The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
160 巻, 1 号
選択された号の論文の10件中1~10を表示しています
  • TAKASHI KURATA, TETSURI KONDO, YOSHIHIRO HAYASHI, YASUYO OHTA, HAJIME ...
    1990 年 160 巻 1 号 p. 1-9
    発行日: 1990年
    公開日: 2006/08/31
    ジャーナル フリー
    KURATA, T., KONDO, T., HAYASHI, Y., OHTA, Y. and YAMABAYASHI, H. Continuous Positive Airway Pressure Breathing in Supine and Upright Postures. Tohoku J. Exp. Med., 1990, 160 (1), 1-9-Continuous positive airway pressure (CPAP) breathing of 10cmH2O was applied to 10 healthy conscious subjects both in supine and 70 degree head-up postures. CPAP increased the end-expiratory lung volume from 2.44±0.66 (S.D.) to 3.07±0.68 liters in supine subjects, and from 3.01±0.57 to 3.64±0.57 liters in head-up subjects. During CPAP, rib cage motion became predominant when compared to abdominal motion in upright posture. Among the respiratory parameters, inspiratory duration was significantly shortened during CPAP in either posture, but was changed less significantly by individual posture change alone. Mean inspiratory flow decreased during CPAP only in upright posture. Abdominal muscles were recruited for expiration during CPAP in either posture, and the EMG recorded from the lower intercostal space developed inspiratory activity during CPAP in head-up posture. All of 10 subjects felt most dyspneic during CPAP with the head-up. We conclude that the mechanism of increase in lung volume during CPAP is mediated by different pathway from that of posture change, and that CPAP in upright posture can alter the respiratory pattern of the subject.
  • HARUO NAKATSUKA, HIROSHI SATOH, TAKAO WATANABE, MASAYUKI IKEDA
    1990 年 160 巻 1 号 p. 11-17
    発行日: 1990年
    公開日: 2006/08/31
    ジャーナル フリー
    NAKATSUKA, H., SATOH, H., WATANABE, T. and IKEDA, M. Possible Urban- Rural Difference in Habitus of School Children in Sendai. Tohoku J. Exp. Med., 1990, 160 (1), 11-17-Right after a large-scale merge involving 2 cities and 2 towns in 1987-1988 to form an enlarged city of Sendai, the body habitus of school children (in the 6th year-grade in primary schools and 3rd year-grade in junior high schools) were compared among the 4 regions (called by the pre-merge names of Akiu, Izumi, Miyagi and Sendai). The analysis showed that primary school boys in Sendai are taller and heavier than the boys in Izumi, and Izumi boys are heavier than Akiu boys. In junior high schools, Izumi girls are taller than Sendai girls with smaller Rohrer's and Quetlet's index. The observation indicates that the difference in body habitus is present in agreement with variation in the extent of urbanization in the regions.
  • SHIGEICHI SHOJI, TERUO FUJIMOTO
    1990 年 160 巻 1 号 p. 19-35
    発行日: 1990年
    公開日: 2006/08/31
    ジャーナル フリー
    SHOJI, S. and FUJIMOTO, T. Induction of Recurrent Glomerulitis with Accentuated Glomerular Lobulation by Intermittent Repetition of Unilateral Masugi Nephritis. Tohoku J. Exp. Med., 1990, 160 (1), 19-35-In order to induce a glomerulitis with lobular features, antirabbit renal glomerular basement membrane hen serum was intravenously injected into rabbits repeatedly at intervals of 3 weeks, during the course of clamping of contralateral renal arteries for 20min. The first injection induced disorganization of the glomerular architecture accompanied by proliferation of local fixed cells and following crowding of the proliferated cells towards the axis of the loops and peripheral recanalization which brought about a lobular appearance of glomerulus. And the repeated injections induced repetition of such processes, resulting in accentuation or exaggeration of the lobular features of the glomeruli. The glomerular lesions presented here resembled closely to those of human lobular glomerulonephritis. Accordingly, the results of this study will offer some clue to understanding of the genesis of the human glomerular disease.
