巻号一覧
154 巻 (1988)
- 4 号 p. 315-
- 3 号 p. 215-
- 2 号 p. 95-
- 1 号 p. 1-
154 巻, 3 号
選択された号の論文の10件中1～10を表示しています
- |<
- <
- 1
- >
- >|
-
NORIYOSHI NAGAMOTO, YASUKI SAITO, HIDEICHI SUDA, TADASHI IMAI, MASAMI ...1988 年 154 巻 3 号 p. 215-231
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーNAGAMOTO, N., SAITO, Y., SUDA, H., IMAI, T., SATO, M., OHTA, S., KANMA, K., SAGAWA, M., TAKAHASHI, S., USUDA, K., NAKADA, T., SATO, H. and HASHIMOTO, K. Roentgenographically Occult Bronchogenic Carcinoma of Non-Polypoid Type: Histological Patterns of Longitudinal Growth within the Bronchus. Tohoku J. exp. Med., 1988, 154 (3), 215-231-Microscopy of the serial block-sections of the entire bronchial tree of all the resected specimens of roentgenographically occult bronchogenic carcinoma revealed new findings with respect to the histological patterns of longitudinal growth within the bronchial wall. Twenty-seven lesions which were non-polypoid on gross appearance with longitudinal extension of 16 mm and above were classified into the following four categories. (A) In standard superficial extension, transmural invasion by carcinoma became shallower and the area involved on section became smaller gradually from the site of the origin of carcinoma to the proximal and distal ends. (B) In intraepithelial extension, carcinoma was confined within the epithelium throughout the bronchi involved except at and near the site of the origin at which it penetrated the basement membrane. (C) In lymphatic extension, carcinoma extended from the site of the origin to the proximal and distal ends in a dual pattern so that it extended longitudinally within the epithelium in parallel with an invasion into the lymphatic vessels in the lamina propria and submucosa. At the site of the origin carcinoma invaded down to the level of the submucosa or adventitia. (D) In massive extension, a massive invasion by carcinoma from the site of the origin to the proximal and distal ends, and a simultaneous invasion and destruction by carcinoma of the epithelium, basement membrane, lamina propria, submucosa, and of adventitia in places were demonstrated. There was no marked difference in bronchoscopic finding among (A), (B) and (C). The length of the lesion as estimated by histology was different from that observed at bronchoscopy. Bronchoscopic examination was not always successful in determining the line of resection precisely. Therefore it is indispensable to examine frozen sections and/or imprint specimens of the margin of resection.抄録全体を表示PDF形式でダウンロード (18340K) -
AKIRA ISHIDA, GORO TAKADA, YASUKO KOBAYASHI, ITARU TOYOSHIMA, KATSUJI ...1988 年 154 巻 3 号 p. 233-239
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーISHIDA, A., TAKADA, G., KOBAYASHI, Y., TOYOSHIMA, I. and TAKAI, K. Effect of Tetrahydrobiopterin and 5-Hydroxytryptophan on Hereditary Progressive Dystonia with Marked Diurnal Fluctuation: A Suggestion of the Serotonergic System Involvement. Tohoku J. exp. Med., 1988, 154 (3), 233-239-A daughter and her mother developed hereditary progressive dystonia with marked diurnal fluctuation (HPD) at the age of 4 and 34, respectively. L-Dopa, tetrahydrobiopterin (BH4) or 5-hydroxytryptophan (5-HTP) was orally administered to them. L-Dopa cured completely their symptoms. 5-HTP as well as BH4 improved their symptoms, especially dystonic movements. Biopterin and 5-hydroxyindoleacetic acid concentrations in CSF increased during BH4 medication. These findings suggest that the serotonergic system of the central nervous system might play some role in the pathogenesis of dystonia in HPD.抄録全体を表示PDF形式でダウンロード (498K) -
RYUICHI NAKAMURA, TAKETOSHI HANDA, SAYURI WATANABE, ISAMU MOROHASHI1988 年 154 巻 3 号 p. 241-244
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーNAKAMURA, R., HANDA, T., WATANABE, S. and MOROHASHI, I. Walking Cycle after Stroke. Tohoku J. exp. Med., 1988, 154 (3), 241-244-Temporal-distance parameters of gait, maximum walking speed, walking rate and stride length, were successively examined in 10 hemiparetic stroke patients for 8 weeks after starting gait training. In patients with walking speed less than 20m/min i.e., walking rate less than 90 steps/min, the increase of walking speed was significantly related to that of walking rate and stride length. In patients with walking speed greater than 20m/min, the increase of walking speed correlated only to that of stride length, indicating that a limiting factor of walking speed in hemiparetic patients was the decreased stride length.抄録全体を表示PDF形式でダウンロード (335K) -
YUYA ABE, KUNIHIRO OKAMURA, YOICHI HAMAZAKI, YUICH WADA, AKIRA YAJIMA1988 年 154 巻 3 号 p. 245-251
