巻号一覧
138 巻 (1982)
- 4 号 p. 341-
- 3 号 p. 239-
- 2 号 p. 121-
- 1 号 p. 1-
138 巻, 4 号
選択された号の論文の12件中1～12を表示しています
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TAKESHI SASAKI, TAKEFUMI KADONO, FUMIO ENDO, YUKIO SEKIGUCHI, TAKAO SA ...1982 年 138 巻 4 号 p. 341-355
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーSASAKI, T., KADONO, T., ENDO, F., SEKIGUCHI, Y., SAITO, T., ARAKAWA, M., FURUYAMA, T. and YOSHINAGA, K. Relationship between Complement-Fixing (Hemolytic) Antibodies to Single-Stranded and Double-Stranded DNA and the Prognosis in Systemic Lupus Erythematosus. Tohoku J. exp. Med., 1982, 138 (4), 341-355-Hemolytic (complement-fixing) antibodies to single-stranded (ss) or double-stranded (ds) DNA, measured by recently developed PHL assay, occurred closely correlated with renal activity in patients with systemic lupus erythematosus (SLE). Approximately one third of the patients with renal disease had hemolytic antibodies to ss-DNA but never to ds-DNA. Hemolytic antibodies were scarcely detectable in patients with mild course. Serial studies also revealed that the estimation of the hemolytic antibodies to ds- and/or ss-DNA was particularly valuable in predicting the future course of the SLE. The emergence of hemolytic antibodies to DNA may be an omenous sign suggestive of grave prognosis in SLE.抄録全体を表示PDF形式でダウンロード (1911K) -
SHIGERU ASAKI, SHIGEAKI HATORI, MICHINORI SATO, TOSHIAKI NISHIMURA, AK ...1982 年 138 巻 4 号 p. 357-365
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーASAKI, S., HATORI, S., SATO, M., NISHIMURA, T., SATO, A. and GOTO, Y. Diagnosis of Submucosal Tumors by Injecting a Water Soluble Contrast Medium: Diagnosis of Tumors and Clinical Presumption of Their Development Patterns. Tohoku J. exp. Med., 1982, 138 (4), 357-365-So far there have been no clinical methods claiming reasonable estimation of the patterns of submucosal tumors. In an attempt to shed some light on this difficult task, we have elaborated an endoscopical procedure; injecting a water soluble contrast medium into the submucosa and immediately applying roentgenography, we have obtained an X-ray image of the object lesion, visualizing its frontal and lateral aspects, which could help us outline the intramural characteristic of the tumor, informing us of its development mode. The device suggests its far-reaching contributions to the possible diagnosis of submucosal tumors prior to treatment and confirmation of their indications adequate for endoscopical treatment. Our method may potentially represent an ideal step to the consummation of endoscopic treatment of tumors, the success of which is dependent on the prevention of major bleeding and perforation.抄録全体を表示PDF形式でダウンロード (1751K) -
IMASU AWANO, ATSUKO MURAMOTO, NAOYUKI AWANO1982 年 138 巻 4 号 p. 367-381
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーAWANO, I., MURAMOTO, A. and AWANO, N. An Approach to Clinical Magnetocardiology. Tohoku J. exp. Med., 1982, 138 (4), 367-381-Magnetocardiograms (MCGs) of normal human subjects and patients with various heart diseases and of fetuses (fetal magnetocardiogram, FMCG) were recorded using a SQUID magnetometer with a built-in second derivative gradiometer in a magnetically unshielded environment. MCGs and ECGs in this study were taken simultaneously at the same precordial chest positions (V1-V6). The following results were obtained: (1) The waves of MCG showed a variety of changes which can never be detected in ECGs. (2) Clear FMCGs could be recorded without being overlapped by MCG of the mother. (3) In MCGs from a patient with complete A-V block, there was a secondary pacemaker spike which was presumably related to ventricular depolarization. (4) There were two kinds of characteristic changes with time in MCGs after onset of anterior myocardial infarction, which could be confirmed in experiments with dogs. Thus, the results obtained so far indicate a bright future of magnetocardiology in clinical medicine.抄録全体を表示PDF形式でダウンロード (1566K) -
