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Volume 145 (1985)
- Issue 4 Pages 353-
- Issue 3 Pages 233-
- Issue 2 Pages 105-
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Volume 145, Issue 1
Displaying 1-13 of 13 articles from this issue
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YOSHIAKI KONDO, IKUO KUROBANE, KIYOSHI OMURA, RYUICHI SANO, RYUZO ABE, ...1985 Volume 145 Issue 1 Pages 1-6
Published: 1985
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKONDO, Y., KUROBANE, I., OMURA, K., SANG, R., ABE, R., CHIDA, N. and TADA, K. Postheparin Plasma Lipoprotein Lipase Activity in Heterozygotes of Familial Lipoprotein Lipase Deficiency. Tohoku J. exp. Med., 1985, 145(1), 1-6 -Serum lipoprotein pattern, apoproteins and two postheparin triglyceride lipases were analyzed in a patient with familial lipoprotein lipase (LPL) deficiency and her family. Serum of the patient showed extreme hyperchylomicronemia and her postheparin plasma LPL activity was distinctly decreased. None of heterozygotes had any type of hyperlipoproteinemia. The mother and brother of the patient had moderately decreased LPL activity. There were no consistent changes in hepatic triglyceride lipase (H-TGL) activity among heterozygotes. These results suggest that assay of LPL may be helpful for detection of heterozygotes in familial LPL deficiency.View full abstractDownload PDF (861K) -
F. AFIFI1985 Volume 145 Issue 1 Pages 7-14
Published: 1985
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSAFIFI, F. Some Red Blood Cell Abnormalities in Patients with Liver Cirrhosis and Ascites. I. Red Blood Cell Sodium, Potassium and Water Content. Tohoku J. exp. Med., 1985, 145(1), 7-14-In 22 normal subjects and 22 patients suffering from liver cirrhosis and ascites, sodium, potassium and water concentrations in the red blood cell and plasma were determined. In patients with liver cirrhosis complicated by ascites (compared with control subjects) we found out: (1) Red blood cell sodium concentration was significantly increased in cirrhotic patients (p<0.001). (2) The potassium and water content in red blood cells was not significantly different in the 2 groups. (3) Sodium concentration in the plasma of cirrhotic patients was significantly decreased (p<0.01).View full abstractDownload PDF (751K) -
AKIRA YAJIMA, HIROSHI SAKAHIRA, YUICHI WADA, SHINJI SATO, RYUJI YAMAUC ...1985 Volume 145 Issue 1 Pages 15-22
Published: 1985
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSYAJIMA, A., SAKAHIRA, H., WADA, Y., SATO, S., YAMAUCHI, R., OZAWA, N., TOKI, T., TASE, T., OIKAWA, N., UEHARA, S. and SUZUKI, M. Concurrent Endometrial Hyperplasia with Carcinoma of the Corpus Uteri. Tohoku J. exp. Med., 1985, 145 (1), 15-22-Using 117 uteri which were extirpated in cases of carcinoma of the corpus uteri, a study was made to investigate the relationship between the site of the cancer and the site of associated endometrial hyperplasia. It was found that 75% of the cases had carcinomas of the upper portion of the uterus primarily of the uterine fundus. About 50% of the cancers were associated with adenomatous or atypical hyperplasia, and these two types of hyperplasia were frequently found in the fundus or upper portion of the uterus. In contrast, there was no site of particular prevalence in cases with concurrent cystic hyperplasia. About 70% of the cases had adenomatous or atypical hyperplasia on one or both of the histological blocks adjacent to the cancer.View full abstractDownload PDF (2266K) -
NORIKO KIMURA, LATIFA GHANDUR-MNAYMEN1985 Volume 145 Issue 1 Pages 23-38
Published: 1985
