The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
120 巻, 4 号
選択された号の論文の12件中1~12を表示しています
  • KOZUI MIYAZAWA, KUNIO SHIRATO, TAKASHI HANEDA, TAKAO HONNA, TORU ARAI, ...
    1976 年 120 巻 4 号 p. 301-308
    発行日: 1976年
    公開日: 2008/11/28
    ジャーナル フリー
    The hemodynamic effects of the site of the artificial cardiac stimulation were studied in 17 open chest dogs. The right atrium and five ventricular sites (the inflow and outflow tracts and apex of the right ventricle, apex and lateral wall of the left ventricle) were stimulated electronically at a given rate, ranging from 130 to 190 per min. When cardiac performance during ventricular pacing was compared with those during right atrial pacing, the former uniformly caused a diminution of cardiac output and systemic blood pressure, without reduction of left ventricular end-diastolic pressure. Ventricular function curves, in which left ventricular stroke work was related to left ventricular end-diastolic pressure, shifted downwards and to the right during ventricular pacing. Stimulation frequency did not alter these variables. It was considered that the left ventricular dysfunction in ventricular pacing resulted from the absence of atrial contribution to ventricular filling, mitral regurgitation present and asynchronous ventricular contraction. No significant difference of cardiac performance was demonstrated by changing the site of ventricular pacing, suggesting that the mode of ventricular depolarization itself was not relevant to a decrease in cardiac performance.
  • RYOSUKE NEMOTO, TETSURO KATO, MASAAKI KUWAHARA
    1976 年 120 巻 4 号 p. 309-312
    発行日: 1976年
    公開日: 2008/11/28
    ジャーナル フリー
    The displacement of kidney was studied by using the combined liver-spleen-kidney scintigraphy and the subsequent subtraction of the kidney seintiphoto-graph to leave the liver-spleen scintiphotograph alone. A suprarenal mass was shown as cold spot between the liver and right kidney on the combined study. When the liver scintiphotograph and kidney scintiphotograph were over-lapped and the differential diagnosis was difficult, the subsequent subtraction of the kidney scintiphotograph was useful in the - diagnosis of the enlarged liver.
  • SHIRO KOSAKA, MASAKI TAZAWA
    1976 年 120 巻 4 号 p. 313-317
    発行日: 1976年
    公開日: 2008/11/28
    ジャーナル フリー
    Thirty-two patients with clinical diagnosis of bronchial asthma were evaluated. Serum IgE levels, measured by the Phadebas IgE test, were clearly increased in the patients with asthmatic attack compared with those without asthmatic attack. When the patients were grouped according to the clinical grading of severity of asthmatic attack, the levels showed the significant elevation in proportion to the intensity of asthmatic attack and were higher in the group of severe attack or moderately severe attack than in the group of mild attack. When the serial determination of serum IgE concentration was performed during the clinical Course of the patients, a high correlation was observed between the levels and the intensity of asthmatic attack.
  • TOSHIO NAKAMURA, TADAO ISHIKAWA, TAKASHI NIWA, FUMIO ARIJI, TAKASHI MA ...
    1976 年 120 巻 4 号 p. 319-327
    発行日: 1976年
    公開日: 2008/11/28
    ジャーナル フリー
    Syrian hamsters were exposed to the aerosol of a 5% solution of papain in the presence of cysteine and ethylenediamine-tetraacetic acid. Pulmonary emphysema in hamsters was observed after exposure to papain for two to three hours. There was no change with time in the severity of emphysema from the second through the fourth weeks after exposure to papain. Pathogenesis of pulmonary emphysema was discussed in relation to proteolysis of glycosaminoglycan-protein complex.
  • KAZUMORI MINAMI, KENJI KONNO, MORIO HONMA, HIDEO MIZUNO, SUMIE FUJIMUR ...
