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Volume 102 (1970)
- Issue 4 Pages 315-
- Issue 3 Pages 209-
- Issue 2 Pages 103-
- Issue 1 Pages 1-
Volume 102, Issue 2
Displaying 1-12 of 12 articles from this issue
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GORO TAKADA, KEIYA TADA1970 Volume 102 Issue 2 Pages 103-111
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn in vivo experiments on rats with experimentally induced hyperaminoacidemia, it was observed that when the plasma concentration of a single amino acid, such as phenylalanine, methionine, histidine or valine was elevated, both the uptake of 14C-leucine by the brain and the incorporation of 14C-leucine into the brain protein were inhibited. These findings suggest that the reduction of brain protein synthesis due to an imbalance of amino acid concentrations in serum may play an important role in the development of the brain damage seen in inbor, errors of amino acid metabolism.View full abstractDownload PDF (472K) -
KOSEI ISHII, KAZUKO ISHII1970 Volume 102 Issue 2 Pages 113-119
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe physiological evidence of the efferent innervation to the chemoreceptor was sought in the carotid labyrinth of the toad. A few-fiber chemosensory preparation was splitted from the glossopharyngeal nerve at its peripheral cut end, and the rest part of the nerve was stimulated electrically. The stimulation reduced remarkably the chemosensory discharge in this nerve strand. To seek the derivation of these inhibitory fibers a few-fiber preparation was peeled from the intact glossopharyngeal nerve, and the sympathetic nerve and the vagus group root were stimulated respectively. The sympathetic stimulation provoked an in-hibitory effect on chemosensory activity in ten of seventeen preparations. In three of these ten the vagus group root stimulation was also effective. In one instance the vagus group root stimulation brought about the inhibitory effect, while the sympathetic did not. In the other six, no remarkable effect was obtained by both stimulations. The mechanism provoking these effects was discussed.View full abstractDownload PDF (357K) -
TAKAFUMI MORISHIMA1970 Volume 102 Issue 2 Pages 121-126
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSWith use of the formaldehyde condensation method of Flack and Hillarp, skin specimens taken from one patient with solitary mastocytosis and four patients with urticaria pigmentosa were examined under a fluorescence microscope. In the case of solitary mastocytosis, some of mast cells in the dermis showed intense yellow fluorescence, which was no doubt due to the presence of serotonin or its immediate precursor, 5-hydroxytryptophan. In four cases of urticaria pigmentosa, no yellow fluorescence could be detected on the mast cells infiltrated around the vessels. However, there were a few mast cells which showed yellow fluorescence, in the dermis of a patient with urticaria pigmentosa. From a biochemical point of view, human mast cells, too, seem to consist of two distinctly different types of cells: monoamine-forming and non-amine-forming mast cells.View full abstractDownload PDF (1458K) -
HIDE-AKI SAITO, TAKESHI SHIMAHARA, YOSHIRO FUKADA1970 Volume 102 Issue 2 Pages 127-133
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSResponse characteristics of the previously categorized four types of cat retinal ganglion cells (ON-I, OFF-I, ON-II and OFF-II) were investigated using light and dark spot stimuli by recordings of unit discharges from the optic tract, and phasic and tonic nature of these four types of cells were further clarified. ON-I and OFF-I are phasic in nature and respond to only a transient increase and decrease in luminance, respectively. ON-II and OFF-II are tonic and continue to respond to a stationary light and dark contrast, respectively. Besides, a difference is also found between ON-I and ON-II in the firing patterns of the transient response to a bright spot stimulus. ON-I responds to the onset of a bright spot with an initial burst followed by dispersed discharges. In ON-II's transient response, initial discharge rate is as high as that of ON-I's burst, but in contrast with the case of ON-I's response, the discharge rate gradually decreases toward a mean rate of sustained responses to the spot.View full abstractDownload PDF (367K) -
EIICHI IWAI, SUSUMU SAITO, SUSUMU TSUKAHARA1970 Volume 102 Issue 2 Pages 135-142
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn an attempt to clarify the neural mechanism of visual discrimination learning in fish, a series of six experiments, four behavioral and two electrophysiological, were performed in goldfish. In the behavioral studies retention of color discrimination was tested following lesions of various brain structures, and in the electrophysiological studies the effects of conditioning stimulations or ablations of different brain structures upon the evoked response in the optic tectum induced by the test stimulation of the contralateral optic disk were investigated. The results obtained suggest that goldfish has a quite characteristic visual mechanism different from those in higher vertebrates. An outline of that distinctive feature in fish was drawn.View full abstractDownload PDF (498K) -
YOSHIFUMI ISHII, MICHIO MORI, TERUO FUJIMOTO1970 Volume 102 Issue 2 Pages 143-157
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAn immunofluorescence study carried out on the relationship between the mode of localization of antigen and that of specific antibody and γ-globulin in the germinal centers of mouse popliteal lymph nodes during the secondary immune response. The germinal centers of popliteal lymph nodes from mice sensitized secondarily with antigen (human γ-globulin) contained both antigen and γ-globulin in a similar distribution, giving lacy or reticular framework of immunofluorescene. Specific fixation of heterologous (guinea pig) complement in the germinal centers was also observed in a distribution similar to that of antigen and γ-globulin. These results strongly suggest the presence of antigenantibody complex mechanism in the germinal centers. The functional significance of this mechanism in the immune reaction is discussed. Large parenchymal cells of the germinal centers were devoid of specific staining for specific antibody as well as for γ-globulin, which may support the view that the germinal centers are not a source of plasma cells but a site of lymphocyte formationView full abstractDownload PDF (1979K) -
