The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 118 , Issue Suppl
Showing 1-28 articles out of 28 articles from the selected issue
  • KUNIHARU ISHIOKA, TETSUTARO TAKEDA, SHOJIRO AYUSAWA, ETSUO NAGANUMA, J ...
    1976 Volume 118 Issue Suppl Pages 1-7
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    The significance of the cytological examination in the diagnosis of gastric cancer, especially in the detection of the early cancer of the stomach, was examined in 1200 cases subjected to the cytological examination in the mass survey, including 181 cases with early cancer of the stomach, 148 cases with advanced cancer of the stomach. Comparison of the detection rates of cancer in cases of surgically confirmed stomach cancer revealed that cytological examination is more reliable than endoscopie and X-ray examinations of the stomach. In only a few instances, the false negative and false positive diagnoses were made, and therefore it is important for correct diagnosis to correlate the cytological finding with the other findings. The importance of cytological examination was clearly indicated by examination of the annual detection rate of early cancer, which showed a sudden increase after the period of the introduction of the cytological method in mass survey.
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  • KUNIHARU ISHIOKA, SHOICHI YAMAGATA, TETSUTARO TAKEDA, SHOJIRO AYUSAWA, ...
    1976 Volume 118 Issue Suppl Pages 9-17
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    To evaluate the clinical value of gastric cytology in the detection of stomach cancer, the results of cytological examinations in 417 cases of early cancer of the stomach in which cancer cell infiltration was limited to the mucosa or submucosa were analyzed. The cytological examination revealed positive for cancer cells in 93% of these cases, and therefore it is concluded that this method is not only useful but indispensable for the diagnosis of early cancer of the stomach. The gastric cytology proved to be more reliable than the endoscopic and X-ray examinations in terms of detection rate of the early gastric cancer. Among various cell collection methods for gastric cytology, which include the washing, abrasive and fibergastroscopic methods, the washing method under direct vision by the use of fiberscope showed the highest value of positivity (92.8%) in the cases of early cancer of the stomach. With the help of endoscopic guidance and biopsy techniques, the cytological examination further increased its reliability and ability in the detection of early gastric cancer. Cancer lesions even smaller than 1cm can now be correctly diagnosed by the gastric cytology.
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  • SABURO OSHIBA, KOTARO UENO, FUKUJI MOCHIZUKI, SHOICHI YAMAGATA
    1976 Volume 118 Issue Suppl Pages 19-22
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Nineteen cases of minute early gastric cancer were diagnosed under endoscopical examinations. Diagnosis was established by endoscopic biopsy in 18 eases, and exceptional one case of type Iib was incidentally found. Some of the endoscopic characteristic features of superficial depressed minute cancer were mentioned. By these findings, the diagnosis of superficial depressed minute cancer is possibly made in certain extent only by endoscopic observation. Prognosis of minute gastric cancer is excel-lent. Especially in the minute early cancer, the actual 7-year-survival rate was 100%. Prognosis of minute advanced cancer is also quite good. Minute gastric cancers can be found clinically and are almost completely curable.
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  • KOTARO UENO, SABURO OSHIBA, SHOICHI YAMAGATA, FUKUJI MOCHIZUKI, MASANO ...
    1976 Volume 118 Issue Suppl Pages 23-38
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Gastric polyp was found in 1, 616 cases or 0.23% of 711, 455 persons through the gastric mass-survey. They were classified into 3 groups; hyperplastic polyp in 61%, gastritis polyposa in 34%, and polyp composed of metaplastic epithelium with marked atypism (ATP) in 5%. Gastritis polyposa was subclassified into 5 groups according to its histoclinical features. Malignant degeneration was suspected in 5 or 2.1% of 236 hyperplastic polyps operated, while no polyp which had changed into cancer was experienced among 974 polyps followed-up by biopsy during the time course of 6 months to 11 years at the longest. On the other hand, coexistence of gastric cancer was found in 13% of cases with ATP. In polyps composed of metaplastic epithelium, there are two kinds of polyp: metaplastic polyp in hyper-plastic proliferation and neoplastic polyp. In the follow-up study of 1, 104 polyps, the growth of polyp was seen in only 14, and 12 of which were hyperplastic polyp. No change from gastritis polyposa to hyperplastic polyp was observed. The increase in size in 14 polyps was seen mostly 3 to 4 years after they were found and was always transient. From these results, it is considered that most of gastric polyps clinically detected have already completed their growth.
