巻号一覧
155 巻 (1988)
- 4 号 p. 305-
- 3 号 p. 213-
- 2 号 p. 107-
- 1 号 p. 1-
155 巻, 4 号
選択された号の論文の13件中1～13を表示しています
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PETER SKOV OLSEN, KIM THERKELSEN, STEEN SEIER POULSEN1988 年 155 巻 4 号 p. 305-310
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーSKOV OLSEN, P., THERKELSEN, K. and POULSEN, S.S. Effect of Omeprazole and Cimetidine on Healing of Chronic Gastric Ulcers and Gastric Acid Secretion in Rats. Tohoku J. exp. Med., 1988, 155 (4), 305-310 - The effect of omeprazole and cimetidine on healing of chronic gastric ulcers and gastric acid secretion was investigated in rats. The effect of three doses of omeprazole given orally once daily for 25 days was investigated. In controls median ulcer healing was 19.6% after 25 days. Omeprazole increased median ulcer healing from 36% at 145 μmole/kg/day to 80% at 580μmole/kg/day. Basal and pentagastrin stimulated gastric acid secretion decresed dose-dependently by nearly 90% at a dose of 580 jimole/kg/day 22-24hr after the last dose of omeprazole. Cimetidine given twice daily, in a dose that initially inhibits gastric acid secretion by 95%, reduced acid secretion by only 50% 11hr after the last dose. Median ulcer healing after treatment with cimetidine for 25 days was 41%. This study demonstrates that omeprazole has a more longacting inhibitory effect on gastric acid secretion compared to cimetidine and accelerates healing of chronic gastric ulcers dose-dependently in rats抄録全体を表示PDF形式でダウンロード (631K) -
HIRONAKA KAWASAKI, HIROAKI WATANABE, SADAKO YAMADA, KAZUHIKO WATANABE, ...1988 年 155 巻 4 号 p. 311-318
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーKAWASAKI, H., WATANABE, H., YAMADA, S., WATANABE, K. and SUYAMA, A. Prognostic Significance of Urinary Neopterin Levels in Patients with Hepatocellular Carcinoma. Tohoku J. exp. Med., 1988, 155 (4), 311-318 - Urinary neopterin levels were measured by high-performance liquid chromatography in 15 patients with liver cirrhosis, 18 patients with hepatocellular carcinoma and 20 normal subjects. The mean levels of urinary neopterin in patients with hepatocellular carcinoma were significantly elevated (p<0.01) compared to those in cirrhotics and normal subjects, but did not significantly differ between cirrhotics and normal subjects. Urinary neopterin levels correlated significantly with tumor size in patients with hepatocellular carcinoma but not with serum α-fetoprotein. Hepatocellular carcinoma patients with high urinary neopterin levels appeared to have more serious hepatic dysfunction than those with normal urinary neopterin levels, and moreover, there was a significant difference (p<0.05) in survival between the two groups. These findings suggest that urinary neopterin excretion may be a good biochemical marker to assess the progression of tumor and a useful prognostic indicator in patients with hepatocellular carcinoma.抄録全体を表示PDF形式でダウンロード (752K) -
KATSUHIRO ENDO, AKIRA TSURUI, HIKARU WATANABE, TSUNEAKI SATO, AKIRA UN ...1988 年 155 巻 4 号 p. 319-325
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーENDO, K., TSURUI, A., WATANABE, H., SATO, T., UNOURA, A., KAYAMA, T. and NAMIKI, T. A Case Report of a “Necrotizing” Entero-Colo-Proctitis in the Adult. Tohoku J. exp. Med., 1988, 155 (4), 319-325 - We experienced a patient who died of diarrhea after an operation for glioblastoma. The mucosa of the small and large intestines were entirely denudated. Although the etiology is not clear, this case is supposed to be a very rare one of “necrotizing” enterocolitis in the adult occuring after an operation on a brain tumor.抄録全体を表示PDF形式でダウンロード (8174K) -
SHINSUKE YOSHIMURA, KOROKU HASHIMOTO1988 年 155 巻 4 号 p. 327-333
