The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
123 巻, 4 号
選択された号の論文の15件中1~15を表示しています
  • SHOZO NAKAMURA, YOSHIAKI TAKEZAWA, TAKASHI SATO, TATSUYA AIKAWA, KIYOS ...
    1977 年 123 巻 4 号 p. 297-306
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    Comparisons were made of hepatic circulation between alcoholic and non-alcoholic cirrhosis. The wedged hepatic venous pressure and per cent intrahepatic shunt measured by the method of continuous infusion of n-galactose-1-14C were similarly markedly increased. On the other hand, the wedged hepatic venography showed the main portal trunk and extrahepatic collaterals, namely, the tendency of reverse or stagnant portal flow, more frequently in alcoholic cirrhosis than in non-alcoholic cirrhosis. The nodules shown by slow low-pressure hepatic sinusoidography were larger in non-alcoholic cirrhosis than in alcoholic cirrhosis.
  • MASATAKA KATO, TOSHIHIKO KOEDA, HIROYUKI INOMATA, ATSUSHI MOTOYAMA, KE ...
    1977 年 123 巻 4 号 p. 307-314
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    A simple method for measuring digital arterial pressure and its recording on usual EKG heat-writing paper was devised. The method enabled us to measure exactly the digital systolic as well as diastolic blood pressure without providing the calibrating scale of pressure, since the pressure scale is recorded on the paper automatically as pulse signals at the interval of 10mmHg. The pulse waves are also registered on the same paper by means of the finger plethysmograph. By use of a right-angled triangle transparent rule, we could estimate the value of digital systolic pressure at which the pulse wave began to appear when the cuff pressure for compressing the artery was gradually lowered. Estimated values of the digital arterial pressures were compared with those obtained by another method of Mendlowitz and his coworkers.
  • HIYOSHIMARU OYAMADA, TOSHIO TABEI
    1977 年 123 巻 4 号 p. 315-321
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    Scintigraphic patterns of cold thyroid nodules taken by the scintillation camera with radioactive iodine-131 were reported. Previous reports published by others on this subject were based on the scintillation scanner which gave us less sharp resolution than the scintillation camera. Our data indicate that the defect pattern is largely dependent upon the existence of the capsule as well as the size of the nodule. In general, a benign nodule shows defect having a rather smooth margin with somewhat distended normal thyroid tissue, whereas malignant one, if it has no capsule, shows an irregular or straight margin. However, the defect pattern of malignant nodule covered with a capsule is similar to that of benign nodule. A defect of the entire unilateral lobe and a highly irregular-shaped defect spread over bilateral lobes are suggestive of malignancy. These findings seem to be generally similar to those reported by others. However, pull-up phenomenon of lower pole coexisting with the defect in the upper half is highly suggestive of malignancy, especially of papillary type. As long as defect (negative) pattern is investigated, the diagnosis of cold nodule inevitably meets certain limitations. To avoid this problem, the radiopharmaceutical which exclusively concentrates in malignant nodule should be searched. Then, the scintigraphic diagnosis of thyroid nodule will become more reliable.
  • TAKESHI YOSHIDA, YUTAKA HATTORI, KIICHIRO NODA
    1977 年 123 巻 4 号 p. 323-327
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    Plasma cortisol was measured in cord and neonatal blood. Cortisol concentration in neonates decreased rapidly during the first three days after delivery and thereafter remained at an almost constant level. The more the delivery was stressful, the higher the cortisol in the 1-day-old infant, but the concentration came down to the same level as in the less stressful delivery on the 3rd day of the infants' life. The cortisol level in vaginal delivery after spontaneous labor was not different from that in vaginal delivery after oxytocin induced labor. Cortisol in small-for-date infants or infants with hyperbilirubinemia was lower than in average-for-date infants or infants without hyperbilirubinemia.
  • YOSHIRO YOSHIDA, TETSUO SATO, ICHIKI KANO, MORIKUNI FUKUDA, TAKASHI SA ...
    1977 年 123 巻 4 号 p. 329-335
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    Four patients with endocardial fibroelastosis were studied by two-dimensional and M-mcde echocardiography. The two-dimensional echocardiography showed the characteristic echo from the abnormally thickened endocardium of the left ventricle in every case. Of the 4 cases, 2 were still suffering from congestive heart failure at the time of the study and the other 2 had been already free from clinical symptoms. In the former group, the ultrasonic findings revealed an enlargement of the left ventricle (large left ventricular dimension index) and poor movement of the anterior mitral leaflet which was indicated by a decrease in the diastolic descent rate. The latter group presented almost normal findings concerning the above points. The ultrasonic method is thus proved to be very useful for the diagnosis and evaluation of clinical conditions in cases of endocardial fibroelastosis.
