巻号一覧
138 巻 (1982)
- 4 号 p. 341-
- 3 号 p. 239-
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138 巻, 1 号
選択された号の論文の14件中1～14を表示しています
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FUMIAKI TEZUKA1982 年 138 巻 1 号 p. 1-6
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーTEZUKA, F. Morphometrical Analysis of Cardiac Hypertrophy: Left Ventricular Shape and Number of Muscle-Fiber Layers across Left Ventricular Wall. Tohoku J. exp. Med., 1982, 138 (1), 1-6-Left ventricular hypertrophy was quantitatively analysed in reference to the relation of ventricular shape and intramyocardial muscle-fiber arrangement. The shape of the ventricle was defined by VL/WL, left ventricular capacity ratio. This ratio was depressed in concentric hypertrophy due to pressure overload and elevated in eccentric hypertrophy due to volume overload. Moreover, VL/WL was reversely correlated with Nf, number of muscle-fiber layers across the left ventricular wall. The results supported the following view on the morphogenesis of left ventricular hypertrophy: The muscle fibers show the strained piling vertically across the ventricular wall to cause wall thickening and cavity narrowing in concentric hypertrophy. On the other hand, the muscle fibers are piled strongly in parallel to the ventricular surface in eccentric hypertrophy to result in attenuation of the wall thickness and dilatation of the ventricular cavity.抄録全体を表示PDF形式でダウンロード (519K) -
MASAKI KURAMOTO, KUNIHIRO OKAMURA, YOICHI HAMAZAKI, KAZUMI FURUKAWA, M ...1982 年 138 巻 1 号 p. 7-15
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーKURAMOTO, M., OKAMURA, K., HAMAZAKI, Y., FURUKAWA, K. and SUZUKI, M. The Role of Circulating Immune-Complex in Pregnancy. Tohoku J. exp. Med., 982, 138 (1), 7-15 The circulating immune complexes (CIC) in pregnancy sera have been thought to be involved in immunosuppression and to be one cause of pre-eclampsia. We detected CIC in human pregnancy sera using Raji cell test. A significant positive correlation was observed between the titers of immune-complexes and the immunosuppression. Although there was no correlation between the titers of CIC and clinical symptoms of pre-eclampsia evaluated at 29 to 31 week, a strong correlation was observed between the titers of CIC at 29 to 31 week and clinical symptoms of pre-eclampsia evaluated just before delivery. These results suggest that CIC in pregnancy sera functions immunosuppressively and also causes pre-eclampsia. It is useful to measure CIC levels for predisposing pre-eclampsia.抄録全体を表示PDF形式でダウンロード (755K) -
KENJI KOYAMA, TSUYOSHI OTOWA, HIDEMI YAMAUCHI, KENJI OKABE, TOSHIO SAT ...1982 年 138 巻 1 号 p. 17-25
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーKOYAMA, K., OTOWA, T., YAMAUCHI, H., OKABE, K. and SATO, T. Significance of Prednisolone Administration for Hepatic Mitochondrial Function of the Rat with Biliary Obstruction. Tohoku J. exp. Med., 1982, 138 (1), 17-25 Mitochondrial respiratory function of the liver is disturbed in biliary obstruction, especially in that caused by tumors in the hepatobiliary system. This study aimed to clarify whether a glucocorticoid, prednisolone succinate, is effective to improve the reduced mitochondrial function of the rat liver in obstructive jaundice. Five doses of 5mg/kg or 25mg/kg prednisolone succinate were administered at 5 consecutive days to the rats after 1, 3 or 6 weeks of biliary obstruction and to the rats without obstruction, and the hepatic mitochondrial function and contents of cytochromes of these rats were investigated. With 25mg/kg prednisolone, hepatic mitochondrial function was improved in rats with biliary obstruction of 3- or 6-weeks duration as compared with the prednisolone-untreated group. Compensatory increase or recuperation of the once decreased cytochrome a(+a3) and/or turnover number of phosphorylation was also observed in 25mg/kg group. Hepatic mitochondrial function of obstruction-free animals was rather impaired by treatment with 25mg/kg prednisolone. In 5mg/kg group, above mentioned effects were scarcely observed. It was concluded that the hepatic mitochondrial function in animals with prolonged biliary obstruction, as same as in animals with short-term obstruction, can be improved by the administration of adequately large amounts of prednisolone.抄録全体を表示PDF形式でダウンロード (767K) -