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーYOSHIMURA, S. and HASHIMOTO, K. Role of Endogenous Beta-Adrenergic Mechanism in the Pathogenesis of Spontaneous Myocardial Fibrosis in Rats. Tohoku J. exp. Med., 1988, 155 (4), 327-333 - The role of endogenous beta-adrenergic activation in the pathogenesis of spontaneous myocardial fibrosis was investigated in male and female Sprague-Dawley (SD) rats. For the purpose of blocking endogenous beta-adrenergic activities, atenolol, a beta-adrenergic blocking a agent, was given at 20, 80 and 320mg/kg/day mixed in the diet for 12 months. The transverse sections of the ventricles including the vulnerable region for spontaneous myocardial fibrosis was stained by Azan-Mallory method for collagen fibers and examined morphometrically, while being compared with the histological findings from standard hematoxylin-eosin procedure. The fibrosis was graded into 4 classes and compared between nontreated groups and treated groups of both sexes. Fibrous foci developed principally in the subendocardial myocardium. Atenolol failed to produce significant systemic toxic effects not only on weight gains and daily intakes of food but also on death rates. Atenolol did not prevent development of myocardial lesions in both sexes, whereas it significantly promoted fibrosis in the medium and high dose groups of male rats but not at any dose levels in female animals. It is suggested that endogenous beta-adrenergic activation plays no major role in the onset or development of spontaneous myocardial lesions, whereas the adrenergic system may probably control collagen synthesis in myocardial fibrosis.抄録全体を表示PDF形式でダウンロード (653K) -
KUNIHIRO OKAMURA, TOMOMI TAKAHASHI, KOZO AKAGI, SHINGO TANIGAWARA, YOS ...1988 年 155 巻 4 号 p. 335-342
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーOKAMURA, K., TAKAHASHI, T., AKAGI, K., TANIGAWARA, S., SHINTAKU, Y., WATANABE, T., ENDOH, H. and YAJIMA, A. Three Gases of Fetal Ascites with Successful Outcome and Seven Year Evaluation of NIHF: 1981-1987. Tohoku J. exp. Med., 1988, 155 (4), 335-342 - Three pregnant women with fetal ascites were admitted to our hospital at 30, 32 and 33 weeks of gestation on diagnosis by sonogram. On sonogram, all the fetuses were initially with marked ascites but without any pleural or pericardial effusion or subcutaneous edema. Under obser-vation by sonogram and cardiotocogram, obstetrical intervention was performed by cesarean section in all 3 cases ; at 31 weeks of gestation due to notably increased ascites, at 32 weeks due to fetal distress and at 35 weeks due to development of subcutaneous edema, respectively, and the subsequent courses were uneventful. On the other hand, in our precious experience with 21 cases of NIHF over a period of 7 years, only 2 babies with NIHF have been born alive. We think fetal ascites should be considered an initial sign of NIHF and the successful outcome of these three cases were due to early diagnosis by frequent sonographic examination.抄録全体を表示PDF形式でダウンロード (2754K) -
TERUYUKI TAKAMATSU, NORIMASA YASUDA, TATSUHARU OHNO, TADASHI KANOH, HA ...1988 年 155 巻 4 号 p. 343-347
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーTAKAMATSU, T., YASUDA, N., OHNO, T., KANOH, T., UCHINO, H. and FUJISAWA, A. Soluble Interleukin-2 Receptors in the Serum of Patients with Chronic Renal Failure. Tohoku J. exp. Med., 1988, 155 (4), 343-347 - The levels of soluble form of the interleukin-2 receptor (sIL-2R) were evaluated in the peripheral blood of 29 patients with chronic renal failure (CRF) using enzyme-linked immunosorbent assay. All patients had undergone hemodialysis and the mean (±S.D.) BUN level before hemodialysis was 80.9±22.4mg/100ml. The mean level of sIL-2R was 1146±258U/ml, which was significantly higher than the level (288±118U/ml) in 12 individuals with a normal BUN level (p=0.01). In patients with CRF, the elevated sIL-2R level was not influenced by hemodialysis, and not correlated with creatinine or 2-microglobulin levels. The kidneys may play an important role in the catabolism of serum sIL-2R. The elevated sIL-2R level may be related to compromised immunoregulation in CRF.抄録全体を表示PDF形式でダウンロード (419K) -
YUSAKU TAZAWA, YOSHIO NUMAZAKI1988 年 155 巻 4 号 p. 349-354