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーABE, Y., OKAMURA, K., HAMAZAKI, Y., WADA, Y, and YAJIMA, A. Human Cytotrophoblastic Antigens Defined by Monoclonal Antibodies. Tohoku J. exp. Med., 1988, 154 (3), 245-251-Monoclonal antibodies have been raised against cytotrophoblast. Two different antigens, defined on cytotrophoblast but not on syncytiotrophoblast were designated ACT-1 and ACT-2, respectively. Chorionic villi were taken from normal early pregnancy and processed for immunization by two different procedures. ACT-1 was demonstrated to be present in lung alveolar cells, endothelial mucosa of the jejunum, colon, ureter, urinary bladder and the fallopian tube, and endometrial gland of the pregnant uterus. On the other hand, ACT-2 was present in the endothelial mucosa of the stomach, endothelium of the renal vessel, and the decidua of the pregnant uterus. Although the monoclonal antibodies did not react with such established cell lines as Bewo, SCH, OVK-18, HHUA, MK-01, FL, BHK and P3×63Ag 8•653, they did react with some of the cell lines when the cell membrane was destroyed with Triton X-100. Each antibody, therefore, may recognize the antigen not on the cell membrane but in the cytoplasm. The atigens might be shed or may disappear in the process of differentiation from cytotrophoblast to syncytiotrophoblast.抄録全体を表示PDF形式でダウンロード (1295K) -
YUICHI WADA, AKIRA TSUIKI, TAKAO FUKAYA, OSAMU SHINKAWA, SHINJI SATOH, ...1988 年 154 巻 3 号 p. 253-260
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーWADA, Y., TSUIKI, A., FUKAYA, T., SHINKAWA, O., SATOH, S., HORIGUCHI, M., HOSHIAI, H. and YAJIMA, A. Effects of Androgen on 17β-Estradiol Production by Cultured Human Granulosa Cells. Tohoku J. exp. Med., 1988, 154 (3), 253-260 -In order to determine whether androgen acts solely as a substrate for aromatization or whether it also influences on the activity of aromatase enzyme, human granulosa cells were incubated in vitro with or without androgen. Although basal production of 17β-estradiol (E2) in cultured granulosa cells obtained from follicles about 26hr after the initiation of the LH surge was restricted in small quantities, a marked increase in E2 production occurred in the presence of testosterone (T) (10-6M) as aromatizable substrate. The non-aromatizable androgen, 5α-dihydrotestosterone (DHT) (10-7M, 10-6M), slightly enhanced E2 production and it did not inhibit T aromatization in these cells. By contrast, DHT did not increase E2 production in granulosa cells obtained from follicles 2-5 days before the LH surge. The results indicate that androgen can enhance the estrogen biosynthesis of granulosa cells obtained from follicles during the LH surge not only by acting as a substrate for aromatization but also by participating in some process of the estrogen synthesis. This effect of androgen was not clearly seen in granulosa cells obtained before the LH surge, suggesting that the response of granulosa cells to exogenous androgen varies with the stage of the cell differentiation.抄録全体を表示PDF形式でダウンロード (735K) -
TAKASHI YOHKAICHIYA, HIROSHI HOSHIAI, AKIRA YAJIMA1988 年 154 巻 3 号 p. 261-269
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーYOHKAICHIYA, T., HOSHIAI, H. and YAJIMA, A. Fibronectin Localization in the Mouse Embryo from the Blastocyst Stage to the Egg Cylinder Stage In Vitro. Tohoku J. exp. Med., 1988, 154 (3), 261-269 - Fibronectin has the characteristics of adhesiveness and cell migration promotion which may play important roles in embryo implantation. Using the direct and indirect immunofluorescence techniques, we found fibronectin on the blastocyst, and the trophoblast cells of the egg cylinder stage embryo, especially at the sites of cell spreading, as well as the inner cell mass. The results show that (i) fibronectin is used for the initial cell attachment to the plastic dish, and (ii) during the course of embryo growth in vitro, the trophoblast cells spread over the plastic dish in the area of cells which contain many granules of fibronectin.抄録全体を表示PDF形式でダウンロード (8413K) -
SHOUKAKU HASHIMOTO, TAKURO OGATA1988 年 154 巻 3 号 p. 271-283
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーHASHIMOTO, S. and OGATA, T. Blood Vascular Organization of the Human Appendix: A Scanning Electron Microscopic Study of Corrosion Casts. Tohoku J. exp. Med., 1988, 154 (3), 271-283 - Blood vascular beds of the human appendix were reproduced with a methacrylate casting medium and observed with a scanning electron microscope. The appendix received some small afferent arterial branches of the appendicular artery. These small arterial branches pierced the muscular layer and reached the submucosal plexus. Small arterioles arising from this plexus, climbed the mucosa and formed honeycomb-like capillary meshes at the luminal surface level. These capillaries were drained by the collecting veins, which descended the mucosa and joined the submucosal plexus. The large efferent veins arising from the submucosal plexus passed through the muscular layer and continued with the appendicular vein. In the mucosal and submucosal layers, several spherical basket-like casts of the germinal center (lymphoid follicle) were seen. In the parafollicular region (primary follicle), casts of postcapillary venules with prominent surface undulations were relatively frequently observed.抄録全体を表示PDF形式でダウンロード (19129K) -
