell carcinoma in the floor of the mouth. A 57-year-old man visited our hospital with a chief complaint of a sense of discomfort in the floor of mouth. A 10 mm×10 mm tumor mass with an irregular, extroverted border was recognized on the right side of the floor of the mouth. No movement disorder or dysesthesia of the tongue was seen and saliva secretion was good. In addition, no enlarged or tender lymph nodes were identified. Diagnostic imaging showed a sublingual tumor mass measuring 10 mm×6 mm and no findings suggestive of metastasis to distant tissue. We excised part of the floor of the mouth under general anesthesia after a diagnosis of spindle cell carcinoma was obtained from the results of histopathological diagnosis following biopsy. As of three and a half years postoperatively, no recurrence has been seen and the patient is considered to have a good prognosis.View full abstractDownload PDF (864K)
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