YUTAKA HASHIMOTO, BENJAMIN M. RIGOR, JOHN A. MORENO1982 年 138 巻 1 号 p. 27-37
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーHASHIMOTO, Y., RIGOR, B.M. and MORENO, J.A. Cardiovascular Effects of Hypotension Induced by Adenosine Triphosphate and Sodium Nitroprusside on Dogs with Denervated Hearts. Tohoku J, exp. Med., 1982, 138 (1), 27-37 Adenosine triphosphate (ATP) and sodium nitroprusside (SNP) are administered to patients to induce and control hypotension during anesthesia. SNP is authorized for clinical use in USA and UK, and ATP is clinically used in other countries such as Japan. We investigated how these two drugs act on the cardiovascular systems of 20 dogs whose hearts had been denervated by a procedure we had devised. ATP (10 dogs) or SNP (10 dogs) was administered to reduce mean arterial pressure by 30% to 70% of control. Before, during and after induced hypotension, we measured major cardiovascular parameters. Hypotension induced by ATP was accompanied by significant decreases in mean pulmonary arterial pressure (p<0.001), central venous pressure (p<0.001), left ventricular end-diastolic pressure (p<0.001), total peripheral resistance (p<0.001), rate pressure product (p<0.001), total body oxygen consumption (p<0.05), and heart rate (p<0.001); all these variables returned normal within 30min after ATP was stopped. Cardiac output did not change. During hypotension produced by SNP similar decreases were observed in mean pulmonary arterial pressure (p<0.01), central venous pressure (p<0.001), left ventricular end-diastolic pressure (p<0.01), total peripheral resistance (p<0.001), rate pressure product (p<0.001), and oxygen content difference between arterial and mixed venous blood (p<0.05), while heart rate (p<0.001) and cardiac output (p<0.05) were increased. Recoveries of heart rate and left ventricular end-diastolic pressure were not shown within 60min after SNP had been stopped. Both ATP and SNP should act on the pacemaker tissue of the heart.抄録全体を表示PDF形式でダウンロード (1060K) -
SOROKU YAGIHASHI, AKIRA TONOSAKI, KEN-ICHI YAMADA, MASAEI KAKIZAKI, YO ...1982 年 138 巻 1 号 p. 39-48
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーYAGIHASHI, S., TONOSAKI, A., YAMADA, K., KAKIZAKI, M. and GOTO, Y. Peripheral Neuropathy in Selectively-Inbred Spontaneously Diabetic Rats: Electrophysiological, Morphometrical and Freeze-Replica Studies. Tohoku J. exp. Med., 1982, 138 (1), 39-48 -Function and structure of peripheral nerves in selectively-inbred spontaneously diabetic rats (SDR) were quantitatively examined in order to clarify the relationship between these two changes. Electrophysiologically, SDR showed a significant decrease in motor nerve conduction velocity of the tail by 2 months of age. Thereafter, the conduction velocity was constantly lower in SDR than in age-matched control rats. Morphometrical analysis of peripheral nerves from light and electron micrographs could not yield any definite structural differences, except for a reduction in caliber of unmyelinated axons, between 2 month-old and age-matched controls, whereas an endoneurial space was widened in 3 month-old SDR as compared with those of controls. In contrast, loss of myelinated nerve fibers, a reduction in nerve fiber size and axonal size were apparent in 6 month-old SDR. By freeze-replica studies, neither any qualitative changes of intramembrane faces nor any quantitative differences in the density of intramembranous particles of internodal myelin and Schwann cell membranes were detected in 2 month-old SDR when compared with those in controls. The results suggested that the delayed nerve conduction velocity was most related to diabetic dysmetabolism and independent of the structural changes of peripheral nerves being in the course of distal axonopathy.抄録全体を表示PDF形式でダウンロード (1876K) -
HIDEMI YAMAUCHI, ULRICH MITTMANN, HANS PETER GEISEN, MANFRED SALZER1982 年 138 巻 1 号 p. 49-61
