Thermal Medicine(Japanese Journal of Hyperthermic Oncology)
Online ISSN : 1881-9516
Print ISSN : 0911-2529
ISSN-L : 0911-2529
Volume 10, Issue 2
Displaying 1-14 of 14 articles from this issue
  • [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1994 Volume 10 Issue 2 Pages 103-109
    Published: June 01, 1994
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
  • Katsushi Taomoto, Akihiro Ijichi, Shoutaro Tatsumi, Masahiko Nozoe, Ma ...
    1994 Volume 10 Issue 2 Pages 110-120
    Published: June 01, 1994
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    Hyperthermia therapy using Nd-YAG Laser for the treatment of malignant brain tumors have recently developed in neurosurgical field. We have developed new thermal probes for localized laser hyperthermia to the peripheral or infiltrating malignant brain tumor cells immediately after the tumor debulking during the surgery. (1) We have made different sizes of expermental ballon probes, which consisted of laser photofiber covered with photo-scattering materials, latex rubber and thermal sensor. The air injection in the balloon was better than soy bean oil injection. An adequate linear correlation was obtained between the temperature of the probe and that of the balloon surface. (2) In the experiment of local laserthermia applied to swine & rat brains, the temperature of the surrounding brain attached to the balloon could be easily controlled at 42.543.5°C by changing the output power between 5W and 15W. In histological examination, remarkable necrosis and multiple small bleeding as well as autolysis were noticed in the peripheral brain tissue attached to the balloon in the acute stage. The peripheral brain tissue consisted of coagulation necrosis and scattered gliosis in the chronic stage. (3) In the cases of hyperthermia for human glioma xenografts in athymic nude mice at 43.5°C for 20 minutes, remaining tumor tissue attached to the balloon revealed masssive necrosis with small hemorrhage and infiltrating inflammatory cells in the peripheral portion. Although there was no viable tumor cells within 5mm distance from the balloon, tumor necrosis was limited and scattered viable tumor cells were found after hyperthermia at 41.5°C for 20 minutes. (4) Intraoperative laserthermia therapies using balloon probes with Nd : YAG laser for 7 patients with malignant gliomas, 12 patients with metastatic brain tumors and 1 patient with primary malignant lymphoma were successfully performed without any complication during past 2 years. Post operative CT and/or MRI revealed no tumor enhancement or poor enhancement of tumor border. Although follow up of our cases is not so long, this local laserthermia is effective and easy to handle, it might be useful in the treatment of malignant brain tumors including metastatic tumors during surgery.
    Download PDF (4739K)
  • [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1994 Volume 10 Issue 2 Pages 121-125
    Published: June 01, 1994
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    Download PDF (990K)
  • [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1994 Volume 10 Issue 2 Pages 126-130
    Published: June 01, 1994
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    Download PDF (1199K)
  • Yasushi Hirata, Yuko Izumr, Shigeaki Shioiri, Daisuke Okamura, Teruo A ...
    1994 Volume 10 Issue 2 Pages 131-137
    Published: June 01, 1994
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    In combination with chemo- and radiotherapy, hyperthemia has lately attracted considerable attention as a reliable mode of anti-cancer treatment. We experienced and reported a case of mandibular squamous cell carcinoma that was most effectively treated by hyperthermia combined with chemo-radiotherapy, as a preoperative therapy.
    In August 1989, a 27-year-old male patient experiencing pain in the left mandibular third molar region, visited a dental clinic, and the tooth was extracted, with a diagnosis of pericoronitis. Subsequently, however, difficulty of mouth opening appeared and persisted. The dentist cosulted with a department of oral and maxillofacial surgery of a dental college hospital. Although antibiotics were administered for mandibular chronic osteomelitis, the symptom was persistent. Biopsy from the extraction wound was then performed, and the diagnosis of squamous cell carcinoma was establised.
    In July 1990, the patient was referred to our department. Radiological examinations revealed destructive change from the mandibular body of the left lower molars to the mandibular ramus, and the tumor extended deeply into the infratemporal fossa. After hospitalization, external irradiation (30 Gy), and administration of PEP (60 mg) and CDDP (20 mg) were carried out in combination with microwave hyperthermia (8 times, 60 minutes each time). After confirmation of the excellent effects of the multimodal preoperative treatment, a radical operation, consisting of left radical neck dissection, hemimandibulectomy, dissection of infratemporal fossa, and reconstruction by PMMC flap and titanium metal plate, was performed.
    Comparing the CT image from the time immediately after the preoperative treatment with that of the patient's first visit to our clinic, the tumor mass around the mandibular ramus remarkably reduced, and the retromaxillary fat space was restored. Furthermore, because of clearness of the contour of the masticatory muscles and disappearance of the intratumor vascularity in, diagnostic imaging, the tumor was considered to have been almost controlled. The histopathological findings of the operation material revealed that almost all the tumor tissue had been replaced by fibrous tissue. For the reasons, we concluded that the chemoradiotherapy combined with hyperthermia was remarkably useful.
