巻号一覧
142 巻 (1984)
- 4 号 p. 351-
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142 巻, 1 号
選択された号の論文の14件中1～14を表示しています
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NORIKO KIMURA, NOBUAKI SASANO, YUKIO MIURA, KIYOSHI KOBAYASHI1984 年 142 巻 1 号 p. 1-11
発行日: 1984年
公開日: 2006/08/31
ジャーナル フリーKIMURA, N., SASANO, N., MIURA, Y. and KOBAYASHI, K. Adrenal and Extra-Adrenal Pheochromocytomas: An Ultrastructural and Formaldehyde-Induced Fluorescence Study with Catecholamine Content. Tohoku J. exp. Med., 1984, 142 (1), 1-44-Twenty-one adrenal and 6 extra-adrenal pheochromocytomas were studied by light and electron microscopy, and formaldehyde-induced fluorescence (FIF). These morphological findings were compared to the content of tumor catecholamines. Based on predominancy of the cell types, pheochromocytomas were classified into three groups: basophilic, chromophobic and oxyphilic (oncocy-tic) types. The basophilic type was characterized by basophilic cytoplasm of the tumor cells with hematoxylin and eosin (H & E) stain, green cytoplasmic fluorescence with FIF and numerous epinephrine type of electron dense granules with electron microscopy. Its epinephrine content was compatible to the normal adrenal medulla. The basophilic type was only of adrenal origin. Chromophobic and oxyphilic tumors contained predominantly norepinephrine, and showed yellow-green or light brown cytoplasmic fluorescence by FIF. By electron microscopy, various granules of different sizes and shapes of the norepinephrine type were noted. Extra-adrenal pheochromocytoma cells demonstrated dark brown cytoplasmic fluorescence by FIF. Morphological findings of the extra-adrenal tumor corresponded to those of chromophobic type adrenal pheochromocytoma. The tumors contained only norepinephrine.抄録全体を表示PDF形式でダウンロード (4980K) -
NAOKI MIZUTANI, TOMOAKI KATO, MITSUO MAEHARA, KAZUYOSHI WATANABE, MASA ...1984 年 142 巻 1 号 p. 15-24
発行日: 1984年
公開日: 2006/08/31
ジャーナル フリーMIZUTANI, N., KATO, T., MAEHARA, M., WATANABE, K. and BAN, M. Oral Administration of Arginine and Citrulline in the Treatment of Lysinuric Protein Intolerance. Tohoku J. exp. Med., 1984, 142 (1), 15-24 In two sibling patients with lysinuric protein intolerance (LPI), the therapeutic effect of oral supplement of arginine and citrulline on postprandial hyperammonemia was investigated. Intravenous load of L-alanine (6.6mmol/kg of body weight), and oral load of L-arginine (0.8mmol/kg of body weight) or of L-citrulline (1.0mmol/kg of body weight) during intravenous load of L-alanine were performed to study the preventive effect of arginine or citrulline supplement on hyperammonemia induced by intravenous amino nitrogen load. In the older sibling, the hyperammonemia induced by the intravenous amino nitrogen load was completely prevented by the oral supplement of citrulline, but not completely prevented in the younger sibling. On the other hand, the hyperammonemia was prevented by the oral supplement of arginine only in the younger sibling, but not in the older sibling. In the light of these results, the younger patient received an oral administration of L-arginine and the older patient L-citrulline for the treatment of postprandial hyperammonemia. Two-year observation of each patient revealed that postpradial hyperammonemia and aversion to protein-rich food completely disappeared and that a marked increase of body weight and height was obtained. Furthermore, there was no side effect with these amino acids supplements. The present study suggests that an oral supplement of arginine or citrulline is effective for preventing postprandial hyperammonemia in this disorder.抄録全体を表示PDF形式でダウンロード (784K) -
