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Volume 167 (1992)
- Issue 4 Pages 247-
- Issue 3 Pages 171-
- Issue 2 Pages 89-
- Issue 1 Pages 1-
Volume 167, Issue 4
Displaying 1-8 of 8 articles from this issue
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MASASHI HONDA, CHISATO TOYODA, MASAO NAKABAYASHI, YASUE OMORI1992 Volume 167 Issue 4 Pages 247-257
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSHONDA, M., TOYODA, C., NAKABAYASHII, M. and OMORI, Y. Quantitative Investigations of Placental Terminal Villi in Maternal Diabetes Mellitus by Scanning and Transmission Electron Microscopy. Tohoku J. Exp. Med., 1992, 167 (4), 247-257-The structure of the terminal villi was observed in placentae from non-diabetic mothers and mothers with diabetes mellitus using scanning and transmission electron microscopy. The metabolic condition of maternal diabetes was tightly controlled. In the diabetic group, the diameter of the terminal villi was significantly smaller than in the control group. The ramification pattern of villi, classified into hypo-, moderate- and hyper-ramifications, was shown to be mostly moderate in the non- diabetics whereas most of the diabetic placentae had either hypo- or hyper-ramifications. Mothers with a longer duration of diabetes and complicated with retinopathy tended to have hypo-ramification; in these mothers, the weight of the neonates was significantly less than normal. Moreover, in the diabetic placentae, syncytial knots were found more frequently, the percentage of vasculo-syncytial membranes tended to be lower, and the trophoblastic basement membrane was significantly thicker than in the control. These abnormalities in the diabetic placentae were independent of the methods of delivery; they seem to be related with fetal growth retardation and poor neonatal outcome, which are commonly seen in diabetic pregnancy.-diabetic placenta; electron microscopy; quantitative investigation; terminal villiView full abstractDownload PDF (3034K) -
SHOGO YAMADA, YOSHIHIRO TAKAI, KENJI NEMOTO, YOSHIHIRO OGAWA, YOSHIHIS ...1992 Volume 167 Issue 4 Pages 259-266
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSYAMADA, S., TAKAI, Y., NEMOTO, K., OGAWA, Y., KAKUTO, Y., HOSHI, A., SAKAMOTO, K., KAYAMA, T. and YOSHIMOTO, T. Treatment Results by Uneven Fractionated Irradiation, Low-Dose Rate Telecobalt Therapy as a Boost, and Intraoperative Irradiation for Malignant Glioma. Tohoku J. Exp. Med., 1992, 167 (4), 259-266-The prognosis of malignant glioma is extremely poor. We applied conventionally fractionated irradiation combined with 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU), uneven fractionated irradiation with ACNU, low dose rate telecobalt therapy as a boost, and intraoperative irradiation against 110 malignant gliomas to investigate the efficacy of these methods as alternative treatments for malignant glioma. Although local tumor control by uneven fractionated irradiation was better than that by the other methods, no significant improvement was obtained in survival rates. As a result of multiple regression analysis, age and histology were major factors for survival rates, and the difference of treatment methods was not important. Both low-dose rate telecobalt therapy as a boost and intraoperative irradiation showed little advantage because of the high risk of brain necrosis associated with them.-malignant glioma; uneven fractionated irradiation; low dose rate irradiation; intraoperative irradiation; 1-(4-amino-2-methyl-5-pyrimidimyl)methyl-3-(2-chloroethyl)-3-nitrosoureaView full abstractDownload PDF (707K) -
WAKIO TORINUKI1992 Volume 167 Issue 4 Pages 267-271
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTORINUKI, W. Photocontact Dermatitis Due to Piroxicam: Photopatch Testing. Tohoku J. Exp. Med., 1992, 167 (4), 267-271-I report a case of photocontact dermatitis due to piroxicam gel, a nonsteroidal anti-inflammatory drug. A 62-year-old man developed pruritic eczematous lesions after applying the gel for 2 days. The patient reacted positively to photopatch testing with ultraviolet A and piroxicam (1% and 0.1% in petrolatum). In addition, the patient had positive patch tests to thimerosal, thiosalicylate, and in vitro-irradiated solution of piroxicam plus human serum albumin, but the tests with the mercurial compounds were negative. These results support the close relationship between sensitivity to thiosalicylate component of thimerosal and photosensitivity to piroxicam, as indicated recently.-photosensitivity; piroxicam; thimerosal; thiosalicylateView full abstractDownload PDF (413K) -
ETSUO KAWADA, KAZUO KUBOTA, HITOSHI KURABAYASHI, KOUSEI TAMURA, JUN'IC ...1992 Volume 167 Issue 4 Pages 273-277
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKAWADA, E., KUBOTA, K., KURABAYASHI, H., TAMURA, K., TAMURA, J. and SHIRAKURA, T. Effects of Long-Term Running on Lymphocyte Subpopulations. Tohoku J. Exp. Med., 1992, 167 (4), 273-277-Thirteen healthy members (11 males and 2 females; mean age 19.8 years) of an athletic club underwent a long-term exercise program (five 8-km runnings per week for 40 weeks) as regular training for their club. The circulating lymphocyte number, T lymphocyte percentage, and OKT4/OKT8 ratio did not change through the 40-week training period. However, suppressor/inducer (Leu3a+Leu8+) and suppressor T cells(Leu2a+Leu15+) significantly increased. In contrast, helper (Leu3a+Leu8-) and cytotoxic T cells (Leu2a+Leu15-) significantly decreased. On the other hand, there was no change in three males (mean age 18.7 years) without the long-term exercise program. These results suggest that long-term running may induce some change in lymphocyte subpopulations.-long-term running; lymphocyte subpopulationsView full abstractDownload PDF (480K) -