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーYAMAUCHI, H., MITTMANN, U., GEISEN, H.P. and SALZER, M. Postischemic Liver Damage in Rats: Amino Acid Analysis and Morphometric Studies. Tohoku J. exp. Med., 1982, 138 (1), 49-61 Normothermic, temporary, total ischemia of the liver was produced for 60-225 min under transient portal decompression with a by-pass between the mesenteric and the femoral vein. Total amino acids in the liver tended to increase after an ischemic period of more than 120min without reperfusion as compared with control with increasing trends in most of the individual amino acids. In a group undergoing 120min of ischemia and 60min of reperfusion, total amino acids and individual amino acids tended to decrease. Total plasma amino acids significantly increased after ischemia of more than 120min. Without reperfusion, elevations of almost all amino acids except for branched chain amino acids were found, whereas after reperfusion most of the individual amino acids also increased including branched chain amino acids. Molar ratios of branched chain amino acids to tyrosine and phenylalanine decreased only after more than 120min ischemia without reperfusion. Volume ratios of organelle disintegration on electron micrographs such as mitochondrial degradation and autophagic vacuoles were moderately increased after 90min ischemia with a further steep rise after more than 120mm ischemia. The survival rates of the animals after 60, 90 and 120min ischemia were 35% (6/17), 27% (3/11) and 25% (3/12), respectively. The following conclusions were obtained: 1) Pre-necrosis of the hepatocytes with simultaneous protein degradation started after ischemia for about 2hr. The survival rates of the animals after 60 and 90min ischemia were very low despite of mild necrosis of the liver. 2) Most of the amino acids in the liver were washed out into the plasma to cause an abnormal plasma amino acid pattern in the acute state. However, the molar ratio of branched chain amino acids to aromatic group was not reduced, in contrast to the ischemic group without reperfusion.抄録全体を表示PDF形式でダウンロード (4457K) -
HIDEMI YAMAUCHI, IBO BACA, ULRICH MITTMANN, HANS PETER GEISEN, MANFRED ...1982 年 138 巻 1 号 p. 63-70
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーYAMAUCHI, H., BACA, I., MITTMANN, U., GEISEN, H.P. and SALZER, M. Postischemic Liver Damage in Rats: Effect of Some Therapeutic Interventions on Survival Rate. Tohoku J. exp. Med., 1982, 138 (1), 63-70 The aim of this paper is to elucidate the cause of death after 90min of normothermic partial (2/3) ischemia of the liver and to examine the effects of glucagon, somatostatin, insulin, prednisolone and oral administration of polymyxin B (PB). The animals 24hr after partial ischemia for 90min were divided into two groups; namely, animals with normal appearance and those with moribund state. There were no significant differences in the plasma level of S-GOT, S-GPT, amino acids, NH3 or insulin, or in morphometrically estimated volume ratio of necrotic hepatocytes between the two groups of rats. The blood glucose level, however, was significantly decreased (31±28mg/100ml, n=6) in the moribund rats with a higher incidence of positive Limulus gelation tests as compared with the rats with normal appearance (149±19, n=5). The 1-day and 1-week survival rates of the animals were 42/62 (69%) and 32/61 (53%), respectively. A glucagon injection (1.5mg/kg, after ischemia) was effective to elevate the 1-day survival rate (14/14), but failed to increase the 1-week survival rate (11/14). On the other hand, a somatostatin injection (100μg/kg, after ischemia) or PB treatment (15mg/kg/day ×5-9, before ischemia) succeeded to increase the 1-week survival rate (20/22 p<0.01 and 17/17 p<0.01, respectively), although no significant amelioration in transaminase levels or volume ratio of necrosis was demonstrated. It could be seen that a moribund state after partial ischemia was accompanied by severe hypoglycemic shock, and that the injection of somatostatin after ischemia or the annihilation of gram-negative bacteria by means of oral administration of polymyxin B before ischemia prevented the occurrence of the hypoglycemic shock. ischemic liver damage; somatostatin; polymyxin B; endotoxin抄録全体を表示PDF形式でダウンロード (857K) -
HOYU TAKAHASHI, AKIRA HATTORI, AKIRA SHIBATA1982 年 138 巻 1 号 p. 71-80