TETSURO NISHIHIRA, MASAKI TAN, YOSHIKI KURIYA, NORIO OHMORI, MICHIHIKO ...1984 年 142 巻 1 号 p. 25-34
発行日: 1984年
公開日: 2006/08/31
ジャーナル フリーNISHIHIRA, T., TAN, M., KURIYA, Y., OHMORI, N., KITAMURA, M., TOYODA, T., HIRAYAMA, K., KURAMOTO, J., KAWACHI, S., AKAISHI, T. and KASAI, M. Postoperative Cancer Therapy for Patients with Carcinoma of the Thoracic Esophagus: An Attempt of Aggressive Chemotherapy Combined with Proper Nutritional Support for Patients with Distant Node Metastasis. Tohoku J. exp. Med., 1984, 142 (1), 25-34-The prognosis of patients with advanced thoracic esophageal carcinoma is still poor. In general, patients having distant lymphnode metastasis do not survive for more than 3 years. Therefore, a new therapeutic regimen employing aggressive chemotherapy for these patients has been attempted. In this regimen, three kinds of anticancer drugs Pepleomycin, and twice as much as Adriamycin and Mitomycin of the conventional level for a short period of time are used. Eleven cases were treated with this chemotherapy under active enteral and parenteral nutritional support of 45 to 50kcal/kg daily. Two patients over 70 years of age died of pneumonitis. Four patients with recurrence of cancer in the lungs, liver and cervical nodes died after 10, 12, 13 and 14 months following surgery, respectively. Five patients have been alive for more than 2 years. These results indicate that this therapy is more effective than other conventional therapies. It has been shown that aggressive chemotherapy combined with proper nutritional support is effective for patients with node metastasis.抄録全体を表示PDF形式でダウンロード (914K) -
Tryptophan Metabolism in Liver Cirrhosis: Influence of Oral Antibiotics on Neuropsychiatric SymptomsKATSUHIKO YOSHIDA, CHISATO HIRAYAMA1984 年 142 巻 1 号 p. 35-41
発行日: 1984年
公開日: 2006/08/31
ジャーナル フリーYOSHIDA, K. and HIRAYAMA, C. Tryptophan Metabolism in Liver Cirrhosis: Influence of Oral Antibiotics on Neuropsychiatric Symptoms. Tohoku J. exp. Med., 1984, 142, (1), 35-41-Oral tryptophan loading tests were performed on patients with cirrhosis of the liver before and after treatment with an oral antibiotic practically unabsorbed from the gastrointestinal tract. After antibiotic therapy, neuropsychiatric manifestations evoked by the oral administration of tryptophan were reduced in duration by about 50% and in severity as well despite a slightly enhanced elevation of serum total and free typtophan levels, compared to pretreatment loading tests, The urinary indican output also showed a significantly greater decrease in the post-treatment test (p<0.05) whereas no appreciable difference was observed in urinary 5-hydroxy-indoleacetic acid excretion between the pre- and post-treatment tests. The data suggest that neuropsychiatric manifestations seen following oral administration of tryptophan may be attributed to intestinal tryptophan metabolites rather than to this aromatic amino acid itself and/or its metabolites in the brain.抄録全体を表示PDF形式でダウンロード (653K) -
YAMAKI SHIGEO, MORIKUNI FUKUDA, OSAMU KAHATA, KEI KOYAMAD1984 年 142 巻 1 号 p. 43-50
発行日: 1984年
公開日: 2006/08/31
ジャーナル フリーYAMAKI, S., FUKUDA, M., KAHATA, O. and KOYAMADA, K. Severe Pulmonary Vascular Disease Consisting of Ventricular Septal Defect and Patent Ductus Arteriosus. A Case Diagnosed as the Indication for Total Correction by the Hemodynamic Study. Tohoku J. exp. Med., 1984, 142 (1), 43-50-A 12-yearold girl with ventricular septal defect, patent ductus arteriosus and pulmonary hypertension was hemodynamically diagnosed as the indication for total correction by the initial cardiac catheterization. However, histologic assessment by lung biopsy revealed the terminal stage of plexogenic pulmonary arteriopathy, i.e. plexiform lesions, dilatation lesions and fibrinoid necrosis of the media which denied the possibility of corrective surgery. We would like to stress that the open lung biopsy should be performed when the hemodynamic study indicates marginal operability, especially in older children and adults in order to investigate the grade of occlusive pulmonary vascular disease.抄録全体を表示PDF形式でダウンロード (1568K) -