  • MASAKI MORIYAMA, SHIN-ICHI MATSUBARA, HIROSHI SAITO, KOKICHI IWATA
    1990 年 160 巻 1 号 p. 37-46
    発行日: 1990年
    公開日: 2006/08/31
    ジャーナル フリー
    MORIYAMA, M., MATSUBARA, S., SAITO, H. and IWATA, K. Community People's Preference of Hand Drawn Face Graph as a Health Informing Device. Tohoku J. Exp. Med., 1990, 160 (1), 37-46-Although the cartoon of a face is an effective device to visualize the image of numerical indices, its use is not popular among community health personnel. In the present study, we used the face graph as an aid for health informing and educating activities in the setting of a community health activity. For this purpose, we designed a special sheet to draw face by hand. By using this sheet, each person can draw his/her 'face' from one's laboratory data index under the guidance of additional lines. The acceptability of this hand drawn face was evaluated by 283 people aged 65 years and over at a health counseling session. For both men and women, a higher percentage preferred face (37% for men, 40% for women) over numeral (23% for men, 17% for women). The preference for the face graph was also observed at each of three age groups within each sex. The highest affinity to face (64%) was observed for the 14 women who reported as cataract patients.
  • WEISHI CHEN
    1990 年 160 巻 1 号 p. 47-54
    発行日: 1990年
    公開日: 2006/08/31
    ジャーナル フリー
    CHEN, W. Changes of Mercury Contents in Hair of Chinese Scholars after They Came to Japan. Tohoku J. Exp. Med., 1990, 160 (1), 47-54-In April 1988, 49 Chinese scholars came to Japan for one year medical training. Their hair samples were collected in June 1988 and March 1989 for analyses of mercury. After they lived in Japan for nearly one year, the mean total-Hg contents in hair were increased from 0.82μg/g to 1.96, and those of methyl-Hg in hair, from 0.19 μg/g to 0.32, both with significant differences (p<0.01). It is suggested that Japanese foods, especially the fish, might be the responsible factor in increasing the mercury contents in their hair.
  • TOSHIHIKO KOEDA, KEIKI AMANO, TAKASHI ICHIKAWA, TOMOMI SUZUKI, MOTOKO ...
    1990 年 160 巻 1 号 p. 55-65
    発行日: 1990年
    公開日: 2006/08/31
    ジャーナル フリー
    KOEDA, T., AMANO, K., ICHIKAWA, T., SUZUKI, T., ISHIKAWA, M., SATO, M., MIURA, S., SUZUKI, T. and KATO, M. Changes in the Mixed Venous Blood Oxygen Saturation during the Acute Phase of Myocardial Infarction and Administration of Dobutamine. Tohoku J. Exp. Med., 1990, 160 (1), 55-65-Clinical significance of the continuous monitoring of mixed venous oxygen satuation (SvO2) by Catheter Oxymetry System was evaluated in 45 patients with acute myocardial infarction (AMI). Patients with AMI were classified into 4 groups acccording to Forrester's hemodynamic classification. The mean SvO2 value for each group was 70.4±4.1% for subset I, 54.7±6.9% for subset II, 55.8±9.8 for subset III, and 47.0±8.0% for subset IV. Subsets II, III, and IV showed significantly low values compared to subset I (p<0.01). The relationship between PCW and SvO2 level was expressed by the negative regression line y=-0.8x+73.8 (r=-0.64, p<0.01). The curve representing the relationship between CI and SvO2 level was expressed by the equation y=53.8 logx+42.7 (r=0.68, p<0.01). The SvO2 level of the 14 patients who showed a significantly low value of 56.9±8.2% before administration of 5μg/kg/min dobutamin, increased to a mean value of 66.8±7.9%, as well as the CI after 60min. However, PCW demonstrated no pronounced changes because of dobutamin administration. Since the SvO2 level highly correlated to the cardiac pumping function in acute phase of myocardial infarction, polygraphic monitoring of SvO2 was found to be a useful index for evaluating changes in the hemodynamics. It was also a very useful measure in evaluating the effects of dobutamin.
  • NAEMI TAKASU, TAKASHI NISHIMURA, TAKASHI MASUKO, KAZUNORI KATO, YOSHIY ...