KUNIHIRO OKAMURA, JUN MUROTSUKI, TAKANORI WATANABE, SHINGO TANIGAWARA, ...1992 Volume 167 Issue 4 Pages 279-285
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOKAMURA, K., MUROTSUKI, J., WATANABE, T., TANIGAWARA, S., UEHARA, S., YANO, M., YAJIMA, A. and SAKAI, T. Relation between Fetal Blood Gas Levels and the Outcome of Babies in Severe Preeclampsia. Tohoku J. Exp. Med., 1992, 167 (4), 279-285-The purpose of this study is to ascertain that fetal blood gas values obtained by cordocentesis could be a clinical standard to decide whether or not we should terminate pregnancy and switch to exutero salvage for avoiding hypoxic damage. Fetal blood sampling was performed 38 times in 36 cases of severe preeclampsia. The relation between fetal blood gas values and the prognosis of the baby was statistically examined. Six of 36 fetuses of severe preeclampsia died prenatally or postnatally. There were significant differences in Δ-values (difference from the normal mean value in each gestational week) of Po2, pCO2, and pH between survivors and non-survivors. ΔpO2 value is most reliable to predict fetal prognosis. Since conventional fetal evaluation methods such as fetal heart rate monitoring are unreliable in the early gestational period, fetal gas evaluation is preferable to decide further intervention.-preeclampsia; fetal blood sampling; cordocentesis; fetal distressView full abstractDownload PDF (696K) -
AKIRA OHNEDA, KINUKO OHNEDA, FUMIAKI KOIZUMI1992 Volume 167 Issue 4 Pages 287-295
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOHNEDA, A., OHNEDA, K. and KOIZUMI, F. Insulin Releasing Action of N-Terminal Peptides of Glucagon in Dogs. Tohoku J. Exp. Med., 1992, 167 (4), 287-295-The relationship between the molecular structure and insulin releasing action of glucagon remains unknown. In order to investigate the direct action of N-terminal peptides of glucagon, glucagon (1-14), and glucagon (1-21) were studied using an in situ local circulation of the canine pancreas. These glucagon fragments as well as glucagon (1-29) were infused into the superior pancreaticoduodenal artery in a dose of 400pmol for 10min during the glucose or arginine infusion, and plasma insulin and glucagon in the superior pancreaticoduodenal vein were determined by radioimmunoassay. During the glucose infusion, glucagon (1-14) elicited a slight increase in plasma insulin, whereas glucagon (1-21) and (1-29) revealed significant changes in plasma insulin. In these experiments plasma glucagon did not change significantly following the administration of glucagon (1-14) or (1-21). During the arginine infusion all of the glucagon fragments studied enhanced insulin secretion markedly, whereas glucagon secretion was not affected. Furthermore, graded doses of glucagon (1- 14) (50, 150, and 400pmol) elicited an increase in plasma insulin in a dose-related manner. It is concluded from the present study that the N-terminal peptides of glucagon stimulate insulin release especially during the arginine infusion.- glucagon fragments; canine pancreas; arginine; glucose; insulinView full abstractDownload PDF (916K) -
YOSHIYUKI OHASHI, SHIGERU TSUCHIYA, HIROMI FUJIE, MASAYOSHI MINEGISHI, ...1992 Volume 167 Issue 4 Pages 297-299
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOHASHI, Y., TSUCHIYA, S., FUJIE, H., MINEGISHI, M. and KONNO, T. Anti- LFA-1 Antibody Treatment of a Patient with Steroid-Resistant Severe Graft- Versus-Host Disease. Tohoku J. Exp. Med., 1992, 167 (4), 297-299-For treatment of steroid-resistant severe graft-versus-host disease, a murine monoclonal antibody (25.3) against the α chain (CD11a) of the lymphocyte function-associated antigen 1 (LFA-1) was infused into a patient with posthepatitic aplastic anemia who had undergone allogeneic bone marrow transplantation. The monoclonal antibody infusion was well tolerated and resulted in appreciable improvement in symptoms of gastrointestinal illness such as diarrhea and abdominal pain, suggesting that this antibody may be useful for controlling severe acute graft-versus-host disease.-graft-versus-host disease; monoclonal antibody; CD11aView full abstractDownload PDF (219K) -
HIDEKI OHNO, HITOSHI YAMASHITA, TOMOMI OOKAWARA, DAIZO SAITOH, KAZUO M ...1992 Volume 167 Issue 4 Pages 301-303
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOHNO, H., YAMASHITA, H., OOKAWARA, T., SAITOH, D., MIMURA, K. and TANIGUCHI, N. Effects of Brief Physical Exercise on the Concentrations of Immunoreactive Superoxide Dismutase Isoenzymes in Human Plasma. Tohoku J. Exp. Med., 1992, 167 (4), 301-303-Effects of cycle ergometer exercise (-75% Vo2max for 15min) on the concentrations of immunoreactive Mn- and CuZn- superoxide dismutases (SOD) in plasma were studied on 10 male students. During the experimental period, Mn-SOD concentration did not vary substantially. On the other hand, CuZn-SOD concentration decreased markedly at 15min and 24hr after the exercise; that is, CuZn-SOD appeared to differ virtually from Mn-SOD in recovery pattern.-physical exercise; Mn-superoxide dismutase; CuZn- superoxide dismutase; ELISAView full abstractDownload PDF (335K)
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