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKIMURA, N. and GHANDUR-MNAYMEN, L. An Immunohistochemical Study of Keratin, Carcinoembryonic Antigen, Human Chorionic Gonadotropin and Alpha-Fetoprotein in Lung Cancer. Tohoku J. exp. Med., 1985, 145(1), 23-38-Immunohistochemical staining utilizing a peroxidase-antiperoxidase (PAP) technique for keratin, carcinoembryonic antigen (CEA), human chorionic gonadotropin (HCG) and alpha-fetoprotein (AFP) was performed on paraffin sections from 72 cases of lung cancer obtained at autopsy. Positive reaction was shown in 44% of the cases for keratin, 77% for CEA, and 58% for HCG. AFP was positive in only one case of large cell carcinoma. Keratin was positive in 100% of squamous cell carcinoma, 53% of adenocarcinoma, 15% of small cell carcinoma and 45% of large cell carcinoma. CEA showed positive staining in 90% of squamous cell carcinoma, 88% of adenocarcinoma, 58% of small cell carcinoma and 69% of large cell carcinoma. CEA was the most useful tumor marker for detection of all types of lung cancer. HCG was positive in 30% of squamous cell carcinoma, 100% of adenocarcinoma, 23% of small cell carcinoma and 56% of large cell carcinoma.View full abstractDownload PDF (6924K) -
KATSUHIRO NAKAMURA, HIROSHI SUE1985 Volume 145 Issue 1 Pages 39-47
Published: 1985
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNAKAMURA, K. and SUE, H. Pepsinogen Isozymes in Borrmann IV Type Gastric Carcinoma. Tohoku J. exp. Med., 1985, 145 (1), 39-47-Immunoperoxidase staining for human group I and group II pepsinogens (PG I, PG II) was performed on stomachs including surgically removed 42 Borrmann IV type gastric carcinomas (B-IV), 6 duodenal ulcers and 6 autopsy cases of traffic accident. Besides, 8 surgical cases of B-IV were examined by polyacrylamide gel electrophoresis (PAGE). All 8 cases examined by PAGE showed positive finding for at least one pepsinogen isozyme. In male, 19/19 were positive while in female 21/23 were positive for PG I and/or PG II by the immuno-peroxidase method.View full abstractDownload PDF (2044K) -
NORIMUNE FUNAKOSHI, TADASHI KANOH, SHIZUE MIZUMOTO, HARUTO UCHINO1985 Volume 145 Issue 1 Pages 49-55
Published: 1985
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSFUNAKOSHI, N., KANOH, T., MIZUMOTO, S. and UCMNO, H. Autoantibodies, Including Antibasement Membrane Antibody, in Patients with Selective IgA Deficiency. Tohoku J. exp. Med., 1985, 145 (1), 49-55-Laboratory data are presented on 48 patients with selective IgA deficiency. Sixty percent of the patients had autoimmune diseases or related disorders. We found antibasement membrane antibody (ABMA) in the sera of four IgA deficient patients and the incidence of ABMA seemed to be related to clinical symptoms. The incidence of various other antibodies was found to be increased in selective IgA deficiency. This phenomenon might be derived from the lack of local immune system. Inadequate IgA barrier might permit the exessive gastrointestinal absorption of food antigens or autoimmunogens in metabolic products which are excreted into the gut lumen.View full abstractDownload PDF (2770K) -
KEI NUMAZAKI, SHUNZO CHIBA, TERUAKI MOROBOSHI, NOBUTADA TACHI, KOKI AO ...1985 Volume 145 Issue 1 Pages 57-63
Published: 1985
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNUMAZAKI, K., CHIBA, S., MOROBOSHI, T., TACHI, N., AOKI, K. and NAKAO, T. An Application of Fluoresein-Conjugated Monoclonal Antibodies to the Diagnosis of Chlamydia trachomatis Infection in Children. Tohoku J. exp. Med., 1985, 145 (1), 57-63-A method for rapid indentification of Chlamydia trachomatis (C. trachomatis) from clinical specimens using fluorescein-conjugated monoclonal antibodies was evaluated. Attempts to isolate C. trachomatis by McCoy cell cultures were simultaneously performed. C. trachomatis was isolated from 8 of 62 newborns with neonatal conjunctivitis in tissue culture as compared with 12 positives using monoclonal antibodies. C. trachomatis was isolated from 2 of 7 infants with pneumonia in tissue cultures as compared with 3 positives using monoclonal antibodies. In order to identify either elementary bodies (EB) or reticulate bodies (RB) in clinical specimens, EB and RB of C. trachomatis L2/434 strain were isolated, purified and reacted with monoclonal antibodies. Majority of fluorescence observed in the clinical specimens was considered to be EB.View full abstractDownload PDF (5039K) -
FUMIAKI KOIZUMI, TAKESHI KAWAMURA, AKIRA ISHIMORI, IWAO SASAKI, JIN-IC ...1985 Volume 145 Issue 1 Pages 65-72
Published: 1985