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーTAKAHASHI, H., HATTORI, A, and SHIBATA, A. Profile of Blood Coagulation and Fibrinolysis in Chronic Myeloproliferative Disorders. Tohoku J. exp. Med., 1982, 138 (1), 71-80 Blood coagulation and fibrinolysis were studied in 65 patients with chronic myeloproliferative disorders (MPD). They consisted of 28 patients with chronic granulocytic leukemia (CGL) in chronic phase, 7 with CGL in blast crisis, 9 with polycythemia vera (PV), 13 with primary thrombocythemia (PTh) and 8 with primary myelofibrosis (MF). Hemorrhagic and thrombotic complications were observed in 19 and 8 patients, respectively. Activated partial thromboplastin time and prothrombin time were prolonged in many patients. Low factor II levels were observed in some CGL patients. Factor V was decreased in CGL patients in chronic phase and in PV patients. Fibrinogen was either normal or increased in most patients, but an elevation of fibrin/fibrinogen degradation products (FDP) was found in some patients. The VIIIR: Ag/VIII:C ratio was increased in CGL patients in blast crisis, in PV patients and in PTh patients. Antithrombin III and plasminogen were below normal in some patients. Most patients showed a decrease in α2-plasmin inhibitor. These findings suggest that blood coagulation and fibrinolysis are involved in the pathogenesis of the thrombotic and hemorrhagic complications in these patients. Chronic low-grade intravascular coagulation might be present in some patients with MPD.抄録全体を表示PDF形式でダウンロード (942K) -
NAOFUMI IWATSUKI, KEISUKE AMAHA, YOSHIHISA KOGA1982 年 138 巻 1 号 p. 81-85
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーIWATSUKI, N., AMAHA, K. and KOGA, Y. Biphasic Change in Human ® Peripheral Vascular Resistance Produced by Carnigen®. Tohoku J. exp. Med., 1982, 138 (1), 81-85-The response of the human peripheral vascular resistance (TPR) to carnigen® was examined on 11 patients by measuring arterial pressure change during cardiopulmonary bypass at a constant pump flow. The administration of 2ml of carnigen into the bypass for the adult and 1ml for the child produced an initial transient (36sec) decrease in arterial pressure (9%) followed by a definite increase (13% at 5min after administration). The present results, therefore, reveal that carnigen possesses a property changing human TPR in bphasic mode; a transient decrease at first followed by a definite increase.抄録全体を表示PDF形式でダウンロード (510K) -
DAMRONGPAN WATANACHOTE1982 年 138 巻 1 号 p. 87-102
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーWATANACHOTE, D. Urethral Responses during Selective Electrostimulation of Lumbosacral Spinal Nerve Roots in the Female Spinal Dog. Tohoku J. exp. Med., 1982, 138 (1), 87-102 Urethral responses on the urethral pressure profile (UPP) during selective electrostimulation of the ventral or dorsal roots in a group of lower lumbar (L5-7) or sacral (S1-3) nerves were observed in female spinal (C1-transected) dogs. The UPPs were recorded by using a balloon catheter, and square pulse wave of 5V, 10Hz, 1msec was applied for electrostimulation of the spinal nerve root. The UPPs were analyzed by dividing the functional profile length (FL) into three equal parts and comparing the height of maximal clossure pressure at each UPP segment. After lumbosacral rhizotomies proximal to the electrodes, stimulation of the lower lumbar ventral roots produced a marked elevation at the proximal third (bladder neck) of UPP, while similar response was found at the middle third (midsphincteric urethra) and distal third (external urethral sphincter) of UPP during the sacral ventral roots stimulation. The stimulation of the dorsal roots of the lower lumbar and sacral nerves also produced a similar response as that of the ventral roots stimulation though less in amplitude. So it could be concluded that in female dog the sphincteric urethra might receive a functional innervation from the lower lumbar and sacral spinal segments in somewhat different manners.抄録全体を表示PDF形式でダウンロード (2139K) -
SHIN-ICHI OIKAWA, MASAEI KAKIZAKI, YOSHIO GOTO1982 年 138 巻 1 号 p. 103-109