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  • HIROYUKI SAKURADA, AKIRA ISHIMORI, HIROMICHI ARAKAWA, SUSUMU YAMAGATA, ...
    1976 Volume 118 Issue Suppl Pages 39-43
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    In cases of elevated type of early cancer and benign polyp of the stomach, gastric analysis was performed and the results were compared with histological findings of gastric mucosa. Both clinical entities were found to show lowered acid and pepsin secretory functions reflecting severe and extensive atrophic changes of gastric mucosa. Dissociation in secretory disturbance between acid and pepsin was also noticed.
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  • SUSUMU YAMAGATA, AKIRA ISHIMORI, HIROYUKI SAKURADA, YOSHIKUNI MIURA, K ...
    1976 Volume 118 Issue Suppl Pages 45-51
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Fasting blood gastrin level among various clinical entities was measured by means of radioimmunoassay. Hypergastrinemia of various degrees was found in some cases of chronic renal failure. During angiography arteriovenous difference of gastrin level was investigated in the kidney in 22 patients without renal diseases. The high rate of gastrin removal from the blood circulation by the kidney was also confirmed in the synthetic human gastrin 1-17 (SHG 1-17) infusion experiment in dogs. In this study, hypergastrinemia seen in renal diseases was thought to be caused partly by impaired gastrin metabolism in the kidney.
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  • SABURO OSHIBA, KOTARO UENO, FUKUJI MOCHIZUKI, SHIGERU ASAKI, SHOICHIRO ...
    1976 Volume 118 Issue Suppl Pages 53-59
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    A forward-viewing fiberscope equipped with two channels was designed for safer and easier gastric polypectomy under endoscopic control using electro-surgical technique. No electrical accident, bleeding, perforation or significant complications were noticed. Mucosal ulcerations at the polypectomy site healed within a month leaving minor scars behind. In 30 cases, U1 II gastric ulcers developed after polypectomy, which healed leaving convergence of mucosal folds behind. Fiberscopic excision of gastric polyps was also useful for establishing a reliable diagnosis of gastric polyp cancer which is sometimes overlooked by routine biopsy procedure. It may be the “perfect biopsy”. The patient with gastric polyp who is aware of his own illness and feels uneasy can be released from his anxiety and regain both physical and mental health at the cost of minimal risk of endoscopic polypectomy.
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  • SABURO OSHIBA, FUKUJI MOCHIZUKI, SHOICHI YAMAGATA, KOTARO UENO, SHIGER ...
    1976 Volume 118 Issue Suppl Pages 61-67
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Roentgenological and endoscopic characteristics of malignant lymphoma of the stomach were studied referring to the gross pathological appearance of the tumors. Based on the results obtained, we classified malignant lymphoma of the stomach into four types, i.e., superficial, ulcer, polypoid and giant fold types.
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  • SHIGERU HISAMICHI, KIMIO NOZAKI, MASANOBU KITAGAWA, FUKUJI MOCHIZUKI, ...
    1976 Volume 118 Issue Suppl Pages 69-77
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Particular method and program of mass survey examination of gastric cancer were introduced into Miyagi Prefecture and the results accumulated during the past 14 years are presented. During this period, 1, 427 cases of gastric cancer (0.18%), as well as many cases of other diseases of the stomach and duodenum, were found by the mass survey. 450 cases were those of early cancer in which invasion of carcinoma was limited to the mucosa and submucosa. The ratio of surgically confirmed early cancer cases to all the stomach cancer cases was 36.4%. Almost in all cases of early stomach cancer there were neither complaints nor clinical symptoms; that is, they were the cases of so-called preclinical cancer of the stomach. The prognosis after surgery of early stomach cancer was remarkably favorable with a five-year survival rate over 90% and the death rate due to stomach cancer was actually decreased in the surveyed population.
