巻号一覧
130 巻 (1980)
- 4 号 p. 311-
- 3 号 p. 209-
- 2 号 p. 105-
- 1 号 p. 1-
130 巻, 4 号
選択された号の論文の11件中1～11を表示しています
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TAIZO KATO, MAKOTO SEIJI1980 年 130 巻 4 号 p. 311-320
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーThe smooth endoplasmic reticulum (smooth-surfaced membrane, SSM) is quite similar in properties to the cytoplasmic membrane which is known to be antigenic. SSM of the melanoma melanocytes can be isolated from the mouse melanoma as a reasonably pure preparation and it contains tyrosinase. Rabbits were immunized by the SSM isolated from Harding-Passey mouse melanomas. Formation of the antibody was detected by the double immuno-diffusion method. Anti-SSM-serum thus formed was found to react with cytoplasmic membrane in the immuno-fluorescent test, and also showed the specific cytotoxicity to the mouse melanoma cells. On the other hand, the tyrosinase activity of SSM was not inhibited by this antiserum.抄録全体を表示PDF形式でダウンロード (1745K) -
CHIKAO MORIMOTO, TOHRU ABE, TAKASHI TOGUCHI, MITSUO HOMMA1980 年 130 巻 4 号 p. 321-334
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーA rabbit antiserum to human fetal brain after multiple absorption reacted with 100% of thymocytes, 55% of peripheral blood lymphocytes and 90% of enriched T lymphocytes, but not significantly with B lymphocytes. Spontaneous SRBC rosette formation was inhib-ited by anti-BAT pretreatment, but EAC-rosette formation remained unaffected. The antiserum was itself highly stimulatory. However, cells treated with the antiserum and complement exhibited marked inhibition of responsiveness to Con A, little effect with PHA and no alteration with PWM. The MLC reaction was inhibited only when the responder cells were treated with the antiserum and complement. Treatment of sensitized lymphocytes with the antiserum and complement caused a dose-dependent suppression of blastogenic response to both PPD and n-DNA. No effect, however, was noted in MIF producing cells. Con A induced suppressor function of lymphocytes was abolished by treatment with the antiserum and complement. These results indicate that the anti-BAT serum obtained by us can be utilized for the isolation of T lymphocyte subsets.抄録全体を表示PDF形式でダウンロード (824K) -
AKIRA B. MIURA, KOSAKU YOSHIDA, AKIHIKO YAMAGUCHI, MITSUYUKI FUKUDA1980 年 130 巻 4 号 p. 335-340
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーLethally irradiated mice were injected with 1×105 normal bone marrow cells taken from mice of the same strain. They were divided into two groups: One was given chloramphenicol (CAP) or thiamphenicol (TAP) in an early stage after marrow transfusion and the other in a later stage. In both groups, more prominently in the former group, some ultrastructural changes were recognized in mitochondria of the early erythroblasts. Mitochondria increased in number and became swollen with electron lucent matrix and paucity of cristae. Condensed mitochondria described in earlier reports were never observed. Intermediate or late erythroblasts seen only in the latter group did not show such alterations. Mitochondrial changes in the early erythroblasts were considered to reflect the dose-related toxic effects of CAP and TAP, and it is assumed that these drugs affect the development of erythroblasts in a very early stage.抄録全体を表示PDF形式でダウンロード (2639K) -
HIYOSHIMARU OYAMADA, SHOJI TERUI, HISATOSHI FUKUMA1980 年 130 巻 4 号 p. 341-352
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーFrom January 1975 to December 1976, 180 cancer patients were found to have abnormal accumulations in the vertebrae on their bone scintigrams. These patients were carefully surveyed through their clinical records for more than two years follow-up, x-ray pictures, and autopsy findings; and finally 115 patients were selected for this study. Abnormal accumulations were classified into two categories; significantly positive and equivocal. Among these 115 patients, significant accumulations were found in 85, and equivocal in 17. The remaining 13 showed both significant and equivocal accumulations. In 81 out of 98 (85+13) patients, the significant accumulations were due to metastases; and in 15 out of 30 (17+13) patients, the equivocal accumulations were due to metastases. However, if the cases with equivocal accumulation only are taken into consideration, the true positive cases are only 3 of