YOSHIHIRO TAKASAWA, NORIYOSHI SUZUKI, WATARU TAKAHASHI, TOSHIO SATO1982 年 138 巻 4 号 p. 383-395
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーTAKASAWA, Y., SUZUKI, N., TAKAHASHI, W. and SATO, T. A Study on the Dissolution and Disintegration of Calcium Bilirubinate Stones, with Special Reference to Effects of Litholytic Agents in Human Bile and to Irrigation of Bile Duct in Dogs. Tohoku J. exp. Med., 1982, 138 (4), 383-395-1) Slices of calcium bilirubinate stones were readily soluble in bile added with tetrasodium salt of ethylene-diaminetetraacetic acid (EDTA•4Na). 2) Bile added with 3 agents, EDTA•4Na, ursodeoxycholate (Urso), and heparin could dissolve calcium bilirubinate stones more easily than, or comparably to, the bile added only with EDTA•4Na. 3) The pH of the bile added with the combination of EDTA•4Na-Urso-heparin was 8.72±0.15, which was slightly more neutral than the bile added with EDTA•4Na alone. 4) In dogs, the bile duct was dilated and irrigated with an EDTA solution for 4 weeks. This irrigation resulted in no abnormalities in hepatic function, the serum calcium level, or the histology of the gallbladder or the common bile duct. In conclusion, the combined solution of EDTA•4Na-Urso-heparin is effective for the dissolution and disintegration of calcium bilirubinate stones with little disturbance of human bodies.抄録全体を表示PDF形式でダウンロード (1121K) -
SHIN-ICHI OIKAWA, YOSHISUKE MARUHAMA, RYUZO ABE, YOSHIO GOTO1982 年 138 巻 4 号 p. 397-400
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーOIKAWA, S., MARUHAMA, Y., ABE, R. and GOTO, Y. Effect of Insulin on the Lysosomal Function of Rat Aortic Smooth Muscle Cells and Subcutaneous Fibroblasts in Tissue Culture. Tohoku J. exp. Med., 1982, 138 (4), 397-400-Extracellular and intracellular activities of N-acetyl-beta-glucosaminidase (NAG), a representative lysosomal enzyme, in rat aortic smooth muscle cells and subcutaneous fibroblasts cultured for 6 days with an insulin-enriched (200μU/ml of insulin) or an insulin-deprived medium were measured. The culture medium was changed every 2 days. The net release of NAG into the medium between the 4th and the 6th day was significantly inhibited in the insulin-enriched culture of both smooth muscle cells and fibroblasts. The inhibition was more marked in the fibroblasts series than in the smooth muscle cell series. On the other hand, the intracellular NAG activity of both cell series was almost similar in the insulin-enriched culture and in the insulin-deprived culture. The results indicate that insulin has an inhibitory effect on the net extracellular release of NAG and, therefore, regulates the lysosomal function in these mesenchymal cells.抄録全体を表示PDF形式でダウンロード (402K) -
MASAHIRO ARAKAWA, JIN SEINO, YASUMICHI KINOSHITA, KAZUO FUKUDA, TAKAO ...1982 年 138 巻 4 号 p. 401-409
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーARAKAWA, M., SEINO, J., KINOSHITA, Y., FUKUDA, K., SAITO, T. and FURUYAMA, T. Nephritic Factor (NeF) of Alternate Pathway (NeFA) and of Classical Pathway (NeFc). Tohoku J. exp. Med., 1982, 138 (4), 401-409-NeFA and NeFc were studied in various cases (115 cases). 5 cases were followed up for a long time. NeFA assay was done by the “microtest plate method”. We detected the NeF activity for the first time in the cases of Sjögren syndrome (SjS) and SjS+SLE+Hashimoto's disease (Hashimoto). In some cases NeF activity disappeared after therapy, and in one case NeFA and NeFc were positive at first, but then only NeFA activity became negative following the adequate therapy. As to the antibody nature of NeF, the possibility was suggested that NeFA might be anti C3b autoantibody and NeFc might be anti C4b and/or C4b2a autoantibody.抄録全体を表示PDF形式でダウンロード (743K) -
HIROSHI UNAKAMI, YOHTARO FURUKAWA, HYO EUY SOHN, SHIGERU YUMITA, RYO M ...1982 年 138 巻 4 号 p. 411-418