    1976 年 120 巻 4 号 p. 329-337
    発行日: 1976年
    公開日: 2008/11/28
    ジャーナル フリー
    In 1973 and 1974, an epidemic of acute hemorrhagic conjunctivitis (AHC) with a tendency of less frequent con-junctival hemorrhage occurred among the staff of the National Railways and their family in Sendai area. Four strains of AHC virus and 4 strains, 1 of type 7 and 3 of type 8, of adenoviruses were isolated from 22 conjunctival swabs of the patients. Thirty-six (66%) out of 55 cases examined were proved serologically to be of AHC virus infection, and 7 cases (13%) were of adenovirus infection. Clinically, infrequent association of hemorrhagic conjunctivitis was most remarkable. Only 10 cases (28%) had detectable signs of hemorrhagic conjunctivitis. There were no substantial changes in antigenicity and optimum temperature for virus multiplica-tion between prototype and isolated strains. The isolated strains, however, seemed to be less neutralizable and less producible at 29°C than prototype strain.
  • MUTSUO HIRANO, KEIGO SUZUKI, HISASHI HIGASHIIWAI, MASAKUNI SUZUKI
    1976 年 120 巻 4 号 p. 339-344
    発行日: 1976年
    公開日: 2008/11/28
    ジャーナル フリー
    Wedge resection of the ovary was carried out in 45 anovulatory women to study the correlation between the degree of disturbance of ovulation and the histopathological findings. Polycystic ovary was always found in patients with anovulatory cycles. The ovaries in grade 1 amenorrhea showing withdrawal bleeding in response to gestagen alone belonged to the nonspecific type, polycystic type and sclerotic type. These histological changes were relatively mild in many cases. The ovaries in grade 2 amenorrhea showing withdrawal bleeding in response to estrogen and gestagen but not to gestagen alone belonged to the non-specific type, polycystic type, sclerotic type, atrophic type and streak type. Even within the same histological entity, the histological findings of the ovaries were more pronounced in grade 2 amenorrhea than in grade 1 amenorrhea. The patients with primary amenorrhea had only hypoplastic and aplastic ovaries with marked histological abnormalities.
  • KAORU SAGISAKA, KENKICHI TAKAHASHI
    1976 年 120 巻 4 号 p. 345-350
    発行日: 1976年
    公開日: 2008/11/28
    ジャーナル フリー
    It has been pointed out that a serum protein specific for pregnancy (pregnancy-associated globulin, PAG) appears in females near term and is maintained during some period after delivery. The incidence and quantitation of PAG in 120 pregnant females and normal subjects, 1, 469 males and 355 females, were studied by double diffusion and single radial immunodiffusion methods. All the pregnant females were proved to have PAG. The incidence of PAG in normal males and in females over 16 years of age was 5.3% and 36.9%, respectively. In the females, the incidence of PAG tended to increase with aging; 63% over 31 years of age and 100% over 51. years. Quantitative analyses, which were expressed as a percentage of the pooled pregnant sera, showed that PAG of pregnant sera ranged from 24 to 240 and that of normal sera from 1 to 33.
  • RIKIYA ABE, NOBUO KUMAGAI, MICHIO KIMURA, AKIO HIROSAKI, TAKASHI NAKAM ...
    1976 年 120 巻 4 号 p. 351-359
    発行日: 1976年
    公開日: 2008/11/28
    ジャーナル フリー
    Biological characteristics of breast cancer in obese patients were investigated in comparison with non-obese patients. 134 patients with breast cancer were divided into three categories; thin, normal and obese based upon the height and weight. Five-year survival rate was 55. 6% in the obese patients, whereas it was 79. 9% in the non-obese patients including thin and normal subjects. A cause for unfavorable prognosis in the obese patients with breast cancer was clinically and histologically investigated. It was found that in the obese patients primary tumor, regional lymph node engorgement and clinical stage were relatively advanced, scirrhous carcinoma was predominant (46%), tumor margin was more infiltrative (γ type 64%), the incidence of vascular involvement was high (73%), lymph node metastasis was also frequent (58%) and nuclear grade was low.