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  • SABURO OSHIBA, FUKUJI MOCHIZUKI, SHIGERU HISAMICHI, NOBUYUKI SUGAWARA, ...
    1976 Volume 118 Issue Suppl Pages 79-84
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    In a mass survey for diseases of the stomach with photofluorography, lesions other than those of the stomach were studied in 85, 040 subjects. Gastric lesions were detected in 2.17%, while other lesions were found in 1.97%, giving an approximately similar ratio. Duodenal lesions were found most frequently and in 1.47%, followed by intraabdominal calcification in 0.44%. Among duodenal lesions, duodenal ulcer was seen in 0.14%, and duodenal diverticulum in 0.34%. Among diseases with abdominal calcifications, calcification of lymph nodes was found most frequently and in 0.24%, followed by cholelithiasis in 0.085% and urolithiasis in 0.004%. Lower esophageal lesions were found in 0.05%, in which esophageal diverticulum was the most frequent and found in 0.034%.
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  • MAKOTO ISHIKAWA, OSAMU MASAMUNE, HIROSHI YAMADA, TSUNEO TAKAHASHI, SHI ...
    1976 Volume 118 Issue Suppl Pages 85-88
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    In order to clarify the correlation between decrease in micellar formation and degree of steatorrhea, upper intestinal content was analyzed after administering a test meal of Borgström et al. Fecal fat was also measured. It was demonstrated that micellar phase was composed chiefly of fatty acid and monoglyceride, with low concentrations of diglyceride and triglyceride. The fat composition of micellar phase was nearly constant in normal subjects and in cases of malabsorption syndrome. The correlation between the ratio of micellar fat to the whole ingested fat in the intestinal content and daily excretion of fecal fat was very marked.
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  • MAKOTO ISHIKAWA, OSAMU MASAMUNE, HIROSHI YAMADA, TSUNEO TAKAHASHI, SHI ...
    1976 Volume 118 Issue Suppl Pages 89-95
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    In order to clarify the abnormal micelle formation in various malabsorption syndromes, the analysis of upper intestinal contents after administering a test meal of Borgström et al. was performed. It was demonstrated that the percentage of micellar fat to total fat and lipase concentrations decreased markedly from the normal controls despite of normal concentrations of bile salts and pH in cases of pancreatitis and pancreatectomy. In contrast, it was shown that the percentage of micellar fat was markedly low and the concentrations of conjugated bile salts were reduced in cases of ileal diseases. Unconjugated bile salts were detected although the concentrations of total bile salts were normal in blind-loop syndrome. The correlation between the percentage of micellar fat and lipase concentrations or bile salts concentrations in normal controls and various malabsorption syndromes was also reported.
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  • MAKOTO ISHIKAWA, HIKARU WATANABE, GORO YAMAGISHI, OSAMU MASAMUNE, TOMO ...
    1976 Volume 118 Issue Suppl Pages 97-109
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Most of the cases of Crohn's disease reported in Japan were originally treated surgically as acute appendicitis and, after appendectomy, they were diagnosed as acute terminal ileitis or acute Crohn's disease, which should belong to a category different from typical Crohn's disease, according to the international nomenclature by the Council for International Organization of Medical Sciences in 1973. Reviewing our university hopsital records from 1954 to 1974, the incidence of typical Crohn's disease and idiopathic proctocolitis has been increasing, while the patients with intestinal tuberculosis have been decreasing. Clinical and histopathological features of operated three groups of our patients with Crohn's disease of the small intestine, non-specific ulcers of the small intestine and prestomal ileitis were comparatively studied. Futhermore, 9 cases of operated Crohn's disease of the colon and 23 cases of operated idiopathic proctocolitis were similarly evaluated. The importance of diagnosing Crohn's disease as a whole from both clinical and histopathological stand points of view was emphasized, and main differential diagnostic criteria between Crohn's disease and idiopathic proctocolitis were discussed.
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  • MASANORI MITA, TIEN-FAI WONG, RIN YAMAGATA, KYOICHI MATSUMOTO, HARUTOS ...