RIKURO SASAKI, TOSHIAKI MORISHITA, SHIZUKA ICHIKAWA, SHOICHI YAMAGATA1970 Volume 102 Issue 2 Pages 159-167
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn order to find DNA synthesis and mitosis of heart muscle cells in experimental cardiac hypertrophy, autoradiographic studies after 3H-thymidine administration and evaluation of mitosis after colchicine treatment were made on Goldblatt rats. The labeling index of heart muscle cells and of interstitial cells in 4 hours was 0.03-0.2% and 0.25-0.7%, respectively. Concomitant mitosis of labeled heart muscle cells and of interstitial cells was found in 0-0.1% and 0.1-0.3%, respectively. The mitotic figures were scarcely found after colchicine administration. Though colchicine yields rather ambiguous results, the autoradiographic studies gave definite evidence for cell division of heart muscle cells in experimental cardiac hypertrophy.View full abstractDownload PDF (5255K) -
OTOTAKA HIGASHI, TETSURO FUJIWARA, TSUNEO ARAKAWA, TASUKE KONNO, EISUK ...1970 Volume 102 Issue 2 Pages 169-178
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn a seven-year-old boy with the protein-losing enteropathy due to an intestinal lymphangiectasia, a marked deficiency of both vitamin E and essential fatty acids of erythrocytes was found and urinary excretion of methylmalonic acid was detectable after an oral loading with valine. The amount of vitamin E, administered parenterally, required to maintain a normal hydrogen peroxide hemolysis test of erythrocytes was found to be about 7mg per day in the patient.View full abstractDownload PDF (1920K) -
TAKASHI IWABUCHI, WILLIAMINA A. HIMWICH1970 Volume 102 Issue 2 Pages 179-183
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe interlacing suture has been applied to vascular suture in the dogs as follows: transection and end-to-end anastomosis of the common carotid artery in 6 instances, transection and end-to-end anastomosis of the external jugular vein in instances, autogenous vein grafting 3cm in length in the external jugular vein in 6 instances, end-to-side portacaval shunt in 9 instances, transverse incision and suture of one-third of the circle of the superior sagittal sinus in 2 instances, and transection and grafting 3mm in length of aut.ogenous dura mater of the superior sagittal sinus in 1 instance. Of this series, 20 instances were satisfactorily patent including suture of the superior sagittal sinus, and 5 instances including the grafted superior sagittal sinus were still patent with slight stenosis occurring 10 to 128 days after surgery. In only 1 instance was the portacaval shunt occluded. This method did not cause shortening of the axial length of the vessel or narrowing of its diameter at the suture site and seemed to be one of the most efficient vascular sutures.View full abstractDownload PDF (1300K) -
YOICHIRO SASAI1970 Volume 102 Issue 2 Pages 185-193
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe histochemical property of amyloid was studied in 2 cases of lichen amyloidosus in fresh unfixed skin sections. Two-step periodic acid Schiff method was used for staining acid mucopolysaccharides containing 1:4 linked uronic acid. To identify various polyanions histochemically, staining was carried out with alcian blue containing different concentrations of electrolytes. The results observed suggest that amyloid in lichen amyloidosus contains heparitin sulfate. However, the possibility of the presence of polycarboxylates was not denied.View full abstractDownload PDF (3743K) -
SHIGETSUGU KATSURA, YASUHIKO KANEKO1970 Volume 102 Issue 2 Pages 195-206
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe present investigation was planned to study the current status of operation for gastric cancer in Japan, and to find measures to improve the operative results. 3, 492 patients with gastric cancer, who were treated in the period of 4 months from October 1967 to January 1968 in 220 hospitals in Japan, were analyzed. The total number of operated cases was 3, 340 cases, of which 2, 659 had gastric resection. However, curative resection was carried out in 1, 613 cases, the curative resection rate being 48%. The factor most responsible for non-curative resection was peritoneal dissemination. Of 3, 340 operated cases, 530 cases were in the stage I (16%), 696 cases stage II (21%), 949 cases stage III (28%) and 1, 165 cases stage IV (35%). The causes of delay of treatment for gastric cancer were found in 2, 177 (67%) of 3, 242 general cases. The patient was responsible for the delay in 24%, the doctor was responsible in 32%, both patient and doctor were responsible in 6% and both were not responsible in 38%. The curative resection rate was 51% in the prefectural capital cities, 27% in the countries, 70% in the cancer hospitals and 51% in the university hospitals. In this survey, 250 cases were detected by mass gastric examination. The discovery rate of cancer localized to mucosal and submucosal layers by this method was 39%, and in these cases the resection rate was 97% and the curative resection rate was 80%. And, the cases in the stages I and II were 68%. 72% of these cases were symptomless. In conclusion, it is evident that the detection of gastric cancer in early stage is the only way to improve the operative results. Mass gastric examination and establishment of detection clinic, where thorough gastric examinations can be easily carried out, are recommended.View full abstractDownload PDF (620K) -
KATSURO IGARASHI1970 Volume 102 Issue 2 Pages 207-208
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSCardiac output of patients with orthostatic dysregulation was examined by the microvibration technique. The decrease of cardiac output by tilting from the supine position was significantly larger in patients with the syndrome than in normal subjects.View full abstractDownload PDF (118K)
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