  • NOBUO ISHIHARA, TSUGUYOSHI SUZUKI
    1976 年 120 巻 4 号 p. 361-363
    発行日: 1976年
    公開日: 2008/11/28
    ジャーナル フリー
    Inorganic mercury formation from methylmercury by the mouse liver and kidney was studied in vitro. With chopped liver or kidney, inorganic mercury was formed from added methylmer-cury, but when the tissue was homogenized, the activity was diminished. Equimolar addition of selenium had no effect on the reaction.
  • NOBORU MATSUMOTO, TADAHIKO SHIOMURA, TOKUHIRO ISHIHARA, HIRONOBU ADACH ...
    1976 年 120 巻 4 号 p. 365-376
    発行日: 1976年
    公開日: 2008/11/28
    ジャーナル フリー
    Human red cell membrane proteins were extracted by incubation of the ghost with hypotonic phosphate buffer (pH 7. 4), N-ethylmaleimide and p-hydroxy-mercuribenzoate. In paroxysmal nocturnal hemoglobinuria (PNH), hereditary spherocytosis (HS) and hereditary elliptocytosis, the amount of proteins extracted by these procedures was significantly less than the amount extractable from the ghost of normal and aplastic anemia red cells. Polypeptide patterns of red cell membranes in these hematological disorders were essentially similar to those of normal ghosts. Analysis of the supernatant by SDS polyacrylamide gel electrophoresis revealed that this reduction was mainly due to the reduced amount of peripheral proteins extracted. The extraction of peripheral proteins by sulfhydryl reagents was accompanied by shape changes resulting in the formation of membrane vesicles, suggesting an important role of peripheral proteins in the maintenance of ghost shape. It is also suggested that qualitative abnormalities of peripheral proteins such as altered reactivity to sulfhydryl reagents and/or strong binding to the membrane are present in PNH, HS and hereditary elliptocytosis red cells.
  • MASAFUMI SHIRAI, MAMORU NAKAMURA, NOBUHISA ISHII, SHIRO MITSUKAWA, YOS ...
    1976 年 120 巻 4 号 p. 377-383
    発行日: 1976年
    公開日: 2008/11/28
    ジャーナル フリー
    In 17 impotent patients, radioisotope penography was performed using 99mTc-red blood cells (the patient's own red blood cells labeled with 99mTc) for the quantitative analysis of intrapenial blood volume. A visual sexual stimulation (VSS) was given to the patient after injecting the 99mTc-red blood cells. Patients showing a complete erection had their intrapenial blood volumes 4.2-11.2 times greater than before VSS (mean increase, 8.0 times). In cases of incomplete erection after VSS the intrapenial blood volumes were 3.3-7.0 times greater than before VSS (mean increase, 4.9 times). In cases showing a gentle rise in their penogram curves without evidence of an erection, intrapenial blood volumes after VSS were 2.0-3.3 times those before VSS (mean increase, 2.9 times). By contrast, in cases showing no response to the VSS or no rise in penogram curve, post-VSS increases in intrapenial pool of blood were very slight, only 1.4-1.7 times the original volume of blood.
  • HITOSHI FUKASAWA
    1976 年 120 巻 4 号 p. 385-398
    発行日: 1976年
    公開日: 2008/11/28
    ジャーナル フリー
    A total of 48 autopsied brains were morphometrically examined for the relation between pontine geometry and structural parameters. In each case, the numerical density of neuroglial cells Nv(G) and the linear density of capillary network Lv(C) of the pontine white matter were determined stereologically from the counts of glial nuclear profiles and capillary transections per constant area of a histological section with a constant thickness. It was revealed that in general the glial numerical density increased with advancing atrophy and decreased with increasing swelling, whereas the capillary linear density remained fairly constant especially in the advanced stage of brain swelling. Further analysis of this relation using a model of pontine geometry has made it clear that the total capillary length in the swollen white matter increases probably at the expense of the capillary caliber as swelling advances. The changes in the ratio Lv(C)/Nv(G) under pathological conditions are emphasized and possible utility of classifying stages of acute brain swelling from a viewpoint of microvascular dimension is suggested.
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