    1976 Volume 118 Issue Suppl Pages 111-116
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    A new type of fiberintestinoscope (FIS-T1) patterned after an intestinal biopsy tube was developed for observing the small intestine beyond the ligament of Treitz. The flexible part of the new FIS has been made as pliable as the Cantor tube or the Miller-Abbott tube so that the tip of the new FIS is carried on into the small intestine by peristaltic activity along its natural configuration. A balloon attached near the tip of the new FIS acted as a bolus, enabling peristaltic activity to carry the fiberscope to the distal portion. In order to facilitiate the passage of the fiberscope, it was also advisable to keep changing the posture and position of the body with a minimum of fluoroscopic exposure. Inflation of the balloon as well as air feeding through the air channel of the fiberscope made possible satisfactory observation. In a patient suffering from protein-losing gastroenteropathy, multiple white spots on the diffuse rough surface of the mucosa were visualized by using the new FIS. Histological finding of the biopsy specimen taken from near the ligament of Treitz by using the fiberduodenoscope showed dilated lymph vessels in the villi.
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  • ICHIRO NAKAZAWA, SHOICHI YAMAGATA, HIKARU WATANABE
    1976 Volume 118 Issue Suppl Pages 117-125
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    17 cases of cancer and 18 cases of adenomatous polyp in the large intestine were subjected to lipid-chemical studies of their tissues in order to clarify the biochemical differences between malignant neoplastic growth and benign growth. Cancerous and adenomatous polypous tissues were collected by biopsy or surgical operation together with the respective control tissues. One part of the total lipid extracted from each tissue was separated into triglyceride and phospholipid fraction by a thin-layer chromatography (TLC). The fatty acid composition and content of each lipid fraction were measured by a gas-liquid chromatography (GLC). When the fatty acid composition of phospholipid was expressed in terms of the deviation rate, that of C14:0 was remarkably increased and that of C20:4 was remarkably decreased in the cancerous cases as compared with the respective values of the cases of adenomatous polyp. More definite differences were recognized between the cancerous cases and the cases of adenomatous polyp, when the ratio of the deviation rate of C14:0 to that of C20:4 was calculated in each case. Namely, the ratios distributed between 2.064 and 4.125 in 10 cancerous cases, and between 0.393 and 1.856 in 16 cases of adenomatous polyp, indicating the biochemical differences between cancerous tissues and adenomatous polypous tissues.
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  • RIKURO SASAKI, HIKARU WATANABE, SHUICHI IWAI, NOBUYUKI SUGAWARA, HIROT ...
    1976 Volume 118 Issue Suppl Pages 127-137
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Although several hundred cases of ischemic colitis have been reported from western countries, no case has been reported in our country. Ischemic colitis is a well established entity. Clinicopathological manifestations, diagnosis, treatment and prognosis of the disease are well known. A majority of reported cases were not particularly unusual. Two cases, of which one showed an unusually long lasting acute episode but good prognosis, and the other presented a diagnostic problem and was found to have a fibrous stricture due to ischemic colitis in the sigmoid colon at surgery, were described and discussed in relation to their symptoms, diagnosis and prognosis.
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  • KAZUO WAKUI, HIROSHI TADAKI, MASUO KANEDA, MASAO OTSUKI, TAKEHISA SUGA ...
    1976 Volume 118 Issue Suppl Pages 139-144
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    51 cases of chronic hepatitis were followed up by serial liver biopsies. 6 cases, all of which were of the active type, showed transition to liver cirrhosis within 5 to 10 months after the initial biopsy which had indicated chronic hepatitis. In 109 cases of liver cirrhosis, the antecedent acute hepatitis had been found within a relatively short period, usually 2 to 3 years before the establishment of the diagnosis of liver cirrhosis. Whether these cases which showed rapid transition to liver cirrhosis after acute hepatitis should be included in the group of chronic hepatitis or in another group remains to be settled.
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  • RIKIO KIMURA, KAZUO WAKUI, KUNIHARU ISHIOKA, HIROSHI TADAKI, JUN YAMAG ...
