巻号一覧
169 巻 (1993)
- 4 号 p. 261-
- 3 号 p. 179-
- 2 号 p. 91-
- 1 号 p. 1-
169 巻, 2 号
選択された号の論文の8件中1～8を表示しています
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KUNIHIKO HANEW, ATSUSHI UTSUMI, AKIRA SUGAWARA, YASUYUKI SHIMIZU, SATO ...1993 年 169 巻 2 号 p. 91-101
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーHANEW, K., UTSUMI, A., SUGAWARA A., SHIMIZU, Y., TAZAWA, S. and ABE, K. Plasma GH Response to the Sequential 3 Day Administrations of GHRH Followed by Arginine Infusion in Patients with Idiopathic GH Deficiency and Normal Short Children. Tohoku J. Exp. Med., 1993, 169 (2), 91-101 - To study the site of lesions in idiopathic growth hormone (GH) deficiency (IGHD), growth hormone releasing hormone (GHRH) was administered sequentially for 3 days to 19 patients with IGHD, 3 patients with GH deficiency (GHD) secondary to hypothalamic tumors, and 7 normal short children (NSC). GHRH (100μg) was injected as a bolus on days 1 and 3, and was infused over 60min on day 2. Of 19 patients with IGHD, 6 showed an improved GH response (group A), 5 a decreased response (group B) and the remaining 8 an unchanged response (group C) to sequential administration of GHRH. The response was unchanged in patients with secondary GHD or NSC. There was no significant correlation between the patterns of GH response and the findings on pituitary MR images or the delivery state at birth in IGHD patients. Ten patients with IGHD (4 of group A; 3 each of groups B & C) and 2 NSC showed much greater GH responses to arginine (0.5g/kg i.v. for 30min) injected with preceding GHRH than to arginine injected without preceding GHRH. These results indicate that hypothalamic lesions were primarily responsible for GH deficiency in about 60% of the patients with IGHD (groups A and B), and group C might have more severe hypothalamo-pituitary damages than the other groups. Hypothalamic somatostatin neurons seems to be functioning to a degree even in severe IGHD patients. -idiopathic GH deficiency; normal short children; GH; GHRH; arginine抄録全体を表示PDF形式でダウンロード (1172K) -
KEN-ICHI YOKOTA, RYUZABURO SHINEHA, TETSURO NISHIHIRA, SHOZO MORI1993 年 169 巻 2 号 p. 103-112
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーYOKOTA, K., SHINEHA, R., NISHIHIRA, T. and MORI, S. Perioperative Alterations in Polymorphonuclear Leukocyte Function of Gastrointestinal Surgery. Tohoku J. Exp. Med., 1993, 169 (2), 103-112 - To characterize the alteration of perioperative polymorphonuclear leukocytes (PMNs) function in surgical stress, we studied twenty six patients undergoing gastrointestinal surgery. Seventeen patients with thoracic esophageal cancer underwent total thoracic esophagectomy through a right thoracotmy (severe surgical stress group). Nine patients underwent cholecystectomy (slight surgical stress group). Phagocytic oxygendependent microbicidal activity in the esophagectomy patients significantly increased postoperatively, by measuring O2- production (35.3±7.0nmol/106 cells/ ml/20min on postoperative day 1 vs. 28.6±6.2 preoperatively, p<0.01) and luminol-dependent chemiluminescence (99.5±29.9×105cpm/ 105 cells on postoperative day 3 vs. 67.5×12.8 preoperatively, p<0.01). On the other hand, only a slight change was seen in the cholecystectomy patients. We conclude that the postoperative PMN function in terms of oxygen-dependent microbicidal activity significantly increases when the degree of surgical stress is sufficient. In order to gain insight into the mechanism of PMN activation, we specifically analyzed the expression of complement receptors. Up-regulation of complement receptors were seen in the esophagectomy patients, which parallels the activation of PMN microbicidal activities. It was suggested that phagocytic PMN function in severe surgical stress significantly increases postoperatively, in part, based on the up- regulation of cell surface complement receptors. - PMN function; O2- production; luminol-dependent chemiluminescence; complement receptors; surgical stress抄録全体を表示PDF形式でダウンロード (1002K) -
KIYOSHI HANEDA, TOSHIAKI KONNAI, NAOSHI SATO, NENO N. NICOLOFF, HITOSH ...1993 年 169 巻 2 号 p. 113-119
