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Volume 110 (1973)
- Issue 4 Pages 311-
- Issue 3 Pages 209-
- Issue 2 Pages 105-
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Volume 110, Issue 1
Displaying 1-11 of 11 articles from this issue
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ENG SEND ANG, TOSHIHIKO NEYAZAKI, CHIGASHI SUZUKI, FUMIO ARIJI, JUNJI ...1973 Volume 110 Issue 1 Pages 1-5
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSExtremely long villous processes projected from endothelium toward capillary canal was observed in the blood vessels of very malignant pulmonary carcinoma. Many of the villous processes appeared to be long enough to interconnect and to interwind each other, and some of them showed waving or rolling shape. There are numerous vesicles in various sizes within the capillary endothelium from which these processes are projected. A correlation between the rapid growth of lung cancer and these unusual findings is not known at present.View full abstractDownload PDF (2735K) -
HIROSHI NAKANO1973 Volume 110 Issue 1 Pages 7-21
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDonryu rats received an infusion of various amounts of N-methyl-N'-nitro-N-nitrosoguanidine from the anus were kept under the observation for a maximum period of 61 weeks and sacrificed at certain intervals for the histopathological studies. A total of 133 tumors was found in 59 out of 138 effective animals. These tumors were histologically 19 adenocarcinomas, 73 adenomatous lesions, 20 hyperplastic lesions, and 21 hyperplastic lymph nodes. All these lesions were found to locate only in the segment of colon where the carcinogen contacted directly. These were all macroscopically elevated types, which included thickened folds. Tumor occurrence in the animals given 0.5ml of 0.25% N-methyi-N'-nitro-N-nitrosoguanidine solution daily for 32 days (total dose of the carcinogen 40mg), was 76 per cent at the end of 40 weeks after anal infusion. Adenomatous lesions were found at the end of 17 weeks or later after infusion, while adenocarcinomas occurred at 35 weeks. Histologically, all the lesions of adenocarcinoma were located immediately adjacent to the adenomatous lesions, and the histological feature of the experimental tumors was similar to that of human colo-rectal tumors. The similarity of adenocarcinomas and adenomatous lesions strongly suggested that the former might, have originated from the latter.View full abstractDownload PDF (5343K) -
ICHIRO NAKAZAWA, SHOICHI YAMAGATA, HIKARU WATANABE1973 Volume 110 Issue 1 Pages 23-32
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS13 cases of cancer and 10 cases of adenomatous polyp in the large intestine were studied lipid-chemically on their tissues, in order to clarify the biochemical differences between malignant neoplastic and benign growth. Cancerous or adenomatous polypous tissues were collected by biopsy or surgical operation. The total lipid was extracted from each tissue, and one part of each total lipid fraction was separated into triglyceride and phospholipid fractions by a thin-layer chromatography (TLC). The fatty acid composition and the fatty acid content of each lipid fraction were measured by a gas-liquid chromatography. When the fatty acid composition of the phospholipid is shown in the form of the deviation rate, the deviation rate of C14:0 was remarkably increased and that of C20:4 was remarkably decreased in the cancerous cases, compared with the respective values of the cases of adenomatous polyp. More definite differences were recognized between the cancerous cases and the cases of adenomatous polyp, when the ratio of the deviation rate of C14:0 to that of C20:4 was calculated in each case. Namely, these ratios distributed between 2.404 and 4.125 in 7 cancerous cases, and in 8 cases of adenomatous polyp between 0.564 and 1.856. Thus, if we use this ratio, it would be possible to distinguish the cancerous tissue from the adenomatous polypous tissue.View full abstractDownload PDF (2911K) -
NAOFUMI IWATSUKI1973 Volume 110 Issue 1 Pages 33-40
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSInotropic effects of thiamylal and propanidid on the contractile state of the isolated dog heart muscle were determined by means of force-velocity relations and compared with those of CT 1341, a new steroid anesthetic. All anesthetics studied produced a dose-dependent leftward shift of the force-velocity curves, indicating a negative inotropism. The percentage decreases in the maximum velocity of muscle shortening (Vmax) and isometric peak force (F) at the concentrations for the clinical induction doses were 5.1±2.8 and 13.2±4.3 for thiamylal, 30.9±4.6 and 61.4±6.3 for propanidid, and 5.8±2.4 and 20.2±2.0 for CT 1341. The changes in Vmax and F were not statistically significant between thiamylal and CT 1341, but clearly significant between propanidid and other two agents. These findings indicate that the depressive effects of thiamylal and CT 1341 on the myocardium seem to be minor and of a similar degree when they are used at the clinical induction doses, while propanidid may produce a definite negative inotropic effect even at the clinical induction dose.View full abstractDownload PDF (473K) -
TADAO ORII, RYOJI MINAMI, AIKO TAKASE, TOORU NAKAO1973 Volume 110 Issue 1 Pages 41-48