    1976 Volume 118 Issue Suppl Pages 145-148
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    The roles played by peritoneoscopic examination, direct cholangiography and cytological examination of aspirated bile at the time of direct cholangiography were studied in 140 patients with various biliary and pancreatic diseases. Both peritoneoscopic and cholangiographic examinations were important in detecting the lesion, and cytological examination was effective in deciding the nature of the lesion. The detection rate of the cancer cells in aspirated bile depended upon the location of aspiration in relation to that of the lesion. The closer the distance the better was the detection rate. The combined use of these three diagnostic methods contributed to correct diagnosis.
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  • ICHIRO NAKAZAWA, SHOICHI YAMAGATA, KIYOMI MIURA
    1976 Volume 118 Issue Suppl Pages 149-158
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    In order to clarify the differences in lipid metabolism between malignant neoplastic and benign cases, livers of patients were biopsied under peritoneoscopy. One half of each sample was subjected to histologic examination and the other half to lipid analyses by means of thin layer chromatography and gas liquid chromatography. Histologic examination was necessary to confirm whether the lipid metabolism in the liver of patients would be influenced by hepatic disease or not. The most significant differences between malignant and benign cases were observed when the ratio of fatty acid content of the phospholipid fraction to that of triglyceride was calculated for each patient. These ratios were over 2.20 in 40 cases out of 47 malignant neoplastic cases without benign hepatic diseases and in 3 out of 4 malignant neoplastic cases combined with benign hepatic diseases, but were under 2.19 in 35 benign cases. Moreover, 4 cases of early gastric cancer and a case of relatively early pancreatic cancer included in the malignant cases mentioned above also showed the ratios over 3.00. This finding would be applicable for the clinical diagnosis of the malignant neoplastic diseases.
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  • AKIO MIYAMORI, TAKAAKI TAKEBE, SHOICHI YAMAGATA
    1976 Volume 118 Issue Suppl Pages 159-172
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    In order to estimate the possible influence of pancreatic disease upon iron absorption, fecal analysis was carried out after administration of 5 mg iron labeled with 59Fe. Twelve cases of pancreatic calcification, 7 cases of chronic pancreatitis, 3 cases each of pancreatectomy and miscellaneous diseases, and 52 cases for control were studied. Significant elevation of iron absorption was observed in 4 of 21 patients with pancreatic diseases. Two of the 4 cases were also found to have low transferrin saturation and the other two have had a long history of heavy alcoholic intake. There was no definite correlation between the iron absorption rate and the total bicarbonate secretion, and duration of the diseases. Three cases treated with pancreatectomy failed to show increased iron absorption. The alternative administration of 59Fe and 55Fe for consecutive 4 days either alone or together with pancreatin or secretin was done to see the effect of these preparations on iron absorption. No significant inhibitory effect of these preparations on the iron absorption was noticed. These observations suggest that exocrine pancreatic function seldom appears to influence directly iron absorption, and that iron deficiency and ingestion of alcoholic beverages can be important factors affecting the iron absorption in pancreatic diseases.
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  • TAKAAKI TAKEBE, HARUO KOIZUMI, SHOICHI YAMAGATA
    1976 Volume 118 Issue Suppl Pages 173-181
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    This paper deals with a pancreatic function test with the submaximal dose of secretin given by continuous infusion after injection of cholecystokinin-pancreozymin (CCK-PZ) in the submaximal dose. The active elimination of bladder bile by CCK-PZ pretreatment decreased the influence of biliary contamination, and the volume output and the bicarbonate concentration were stabilized by the continuous infusion of secretin. As a result, the coefficients of variation in the volume output and the bicarbonate concentration were calculated to be about 15 and about 5%, respectively. These variations were considerably smaller than those obtained in the standard secretin test. Therefore, the present study is expected to improve the diagnostic means for pancreatic excretory dysfunction.
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  • SHOICHI YAMAGATA, MAKOTO ISHIKAWA, MORIMASA SAIJO, SHOJI FUKUSHIMA, KE ...