    Download PDF (3015K)
  • Takashi Sakamoto, Tetsuro Shimizu, Shigeru Takemori, Toshihiro Sakakib ...
    1994 Volume 10 Issue 2 Pages 138-142
    Published: June 01, 1994
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    A 49-year-old man with advanced esophageal cancer was admitted to our hospital to have an operation. X-ray examination of the esophagus showed a ulcerative and localized type tumor located in middle to middle third of the esophagus. The tumor was measured 5.5cm in vertical extension. Endoscopic biopsy revealed moderately differentiated squamous cell carcinoma. We performed preoperative treatment using hyperthermochemoradiotherapy. Subtotal esophagectomy was carried out after preoperative treatment. Histological study of the surgical specimen revealed no cancer cells in the lesion, so preoperative hyperthemochemoradiotherapy was markedly effective. Nevertheless this patient died of liver metastasis 32 months after operation. To improve the survival time, the more sophisticated multimodality therapy is expected.
    Download PDF (1889K)
  • Michio Hayashi, Yasumasa Nishimura, Masahiro Hiraoka, Mitsuyuki Abe
    1994 Volume 10 Issue 2 Pages 143-149
    Published: June 01, 1994
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    A case of recurrent rectal cancer who survived more than 5 years following thermo-radiotherapy was presented. A 76-year-old male patient with unresectable recurrent rectal cancer in the perineum was treated with radiation therapy combined with hyperthermia. Total radiation dose was 66Gy/2Gy, and an 8MHzRF capacitive heating device was used for reginal hyperthermia. Although the recurrent tumor showed complete regresion 4 months after the combined therapy, a small marginal recurrence behind sacrum was noted on CT scan. Thermoradiation therapy was performed again for the recurrent tumor. Total radiation dose for the tumor was 50Gy/2Gy, and a 430MHz microwave hyperthermia system was used for local hyperthermia. An average intratumoral temperature was 43.0°C. In terms of toxicity, radiation skin ulcer was noted in the hip region 4 years after the initial treatment. He died of pulumonary infection 5 years and 8months after the combined treatment. At autopsy, neither residual tumor nor distant metastasis was demonstrated. Hyperthermia combined with radiation therapy seems effective in the treatment of locally recurrent rectal cancer.
    Download PDF (2773K)
  • Kousuke Ueda, Takehiko Okamira, Kazuhiro Tajima, Kaoru Saitou
    1994 Volume 10 Issue 2 Pages 150-155
    Published: June 01, 1994
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    Combined treatment with local hyperthermia, radiation and chemotherapy was performed for a young female with a retrovesical tumor histologically diagnosed as an undifferentiated mesenchymal tumor.
    The patient was 17 years old and had suffered from left flank pain since October 1991. Computed tomography and magnetic resonance imaging revealed a large retrovesical tumor. She was operated in December 1991, but the tumor was not resected completely due to adhesion to the pelvis. After the operation, she received intra-arterial infusion of cisplation, doxorubicin, and mitomycin C, and thereafter received Lineac irradiation to a total dose of 50.4 grays. Hyperthermia of the pelvis was conducted from March 1991 to December 1993 for 26 sessions as an outpatient using a Thermotron RF-8.
    The tumor decreased markedly in size after this combination of hyperthermia, chemotherapy, and radiation. The patient is currently well and is receiving hyperthermia, chemotherapy, and radiation. The patient is currently well and is receiving hyperthermia once a month.
    This case indicates that combined local hyperthermia, chemotherapy, and radiation is useful for the treatment of retrovesical tumors.
    Download PDF (1802K)
  • Yuji Kobashi, Hideaki Sawai, Ryoji Hayase, Takahumi Kudo, Katsuyoshi S ...
    1994 Volume 10 Issue 2 Pages 156-161
    Published: June 01, 1994
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    Download PDF (2319K)
  • Motoharu Kondo, Kenji Itani, Toshikazu Yoshikawa, Yoshimasa Tanaka, Na ...
    1994 Volume 10 Issue 2 Pages 162-167
    Published: June 01, 1994
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    To evaluate the efficacy of intra-arterial chemotherapy combined with hyperthermia for malignant liver tumors, our cooperative study group carried out a randomized clinical trial of intra-arterial chemotherapy alone and intraarterial chemotherapy combined with hyperthermia. Fifteen patients were registered by telephone contact and allocated at random to groups treated with either intra-arterial chemotherapy alone or combined therapy. Patients were treated with combined chemotherapy of 5-fluorouracil (5-FU), epirubucin (EPIR), mitomycin C (MMC) by hepatic infusion using a subcutaneously implanted reservoir. Hyperthermia (8MHz radiofrequency) was usually performed for 40-60 min every week, and intra-arterial chemotherapy was performed immediately before hyperthermia. Therapeutic effects were evaluated by examining the changes in tumor size on computed tomography, and/or intratumor low density areas on posttreatment computed tomography. There were no favorable responses obtained in the patients treated with intra-arterial chemotherapy alone. Among patients treated with combined therapy, PRh was observed in one patient with hepatocellular carcinoma, PR in one patient with hepatocellular carcinoma and two patients with metastatic liver cancer, These results suggest that intraarterial chemotherapy combined with hyperthermia may be a useful modality for the treatment of either non-resectable hepatocellular carcinoma or metastatic liver cancer.