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーUNAKAMI, H., FURUKAWA, Y., SOHN, H.E., YUMITA, S., MIURA, R., SASAKI, A., KOKUBUN, M., MIURA, Y., YOSHINAGA, K. and NAKANOME, C. 1, 25-Dihydroxyvitamin D Production Stimulated by Dibutyryl 3', 5'-Cyclic AMP in Normal Subjects and a Patient with Pseudohypoparathyroidism. Tohoku J. exp. Med., 1982, 138 (4), 411-418-Dibutyryl 3', 5'-cyclic AMP (DBcAMP) was infused in 4 normal subjects and a patient with pseudohypoparathyroidism (PHP) to study its effect on the production of 1, 25-dihydroxyvitamin D [1, 25(OH)2D]. In normal subjects, 2.5mg/kg of DBcAMP increased plasma 1, 25(OH)2D. reaching the peak at 6hr after infusion, while, 6.0mg/kg of DBcAMP delayed the peak to 12hr. The maximal increment of plasma 1, 25(OH)2D was 19.7±2.8pg/ml (mean±S.D.) in normals with 6.0mg/kg of DBcAMP and 12.2±1.0pg/ml (mean±S.D.) with 2.5 mg/kg, respectively. There was a significant difference between the doses (p<0.01). Plasma 24, 25-dihydroxyvitamin D [24, 25(OH)2D] showed no significant change after DBcAMP infusion in normal subjects. In a patients with PHP, however, 2.5mg/kg of DBcAMP markedly increased plasma 1, 25(OH)2D to reach the peak (48.9pg/ml) at 14hr and plasma 24, 25(OH)2D was decreased reciprocally. After DBcAMP infusion, depression of serum P, slight decrease in %TRP and the elevation of IRI were proved in normal subjects, while in a patient with PHP, there was a marked depression of %TRP. It is suggsted that the increments of plasma 1, 25(OH)2D by infusion of DBcAMP is dose-dependent in normal subjects, and that the 1, 25(OH)2D productivity by DBcAMP may be accelerated in a patient with PHP.抄録全体を表示PDF形式でダウンロード (704K) -
YOSHISUKE MARUHAMA, FUMIKO SAITO, ISAO HIKICHI, TAKASHI HASHIMOTO, KAZ ...1982 年 138 巻 4 号 p. 419-425
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーMARUHAMA, Y., SAITO, F., HIKICHI, I., HASHIMOTO, T., TAKAHASHI, K. and KAITO, I. Apoprotein B-Poor Very Low Density Lipoprotein in Diabetic Patients without Hyperlipoproteinemia. Tohoku J. exp. Med., 1982, 138 (4), 419-425-In order to see if there is a latent metabolic disorder of plasma very low density lipoprotein (VLDL) in uncontrolled diabetic patients without hyperlipoproteinemia, 28 diabetic patients and 13 matched normal subjects were analyzed for the compositions of fasting plasma VLDL. Although the lipid profiles and total apoproteins were similar among the normals, normolipoproteinemic well-controlled diabetics and normolipoproteinemic poorly-controlled diabetics, VLDL apoprotein B content tended to be decreased in poorly-controlled diabetics. Consequently, triglyceride/apoprotein B ratio was found to be increased significantly (p<0.02) to 12.5±1.3 (mean±S.E.) in the normolipoproteinemic poorly-controlled diabetics as compared with that in the normals (8.1±0.7). Since plasma VLDL is known to become relatively enriched with apoprotein B as the VLDL delipidation proceeds, the aproprotein B-poor VLDL in the normolipoproteinemic poorly-controlled diabetics seems to reflect a latent delayed turnover of circulating VLDL and this might be the disorder characteristic to diabetes mellitus.抄録全体を表示PDF形式でダウンロード (727K) -
TAKEAKI SAKAI, AKIRA OHNEDA, JIRO NIHEI, TAKASHI KOBAYASHI1982 年 138 巻 4 号 p. 427-440
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーSAKAI, T., OHNEDA, A., NIHEI, J. and KOBAYASHI, T. Analysis of Insulin Secretion Based on Changes in Plasma Insulin and C-Peptide in Man. Tohoku J. exp. Med., 1982, 138 (4), 427-440 - In order to clarify the mechanism of insulin secretion, responses of insulin (IRI) and C-peptide (CPR) in plasma to various stimuli were investigated in normal subjects and patients with diabetes mellitus, liver cirrhosis, chronic nephritis or insulinoma. The response of plasma IRI and CPR to oral glucose load was less marked in the mild and moderate diabetes groups than in the normal controls. Neither IRI nor CPR in the severe diabetes group responded to oral glucose. The patients with liver cirrhosis revealed an exaggerated