  • MASAHITO SAITOH, HIROSHI OHE, SHIGEKI TANAKA, TERUO MISHINA, HIROKI WA ...
    1977 年 123 巻 4 号 p. 337-341
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    Our brief experience of the use of ultrasonography and the ultrasonic Doppler method for the diagnosis of intrascrotal contents were described. Five cases of testicular tumor, two cases of hydrocele and one case of epididymal tuberculosis were successfully diagnosed by ultrasonography. Only one case of chronic inflammation was misdiagnosed as a testicular tumor. Two cases of testicular torsion and two cases of acute epididymitis were easily differentiated by the ultrasonic Doppler method. We suggest that this is the most reliable technique for differentiation between these two diseases.
  • TADASHI KANOH, HARUTO UCHINO, MOTOO KUSAKA
    1977 年 123 巻 4 号 p. 343-349
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    The bone marrow of a patient with IgA monoclonal gammopathy associated with gastric carcinoma was massively infiltrated with extracellular globules of varying sizes from 2 to 110μm. These exposed globules were not found in the metastatic lesions heavily infiltrated with plasma cells, but were exclusively confined to the bone marrow. They were indistinguish-able from Russell bodies and composed of monoclonal immunoglobulin (IgA, λ). Of interest is the fact that, despite a small number of plasma cells, there was an intramedullary extensive infiltration of exposed globules. The following conditions may be related to these changes. (1) The globules were not removed rapidly by effectual phagocytosis. (2) The environment of the bone marrow may be favor-able for their remaining. In our case, however, the possibility that the plasma cells around the tumor were not of the same clonal origin as the marrow plasma cells cannot be ruled out. (3) The marrow plasma cells may produce immunoglobulin more vigorously, whereas their survival time be shorter than usual. As a result, these exposed globules released on the death of the cells accumulated massively in the bone marrow.
  • SHOZO NAKAMURA, YOSHIAKI TAKEZAWA, TAKASHI SATO, TATSUYA AIKAWA, KIYOS ...
    1977 年 123 巻 4 号 p. 351-358
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    Sixteen cases of alcoholic hepatitis with alcoholic hyaline (Group I) and 13 cases without alcoholic hyaline (Group II) have been collected since 1970. These were most frequently found in the fifth decade in both groups. One female was found in Group I. Cases of about two-thirds of both groups were consumers of 110g or more of alcohol per day. No significant differences except fever and erythrocyte sedimentation rate were found in clinical and laboratory changes between both groups. Fatty change in liver biopsy specimens were more frequently seen in Group I than in Group II. The wedged hepatic venous pressure was markedly elevated in alcoholic hepatitis with cirrhosis and moderately elevated in alcoholic hepatitis without cirrhosis. Wedged hepatic venography showed the main portal trunk and extrahepatic collaterals, namely, reversal of the portal flow or such tendency in 2 out of 5 patients of Group I.
  • TAKAYOSHI TOYOTA, MIKIHIKO KUDO, YOSHIO GOTO
    1977 年 123 巻 4 号 p. 359-364
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    Twelve apparently healthy subjects who showed a low insulin response to glucose were selected from two different age groups, 6 from youngers aged 19 to 22 and 6 from olders above 65 years old, and responses of insulin and growth hormone secretion to an intravenous administration of arginine were investigated. Incidence of low insulin responders, who showed the peak value of plasma insulin during GTT below 45μU/ml, was 9% among the young subjects and 24% among the old ones. Insulin secretion stimulated by arginine in 6 young low responders was not different from that in the control group matched with regard to age and body weight, and the values of growth hormone during arginine infusion were higher than those of the control group. In the old low insulin responders, insulin secretion stimulated by arginine was significantly lower than that in the control group, but the growth hormone secretion was not different from that in control. The present study showed that insulin and growth hormone secretion stimulated by arginine in young low-insulin-responders were different from those in the old ones. The low insulin responders are discussed in regard to prediabetes.