YASUKO KOBAYASHI, YUSAKU TAZAWA, MICHIKO NAKAGAWA, OTOTAKA HIGASHI, TO ...1988 年 154 巻 3 号 p. 285-296
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーKOBAYASHI, Y., TAZAWA, Y., NAKAGAWA, M., HIGASHI, O. and YAMAMOTO, T.Y. Ultrastructural Abnormalities in the Skeletal Muscle of Children with Chronic Cholestasis and a Long-Term Vitamin E Replacement. Tohoku J. exp. Med., 1988, 154 (3), 285-296 - We investigated the effects of long-term oral and intramuscular vitamin E repletion in children with chronic cholestasis. Clinical improvement or supression of neuromuscular involvement after adequate vitamin E repletion was demonstrated. Light and electron microscopic abnormalities of the skeletal muscle, however, did not completely disappeared despite the correction of the biochemical abnormalities for more than 3 years. The muscle fibers showed less variety of pathologic features than before vitamin E repletion. Inclusions observed in the skeletal muscle fibers before vitamin E treatment were still observed in subsarcolemmal cytoplasm and the perinuclear regions. They were more irregularly curved and consisted of various substances. Similar inclusions were also observed in Schwann cells, perineural cells, fibroblasts, pericytes, endothelial cells and smooth muscle cells of intramuscular vessels. Although the external lamina was not disrupted, separation of the external lamina from the plasma membrane and multilayered external lamina were often observed. The nerves among muscle fibers still showed degenerative features. Morphological changes of the skeletal muscle during vitamin E therapy have not so far been reported in cases of chronic cholestasis. We discuss the relationship of these findings to vitamin E replacement in children with chronic cholestasis.抄録全体を表示PDF形式でダウンロード (9855K) -
RYUICHI SANO, RYUZO ABE, SHIN-ICHI OIKAWA, YUTAKA FUJII, SABURO HORI, ...1988 年 154 巻 3 号 p. 297-303
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーSANO, R., ABE, R., OIKAWA, S., FUJII, Y., HORI, S., SUZUKI, N., TOYOTA, T. and GOTO, Y. Apolipoprotein E Phenotypes of Normo- and Hyperlipoproteinemia in Japanese. Tohoku J. exp. Med., 1988, 154 (3), 297-303 - Apolipoprotein E phenotypes of normo- and hyperlipoproteinemia in Japanese were examined by the disc gel isoelectric focusing technique, which was modified according to the method of Kashyap et al. (1981). Apoprotein E isoproteins were clearly separated by this method. Six phenotypes (E2/2, E3/3, E4/4, E2/3, E2/4 and E3/4) were determined in 107 cases of normolipoproteinemia and 75 cases of hyperlipoproteinemia. In normolipoproteinemia, apoE phenotype frequencies were similar to those of the Japanese and Caucasian populations which were reported previously. In hyperlipoproteinemia, a higher frequency of phenotype E2/2 and a lower frequency of E3/3 were observed. The apo E phenotypes of type IIa and IIb were distributed similarly to that of normal subjects. In contrast, only 27.8% of type IV patients had E3/3 phenotype. Among type V patients 64.3% was homozygous or heterozygous for E-4, and only 14.3% was homzygous for E-3 (E3/3). The results suggest that the apolipoprotein E phenotypes are similarly distributed among different human races and the apolipoprotein E phenotypes could be one of the etiological factors associated with some types of hyperlipoproteinemia.抄録全体を表示PDF形式でダウンロード (785K) -
TOMOKO KUTSUZAWA, HAJIME YAMABAYASHI1988 年 154 巻 3 号 p. 305-314
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーKUTSUZAWA, T. and YAMABAYASHI, H. Kinetics of Mixed Venous Oxygen Tension during Rhythmic Contraction of the Hindlimb of Dogs. Tohoku J. exp. Med., 1988, 154 (3), 305-314 - Change in mixed venous oxygen tension (PvO2) during transition from rest to exercise induced by rhythmic contractions of the hindlimb of dogs was continously monitored using intravascular oxygen electrodes. The rapid fall in PvO2, on the average 9.5sec after the onset of rhythmic contraction, was found. The time course of change in PvO2 was not altered by ligation of the splenic artery and vein. Oxygen tension of venous blood in the superior vena cava and the inferior vena cava was monitored in order to elucidate the mechanism of rapid fall in PvO2 following induced exercise. Oxygen tension of venous blood in the superior vena cava did not fall at the onset of contraction. Oxygen tension of venous blood in the distal and proximal end of the inferior vena cava began to fall at 4.4sec and at 6.9sec after the onset of contraction on the average, respectively. There was no significant difference between the hematocrit of mixed venous blood at rest and after 15sec of exercise. These findings suggest that the rapid fall of PvO2 results from a surge of low oxygenated blood from the exercising hindlimb and that this change in blood gas tensions possibly reaches the lung within 10sec after the onset of exercise.抄録全体を表示PDF形式でダウンロード (867K)
- |<
- <
- 1
- >
- >|