巻号一覧
160 巻 (1990)
- 4 号 p. 287-
- 3 号 p. 169-
- 2 号 p. 97-
- 1 号 p. 1-
160 巻, 2 号
選択された号の論文の9件中1～9を表示しています
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SHUKO TAKAGI1990 年 160 巻 2 号 p. 97-107
発行日: 1990年
公開日: 2006/08/31
ジャーナル フリーTAKAGI, S. Chronic Toxicity of 2-Methyl-4-Chlorophenoxyacetic Acid (MCPA) in Mice. Tohoku J. Exp. Med., 1990, 160 (2), 97-107-One of the phenoxy herbicides, 2-methyl-4-chlorophenoxyacetic acid (MCPA) was soaked with pellet dissolved by corn oil and given to ICR male mice for 18 months at levels of 40, 200, 1, 000 and 5, 000ppm (about 3.9, 19.0, 95.6 and 566.4mg/kg/day, respectively). The animals were then placed on a control diet for 12 months. Treatment with 5, 000ppm of MCPA resulted in a significantly decreased survival rate of the mice. Histopathological examination of mice treated with 40ppm MCPA revealed the occurrence of leukemia which showed neoplastic infiltration in the liver. No adverse effect of the gallbladder, except for papillary proliferation, was noted at all the dose levels of the experimental groups.抄録全体を表示PDF形式でダウンロード (2076K) -
KOICHI TABAYASHI, MITUAKI SADAHIRO, GENYA YAGINUMA, YASUHIRO ITO, MASA ...1990 年 160 巻 2 号 p. 109-115
発行日: 1990年
公開日: 2006/08/31
ジャーナル フリーTABAYASHI, K., SADAHIRO, M., YAGINUMA, G., ITO, Y., ENDO, M., AKIMOTO, K., SUZUKI, Y. and MOHRI, H. Aortic Regurgitation: Ventricular Response after Aortic Valve Replacement. Tohoku J. Exp. Med., 1990, 160 (2), 109-115-This study was designed to evaluate the usefulness of the ratio of the preoperative regurgitant stroke volume to left ventricular end-diastolic volume (RSV/LVEDV) for assessing the left ventricular function preoperatively. In 26 patients with aortic regurgitation (AR), the percent decrease in LVEDV was compared with the preoperative RSV/LVEDV, ejection fraction (EF), LVEDV, left ventricular end-systolic volume (LVEDV) or left ventricular end-diastolic pressure (LVEDP). There was a significant correlation between the percent decrease in LVEDV and RSV/LVEDV. Patients with RSV/LVEDV of more than 0.26 had a significantly smaller postoperative left ventricular end-diastolic volume index (LVEDVI) and left ventricular end-systolic volume index (LVESVI), and a grater postoperative EF than patients with smaller RSV/LVEDV. All but one patient with RSI/LVEDVI larger than 0.0016 LVEDVI had normal postoperative LVEDVI. Based on these findings, it is concluded that the RSV/LVEDV is an useful indicator for preoperative evaluation of left ventricular functions in patients with AR. Surgical intervention for patients with AR should be recommended before the RSI/LVEDVI drops to less than 0.0016 LVEDVI, to expect good postoperative ventricular responses.抄録全体を表示PDF形式でダウンロード (604K) -
KIYOSHI KATOH, TORU YAMAUCHI, KOUICHI HIRAIWA1990 年 160 巻 2 号 p. 117-128
発行日: 1990年
公開日: 2006/08/31
ジャーナル フリーKATOH, K., YAMAUCHI, T. and HIRAIWA, K. Blood Pressure, Obesity and Urine Cation Excretion in Two Populations of the Cook Islands. Tohoku J. Exp. Med., 1990, 160 (2), 117-128-As part of a physical anthropological and linguistic research in the Cook Islands, blood pressure levels, the degree of obesity, and urine cation excretion were measured in the residents of Rarotonga (the most westernized) and Mangaia (a less westernized island) in 1986. The rise of blood pressure with age was observed in both sexes in each island, with the mean systolic pressures of the oldest male group (155.8 vs. 137.3mmHg) significantly higher, and those of older female groups (137.4 vs. 127.1 and 154.7 vs. 145.9mmHg) relatively higher in Rarotonga than in Mangaia. The mean body mass index was much the same between the two islands, but mean skinfolds at triceps and subscapular sites were thicker in Rarotonga than in Mangaia in each sex and age group. The