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSQualitative and quantitative determinations of urinary acid mucopolysaccharides in five patients with Hurler, Morquio and Scheie syndromes have been studied by several methods including ECTEOLA-cellulose column chromatography, Dowex 1×2 column chromatography, electrophoresis and enzymatic digestion with testicular hyaluronidase and chondroitinase. 1) Considerable amounts of chondroitin sulfate B, heparitin sulfate and keratosulfate were detected in the urine of two patients with Hurler syndrome compared with that of normal male children. 2) Keratosulfate constituted respectively about one-third (34.5% and 29.4%) of the total acid mucopolysaccharide excreted in two sisters with Morquio syndrome. Each content of all of the acid mucopolysaccharide excreted was greater than that excreted in normal male children. 3) Chondroitin sulfate B and heparitin sulfate comprised 39.0% and 24.3% of the total acid mucopolysaccharide excreted in a patient with Scheie syndrome. 4) With the exception of chondroitin sulfates A and C in two brothers with Hurler syndrome, all of the acid mucopolysaccharides found in the urine of normal male children were also identified in the urine of five patients with genetic mucopolysaccharidoses.View full abstractDownload PDF (470K) -
TSUNEO ARAKAWA, YOSHIYUKI HONDA, KUNIAKI NARISAWA1973 Volume 110 Issue 1 Pages 49-57
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDecreased urinary excretion of FIGLU after an intraperitoneal injection of L-histidine monohydrochloride in rats with diphenylhydantoin admini-stration was partly resulted from a decreased activity of the hepatic histidase due to the drug administration.View full abstractDownload PDF (445K) -
TSUNEO ARAKAWA, TOSHIO YOSHIDA, YOSHIYUKI HONDA, KUNIAKI NARISAWA, HAR ...1973 Volume 110 Issue 1 Pages 59-68
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSEither a rise or fall in serum folate levels was observed in mentally retarded epileptics with diphenylhydantoin therapy. Urinary excretion of FIGLU after an oral histidine load was decreased sienificantly in patients with the anticonvulsant therapy. Eleven cases out of 37 cases with diphenvlhvdantoin administration showed aa positive ferric chloride reaction of urine collected after an oral histidine load. The positive ferric chloride reaction was proved to be due to the presence of imidazole pyruvic acid, suggesting a defective activity of the hepatic histidase of epileptics with the drug therapy. Tt was suygested that the decreased urinary FIGLU during the drug therapy might be partly resulted from a defective activity of the hepatic histidase which was caused by diphenylhydantoin therapy. Serum vitamin B12 levels, MCV and an incidence of hyPersegmentation of neutrophil nuclei showed no difference between patients with diphenylhydantoin therapy and those without it.View full abstractDownload PDF (463K) -
MAMORU NAKAMURA, YOSHIKAZU SAWAI, MITSUNOBU ABE, FUMIHIKO HOSHINO1973 Volume 110 Issue 1 Pages 69-80
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe application of 4096 channel memory unit to the radioisotope imaging is described. At the time of scanning, the radioactive distribution in the organ is stored in digital form. The content of the memory unit is displayed on the oscilloscope during or after examination. The digital scan can be trans-ferred to magnetic tape or paper tape for further processing. Since data are digital, image smoothing or scan mixing are possible. With this system, total counts of scintiscan matrix can be summed up. The uptake of radionuclide in the organ is calculated with a proper phantom. We have applied this method to thyroid uptake. As a result of this method, digital data storage has proved to be useful for diagnosis of scintigrams.View full abstractDownload PDF (6035K) -
KOZUI MIYAZAWA, MASAAKI YAMAKI, KINJI ISHIKAWA, KAI TSUIKI, YOSHINORI ...1973 Volume 110 Issue 1 Pages 81-87
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSHemodynamic responses to administration of metaproterenol and deslanoside were studied in 5 and 3 patients with aortic regurgitation, respectively. Metaproterenol produced an increase in forward stroke volume and aortic flow and a reduction in aortic regurgitant flow. In pure aortic regurgitation, these effects were related to a decreased left ventricular work. Deslanoside uniformly increased stroke volume, forward and regurgitant flows. Left ventricular work also increased after deslanoside administration. Calculated regurgitant valve orifice was changeable in association with alteration of inotropy and heart rate following administration of these drugs. The change of regurgitant flow was positively correlated with the change of regurgitant orifice area (r=0.988) and diastolic time (r=0.696). There was no close correlation between the regurgitant flow and systemic vascular resistance or diastolic pressure gradient from the aorta to left ventricle. It was concluded that when the hemodynamics in aortic insufficiency were altered by drug administration, the size of regurgitant orifice area and the duration of diastole were the important determinant of aortic regurgitation.View full abstractDownload PDF (444K) -
KATSUHIRO OGAWA, TAKASHI MINASE, KATSUHIRO ENOMOTO, TAMENORI ONO&Eacut ...1973 Volume 110 Issue 1 Pages 89-101
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSElectron microscopic study of the sinusoidal wall was made on the rat liver fixed by perfusion with glutaraldehyde. The majority of sinusoidal lining cells could be divided into two groups; endothelial cells and Kupffer cells. The former appeared general wall-forming cells, while the latter frequently protruded into the sinusoidal lumen, exhibiting intense phagocytic activity. The endothelial calls possessed numerous pores in their attenuated part of the cytoplasmic processes, forming a sieve plate-like structure as described by Wisse. Additional findings also suggested the actual exchange of the materials including the lipoprotein through these pores. On the contrary, there was no elaborate fenestration in the cytoplasm of Kupffer cells. But, a small number of cells, which showed abundant lysosomes, protuberant cytoplasm and fenestrated cytoplasmic processes, exhibited the transitional features between the endothelial cell and the Kupffer cell.View full abstractDownload PDF (3810K) -
1973 Volume 110 Issue 1 Pages 103
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDownload PDF (35K)
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