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーHANEDA, K., KONNAI, T., SATO, N., NICOLOFF, N.N. & MOHRI, H. Acute Hemodynamic Changes after Fontan Operation: An Experimental Study. Tohoku J. Exp. Med., 1993, 169 (2), 113-119 - Seven adult mongrel dogs with an average body weight of 11.3kg were subjected to experimental Fontan operation in order to evaluate acute hemodynamic changes at the Fontan circulation. The Fontan circulation was established by occlusion of the tricuspid valve with tightening a purse-string suture which was placed around the valve under inflow occlusion and was passed through the anterior right atrial wall, and by connection with a 10mm Gore-Tex graft between right atrium and pulmonary artery. When the Fontan circulation was established, aortic pressure and cardiac output (CO) decreased from 94.9±22.0mmHg to 41.9±6.0mmHg and 0.907±0.179 liter/min to 0.259±0.072 liter/min, respectively. There were no significant changes in heart rate and systemic vascular resistance between normal and the Fontan circulations. On the other hand, pulmonary vascular resistance (PVR) increased from 11.6±7.3 units in the normal circulation to 21.8±13.0 units in the Fontan circulation. From this study it was concluded that main changes in hemodynamic parameters immediately after establishing the Fontan circulation were marked decrease in systemic arterial pressure and CO, and an increase in PVR. Therefore, one should consider a possibility of an increase in the PVR to the critical level when the Fontan operation was applied to patients with pulmonary hypertension. - Fontan operation; tricuspid atresia; pulmonary hypertension抄録全体を表示PDF形式でダウンロード (639K) -
SATOSHI SUZUKI, TATSUO TANITA, HIROSHI KUBO, YUGO ASHINO, MASAYUKI CHI ...1993 年 169 巻 2 号 p. 121-130
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーSUZUKI, S., TANITA, T., KUBO, H., ASHINO, Y., CHIDA, M., KOIKE, K. and FUJIMURA, S. Stimulation of Pulmonary Intravascular Macrophages Increases Microvascular Permeability in Awake Sheep. Tohoku J. Exp. Med., 1993, 169 (2), 121-130 - The purpose of this study is to determine if stimulation of pulmonary intravascular macrophages (PIMs) increase microvascular permeability in sheep. We infused latex microbeads, 1μm in diameter, for 1hr continuously and analysed lung hemodynamic and lymph-dynamic changes. More than 70% of latex microbeads in the lung were assigned to PIMs, and caught in their phagosomes as determined by morphological examination. This implies that infused latex microbeads predominantly stimulate PIMs. Pulmonary arterial pressure increased during the infusion period, and returned to baseline after the infusion period. Lung lymph flow increased and remained high while the lymph to plasma protein ratio ultimately increased above baseline. This implies that infusion of latex microbeads increases pulmonary microvascular permeability. The increase in lung lymph protein clearance was blocked completely by pretreatment with indomethacin, but not with a thromboxane synthetase inhibitor (OKY-046). These data indicate that the increase in microvascular permeability is mediated by an arachidonic acid cyclooxygenase metabolites but not by thromboxane. We conclude that PIMs can act as an initiator to increase pulmonary microvascular permeability by releasing arachidonic acid cyclooxygenase metabolites through their stimulation with latex beads. - index terms; sheep with chronic lung lymph fistulas; latex microbeads; arachidonic acid cyclooxygenase metabolites抄録全体を表示PDF形式でダウンロード (979K) -
TAKAYOSHI TADAKI, MARIKO WATANABE, KUMIKO KUMASAKA, YASUO TANITA, TAIZ ...1993 年 169 巻 2 号 p. 131-139
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーTADAKI, T., WATANABE, M., KUMASAKA, K., TANITA, Y., KATO, T., TAGAMI, H., HORII, I., YOKOI, T., NAKAYAMYA., and KLIGMAN, A.M. The Effect of Topical Tretinoin on the Photodamaged Skin of the Japanese. Tohoku J. Exp. Med., 1993, 169 (2), 131-139 - Fifteen middle aged or elderly patients with chronic solar damage of the skin, eight patients with melasma and three patients with xeroderma pigmentosum were treated with topicial tretinoin for 6 months. There was a significant improvement in fine surface lines in periorbital region, but no significant improvement was observed in deep furrows. No significant change was induced in melasma despite the improvement in smoothness of the skin surface. Global improvement was also seen in one patient with xeroderma pigmentosum. With regard to the functions of the stratum corneum that was assessed on the flexor surface of the forearms, values of water content as well as transepidermal water loss were found to increase one month after start of the application of tretinoin cream. On the other hand, there was no significant change in the amino acid content of the stratum corneum when measured after 4 months of the treatment. It is concluded that tretinoin cream is capable of partly reversing fine surface lines in photodamaged facial skin of the Japanese. However the irritation induced by 0.1% tretinoin cream was unexpectedly severe in the Japanese as compared to that reported in Caucasians. - tretinoin; photodamaged skin; water content; transepidermal water loss抄録全体を表示PDF形式でダウンロード (1304K) -
KAZUHISA TAKEUCHI, YUTAKA IMAI, KEN OMATA, HIROSHI SATO, TAKAO SAITO, ...1993 年 169 巻 2 号 p. 141-157