    1976 Volume 118 Issue Suppl Pages 183-189
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Diagnostic re-evaluation of measurement of electric skin resistance (ESR), skin temperature (ST) and deeper tenderness (DT) was performed in patients with abdominal pain due to pancreatitis, cholecystopathy and duodenal ulcer. These determinations were conducted when the pain was complained of and after the pain ceased by paravertebral anesthesia. ESR was decreased on the opposite tender points of the abdominal walls as compared with those values of the healthy abdominal walls. On the contrary, ESR was increased on the suffered body areas in patients with active mye.itis. ESR was decreased on the abdominal walls where visceral pain was induced by inflation of a balloon attached to the apex of a Miller-Abbott double lumen tube. DT tended to show decrease, while ST a slight increase, when the pain was evoked. However, in these pain induced experiments, ST changes were not so remarkable as those of ESR. A viscero-cutaneous reflex machanism and the predominance of sympathetic nerve control might be possible causes to produce these changes. Several important factors influencing the deter-mination of the ESR were also discussed.
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  • EIETSU OUCHI, NOBUO NOMURA, SHIGERU WATABE, KUNIO SEIJI, JYO SATO, TOS ...
    1976 Volume 118 Issue Suppl Pages 191-198
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Clinical significance of Congo red test was studied, especially on its relation to the liver function and amyloidosis. No significant relationship was observed between Congo red test and Indocyanin green test in cases of various liver diseases except liver cirrhosis. Histological studies also revealed that there were no pathologic features specifically affecting Congo red index (CRI), even though CRI in cases of various liver diseases tended to be increased as compared with other diseases. As a cause of increased CRI which was seen most remarkably in cases of liver cirrhosis, obstructive change of the liver blood flow followed by the hepatic tissue damage is suspected. The concept that Congo red test is a kind of the hepatic excretory function test does not have, from our data, enough evidence. The present study confirmed our previous data on the fate of Congo red injected intravenously, which indicated that this test is one of the best tests available for RES function and this test is related mainly to Kupffer's cell rather than to the so-called hepatic excretory function. There were no cases which showed notable decrease of CRI in experi-mental amyloidosis and in clinical amyloidosis, and it can be said that Congo red test is not the best test for the diagnosis of amyloidosis.
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  • EIETSU OUCHI, KUNIO SEIJI, JYO SATO, NOBUO NOMURA, SHIGERU WATABE, TOS ...
    1976 Volume 118 Issue Suppl Pages 199-205
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Erythrocyte rosette forming activities of the rat lung macrophage, peritoneal macrophage, Kupffer cells and expressed splenic cells were studied. The erythrocytes employed were fresh human red blood cell (RBC), fresh sheep RBC (SRBC), and tanned SRBC coated with bovine albumin or with bovine gamma-globulin. The macrophages were mixed with RBC at a ratio of 1 to 100 or 200 in gelatin veronal buffer or phosphate buffered saline. The experiments were carried out at 4°C. No autologous serum nor anti-RBC serum was added to the experimental system. 10 to 20 per cent of the lung macrophages formed rosette and their entire surfaces were covered with RBC. The peritoneal macrophage and Kupffer cells were also capable of forming rosette with fresh SRBC as well as with SRBC coated with bovine albumin or with bovine gamma-globulin. Examinations for cell surface immunoglobulin of alveolar macrophage, peritoneal macrophage, Kupffer cells and splenic cells revealed that alveolar and peritoneal macrophages apparently possessed surface gamma-globulin and that almost all of these macrophages possessed surface immuno-globulin. In order to examine the effect of different natures of SRBC on in vivo phagocytosis, rats were immunized with SRBC by injecting various SRBC into the femoral or the portal vein and the hemagglutinin titer was studied. The maximum hemagglutinin titer was observed in the rat injected with fresh SRBC into the femoral vein and the minimum hemagglutinin titer was observed in the splenectomized rat injected with fresh SRBC and in the rat injected with SRBC coated with albumin or gamma-globulin into the femoral or portal vein. Immunological role of Kupffer cells was discussed.