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKOIZUMI, F., KAWAMURA, T., ISHIMORI, A., SASAKI, I. and KAMEYAMA, J. Gastric Acid Secretion, Intraduodenal pH and Gastroenteropancreatic Hormone Release to Bombesin in Antrocolic Transposition Dogs. Tohoku J. exp. Med., 1985, 145 (1), 65-72-The effects of Bombesin on gastric acid secretion from the Heidenhain pouch (HP), intraduodenal pH and gastroenteropancreatic (GEP) hormone levels were compared between 4 dogs with antrocolic transposition (ACT) and 4 non-ACT dogs. Bombesin, infused iv. at a dose of 0.5μg/kg for one hr, produced a significant increase in gastric acid secretion from HP and a decrease in intraduodenal pH in both groups. However, these changes were more marked in ACT dogs. The intravenous infusion of bombesin also produced, in both groups, an increase in the plasma levels of gastrin, secretin, motilin, insulin, glucagon and pancreatic polypeptide (PP) with a different shape of curve for each hormone. Comparison between the two groups showed significantly greater plasma gastrin, secretin and insulin responses, and smaller plasma PP response in ACT dogs than in non-ACT dogs. These results demonstrate that the mechanism of GEP hormone release by bombesin may be complex and hormone responses to infusion of bombesin are influenced in a state of acid hypersecretion induced by ACT.View full abstractDownload PDF (748K) -
SHIGEKI KATAOKA, TAKAO KIKUCHI, TAKAYOSHI TOYOTA1985 Volume 145 Issue 1 Pages 73-84
Published: 1985
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKATAOKA, S., KIKUCHI, T. and TOYOTA, T. Expression of Receptors for Fc Portion of IgM (Fcμ•R) and Surface Neuraminic Acid on the Human Peripheral Lymphocytes. Tohoku J. exp. Med., 1985, 145 (1), 73-84-The purpose of this investigation is to establish a method of quantitation of sialic acid on the lymphocyte membrane surface and to clarify the importance of sialic acid in the functional manifestation of the lymphocyte receptor for the Fc portion of IgM (Fcμ•R) as well as the cell surface. The experiments yielded results leading to the following conclusions: (1) Cell surface sialic acid can be exclusively recovered at consistent rates by treatment of lymphocytes with 0.1 IU of neuraminidase in the presence of Ca++ at 37°C for 30min. (2) The sialic acid obtained, though in minute quantities, was accurately quantitated by the TBA method. (3) By these procedures, the amount of sialic acid present on the cell membrane of human peripheral blood lymphocytes was determined to be 2.46μg/107. (4) Surface sialic acid on lymphocytes cultured at 37°C after treatment with neuraminidase was resynthesized sufficiently at about 6hr. (5) On the cell membrane of lymphocytes deprived of Fcμ•R by treatment with neuraminidase, the receptor for IgM Fc became redetectable following incubation of the cells at 37°C; the time-course of redevelopment of Fcμ•R showed a striking coincidence with that of sialic acid resynthesis. (6) A sufficient redevelopment of Fcμ•R occurred in 6 hr of incubation of neuraminidase-treated Fcμ•R-deprived lymphocytes; the time required for sufficient redevelopment was comparable to that reported for pronase-treated lymphocytes. It is concluded from these findings that Fcμ•R deprived of sialic acid is no longer repaired while the receptor is resynthesized de novo on incubation of lymphocytes under adequate conditions.View full abstractDownload PDF (1099K) -
KUNIAKI ISHII, TERUYUKI YANAGISAWA, KEISUKE SATOH, NORIO TAIRA1985 Volume 145 Issue 1 Pages 85-90
Published: 1985
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSISHII, K., YANAGISAWA, T., SATOH, K. and TAIRA, N. Abolition of Spontaneous Rhythmic Contractions of Isolated Monkey Coronary Arteries by Diltiazem, Nifedipine, Verapamil and Nicorandil but Not by Nitroglycerin. Tohoku J. exp. Med., 1985, 145 (1), 85-90-Three of 12 coronary artery rings obtained from one of 9 rhesus monkeys (Macaca mulatta) (113 rings in all) and 4 of 12 coronary artery rings obtained from one of 2 patas monkeys (Erythrocebus patas patas) (28 rings in all) developed spontaneous rhythmic contractions. In 5 of these 7 coronary artery rings, rhythmic contractions occurred long enough to be subjected to examinations of drug effects. In