  • ICHIRO NAKAZAWA, SHIGERU ASAKI, SHOICHIRO ITO
    1977 年 123 巻 4 号 p. 365-370
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    Fourteen cases of gastric cancer, 9 cases of gastric polyp and 4 cases of gastric ulcer were studied on their tissues lipid-chemically with the aim to clarify the biochemical differences between malignant and benign growth of the human gastric tissue. Tissues were collected by surgical operation or a biopsy together with the normal tissues surrounding the lesions. One part of each tissue was subjected to histologic examination and the other part to lipid analyses by means of TLC and GLC. The total lipid content was decreased in 71% of gastric cancerous cases and in 75% of both cases of gastric polyp and gastric ulcer as compared with the respective control tissues. The phospholipid fatty acid content of the lesions was decreased in 83% of cancerous cases but in 50% of polypous cases as compared with the respective control tissues. As for the phospholipid fatty acid composition, the percentage value of C20:4 was increased and the percentage value of C18:2 was decreased in gastric cancerous tissues, when compared with those of gastric polypous tissues. Such a change of the phospholipid fatty acid composition may produce the change of the fluidity of the cell membrane and may provoke a malignant growth of human gastric cancer cells.
  • KENTARO TOH, NORIYUKI SATO, KOKICHI KIKUCHI
    1977 年 123 巻 4 号 p. 371-380
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    The DNA synthesis in syngeneie, allogeneic and xenogeneic cells was inhibited by peritoneal macrophages of normal WKA rats. This inhibitory effect of macrophages was found to be mediated by a soluble factor (MfID) released into a culture medium from macrophages which was heat-stable and non-dialyzable. The MfID was also responsible for the inhibition of lymphocyte DNA synthesis by MIX reaction. The action of MfID was indicated to suppress rather than to kill cell growth. It was interpreted that the inhibitory effect of macrophages on cellular DNA synthesis is their inherent property and macrophages may play the role of regulating the proliferation of lymphocytes and other cells.
  • SUSUMU MAJIMA, MASANOBU FUKUSHIMA, YOSHIHIRO FUJITA, TAKAO OUCHI
    1977 年 123 巻 4 号 p. 381-388
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    This study was undertaken to determine the effect of ulcer induced by iodoacetamide on the development of gastric carcinoma by N-methyl-N'-nitro-N-nitrosoguanidine in male Wistar rats. Fifty-six of the 62 ulcers induced by IAM were located in the fundic gland area along the limiting ridge. The incidence of fundic carcinoma was 16% in the groups treated with IAM and MNNG, while no fundic carcinoma was found in the group treated with MNNG alone. This difference was statistically significant. All the carcinomas in the fundic gland area were confined within the ulcer itself or its scar tissue, produced by IAM. These findings indicate that if an ulcer is present, carcinoma develops even in the fundic mucosa which is, if intact, resistant to the carcinogenic stimulation of MININNG. It was concluded that gastric ulcer predisposes the development of gastric carcinoma.
  • RYOSUKE NEMOTO, KIYOSHI ISHIKAWA, TETSURO KATO
    1977 年 123 巻 4 号 p. 389-391
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    Stimulation of normal peripheral blood lymphocytes (PBL) by phytohemagglutinin (PHA) and production of PHA-induced cytotoxicity were investigated. PBL transforma-tion stimulated by PHA was measured by 3H-thymidine incorporation, and the cytotoxicity was assayed by measuring the reduction of 14C-leucine incorpora-tion into target cells after interaction with PHA-treated PBL. The cytotoxicity of PHA-treated PBL showed dose response curves which corresponded with that of PBL transformation. Reduced 14C-Leucine incorporation of target cells caused by cytotoxic PBL would be a reliable measure of immune reactions.
  • MASAKI MORIYAMA, HIROSHI KASHIWAZAKI, TAI-ICHIRO TAKEMOTO, TSUGUYOSHI ...
    1977 年 123 巻 4 号 p. 393-394
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    A secular trend in age at menarche was examined for 1, 333 women living in Sendai city and its surroundings by applying the birth-year cohort analysis and the cross-sectional probit analysis. The trend toward younger menarcheal ages was consistently observed by both analyses, and it started off soon after the second World War. The speed was 0.11 year/year for the observation period of 1946 to 1966.
  • TAKUSEI UMENAI, HIROSHI CHIBA
    1977 年 123 巻 4 号 p. 395-396
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    We demonstrated 2 different antibodies against Candida albicans in patients' sera, the detection rates were proportional to the severity of candidiasis. One antibody was directed toward antigen shared by Candida in both blastospore and mycelial phases and the other was directed against antigen found only in the mycelial phase of Candida. The presence of the latter may reflect the invasive form of candidiasis.
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