The stimulatory effects of nucleotides and related compounds on the lip chemorecepors of the puffer,
Fugu pardalis, were studied by recording electrical responses from the facial nerve innervating the upper lip.
AMP, ADP, ATP, IMP and UMP elicited a response in the nerve, while other ribonucleotides, CMP, GMP and XMP, and deoxyribonucleotides, dAMP, dCMP, dGMP and TMP, did not at 10
-3M. Studies with single-fiber preparations showed that all of the above effective nucleotides tend to stimulate the same taste units.
While AMP at 10
-3M had a marked stimulatory effect, its component compounds, adenine, D-ribose, inorganic phosphate, adenosine and D-ribose-5-phosphate at the same concentration, all failed to elicit any detectable responses. Adenosine-3'-monophosphate and adenosine-3', 5'-monophosphate at 10
-3M also did not elicit any appreciable responses.
A sample of RNA from yeast was also tested. It did not appear to be effective.
抄録全体を表示