The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
112 巻, 1 号
選択された号の論文の10件中1~10を表示しています
  • Takeshi Hoshi
    1974 年 112 巻 1 号 p. 1-2
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
  • RYO KATORI
    1974 年 112 巻 1 号 p. 3-13
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
    Effects of voluntary submaximal ventilatory drive on the pulmonary circulation were studied under the right and left cardiac catheterizations in 10 patients. In supine position, the patient was forced to make a voluntary deep inspiration of the duration of at least 20 seconds, and succeedingly deep expiration of the same duration while pulmonary artery (PA), left atrial (LA) and intraesophageal pressures were recorded continuously. The dye-dilution curve was recorded from the left atrium after injection of indocyanine green into the main pulmonary artery at 10 seconds from the start of the ventilatory maneuver, for measurement of cardiac output, mean transit time and pulmonary blood volume. Mean pressure difference between PA and LA significantly increased in inspiration and decreased to a value slightly lower than resting ventilation value in expiration. Pulmonary vascular resistance increased in inspiration but did not show a consistent change in expiration. Pulmonary blood volume tended to increase in inspiration and to decrease in expiration. It is suggested that the increased PA-LA pressure difference during inspiration would be due to a reduction in the capacity of small-sized pulmonary vessels adjacent to the alveoli by lung inflation which are acting as resistance vessels of pulmonary circulation, so that pulmonary vascular resistance is increased.
  • HIROAKI OKABE, KAZUO FUJIKAWA
    1974 年 112 巻 1 号 p. 15-23
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
    The purification and preparation of undegraded prothrombin from bovine plasma was studied with various methods. The more simple and reproducible method for the preparation of undegraded prothrombin is reported in this paper and highly active prothrombin was obtained in good recovery by DEAE-Sephadex column chromatography following ammonium sulfate precipitation. The prothrombin thus purified showed a single band on the disc electrophoresis.
  • TAKASHI NATORI, HISAMI IKEDA, HIROMITSU YOKOTA, SABURO MATSUMOTO, KATS ...
    1974 年 112 巻 1 号 p. 25-34
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
    Rat specific thymocyte antigen (RSTA) was detected by the heterologous antiserum (ATS) raised in rabbit against the soluble antigen from the rat thymocyte membrane fraction. Quantitative absorption studies revealed that thymus cells could absorb the reactivity of ATS, but spleen cells, lymphnode cells and bone marrow cells showed little absorbing activity. Liver, kidney, red blood cells and skin had no absorbing activity, while the brain could react with the ATS, suggesting that brain had a common antigenic activity with thymocytes. As the brain tissue of mice had no such reactivity, the common antigenicity is considered to be species-specific. RSTA could be detected in the thymus of rats after 10 days of age. Cortisone treatment had drastically decreased the size of thymus and decreased the number of thymocytes to 5% which had no sensitivity to ATS. Therefore it is suggested that RSTA is located in the cortical cells of the thymus.
  • TOSHIRO SAKURADA, TORU YAMAGUCHI, MAKIKO YAMAMOTO, REIKO DEMURA, MITSU ...
    1974 年 112 巻 1 号 p. 35-46
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
    In a family with X-chromosome-linked inheritance of thyroxine (T4)-binding globulin (TBG) deficiency, serum free T4 values were low in three of four members, but free triiodothyronine (T3) values were normal in all four of them. Binding capacities of T4-binding prealbumin (TBPA) were high in three of four members. In the propositus, a 47-year-old male, whose T4-binding capacity of TBG was null, half-time of serum T4 was shortened, turnover rate, distribution space and clearance rate all increased, extrathyroidal organic iodine pool decreased and degradation rate of T4 was unchanged compared with normal values. While half-time of his serum T3 was prolonged, turnover rate, extrathyroidal pool and degradation rate of T3 decreased, and T3 distribution space and clearance rate increased compared with normal values. When 0.24mg of ethinylestradiol-3-methylester was administered daily by mouth to the propositus for 1 month, halftime of serum T4 was prolonged, total T4 increased and T4-binding capacity of TBPA decreased but free T4, T4-binding capacity of TBG and the degradation rate of T4 were unchanged. Meanwhile half-time of his serum T3 was shortened, total and free T3 levels and degradation rate of T3 increased.
  • SHIGERU IKEDA, SHUNZO CHIBA, YOSHITAKA AGATSUMA, MASAHIRO SUZUKI, YASU ...