MASUE IMAIZUMI, SHIGERU TSUCHIYA, YASUKO KOBAYASHI, YOSHIKO YAMAGUCHI, ...1984 年 142 巻 1 号 p. 51-58
発行日: 1984年
公開日: 2006/08/31
ジャーナル フリーIMAIZUMI, M., TSUCHIYA, S., KOBAYASHI, Y., YAMAGUCHI, Y., MINEGISHI, M., TAMURA, M., KONNO, T. and TADA, K. An Ia-like Antigen Positive Null Cell Leukemia Cell Line (THP-5) Lacking in the Stimulating Capacity in Autologous and Allogeneic Mixed Lymphocyte Reaction. Tohoku J. exp. Med., 1984, 142(1), 51-58-A null cell leukemia cell line, THP-5, was established from the peripheral blood of a patient with acute null cell leukemia. THP-5 cells were characterized by the presence of Ia-like antigen and the absence of other cell surface markers examined. Despite the presence of Ia-like antigen, THP-5 cells had no stimulating capacity in autologous or allogeneic mixed lymphocyte reaction.抄録全体を表示PDF形式でダウンロード (2381K) -
KUNIHIKO HANEW, ATSUSHI SASAKI, SHUICHI SATO, MIDORI KASAI, YASUYUKI S ...1984 年 142 巻 1 号 p. 59-65
発行日: 1984年
公開日: 2006/08/31
ジャーナル フリーHANEW, K., SASAKI, A., SATO, S., KASAI, M., SHIMIZU, Y., MURAKAMI, O. and YOSHINAGA, K. The Mechanism of Postinhibitory Rebound Increases in Plasma GH in Acromegalic Patients. Tohoku J. exp. Med., 1984, 142 (1), 59-65-The mechanism of postinhibitory rebound increase in GH secretion was studied in 5 normal and 7 acromegalic subjects. Both normal and acromegalic subjects showed prompt GH decreases during the infusion of somatostatin (500μg/75min) (% decrease: 69.1±10.4 vs. 73.9±6.5) and rebound rises after its termination. The rebound rises occurred more promptly and markedly in normal controls than in acromegalic subjects, i.e. the rebound peak appeared at 15min in normal controls and at 45min in acromegalic patients after the cessation of somatostatin infusion. Dopamine (DA) infusion (5μg/kg/min for 90min) also induced similar inhibition and postinhibitory rebound rises in GH secretion in 6 patients with acromegaly. Although the maximum inhibitions (67.1±7.3% vs. 73.7±7.1%) and the inhibitory areas (4354.5±471.0%•min vs. 3796.5±322.5%•min) during the DA and somatostatin infusions were not different, the rebound at 15min was significantly greater after DA than after somatostatin (p<0.05). All seven patients with acromegaly were TRH responsive in their plasma GH (% of basal: 93.5 to 944.3) When TRH was injected at the termination of somatostatin infusion, the rebound increase was significantly enhanced and the rebound peak appeared 30 min earlier than after single somatostatin administration. These results indicate that the mechanisms participating in the postinhibitory rebound rise are different in normal controls and acromegalic patients, and that the magnitude of the rebound differs with agents employed. Also, it is evident that the rebound phenomenon in acromegaly is possibly modified by exogenous hypothalamic releasing factors.抄録全体を表示PDF形式でダウンロード (617K) -
MASAHIDE SEINO, KEISHI ABE, SADAYOSHI ITO, MINORU YASUJIMA, SATORU CHI ...1984 年 142 巻 1 号 p. 67-76
発行日: 1984年
公開日: 2006/08/31