the 17. The major factor for false positive was degenerative changes of the vertebrae in either group of significant or equivocal accumulations. Although it is difficult to differentiate benign changes of the vertebrae from the metastases on the bases of scintigram findings only, a cushion-like pattern in disc degeneration as well as in collapse of the vertebral body, a vague concentration with indistinct margin in spondylosis deformans, and sym-metrical accumulations in the intervertebral joints due to sclerotic changes are helpful in evaluating the bone scintigram of cancer patients, together with the site of abnormal accumulation and the age of the patient.抄録全体を表示PDF形式でダウンロード (3248K) -
ASAO TOMOE, YOSHIRO YOSHIDA, HIROSHI OGATA, HWEI CHUCHEN, MORIKUNI FUK ...1980 年 130 巻 4 号 p. 353-358
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーA 1-year-old girl had cyanosis and sings of a “normal heart”. Peripheral contrast echocardiography (M-mode and real time, two-dimensional) was performed with injection of saline into a superficial vein of the right hand. Contrast echoes did appear in the left atrium and ventricle, but did not in the right atrium or ventricle. From these findings anomalous drainage of the right superior vena cava into the left atrium was suspected and was confirmed by cineangiocardiography.抄録全体を表示PDF形式でダウンロード (2420K) -
TETSURO OGAWA, SEISHO ITO, HIROSHI KATO1980 年 130 巻 4 号 p. 359-368
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーExtra- and intracellular recordings were performed from neurons in in vitro slices of the lateral geniculate nucleus (LGN) prepared from cats anesthetized with Nembutal. Based on responses to stimulation of the optic tract (OT), neurons were classified into three types, i. e., P-cells (principal relay cells), I-cells (intrinsic cells) and unclassified cells. P-cells were characterized by an IPSP following an EPSP or an action spike which appeared at a short latency in response to OT stimulation, while I-cells were characterized by a long lasting EPSP on which a burst of spikes were superimposed. These observations were com-parable with those reported in situ. The incidence of P- and I-cells was in-vestigated for a total of 118 neurons recorded intracellularly from in vitro slices of LGN of cats at various ages; 73.0% and 5.4% for P- and I-cells respectively in 1-day-old kittens, 71.4 and 9.5% in 3-day-old, 81.8 and 9.1% in 1-week-old, 80.8 and 7.7% in 6-week-old kittens, and 82.6 and 13.0% in adult cats. From these findings it was concluded that there exist physiologically differentiated P-and I-cells in the LGN even at birth and that I-cells are responsible for intrageni-culate inhibition.抄録全体を表示PDF形式でダウンロード (1170K) -
MASAYOSHI NISHIDA, TATSUYA MIKI, KIYOHIRO IRIMAJIRI, ATSUSHI HORIUCHI1980 年 130 巻 4 号 p. 369-380
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーEffects of the humoral factor extracted from the calf thymus (thymosin: Goldstein et al. ) and the supernatant of cultured mouse thymus reticuloepithelial cell (TRC) on immunological functions of the mouse lymphocytes were studied, and the following conclusions were drawn: Thymosin treatment did not alter the capacity to form anti-SRBC antibody in adult mice which were lethally irradiated and reconstituted with bone marrow cells. When the spleen cells from JCL-ICR mice thymectomized within 24 hr after birth were cultured with thymosin or supernatant of cultured ICR-TRC, the Thy 1 positive cells were increased. A significant increase in the mitogenic (PHA, Con A) reactivity of BALB/C spleen cells was observed when these cells were preincubated in medium containing thymosin for 24 hr. The NZB spleen cells, however, exhibited no potentiated responses even when precultured with thymosin, and the nu/nu spleen cells showed a slightly potentiated response only to Con A. Similarly, thymosin enhanced the MLC reaction of the spleen cells from BALB/C mice with preincubation for 2 hr, but not enhanced that from NZB mice.抄録全体を表示PDF形式でダウンロード (696K) -
RYOJI MINAMI, YOKO WATANABE, TOORU KUDOH, KAZUHIKO OYANAGI, TOORU NAKA ...1980 年 130 巻 4 号 p. 381-384