mean sodium to potassium excretion ratio fell with age (2.97 to 0.94 in males, 2.24 to 1.09 in females) in Rarotonga, and was consistently low (1.09 to 0.73) in Mangaia. Body mass index correlated with both systolic and diastolic pressures in each sex and island group but indeces of sodium excretion did not. Obesity was considered a more important risk factor for hypertension than sodium-intake in the surveyed population, and skinfolds, related to daily physical activity, probably associated with the difference in blood pressure levels observed between the two islands.抄録全体を表示PDF形式でダウンロード (1180K) -
YUKITAKA FUKUSHIMA, MASAKO YANAGISAWA, YASUSHI NAKAMOTO, AKIRA B. MIUR ...1990 年 160 巻 2 号 p. 129-140
発行日: 1990年
公開日: 2006/08/31
ジャーナル フリーFUKUSHIMA, Y., YANAGISAWA, M., NAKAMOTO, Y. and MIURA, A.B. Localization of Renal Erythropoietin and the Role of Ia Antigen Expression in Hypoxic Rat Glomeruli. Tohoku J. Exp. Med., 1990, 160 (2), 129-140-Erythropoietin (EPO) producing cells were examined by the immunofluorescent antibody technique, and the alterations in the Ia antigen expression in glomeruli by hypoxic stimuli. Antisera were obtained from rabbits immunized with pure human EPO. Positive fluorescence was localized in glomerular mesangial regions of the hypoxic rat kidney. Although hypoxia showed neither increase in the number of glomerular cells nor hypertrophy of the mesangial matrix, it induced an increase of the Ia antigen expressions in glomeruli. The peak of the increase occurred 2hr after hypoxia and then decreased until 24hr later. The increase of Ia antigen after 2 hr of hypoxic stimuli was 176.5±7.0% of normal controls, and ranged from 151 to 209%. In conclusion, Ia positive cells in glomeruli may have some relationship to the stimulation of EPO production.抄録全体を表示PDF形式でダウンロード (10844K) -
RYUICHI NAKAMURA, MASAAKI FUJITA1990 年 160 巻 2 号 p. 141-143
発行日: 1990年
公開日: 2006/08/31
ジャーナル フリーNAKAMURA, R. and FUJITA, M. Effect of Thyrotropin-Releasing Hormone (TRH) on Motor Performance of Hemiparetic Stroke Patients. Tohoku J. Exp. Med., 1990, 160 (2), 141-143-The maximum walking speed, the stability of standing balance, and isokinetic strength for knee extension on the both sides were examined in 7 hemiparetic stroke patients before and 10-20min after intravenous administration of 2-mg TRH. The maximum walking speed, the stabilibity of standing balance and the strength of the affected side increased significantly with TRH but the strength of the non-affected side did not change. It seems that TRH enables functionally depressed areas to resume activity.抄録全体を表示PDF形式でダウンロード (291K) -
SUSUMU YAMADA, ROKO KUBOTA, KENJI YAMADA, SHUICHI ONO, TAKASHI HISHINU ...1990 年 160 巻 2 号 p. 145-148
発行日: 1990年
公開日: 2006/08/31
ジャーナル フリーYAMADA, S., KUBOTA, R., YAMADA, K., ONO, S., HISHINUMA, T., MATSUZAWA, T. and FUJIWARA, S. T1 and T2 Relaxation Times on Gadolinium-Diethylenetriaminepentaacetic Acid Enhanced Magnetic Resonance Images of Brain Tumors. Tohoku J. Exp. Med., 1990, 160 (2), 145-148-MRI of brain tumors was performed with CPMG pulse sequence, and T1 and T2 relaxation times were measured before and after the administration of 0.1mmol/kg Gd-DTPA. T1 and T2 became significantly shorter than before with the T1 shortening being about twice the T2's. Three types of T2 shortening were classified by the difference in the intra-tumoral transport of Gd-DTPA in the time-course study after the administration. Transportal activity of Gd-DTPA seemed to be reflected by the physiologic viability of tumor suggested by pre-contrast T2.抄録全体を表示PDF形式でダウンロード (387K) -
JUNJI SAGAWA, TAEKO MIYAGI, SHIGERU TSUIKI1990 年 160 巻 2 号 p. 149-156
発行日: 1990年
公開日: 2006/08/31