ジャーナル フリーSEINO, M., ABE, K., ITO, S., YASUJIMA, M., CHIBA, S., HIWATARI, M., SATO, K., GOTO, T., OMATA, K., TAJIMA, J., TANNO, M. and YOSHINAGA, K. Effects of Nifedipine on Renal Vascular Responses to Vasoactive Agents in Rabbits. Tohoku J. exp. Med., 1984, 142 (1), 67-76-The present study was designed to investigate the effects of the Ca-antagonist, nifedipine, on receptor-mediated renal vascular responses to vasoconstrictors (angiotensin II, norepinephrine and vasopressin) and vasodilators (bradykinin and prostaglandin E2). Renal blood flow was estimated by noncannulating electromagnetic flowmetry in anesthetized rabbits. Vasoactive substances were infused directly into the renal artery. After the intravenous administration of nifedipine (50μg/kg), decreases in renal blood flow in response to angiotensin II infused at rates of 2.5, 5 and 10ng/kg/min were attenuated by 64% (p<0.01), 45% (p<0.05) and 42% (p<0.05), respectively. Decreases in renal blood flow in response to vasopressin infused at rates of 10, 20 and 50mU/kg/min were also attenuated by nifedipine, 50% (p<0.05), 57% (p< 0.05) and 38% (p<0.05), respectively. However, renal vasoconstrictor responses to norepinephrine (25, 50 and 100ng/kg/min) did not change significantly after the administration of nifedipine. Increases in renal blood flow induced by the intrarenal infusion of bradykinin (2.5, 5 and 10ng/kg/min) and prostaglandin E2 (20, 50 and 100ng/kg/min) were not affected by nifedipine. These results suggest that receptor-mediated vasoconstrictor responses of the renal vascular bed to angiotensin II and vasopressin are produced mainly by Ca++ influx but that of norepinephrine is not. Furthermore, it is confirmed that the renal vasodilator effect of bradykinin and prostaglandin E2 is not altered by nifedipine in anesthetized rabbits.抄録全体を表示PDF形式でダウンロード (979K) -
TAKESHI KOKUBO, MICHIHITO TAKAHASHI, FUMIO FURUKAWA, KASUKE NAGANO, YU ...1984 年 142 巻 1 号 p. 77-88
発行日: 1984年
公開日: 2006/08/31
ジャーナル フリーPDF形式でダウンロード (1344K) -
MAMORU ISEMURA, NARIKAZU SATO, HIROSHI MUNAKATA, JUNICHIRO AIKAWA, NOB ...1984 年 142 巻 1 号 p. 89-95
発行日: 1984年
公開日: 2006/08/31
ジャーナル フリーISEMURA, M., SATO, N., MUNAKATA, H., AIKAWA, J., OTOTANI, N., YOSIZAWA, Z., SAKUMA, A., MASUDA, T., AOYAGI, Y. and ICHIDA, F. Glycosaminoglycans of Human Colonic Mucosa and Colonic Adenocarcinoma. Tohoku J. exp. Med., 1984, 142 (1), 89-95-The mucosal scrapings of the normal human colons and the colonic adenocarcinoma tissues were digested with pronase, and the glycosaminoglycan fractions were preparad by fractionation with cetylpyridinium chloride after treatment with deoxyribonuclease. Chondroitin sulfate A/C, heparan sulfate, and hyaluronic acid were contained in the glycosaminoglycan fraction of the normal tissue, but dermatan sulfate was undetectable. In contrast, the glycosaminoglycan fractions derived from the tumors contained substantial amounts of dermatan sulfate together with the foregoing three glycosaminoglycans. The total content of glycosaminoglycans per wet tissue weight was elevated in the tumor tissues, which was consistent with histochemical findings.抄録全体を表示PDF形式でダウンロード (5124K) -
FUMIAKI KOIZUMI, RYOKO USHIZAWA, TAKESHI KAWAMURA, AKIRA ISHIMORI, TSU ...1984 年 142 巻 1 号 p. 97-103
発行日: 1984年
公開日: 2006/08/31
ジャーナル フリーKOIZUMI, F., USHIZAWA, R., KAWAMURA, T., ISHIMORI, A. and SATO, T. Plasma Gastrin and Pancreatic Polypeptide Response to Atropine and Sham Feeding in Man. Tohoku J. exp Med., 1984, 142 (1), 97-103-We studied the effects of atropine, both in the basal state and after stimulation by modified sham feeding (MSF), and the effect of MSF alone, on the plasma gastrin and pancreatic polypeptide (PP) responses in 8 healthy human subjects. Atropine 1mg in the basal state had no effect on the plasma gastrin concentrations but led to significant decrease in plasma PP concentrations. Plasma gastrin response to MSF was negligible but increased by atropine. The plasma PP level was markedly increased by MSF, and was antagonized by atropine. This study shows that the release of plasma PP during basal state and after MSF is under the control of the vagal-cholinergic mechanism, but plasma gastrin is controlled by a different mechanism.抄録全体を表示PDF形式でダウンロード (596K) -