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーTAKEUCHI, K., IMAI, Y., OMATA, K., SATO, H., SAITO, T., OTA, K., KIMURA, T., YOSHINAGA, K. and ABE, K. A Case of Secondary Aldosteronism Similar to Bartter's Syndrome with No Abnormality in Renal Chloride Reabsorption. Tohoku J. Exp. Med., 1993, 169 (2), 141-157 - We had a 20-year-old male patient of secondary aldosteronism similar to Bartter's syndrome, which had proved to be evident after the remission of nephrotic syndrome. In the patient, hypokalemic alkalosis and hyperreninemic hyperaldosteronemia were observed, although the blood pressure was normal. Hyperplasia of juxtaglomerular cells was observed and no abnormalities indicating either glomerulonephritis or renal artery stenosis were found; the pressor response to intravenously infused angiotensin (ang) II was markedly decreased; urinary prostaglandin (PG) E2, kallikrein and kinin excretion were elevated. The inhibition of PG synthesis with indomethacin decreased renal PG production and partially corrected both hypokalemia and pressor responsiveness to ang II. Thus, this case is considered to be a case of Bartter's syndrome. Contrary to the previously reported observations, the effective fractional chloride reabsorption rate in the renal distal tubules was normal (>80%) and not changed by PG inhibition. Plasma atrial natriuretic peptide level was normal. An interaction between renin-angiotensin and PG systems appears to play a prior role in this case. To explain the pathophysiology, we have hypothesized an abnormal function of ang II receptor signal transduction which excessively stimulates PLA2, resulting in overproduction of PG synthesis in tissues. - prostaglandin; nephrotic syndrome; angiotensin II receptor; kallikrein-kinin system; atrial natriuretic peptide抄録全体を表示PDF形式でダウンロード (2462K) -
HISAKO OHGAWARA, MAKIKO KAWAMURA, MASASHI HONDA, SACHIYO KARIBE, NAOKO ...1993 年 169 巻 2 号 p. 159-166
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーOHGAWARA, H., KAWAMURA, M., HONDA, M., KARIBE, S., IWASAKI, N., TASAKA, Y. and OMORI, Y. Reversal of Glucose Insensitivity of Pancreatic B-Cells Due to Prolonged Exposure to High Glucose in Culture: Effect of Nicotinamide on Pancreatic B-Cells. Tohoku J. Exp. Med., 1993, 169 (2), 159-166 Prolonged in vitro exposure to high glucose has been shown to induce a decrease in pancreatic B-cell sensitivity to glucose stimulation. This experiment was designed to study whether nicotinamide affects the B-cells' response to regulatory stimuli of glucose after prolonged culture with high glucose. Neonatal pig pancreatic islet-like cell clusters (ICCs) formed from single cells were embedded in agarose-gel. Some of them were maintained in RPMI 1640 containing a high glucose concentration (16.7 mM) and 10% fetal bovine serum (FBS) with or without nicotinamide. Then, the embedded-ICCs were stimulated by glucose at concentrations of 5.5mM and 16.7 mM. After the prolonged culture with high glucose, the ICCs showed no response to acute glucose stimulation. There was a significant increase in glucose-mediated insulin secretion when the ICCs were maintained with the medium containing nicotinamide. We conclude that nicotinamide could protect B-cell desensitization to glucose after prolonged exposure to high glucose. - desensitization to glucose; pancreatic islet; ICCs; agarose; embedded-culture抄録全体を表示PDF形式でダウンロード (1839K) -
MASASHI TSUNODA1993 年 169 巻 2 号 p. 167-178
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーTSUNODA, M. Simultaneous Determination of Organotin Compounds in Fish and Shellfish by Gas Chromatography with a Flame Photometric Detector. Tohoku J. Exp. Med., 1993, 169 (2), 167-178 - In the present study the levels of the organotin compounds were determined in fish and shellfish which were purchased from retail markets in Niigata, Japan. The concentrations of dibutyltin (DBT), tributyltin (TBT), diphenyltin (DPT) and triphenyltin (TPT) compounds were separately determined by FPD-gas chromatography. Eight species (yellowtail, tuna, cuttlefish, olive flounder, northern shrimp, cinnamon flounder, Japanese sea bass and oyster) were studied and five samples of each species were analyzed in each season, which meant 40 samples in one season, and 160 in total. Among the compounds of interest, DBT, TBT and TPT were detected. The highest concentrations detected were 0.674μg/g for DBT, 0.669μg/g for TBT and 0.186μg/g for TPT. DBT was detected as much as TBT, however, its concentration was not correlated with that of TBT. Seasonal changes of the mean value of the concentration of DBT and TBT were observed. In some species, such as yellowtail and Japanese sea bass, combined contaminations of these organotin compounds were also evident. This study is the first step to elucidate possible health hazards by environmental pollution of organotin compounds on human beings.- dibutyltin; tributyltin; diphenyltin; triphenyltin; fish抄録全体を表示PDF形式でダウンロード (1190K)
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