    1990 年 160 巻 1 号 p. 67-79
    発行日: 1990年
    公開日: 2006/08/31
    ジャーナル フリー
    TAKASU, N., NISHIMURA, T., MASUKO, T., KATO, K. and HASHIMOTO, Y. Increase in Colony Stimulating Fctor (CSF) in Serum and Augmentation of CSF Responsiveness of Lymphoid Mononuclear Cells by Acute Trypanosoma cruzi Infection in Mice. Tohoku J. Exp. Med., 1990, 160 (1), 67-79-Acute infection of Trypanosoma (T.) cruzi to C3H/HeN mice caused the induction of a higher level of serum colony stimulating factor (CSF) activity to support the proliferation of mouse bone marrow cells. The CSF activity reached a maximun 2 days after the infection and declined thereafter. Spleen cells of the T. cruzi-infected mice showed higher levels of responsiveness to CSF in L929-conditioned medium, mouse recombinant GM-CSF and infected mouse sera as compared with normal mouse spleen cells. The induction of CSF-responding cells became plateau 4 days after the infection and it decreased thereafter. In concomitant with the production of CSF activity in the infected mouse sera, large granular cells bearing high intensity of Mac-2 antigen increased in the infected mouse spleen. These cells were nylon nonadherent and displayed inhibitory effect on T cell response to Con A. These findings indicate that T. cruzi infection induces augmentation of in vivo CSF production, leading to the abnormal proliferation of CSF-responding cells and that augmented production of, and responsiveness to, CSF might be one of important mechanisms responsible for the induction of immune abnormalities in T. cruzi-infected mice.
  • KATSUHIKO SAITO, YASUNI NAKANUMA
    1990 年 160 巻 1 号 p. 81-92
    発行日: 1990年
    公開日: 2006/08/31
    ジャーナル フリー
    SAITO, K. and NAKANUMA, Y. Lectin Binding of Intrahepatic Bile Ducts and Peribiliary Glands in Normal Livers and Hepatolithiasis. Tohoku J. Exp. Med., 1990, 160 (1), 81-92-Histochemical features of the intrahepatic bile ducts and peribiliary glands were examined with five biotinylated lectins in 12 normal human livers and 12 livers with hepatolithiasis. There was a marked proliferation of peribiliary glands, especially mucous cells, in the stone-containing bile ducts. Based on the carbohydrate binding specificity for each lectin, it was found in both the normal and hepatolithiasis livers, that N-acetylglucosamine, N-acetylgalactosamine, D-galactose and L-fucose were abundant in the mucous acinar cells of the intrahepatic peribiliary glands, and mannose (or glucose) was present exclusively in the serous acinar cells and surface lining epithelium. Considerable case to case and cell to cell variations, however, were noted in the expression of lectin binding activity. It has been shown that major monosaccharide components of biliary glycoproteins are N-acetylglucosamine, galactose and fucose. All of these carbohydrates were detected in the peribiliary glands, especially mucous acinar cells, in this study. Therefore, the peribiliary mucous cells are mainly responsible for the secretion of the glycoproteins with these carbohydrates into the hepatic bile, and may play a role in the calculi formation in the intrahepatic biliary tree.
  • SATOSHI SUMI, TATSUYA ISHIKAWA, YASUHIKO ITO, HIDETSUNE OISHI, KIYOFUM ...
    1990 年 160 巻 1 号 p. 93-94
    発行日: 1990年
    公開日: 2006/08/31
    ジャーナル フリー
    SUMI, S., ISHIKAWA, T., ITO, Y., OISHI, H., ASAI, K. and WADA, Y. Probable Assignment of the Dihydropteridine Reductase Gene to 4p15.31. Tohoku J. Exp. Med., 1990, 160 (1), 93-94-We report the dihydropteridine reductase (DHPR) activity in cases with interstitial deletion of the short arm of chromosome 4. Case 1 with the segment 4p15.32-4p16 deleted has normal DHPR activity. Case 2 with 4p15.2-4p15.32 deleted has reduced DHPR activity, less than 50% of normal.
  • YASUYUKI AKUTSU, KAZUO MORI, SOZO SUZUKI, MASAAKI ISHIKAWA, HIDEAKI SA ...
    1990 年 160 巻 1 号 p. 95-96
    発行日: 1990年
    公開日: 2006/08/31
    ジャーナル フリー
    AKUTSU, Y., MORI, K., SUZUKI, S., ISHIKAWA, M. and SAKAI, H. High Dose Intact-Immunoglobulin Treatment for an HIV-Infected Asymptomatic Carrier with Hemophilia. Tohoku J. Exp. Med., 1990, 160 (1), 95-96-Intravenous administration of a high dose of intact-Immunoglobulin to a human immunodeficiency virus (HIV) infected patient with hemophilia A, whose total lymphocyte and CD4 positive lymphocyte counts showed a decreasing tendency, resulted in a gradual rise in these cell counts. The results were quite reproducible on another occasions. Therefore, intravenous administration of gammaglobulin (IVGG) was thought to be effective for preventing further deterioration of cellular immunity and progression from asymptomatic carrier (AC) to AIDS related complex (ARC)/AIDS in hemophilia patients.
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