ジャーナル フリーSAGAWA, J., MIYAGI, T. and TSUIKI, S. Effects of OK-432 Activation on the Sialidase Activities of Rat Peritoneal Macrophages. Tohoku J. Exp. Med., 1990, 160 (2), 149-156-Intraperitoneal treatment of rat peritoneal macrophages with OK-432 results in more than 9-fold increase in the activity of ganglioside sialidase, which seems to coincide with the appearance of a cell surface antigen, asialo-GM1. The results of subsequent studies suggest that the ganglioside sialidase is located in the plasma membrane, where the enzyme may be responsible for the formation of asialo-GM1 from GM1. In the macrophages activated with OK-432, sialidase activity toward 4-methylumbelliferyl-N-acetylneuraminic acid (4MU-NeuAc) is also increased. It appears that the 4MU-NeuAc sialidase is intralysosomal and is increased together with other acid hydrolases present in the lysosomes.抄録全体を表示PDF形式でダウンロード (790K) -
MINORU YASUJIMA, KEISHI ABE, MASAYUKI KANAZAWA, KAZUNORI YOSHIDA, MAKI ...1990 年 160 巻 2 号 p. 157-165
発行日: 1990年
公開日: 2006/08/31
ジャーナル フリーYASUJIMA, M., ABE, K., KANAZAWA, M., YOSHIDA, K., SATO, M., TAKEUCHI, K., TSUNODA, K., KUDO, K., KOHZUKI, M., OMATA, K., YABE, T., HIWATARI, M., SATO, T. and YOSHINAGA, K. Calcium Channel Blockers Reverse the Sustained Elevation of Blood Pressure Induced by Chronic Infusion of Endothelin in Conscious Rats. Tohoku J. Exp. Med., 1990, 160 (2), 157-165-To determine whether endothelin could act as a circulating hormone in the regulation of blood pressure and sodium-water excretion, we assessed the chronic effects of synthetic endothelin on systolic blood pressure, urine volume and urinary sodium excretion in conscious rats, and also evaluated the effects of benidipine or nilvadipine, newly developed calcium channel blockers, in rats infused chronically with synthetic endothelin. Continuous infusion of endothelin at a rate of 60μg/kg/day into the jugular vein via osmotic minipumps induced a significant increase in systolic blood pressure, but did not induce any significant changes in urine volume and urinary sodium excretion, compared to those in vehicle-infused rats. On the contrary, the infusion of endothelin at a rate of 6μg/kg/day did not induce any significant changes in systolic blood pressure, urine volume and urinary sodium excretion, compared to those in vehicle-infused rats. When 6mg/kg/day of benidipine or 10mg/kg/day of nilvadipine was administered simultaneously with 60μg/kg/day of endothelin, the systolic blood pressure rose on Day I to only 137.0±2.4mmHg (p<0.05) and 119.7±5.9mmHg (p<0.05) compared to the rise to 163.8±4.7mmHg when endothelin alone was infused. The antihypertensive effect of benidipine or nilvadipine was sustained for the entire experimental period and was not associated with any significant changes in urine volume and urinary sodium excretion. The present results suggest that endothelin can act as a circulating hormone and might be involved in the regulation of blood pressure. In addition, they clearly demonstrate that the calcium channel blockers attenuate the elevation of blood pressure induced by endothelin, although the exact mechanisms whereby these drugs could interact remain to be determined.抄録全体を表示PDF形式でダウンロード (902K) -
NORIO SHIBUYA, TATSUO OHTA, HIROSHI SAKAI, SHUKO TAKAGI, JUNKO MAGARA, ...1990 年 160 巻 2 号 p. 167-168
発行日: 1990年
公開日: 2006/08/31
ジャーナル フリーSHIBUYA, N., OHTA, T., SAKAI, H., TAKAGI, S., MAGARA, J. and YAMAMOTO, M. Co-Mutagenic Activity of Phenoxyherbicides MCPA- and MCPB-Ethylester in the Ames Assay. Tohoku J. Exp. Med., 1990, 160 (2), 167-168-Mutagenicity and co-mutagenicity of MCPA- and MCPB-ethylester were examined in the Ames assay. It was found that they enhance the mutagenic action of 2-aminoanthracene in the Ames assay, although they were not mutagenic.抄録全体を表示PDF形式でダウンロード (168K)
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