Persimmon fruit has a characteristic fatty acid (FA) composition with a high
cis-vaccenic acid (
cis-VA: C18:1, n-7) ratio;
however, the effect of ingesting
cis-VA is unknown. Therefore, to elucidate the effect of
cis-VA upon ingestion, it was
orally administered to normal (C57BL/6JJcl) and diabetic (KK-
Ay/TaJcl) mice for 7 d. The FA composition of each tissue
was analyzed to identify the tissues in which
cis-VA acts, as well as those that may be affected by FA metabolism.
cis-VA
administration altered the FA composition of the pancreas in normal mice and the hearts of diabetic mice. Multiple FA
ratios were altered, with five FA showing common changes between the heart and pancreas. This suggests that
cis-VA
ingestion may affect the pancreas and heart, and cause common changes in FA metabolism. Overall,
cis-VA may have
unique actions that differ from those of other monounsaturated FA.
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