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーUsing 4-meth-ylumbelliferyl-α-L-iduronide as a substrate, α-L-iduronidase activity was meas-ured in leukocytes and in lymphoblastoid cells obtained from patients with α-L-iduronidase deficiency and from obligate heterozygotes for this disease. There was complete discrimination between α-L-iduronidase activities measured using 4-methylumbelliferyl-α-L-iduronide in leukocytes and in lymphoblastoid cells from the patients and controls. However, overlap was observed between values of the activity in the obligate heterozygotes and those in the controls. 4-Methylumbelliferyl-α-L-iduronide is superior to phenyl-α-L-iduronide for the determination of α-L-iduronidase activity because of greater sensitivity, easier assay procedure and shorter incubation period.抄録全体を表示PDF形式でダウンロード (243K) -
YUKIO HIROSHIGE1980 年 130 巻 4 号 p. 385-402
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーIn the presence of albumin, cytotoxic effects of copper on erythrocytes in vitro were reduced. The presence of o-phenanthroline, on the other hand, accelerated deleterious effects of copper on the erythrocytes resulting in a decrease in GSH level, accumulation of copper in the cell, loss of potassium and gain of sodium, cross-linking of membrane proteins mainly involving spectrin and band 3, and echinocyte formation. These changes were not reversible. Prior treatment of the cells with N-ethylmaleimide inhibited the cross-linking of membrane proteins and echinocytic transformation by copper•o-phenanthroline complex (CuP) or diamide to a certain extent. Treatment of the cells with vinblastine, a stomatocytogenic agent, restored biconcave disc shape of CuP-treated eryth-rocytes, although it did not inhibit the cross-linking of spectrin. Blocking of sulfhydryl groups was not the prerequisite for the copper to be accumulated in the erythrocyte. These results may be helpful for the understanding of the mechanism of hemolysis associated with copper intoxication in vivo.抄録全体を表示PDF形式でダウンロード (4200K) -
TAKEO TAKAHASHI, YASUO TSUKAHARA, SATORU KANEDA1980 年 130 巻 4 号 p. 403-409
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーThe efficiency of the following visual stimuli in activating high amplitude (over 50 μV) photic driving (PD) and photoconvulsive response (PCR) was studied in 536 cases of patients including 340 (63%) epileptics. Their ages ranged from 3 to 78 years. An intermittent photic stimulation (IPS) of 5 and 15 Hz produced by a stroboscope was given to the subjects with eyes closed and open. A visual stimulator which was designed by us and is now commercially available (SLS-5100, Nihon Kohden) was used to give red-flicker, flickering-dot-pattern and flickering-grating-pattern. The average brightness of the illuminated screen of the SLS-5100 was 20 cd/m2 and the flicker frequencies were 5 and 15 Hz. The number of cases in which high amplitude PD was evoked by (1) 5 Hz IPS to eyes closed, (2) 5 Hz IPS to eyes open, (3) 5 Hz red-flicker, and (4) 5 Hz flickering-dot-pattern was 28 (5.2%), 6 (1.1%), 44 (8.2%), and 36 (6.7%), respectively. On the other hand, PCRs provoked by the above 4 kinds of stimuli as well as (5) 15 Hz IPS to eyes closed, (6) 15 Hz IPS to eyes open, (7) 15 Hz red-flicker, and (8) 15 Hz flickering-grating-pattern were found in 5 (0.9%), 2 (0.4%), 6 (1.1%), 4 (0.7%), 5 (0.9%), 6 (1.1%), 44 (8.2%), and 36 (6.7%) cases, respectively. The total number of cases in which PCR was provoked by these 8 stimuli was 56 (10.4%) out of 536 cases. From these results, it was concluded that the visual stimuli of flickering-patterns and red-flicker produced by the visual stimulator SLS-5100 are superior to the IPS produced by the commonly used stroboscope for EEG activation.抄録全体を表示PDF形式でダウンロード (1173K) -
YOSHISUKE MARUHAMA, FUMIKO MINAMI, TOSHIKI SATO1980 年 130 巻 4 号 p. 411-412
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーIn order to see whether diabetes control is affected by eating behavior, 22 outpatients with mild form of maturity-onset diabetes were examined for their eating behavior after an approximately 17 hr fast by measuring eating-up time of a test diet. When the standard deviation of 5 fasting blood glucose values during the preceding 5 months was adopted as an indicator of the glucose unstability, it was found to be greater in the patients with shorter eating-up time of the test diet. The hasty eaters also showed a fluctuation in body weight. Thus, an adequate instruction on eating habit seems to be needed in the manage-ment of diabetic patients.抄録全体を表示PDF形式でダウンロード (135K)
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