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーTAZAWA, Y. and NUMAZAKI, Y. Cytomegalovirus Infection in Acute Respiratory Tract Disease Accompaning Hepatitis in Infancy. Tohoku J. exp. Med., 1988, 155 (4), 349-354 - To elucidate relationship between acute respiratory tract diseases (ARTD) accompaning hepatitis and cytomegalovirus (CMV) infection in infancy, 74 full-term inpatients with ARTD and 34 control patients without ARTD or hepatitis were subjected to this study. By determining specific antibodies to CMV, IgG early antigen (IgG EA) and IgM membrane antibody (IgM MA) which are markers of active CMV replication, the following results were obtained. Thirty-one (41%) of the 74 patients with ARTD and 12 of the 34 control group (35%) had significant IgG EA (≥1:8). The geometric mean reciprocal titer in the group with ARID (1:33.0) was higher than that in the control group (1:15.3). On the other hand, while 6 of the 74 patients with ARTD (8%) had significant IgM MA (≥1:8), none of the control group had positive IgM MA. Out of the 74 patients with ARTD, 8 (10%) patients, all except one being younger than 2-month-old, also had hepatitis. Of the 8 patients with hepatitis, 6 (75%) had significant IgG EA. The geometric mean reciprocal titer of the patients with hepatitis was higher than that of the patients without hepatitis, the titer being 1:42.6 and 1:30.7, respectively. On the other hand, 3 of the 8 patients with hepatitis (37%) had significant IgM MA while only 3 of the 66 patients without hepatitis (4.5%) had IgM MA. The frequencies of IgM MA between two groups were significantly different (p<0.05). CMV infection may be involved in some infants with ARTD, particularly in younger infants with both of ARTD and hepatitis.抄録全体を表示PDF形式でダウンロード (514K) -
KOICHI TABAYASHI, MASAO ENDO, MITUAKI SADAHIRO, TAKASHI ITO, KIYOSHI H ...1988 年 155 巻 4 号 p. 355-361
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーTABAYASHI, K., ENDO, M., SADAHIRO, M., ITO, T., HANEDA, K., SUZUKI, Y. and MOHRI, H. Assessment of Left Ventricular Function in Patients with Mitral Regurgitation: Value of the Forward Ejection Fraction. Tohoku J. exp. Med., 1988, 155 (4), 355-361 - This study was aimed at assessing the value of preoperative forward ejection fraction (FEF) and corrected forward ejection fraction (CFEF) as an index of postoperative myocardial function. Utilizing 34 patients with mitral regurgitation, usefulness of the preoperative FEF and CFEF was evaluated with special reference to incidence of postoperative low output syndrome (LOS) and improvement in the New York Heart Association (NYHA) classification, comparing other indices of left ventricular function such as cardiac index (CI), stroke index (SI), left ventricular end-diastolic volume index (LVEDVI) and left ventricular end-systolic volume index (LVESVI). There was a significant correlation between FEF and CI, SI, LVEDVI or LVESVI, and between CFEF and CI, SI, LVEDVI or LVESVI. The FEF and CFEF, however, were better indicators for predicting the occurrence of postoperative LOS than EF. Postoperative improvements in the NYHA classification were parallel to that of the FEF and CFEF changes, but did not coincide with that of the EF. Based on these findings, it is concluded that FEF and CFEF are more useful indicators than EF for evaluation of left ventricular myocardial performance in patients with mitral regurgitation.抄録全体を表示PDF形式でダウンロード (612K) -
ATSUSHI KANNO, HIROSHI SUZUKI, YUTAKA MIYAZAKI, SCHUICHI SATO, MASAO O ...1988 年 155 巻 4 号 p. 363-371
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーKANNO, A., SUZUKI, H., MIYAZAKI, Y., SATO, S., OTSUKI, M., GOTO, Y. and OHORI, H. Severe Acute Exacerbation in Chronic Hepatitis B Virus Infection in Sendai, Japan. Tohoku J. exp. Med., 1988, 155 (4), 363-371 - In order to examine the clinical features of severe acute exacerbation in chronic hepatitis B virus (HBV) infection, 297 hepatitis B surface antigen (HBsAg) carriers were followed for 35±22 months (mean±S.D.) in Tohoku University Hospital from 1976 to 1987. Of these, 10 experienced severe acute exacerbation with hepatic decompensation. All of these patients had intense subjective symptoms related to the