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーOIKAWA, S., KAKIZAKI, M. and GOTO, Y. Inhibitory Effect of Pancreatic Elastase on Thickening of the Renal Glomerular Basement Membrane in the Spontaneously Diabetic Rat. Tohoku J. exp. Med., 1982, 138 (1), 103-109-Effect of pork pancreatic elastase on thickening of the renal glomerular basement membrane was studied in three litter mates of the spontaneously diabetic rats by electron microscopic morphometry. Intramuscular injection of physiologic saline solution or elastase solution (5mg/kg body weight/day) was repeated daily for 30days. Renal cortex specimens were obtained before and after the injection in two litter mates. Renal glomerular basement membrane thickness (RGBMT) of the rats injected with saline increased markedly, whereas RGBMT of the rats treated with elastase remained close to the initial value. In each of the three litter mates, RGBMT after the treatment was significantly thinner in the elastase injected rats than in the saline injected rats.抄録全体を表示PDF形式でダウンロード (1748K) -
SHINJI SATO, AKIRA YAJIMA, RYUJI YAMAUCHI, HIROSHI SAKAHIRA, TOSHIAKI ...1982 年 138 巻 1 号 p. 111-116
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーSATO, S., YAJIMA, A., YAMAUCHI, R., SAKAHIRA, H., WAKISAKA, T., MORI, T., SUZUKI, M. and KIKUCHI, A. The Effects of Postoperative Radiotherapy in Cases of Invasive Carcinoma of the Uterine Cervix. Tohoku J. exp. Med., 1982, 138 (1), 111-116 -An investigation was made of the effects on cure rate of postoperative radiotherapy following radical hysterectomy with lymphadenectomy for cases of invasive carcinoma of the uterine cervix performed over 7 years between 1969 and 1975 at the Department of Obstetrics and Gynecology, Tohoku University Hospital. For cases in which resection was complete but the cancer extended to the pelvic wall, the 5 year survival rate was similar to that in comparable cases of the same clinical stage regardless of whether or not postoperative radiotherapy was employed. The 5 year survival rate in cases undergoing postoperative radiotherapy because of lymph node metastasis was lower than that of cases where the lesion approached the pelvic wall and for which postoperative radiotherapy was employed. An investigation of the 5 year survival rate among those cases with lymph node metastasis and receiving postoperative radiotherapy indicated that survival in cases with metastasis to only one lymph node was similar to that of cases of the same clinical stage which received the operation only, whereas the survival rate of cases with multiple lymph node involvement was markedly lower.抄録全体を表示PDF形式でダウンロード (574K) -
TAKAO SAITO, KEI YAMAKAGE, TAKASHI FURUYAMA, KAORU YOSHINAGA1982 年 138 巻 1 号 p. 117-118
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーSAITO, T., YAMAKAGE, K., FURUYAMA, T. and YOSHINAGA, K. Persistent Nephrotic Syndrome and Focal Glomerular Sclerosis Produced in Rats by Aminonucleoside and Protamine. Tohoku J. exp. Med., 1982, 138 (1), 117-118 Aminonucleoside of puromycin (AN) is known to produce nephrotic syndrome in rats. Protamine sulfate (Ps) enhanced the effect of AN. So we tried in rats four series of repeated administration of Ps in combination with AN at a reduced dose. The animals developed nephrotic syndrome and without debilitation kept it for a long time. Their kidneys demonstrated an abundance of focal glomerular sclerosis, accompanied by a notable interstitial proliferation.抄録全体を表示PDF形式でダウンロード (360K) -
SHOZO NAKAMURA, YOSHIAKI TAKEZAWA1982 年 138 巻 1 号 p. 119-120
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーNAKAMURA, S. and TAKEZAWA, Y. Obstruction of the Inferior Vena Cava in the Hepatic Portion and Hepatocellular Carcinoma. Tohoku J. exp. Med., 1982, 138 (1), 119-120 High incidence of hepatocellular carcinoma in patients with obstruction of the inferior vena cava in the hepatic portion (Build-Chiari syndrome) was previously pointed out by us from the review of Japanese literature of autopsied cases. This was confirmed by the follow-up study of 16 patients with obstruction of the inferior vena cava in the hepatic portion hospitalized in 1958 to 1974. Follow-up information was available on 13 of the 16 patients. Deaths due to hepatocellular carcinoma occurred in 6 patients (46%), and those due to other causes in 4 patients (31%). Three patients were alive. Hepatocellular carcinoma occurred most frequently in the patients who were found to have obstruction of the inferior vena cava at less than 44 years of age and were followed up for more than 10 years.抄録全体を表示PDF形式でダウンロード (214K)
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