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Volume 63, Issue 2
Displaying 1-4 of 4 articles from this issue
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SPECIAL PROGRAM 1
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Tsuyoshi TAKATO, Yuko FUJIHARA, Kazuto HOSHI, Toru OGASAWARA, Hideto S ...2014 Volume 63 Issue 2 Pages 207-215
Published: 2014
Released on J-STAGE: April 17, 2014
JOURNAL RESTRICTED ACCESSRecently, there have been remarkable advances in regenerative medicine, and almost all disorders in the oral and maxillofacial region could be research targets of regenerative medicine. Meanwhile, treatments in this region have been well established using biomaterials, prostheses and microsurgery. Therefore, in order to be used instead of such conventional approaches, regenerative medicine should take a less invasive, more effective approach. In this report, we present our basic and clinical research on bone and cartilage regenerative medicine in the oral and maxillofacial region.
Regarding bone regenerative medicine, we have tried to develop artificial bone that maximizes bone formation at the transplanted site, but that would be subsequently replaced by autologous bone. We have made custom-made artificial bone (CT-Bone) using α-TCP particles and an ink-jet printer, and have conducted clinical research and trials on 30 patients.
Present protocols of autologous chondrocyte transplantation mostly utilize chondrocytes suspended in solution or gel, and thus the regenerated cartilage may fail biologically and biophysically. To develop tissue-engineered cartilage with proper 3D morphology and mechanical strength, we have optimized the culture medium of chondrocytes and scaffold. Following a preclinical study confirming efficacy and safety, our protocol has been approved by the Institutional Review Board as well as the Ministry of Health, Labour and Welfare, Japan. We have conducted clinical research for 3 patients with nasal deformity in cleft lip and palate, and are now starting multicenter clinical research. Also, we are preparing for investigator-initiated clinical trials of tissue-engineered trachea for reconstruction of trachea.View full abstractDownload PDF (1314K)
ORIGINAL ARTICLE
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Clinical stage and prognostic value of primary FDG-PET in patients with oral squamous cell carcinomaTadahide NOGUCHI, Yoshiyuki TSUCHIYA, Michiko OZAWA, Hiroto ITOH, Yosh ...2014 Volume 63 Issue 2 Pages 216-221
Published: 2014
Released on J-STAGE: April 17, 2014
JOURNAL RESTRICTED ACCESSWe analyzed the clinical stage and prognostic value of primary 18F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) standardized uptake value (SUV) in patients with oral squamous cell carcinoma. The subjects were 119 patients newly diagnosed with oral squamous cell carcinoma who underwent positron emission tomography between May 2004 and December 2011 before treatment. The cut-off between high- and low-uptake tumors was set at an SUV of 5.0. High uptake of FDG is associated with advanced disease, cervical lymph node metastasis and poor prognosis. High SUV (≥ 5.0) was significantly predictive of low rates of disease-specific and disease-free survivals, as compared with low SUV(< 5.0). These findings indicate that pretreatment tumor FDG uptake represents an independent prognostic factor in patients with oral cancer. Patients with tumors showing high FDG uptake should be considered as high risk when planning treatment and follow-up.View full abstractDownload PDF (518K)
CASE REPORTS
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Seidai KITA, Kinuko OGATA, Shingo HIRASHIMA, Masayo TAKANO, Osamu IWAM ...2014 Volume 63 Issue 2 Pages 222-225
Published: 2014
Released on J-STAGE: April 17, 2014
JOURNAL RESTRICTED ACCESSNumb chin syndrome (NCS) is a sensory disturbance characterized by numbness of the chin and lower lip and is most often associated with malignant tumor.
A 62-year-old woman who had undergone radical mastectomy for mammary carcinoma 17 years previously noticed numbness in the left chin. An aberrant left mandibular ramus lesion was revealed by computed tomography and magnetic resonance imaging, and an abnormal accumulation of FDG was observed only in the left mandibular ramus by PET. A biopsy of the left mandible suggested metastatic mammary adenocarcinoma. She has been treated with aromatase inhibitor and bisphosphonate, and the numbness of the left chin has improved.View full abstractDownload PDF (567K) -
Toshihiko KIYOKAWA, Hisao SHIGEMATSU, Yuka OKU, Miyako HOSHINO, Kentar ...2014 Volume 63 Issue 2 Pages 226-232
Published: 2014
Released on J-STAGE: April 17, 2014
JOURNAL RESTRICTED ACCESSThis report describes an unusual case of verruciform xanthoma (VX) occurring in a patient with multiple stomatitis. A 43-year-old woman visited our hospital on May X, 2012, because of a white lesion on the left side of the tongue. She had been suffering from multiple stomatitis for 6 years. She had experienced burning sensations during mastication on her oral mucosa and so had been treated with oral hygiene products at the time of symptom onset. Her dentist noticed the white lesion in May 2012, and referred her to our hospital. Intra-oral examination revealed a relatively well-circumscribed, slightly raised lesion. The lesion was rough granular with a white surface, measuring 8 × 6mm in size, without induration around the lesion. A benign tumor was suspected, and an excisional biopsy was performed under local anesthesia on May Y. There has been no evidence of recurrence. Histopathological examination revealed a papillary proliferation of stratified squamous epithelium associated with hyperparakeratosis and uniformly elongated rete pegs. The connective tissue papillae were largely filled with foamy cells, which were positive for CD 68, and negative for S-100 protein. Based on these findings, a final diagnosis of VX was made.View full abstractDownload PDF (1100K)
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