TSUNEO CHIBA, E. Jr. THOMAS BOLES, GLORIA STAPLES1984 年 142 巻 1 号 p. 105-113
発行日: 1984年
公開日: 2006/08/31
ジャーナル フリーCHIBA, T., BOLES, E.T., Jr. and STAPLES, G. Staged Orchidopexy with Division of Spermatic Vessels: An Experimental Study. Tohoku J. exp. Med., 1984, 142 (1), 105-113-To improve the therapeutic results of high undescended testis, we conducted experiments with division of spermatic vessels and replacement of the testis into the scrotum after preparation of undescended testis in rats. The results of this experiment show that 1) testis in which the vessels were divided at the inguinal level showed distinct degeneration from infarction one month postoperatively, 2) testis in which the vessels were divided at the abdominal level appeared normal, and 3) in the rats with preparation of undescended testis, bringing down the testis at some interval after division produces better results as to the recovery of the testis.抄録全体を表示PDF形式でダウンロード (1480K) -
SHOZO NAKAMURA1984 年 142 巻 1 号 p. 115-116
発行日: 1984年
公開日: 2006/08/31
ジャーナル フリーNAKAMURA, S. Serological Markers of Hepatitis A and B Virus Infection in Overseas Students. Tohoku J. exp. Med., 1984, 142 (1) 115-116-Serological markers of hepatitis A and B virus infection were determined by radioimmunoassay in 83 overseas university students. Hepatitis B surface antigen (HBsAg) was detected in 8 students (9.6%), antibody to HBsAg and/or antibody to hepatitis B core antigen in 38 (46%), and antibody to hepatitis A virus (anti-HAV) in 74 (89%). These prevalences of hepatitis A and B markers were significantly higher than those in Japanese students. Liver function tests were abnormal in 7 overse asstudents (8%). Among groups of the overseas students, East Asian groups showed high prevalences of hepatitis B markers. High prevalences of anti-HAV were demonstrated not only in Asian groups but also in South American group.抄録全体を表示PDF形式でダウンロード (211K) -
TAKASHI IKEDA1984 年 142 巻 1 号 p. 117-118
発行日: 1984年
公開日: 2006/08/31
ジャーナル フリーIKEDA, T. Comparison of Ascorbic Acid Concentrations in Granulocytes and Lymphocytes. Tohoku J. exp. Med., 1984, 142 (1), 117-118-The author measured the ascorbic acid concentration (μg/108 cells) in leukocytes from fourteen healthy male subjects aged 20 to 28 years. The mean values were 10.9 (range 3. 7 to 15.8) in granulocytes and 88.5 (range 35.3 to 122.2) in lymphocytes. These findings suggest that ascorbic acid metabolism in lymphocytes differs from that in granulocytes. In the second experiments the changes in ascorbic acid concentrations were measured in the course of an ascorbic acid loading test to a 33-year-old healthy male volunteer, in which increasing doses (1, 3, 5, 10g/day×7 days) were weekly loaded for 4 successive weeks and the ascorbic acid concentrations were examined at the end of each week. As the loading dose increased, ascorbic acid concentration in lymphocytes decreased during the 4 week period while the counterpart value in granulocytes stayed essentially constant. The present findings suggest the differences in ascorbic acid metabolism between granulocytes and lymphocytes.抄録全体を表示PDF形式でダウンロード (193K)
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