these preparations the effects of the calcium entry blockers, diltiazem, nifedipine and verapamil, and nicorandil, a nitrate vasodilator thought to produce vasodilatation by an increase in membrane potassium permeability, and nitroglycerin were investigated on rhythmic contractions. Diltiazem (10-7 and 10-6M), nifedipine (10-8 and 10-7M), verapamil (10-7 and 10-6M) and nicorandil (10-5 and 10-4M) suppressed rhythmic contractions in a concentration-dependent manner, but nitroglycerin (10-7-10-5M) was entirely ineffective. The results were discussed in relation to the mechanisms underlying spontaneous rhythmic contractions of coronary arteries and their role in vasospastic angina pectoris.View full abstractDownload PDF (566K) -
EIJI ISHIZAWA, MASAMICHI TADOKORO, SHIGEKAZU SATOH, YASUYUKI SUZUKI, K ...1985 Volume 145 Issue 1 Pages 91-96
Published: 1985
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSISHIZAWA, E., TADOKORO, M., SATOH, S., SUZUKI, Y., HANEDA, K., KAGAWA, Y. and HORIUCHI, T. Mustard Procedure for Simple Transposition of the Great Arteries. Tohoku J. exp. Med., 1985, 145 (1), 91-96-From May 1980 through April 1982, 9 patients underwent the Mustard operation for simple transposition of the great arteries (simple TGA) at the Tohoku University Hospital, Sendai. There was no early postoperative death, although one patient was lost with pulmonary venous obstruction in the late postoperative period. No pulmonary venous obstruction occurred since the introduction of expanded polytetrafluoroethylene (EPTFE) intraatrial baffle. Normal sinus rhythm has been preserved in all patients since direct, high superior vena cava cannulation was adopted. Postoperative hemodynamic study at an average 12 months after surgery revealed normal right ventricular function at rest. Work-function curve which is related to the right ventricular end-diastolic pressure and minute work index revealed good response of the right ventricle in two of three patients after methoxamine infusion test. All late survivors are acyanotic and clinically well. The Mustard procedure has dramatically improved the survival rate and quality of life for those with simple TGA. Presently, we continue to utilize the Mustard procedure for simple TGA until the superiority of other operations are demonstrated.View full abstractDownload PDF (618K) -
TOSHIFUMI TAKABAYASHI, MORISHIGE MURAKAMI, HAJIME YAJIMA, MASASHI TSUJ ...1985 Volume 145 Issue 1 Pages 97-101
Published: 1985
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTAKABAYASHI, T., MURAKAMI, M., YAJIMA, H., TSUJIEI, M., OZAWA, N. and YAJIMA, A. Influence of Maternal Antibody Anti-Jra on the Baby: A Case Report and Pedigree Chart. Tohoku J. exp. Med., 1985, 145 (1), 97-101-A Jr(a-) female (proposita) who has developed anti-Jra during her second pregnancy and her pedigree chart are reported. The antibody anti-Jra of the proposita and her baby was determined to be IgG and was eluted from their red cells. The baby's bilirubin rose to a peak on day 4 without clinical problem except for prophylactic phototherapy carried out. Two other examples of Jr(a-) blood type were detected in her elder siser and the first baby of the proposita with investigation of her pedigree chart.View full abstractDownload PDF (373K) -
HIDEMI YAMAUCHI, KAZUNORI TAKEDA, MAKOTO SUNAMURA, KIKUO MIYAGAWA, SCH ...1985 Volume 145 Issue 1 Pages 103-104
Published: 1985
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSYAMAUCHI, H., TAKEDA, K., SUNAMURA, M., MIYAGAWA, K., MATSUBARA, S., ASANUMA, Y. and SATO, T. Effect of Plasma Exchange on Acute Pancreatitis. Tohoku J. exp. Med., 1985, 145 (1), 103-104-Plasma exchange was performed in dogs with acute experimental pancreatitis to examine clearance of pancreatic enzymes. Plasma exchange of about 1.6 liters reduced levels of serum amylase, lipase, and phospholipase A2 in a graded fashion down to about 50%. Plasma exchange of 4 liters in a patient with severe pancreatitis produced similar clearance curves of amylase, lipase, trypsin and elastase levels.View full abstractDownload PDF (215K)
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