    1974 年 112 巻 1 号 p. 47-61
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
    The relationship between clinical manifestations and etiologic viruses was discussed based on 23 cases of Japanese children with infectious mononucleosis-like disease. 1) Five cases were caused by cytomegalovirus, 6 caused by Epstein-Barr virus, 2 caused by adenovirus, and 2 caused by a double infection with cytomegalovirus and Epstein-Barr virus. The other 8 cases were caused by unknown etiologic agents. 2) In the group due to cytomegalovirus the onset age was under 1 year, and the frequency of hepatosplenomegaly and liver involvement was high. In the group due to Epstein-Barr virus the onset age was over 1 year, and the frequency of pharyngitis and lymphadenopathy was high. 3) These characteristics of clinical manifestations of the diseases due to both viruses in Japanese children were almost coincident with those of infectious mononucleosis due to Epstein-Barr virus and cytomegalovirus mononucleosis seen in adults in America or Europe.
  • W. J. DEMPSTER
    1974 年 112 巻 1 号 p. 63-77
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
    Previous reports have suggested that the conversion of nor-adrenaline to adrenaline is dependent on very high plasma levels of glucosteroids. It has been postulated that this is achieved because the very high level of glucosteroid in the adrenal cortical venous effluent preferentially perfuses the phaeochromocytes before entering the main adrenal vein. No evidence for this portal circulation has been found. It has now been demonstrated that the venous drainage from the phaeochromocytes enters the large venous trunks emerging from the adrenal cortex and not the reverse. The adrenal gland is a composite gland made up by the incorporation by the adrenal cortex of chromaffin tissue during foetal life at a stage when the primitive vasculature of the cortex has already been laid down. The current data suggest that there are two circulations in the adrenal gland, one cortical and the other medullary, and that although the two become closely interlinked during foetal life, some independence remains in adult life. The cortical circulation consists of the cortical arteries and their veins which drain into large trunks at the corticomedullary interface and then directly via larger trunks into the central vein. The medullary circulation consists of the medullary arteries of Flint and their venae comites enclosed in a capsular sheath and an alternative venous exit via the delicate, spidery sinusoids which enter the radicles of the central vein. There is a limited alternative route for cortical blood via the venae comites of the medullary arteries.
  • GORO KAKIZAKI, TAKAYUKI SAITO, TAKEHIKO SOENO, YOSHIYUKI FUJIWARA, TET ...
    1974 年 112 巻 1 号 p. 79-88
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
    In 10 control rats and 9 rats with common bile duct obstruction, histological studies were conducted on the pancreas and the parotid. Amylase activity was measured in these tissues and serum. The following results were obtained 1. After common bile duct obstruction, the parotid gland showed almost normal histological findings. 2. Amylase content of the parotid gland was normal after the common bile duct obstruction. 3. Serum amylase was decreased in the activity after the common bile duct obstruction. 4. In mild change in histological findings of the pancreas after bile duct ligation, the parotid gland showed no histological or functional changes. These results would rule out an influence, if any, of common bile duct obstruction on histology and function of the parotid gland.
  • SHIGEAKI IKEDA
    1974 年 112 巻 1 号 p. 89-100
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
    Effects of heart rate on ventricular performance, myocardial contractile state and coronary circulation were studied under constant cardiac output in right heart by-passed anesthetized dogs. Myocardial contractile state (Vmax) was elevated as heart rate increased, and this was considered to play an important role in impeding further increase of systolic time ratio which would have occurred unless this elevation had occurred. Myocardial oxygen consumption (MVO2) was mainly influenced by heart rate, left ventricular systolic peak pressure and the contractile state of the left ventricle, but neither by stroke volume of the left ventricle nor left ventricular work. After administration of propranolol, the left ventricle was deteriorated at tachycardia more than 210 beats per minute, and Vmax did not rise at such a tachycardia. These results suggest that adrenergic beta-receptor plays an important role in augmenting the contractile state of the left ventricle and in preventing it from being deteriorated at tachycardia.
  • TSUGUYOSHI SUZUKI, SACHIKO SHISHIDO
    1974 年 112 巻 1 号 p. 101-102
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
    The level of urinary organic mercury was compared among groups with varying extents of inorganic mercury exposure. It was shown that the level of urinary organic mercury became higher along with the increase of urinary inorganic mercury level. This result suggests three possibilities; (1) the methylation of inorganic mercury may occur, though slight in the extent, in the human body, (2) methylmercury accumulated by the background exposure and bound to the binding site of tissues may be exchanged by inorganic mercury, and (3) the elevation of urinary organic mercury may be only a contingency due to the error of measurements.
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