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  • YOSHIRO UZUKA, AKIO MIYMORI, MASUYUKI OKA, SHOICHI YAMAGATA
    1976 Volume 118 Issue Suppl Pages 207-216
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    The results of a long-term corticosteroid therapy performed in 55 patients with idiopathic aplastic anemia are reported. Of these patients, cure was attained in 20 patients, remission in 5, and improvement in 10. The duration of the treatment of cured cases ranged from 138 to 1109 days with a median of 522 days. The results were much better than those with other treatments conventionally performed. However, necessity of paying attention to side-effects was pointed out.
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  • YOSHIRO UZUKA, SING KHIONG LIONG, SHOICHI YAMAGATA
    1976 Volume 118 Issue Suppl Pages 217-225
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    A regime of treatment of acute non-lymphoblastic leukemia in adult, employing DMCP protocol, especially two step method consisting of daunorubicin, cytosine arabinoside, 6-mercaptopurine and prednisolone is described. Out of 32 adult patients with ANLL treated with DCMP regime 26 (81.3%) achieved complete remission. The median durations of complete remission and survival were 53 weeks and 54 weeks, respectively. The longest duration of complete remission was more than 220 weeks, and 3 cases are still maintaining initial complete remission more than 3 years.
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  • KAZUO MORI, IWAO HIRATSUKA, HIDEAKI SAKAI, KATSUHIDE HIWATASHI, TSUNEO ...
    1976 Volume 118 Issue Suppl Pages 227-243
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    A case of a 21-year-old woman with Weber-Christian disease, associated with consumption coagulopathy and adequately controlled over the past year or more by corticosteroid and heparin therapy, has been described. Through the study on this case, it was concluded that a hemorrhagic diathesis complicating Weber-Christian disease, at least in advanced cases, was characterized by consumption coagulopathy associated with enhanced blood coagulability which arises from hyperlipemia due to abnormal lipid metabolism and further, that the consumption coagulopathy was modified by diminished synthesis of clotting factors and activation of the fibrinolytic system due to the secondary hepatic impairment. It might also be likely that systemic vascular changes contribute to the activation of the clotting system as a trigger of clotting factor consumption. The complex pathophysiology of a hemorrhagic diathesis in this disease seemed to be brought about by a complex combination of such a variety of factors. In addition, decreased erythrocyte sedimentation rate observed characteristically during hemorrhage might probably have a direct correlation with hypofibrinogenemia due to consumption coagulopathy in advanced cases.
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  • JINICHI SUZUKI, YUICHI YAMAUCHI, MASATOSHI HORIKAWA, SHOICHI YAMAGATA
    1976 Volume 118 Issue Suppl Pages 245-259
    Published: 1976
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    It has been well known that the fasting therapy which was invented in Medical School of Tohoku University reveals an excellent effect upon various kinds of psychosomatic diseases, but its therapeutic mechanism and suitable indication are not yet explained completely. In order to corroborate these problems, this study was undertaken on 262 cases of psychosomatic diseases in the field of internal medicine. It is a complete fasting for 10 days with nothing by mouth except for drinking water, and 500 ml of parenteral fluid containing vitamins are administered intravenously every day. Absolute bed rest and self meditation are required in a closed individual room, and patients are not allowed to meet anyone but physician and nurse in charge. The return to normal ordinary diet follows the order of fluid diet, soft diet and semiordinary diet during 5 days. In the period of the therapy, various clinical and laboratory examinations were carried out. Significance of these examinations consists in prediction of possible danger during the fasting period and elucidation of its therapeutic mechanism. Consequently, an outstanding efficacy rate of 87% with excellent prognosis was attained, and the following diseases were determined as suitable indication of this therapy; irritable colon, dysorexia nervosa, borderline hypertension, neuron-circulatory asthenia, bronchial asthma, mild diabetes mellitus, obesity, lumbago without organic findings, conversion hysteria, various neurosis with somatic symptoms and masked depression. Possible mechanism of action of the therapy is that fasting acts as an extreme stress on the function of the autonomic nervous and endocrine systems, then it regulates the function of whole body including the brain, also it acts as one of the behaviour therapy for abnormal conditioning.
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