hepatitis. They were all icteric and 8 had ascites. Three developed to fulminant hepatic failure, eventually died. Histology after the exacerbation showed severe hepatic damage such as massive hepatic necrosis and bridging hepatic necrosis in a half of them. Six cases were suspected to result from spontaneous reactivation and 2 from drug-induced reactivation of chronic HBV infection, and the other 2 from superinfection with non-A, non-B hepatitis agent (s). These results suggest that the reactivation of chronic HBV infection is an important factor of severe acute exacerbations in chronic HBV infection in Japan.抄録全体を表示PDF形式でダウンロード (1652K) -
KUNIAKI TAKAHASHI, AKIRA HARA, TETSUAKI KAWASE, JUN KUSAKARI, TOMONORI ...1988 年 155 巻 4 号 p. 373-377
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーTAKAHASHI, K., HARA, A., KAWASE, T., KUSAKARI, J. and TAKASAKA, T. Relation of Prognosis of Peripheral Facial Nerve Palsy to the Period between Onset of Illness and Date of Denervation. Tohoku J. exp. Med., 1988, 155 (4), 373-377 - The presence or absence of the denervation is one of the important factors to determine the prognosis of peripheral facial nerve palsy and it is generally accepted that the denervation becomes apparent within 2 weeks from the onset of illness. In the present study, 62 cases with denervation in which nerve excitability test (NET) was possible within 1 week from the onset of illness were selected for analysis. Although 47 cases exhibited the denervation within 2 weeks, it was first detected after 2 weeks in other 15. Although the prognosis was far better in the latter group, 2 cases exhibited the unfavorable recovery. These results indicate the importance of NET even 2 weeks after the onset of illness.抄録全体を表示PDF形式でダウンロード (405K) -
KAZUHIRO TAKAHASHI, NORIAKI ANDOH, TORAICHI MOURN, NOBUAKI SASANO1988 年 155 巻 4 号 p. 379-383
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーTAKAHASHI, K., ANDOH, N., MOURI, T. and SASANO, N. Distribution of Crooke's Cells and ACTH Cells in the Human Pituitary Glands. Tohoku J. exp. Med., 1988, 155 (4), 379-383 - Distribution of ACTH cells and Crooke's cells in the human pituitary glands was studied in 5 autopsy cases. ACTH cells were distributed throughout the anterior pituitary lobes, in particular densely in their anterior halves. Some ACTH cells were found in the posterior pituitary lobes in three cases. Crooke's cells were distributed limitedly in the anterior halves of anterior pituitary in two cases. In the remaining three cases, Crooke's cells were widely distributed in the anterior pituitary lobes but predominantly in their anterior halves. No Crooke's cells were found in the posterior pituitary. These findings suggest that cells in the anterior part of anterior pituitary are more likely to show Crooke's hyaline change than those in the other parts.抄録全体を表示PDF形式でダウンロード (439K) -
MASAHARU YAMAMOTO, JUNKO MAGARA, SHUKO TAKAGI, NORIO SHIBUYA, WEISHI C ...1988 年 155 巻 4 号 p. 385-386
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーYAMAMOTO, M., MAGARA, J., TAKAGI, S., SHIBUYA, N., CHEN, W. and ENDOH, K. Activity of Agricultural Chemicals to Modify Mitomycin C Induced Growth Inhibition of Bacillus subtilis in the Rec Assay. Tohoku J. exp. Med., 1988, 155 (4), 385-386 - Rec assay of agricultural chemicals, MCPA-E, MCPA, CNP and PCNB was conducted. It was found that MCPA-E and MCPA accelerated the growth-inhibition originally induced by Mitomycin C in the rec- strain.抄録全体を表示PDF形式でダウンロード (206K) -
TAKASHI SATO1988 年 155 巻 4 号 p. 387-388
発行日: 1988年
公開日: 2006/08/31
ジャーナル フリーSATO, T. Sequentially-Occurring Transmission of Hepatitis A in a Family. Tohoku J. exp. Med., 1988, 155 (4), 387-388 - Most hepatitis A infections are acquired through sporadic transmission and it has been suggested that the intraf amilial spread of HAV is important in most sporadic outbreaks. An intra-household outbreak of hepatitis A involving three cases occurring sequentially is reported.抄録全体を表示PDF形式でダウンロード (176K)
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