and delayed response of IRI and CPR, and a lowered CPR/IRI ratio, indicating a remarkable response of IRI to glucose. In contrast, the patients with chronic nephritis showed a prominent rise of CPR alone. In the insulinoma patients, both plasma IRI and CPR increased after glucose load. In the response to glucose, there was approximately 30-min lag time between the peaks of IRI and CPR in the normal controls and the patients with various diseases. Following arginine infusion, plasma IRI and CPR increased in the normal subjects and the patients with moderate diabetes. In the normal subjects, plasma IRI reached a peak at 6min and 3min in response to tolbutamide and glucagon, respectively, which elicit an abrupt and sharp rise of insulin from B-cells. However, diabetic patients showed a minimal change in plasma IRI and CPR, whereas there was an exaggerated response of plasma IRI and CPR in insulinoma patients. In analysis of responses of plasma IRI and CPR to tolbutamide or glucagon, there was a lag time longer than 10min in the normal subjects. The present studyconfirms the concurrent release of C-peptide from the B-cells in the secretion of insulin. In addition, it was suggested that insulin and C-peptide are mainly handled in the liver and the kidney, respectively. Furthermore, a longer lag time between the peaks of IRI and CPR in response to tolbutamide or glucagon did not necessarily indicate a simultaneous release of insulin and C-peptide from the B-cell, but a delayed release of the latter.抄録全体を表示PDF形式でダウンロード (1230K) -
MAMORU ISEMURA, ZENSAKU YOSIZAWA, NOBUO KOJIMA, FUMIHIRO ICHIDA1982 年 138 巻 4 号 p. 441-442
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーISEMURA, M., YOSIZAWA, Z., KOJIMA, N. and ICHIDA, F. Fibronectin in Human Hepatocellular Carcinoma. Tohoku J. exp. Med., 1982, 138 (4), 441-442-Human liver specimens with hepatocellular carcinoma were studied for distribution of fibronectin by immunofluorescence staining. Fibronectin was detected in the cytoplasm and/or on the cell surface in certain cases, which is in contrast to the observations in vivo for hepatocytes of normal and other fibrotic livers. The present finding is also in contrast to those for various other carcinomas so far reported.抄録全体を表示PDF形式でダウンロード (1365K) -
Effects of Aging and Smoking on the Cadmium Levels in the Blood of Inhabitants in Non-Polluted AreasTAKAO WATANABE, AKIO KOIZUMI, HIROYOSHI FUJITA, HIDEIE FUJIMOTO, AKIRA ...1982 年 138 巻 4 号 p. 443-444
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーWATANABE, T., KOIZUMI, A., FUJITA, H., FUJIMOTO, H., ISHIMORI, A. and IKEDA, M. Effects of Aging and Smoking on the Cadmium Levels in the Blood of Inhabitants in Non-Polluted Areas. Tohoku J. exp. Med., 1982, 138 (4), 443-444-By the determination of cadmium in 556 blood samples from the inhabitants of non-polluted areas, it is evidenced that the blood cadmium is low in infants (ca. 1.5-2.0ng/ml) and gradually increases to reach a plateau level (3.5- 4.0ng/ml) at the ages of 40's to 50's, that the female values (ca. 4.0ng/ml) are higher than the male values (ca. 3.5ng/ml) among non-smoking adults, and that the smoking habit elevates the cadmium level by 1.0-1.5ng/ml.抄録全体を表示PDF形式でダウンロード (225K) -
TOSHIO SATO, KIMIHIKO TAKUSAGAWA, NOBORU ASOO, KIYOSHI KONNO1982 年 138 巻 4 号 p. 445-446
発行日: 1982年
公開日: 2006/08/31
ジャーナル フリーSATO, T., TAKUSAGAWA, K., ASOO, N. and KONNO, K. Antitumor Effect of 1α-Hydroxyvitamin D3. Tohoku J. exp. Med., 1982, 138 (4), 445-446-Sarcoma 180 and the Lewis lung carcinoma were implanted s.c. into male ddY mice and C57B1/6 mice, respectively. 1α-Hydroxyvitamin D3 was administered orally by a stomach tube at a dose of 0.1μg/kg and 0.2μg/kg daily. The results demonstrated that 1α-hydroxyvitamin D3 suppressed s.c. tumor growth of sarcoma 180 and inhibited pulmonary metastases of the Lewis lung carcinoma.抄録全体を表示PDF形式でダウンロード (198K)
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