    Download PDF (979K)
  • Masashige Shinkai, Masaaki Matsui, Takeshi Kobayashi
    1994 Volume 10 Issue 2 Pages 168-177
    Published: June 01, 1994
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    The magnetoliposomes for hypertermia of cancer were developed. These were prepared by the coating of a phospholipid to the magnetite fine particles. The magnetoliposomes generated heat in the high frequent magnetic field. The heat evolution rates of the magnetoliposomes varied with core magnetite's size. When the magnetite's size was 40nm, the heat evolution rate was highest. Hyperthermia simulation using the magnetoliposomes was performed according to concentric spherical tumor perfusion model with a necrotic core surrounded by intermediately and highly perfused shells of blood. When 45.5 kA/ m (572 Oe) of magnetic field and 240 kHz of frequency were applied, 0.74mg/cm3-tissue of the magnetoliposomes were simulated to be necessary for heating tumor tissue of 6 cm in diameter to 42-45°C.
    Download PDF (1133K)
  • Viability of the Cells Accumulated in G2M Phase after Heating
    Setsujo Shiota
    1994 Volume 10 Issue 2 Pages 178-188
    Published: June 01, 1994
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    Perturbation of the cell cycle, particularly accumulation into the G2M phase occurs after hyperthermia. However, the viability of the G2M phased cells has not been examined. The effects of hyperthermia and hyperthermia combined with mitomycin C on the cytotoxity and cell kinetics of WiDr cells, human colon cancer cell line, were studied by clonogenic assay and flow cytometrical cell cycle analysis. Next, cells accumulated into the G2M phase after heating must be separated for evaluation of their clonogenic potential by the flow cytometrical cell sorting technic. The surviving fraction of WiDr cells decreased with the rise of heating temperature and the prolongation of heating time, especially at 44°C.
    In flow cytometrical cell cycle analysis, accumulation into the G2M phase was observed after heating. In the 44°C group, accumulation into the G2M phase lasted for 48 hours after heating. In the cell cycle analysis of the cells heated in combination with mitomycin C, the proportion of G2M phased cells increased in comparison with the heating alone group. The surviving fraction of sorted GOG1 phased cells and G2M phased cells decreased with increasing temperature. The degree of reduction of the surviving fraction was marked in the G2M phased cells. The surviving fraction of the cells heated in combination with mitomycin C was markedly reduced in comparison with the cells heated alone. Consequently, the marked accumulation into the G2M phase resulting from hyperthermia shows the severity of damage of the cells, and these G2M phased cells were presumed to be the population of cells which were subject to lethal damage. The proportion of G2M phased cells after heating was considered to be a parameter of the anti-tumor effect and the sensitivity of hyperthermia.
    Download PDF (1105K)
  • Masahiro Kuroda, Keiji Inamura, Seiji Tahara, Hirofumi Uno, Kazumi Tak ...
    1994 Volume 10 Issue 2 Pages 189-197
    Published: June 01, 1994
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    The authors developed and evaluated the performance, using a phantom, of a new capacitive heating applicator designed for the “parallel method” of applying clinical simultaneous radiohyperthermotherapy (SRH) in which electron beam irradiation is provided from above an external capacitive heating applicator for the treatment of superficial and shallow-seated tumors. The trial applicator was made to fulfill the following conditions : (1) use of an electrode plate which does not affect the electron beam depth dose, (2) a uniform tickness to maintain flatness of the electron beam, (3) an attachment site between the electrode and lead wire at the electrode margin to avoid entering the irradiation field, and (4) cooling function to enhance therapeutic gain factor and avoid damage to normal skin tissue. This applicator consisted of a 0.1-mm-thick copper electrode and a 5-mm-thick cooling chamber. The depth of the 80% dose of the new applicator was 21 mm with a 9-MeV electron beam and 36 mm with a 15-MeV electron beam, which was comparable to the effect of a conventional irradiation bolus. The temperature distribution produced by the trial applicator was symmetrical on both the right and left from the center of the applicator. The 50% specific absorption rate region was a width of 6.4 cm at a depth of 1 cm from the phantom surface and a width of 2.8 cm at a depth of 3 cm. There have been no previous reports on the development of an external capacitive heating applicator designed for the SRH of superficial and shallow-seated tumors; this is the first report. SRH of these tumors can be performed simply, noninvasively and repeatedly by means of this new applicator.
    Download PDF (2425K)
  • Takashi Fujimura, Yutaka Yonemure, Itasu Ninomiya, Kazuo Sugiyamau, Ge ...
    1994 Volume 10 Issue 2 Pages 198-201
    Published: June 01, 1994
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    Download PDF (297K)
feedback
Top