A 60s woman with an in-operable stage IVA (T4N0M0) gallbladder carcinoma invaded to liver, duodenum and transverse colon visited our hospital in May 200X. 61.2 Gy of Radiotherapy, chemotherapy (weekly gemcitabine), hyperthermia and hyperbaric oxygen therapy (HBO) was performed for abdominal tumor. After chemo-radiotherapy, maintenance biweekly chemo-hyperthermia and HBO was performed for a year. Clinical complete response was obtained at April 200X+1. After that, she ingested S-1 for 18 months. She survives with no evidence of disease for 6 years and 9 months after treatment. Late adverse event was only grade 2 radiation duodenitis controlled with medical treatment.
Chemo-radiotherapy combined with hyperthermia and HBO for locally advanced gallbladder carcinoma could contribute to a better clinical outcome and it was suggested that these treatment was very useful.

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