巻号一覧
170 巻 (1993)
- 4 号 p. 207-
- 3 号 p. 135-
- 2 号 p. 63-
- 1 号 p. 1-
170 巻, 4 号
選択された号の論文の8件中1～8を表示しています
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HIDEKI HIROSE, TETSUO KITAGUCHI, TAKESHI TABIRA1993 年 170 巻 4 号 p. 207-218
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーHIROSE, H., KITAGUCHI, T, and TABIRA, T. Neurite Promoting Activity of Collagens on Embryonic Neurons: Decreased Effect at the Postnatal Stage. Tohoku J. Exp. Med., 1993, 170 (4), 207-218 - We studied the in vitro neurite outgrowth activity of fibronectin, laminin, heparan sulfate proteoglycan, type I collagen, type IV collagen, and type VIII collagen in cholinergic neuronal cell lines and primary cultured neurons. All these substances had high neurite promoting activity on primary cultured neurons from embryonic mouse brain. However, collagens had no such an effect on primary cultured neurons from postnatal brain. When neuronal cell lines were used, collagens and other extracellular matrix substances were equally and highly effective on cells originated from embryonic brain, but collagens were less effective on cells from postnatal brain. These findings suggest that postnatal neurons lose the neuritic responsiveness to collagens earlier than that of other ECM.抄録全体を表示PDF形式でダウンロード (2793K) -
MIKI YAMADA, MOTOYASU ISHII, MASAHITO MIURA, SHUICHI SATO, ATSUSHI KAN ...1993 年 170 巻 4 号 p. 219-228
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーYAMADA, M., ISHII, M., MIURA, M., SATO, S., KANNO, A., OHORI, H. and TOYOTA, T. Three Distinct Southern Blot Hybridization Patterns of HBV-DNA in the Sera of HBV Carriers. Tohoku J. Exp. Med., 1993, 170 (4), 219-228 -The molecular species of hepatitis B virus (HBV)-DNA of 44 sera taken from 25 HBV carriers were examined by Southern blot hybridization with a biotin-labeled HBV-DNA probe and classified into three patterns. Type I consisted of two distinct bands of 4.0kb and 3.2kb. Type II consisted of the 4.0kb and 3.2kb bands and a smear between these two bands. Type III showed a broad band below 4.0kb. With endogenous HBV-DNA polymerase reaction, the smear disappeared and 4.0kb and 3.2kb bands appeared. After EcoRI digestion, the 4.0 kb band disappeared to form a single band of 3.2kb. These results suggest that the 4.0kb and 3.2kb forms are a relaxed circular, fully double-stranded DNA and a linear, fully double-stranded DNA, respectively, and that the smear between 4.0 kb and 3.2kb is formed from the sum of relaxed circular, partially double-stranded DNAs with various length of plus strands. Comparison between histological diagnosis and Southern blot hybridization patterns of 25 HBV carriers indicates that these three patterns are closely related to the degree of hepatitis.抄録全体を表示PDF形式でダウンロード (1257K) -
SHINJI SATO, KUMIKO JIKO, KIYOSHI ITO, NOBUYOSHI OZAWA, AKIRA YAJIMA, ...1993 年 170 巻 4 号 p. 229-234
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーSATO, S., JIKO, K., ITO, K., OZAWA, N., YAJIMA, A., MIYAZAKI, S. and SASANO, H. Expression of c-myc mRNA and Protein in Human Endometrial Carcinoma; Simultaneous Study of In Situ Hybridization and Immunohistochemistry. Tohoku J. Exp. Med., 170 (4), 229-234 - We examined the c-myc gene at both mRNA and protein levels in tumors of 10 endometrial carcinomas by simultaneous in situ hybridization and immunohistochemistry. Expression of c-myc mRNA was observed in all cases by in situ hybridization. Immunohistochemically, c-myc protein expression was also observed in all cases and immunoreactivity was recognized as nuclear staining. The site of c-myc protein expression was mostly consistent with that of c-myc mRNA expression. While there has been no clear correlation between the expression of c-myc mRNA and/or protein and prognostic parameters so far, this approach will contribute to an understanding of oncogene expression and its biological significance in human gynecological malignancies.抄録全体を表示PDF形式でダウンロード (1019K) -
HIDEMI YAMAUCHI, ATSUSHI NITTA, KENJI KAKIZAKI, MIKIO IMAMURA, TSUNEO ...1993 年 170 巻 4 号 p. 235-244
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーYAMAUCHI, H., NITTA, A., KAKIZAKI, K., IMAMURA, M., NAMIKI, T. and ICHINOHASAMA, R. Different Distribution of CA19-9 in Carcinomas Arising in the Papilla of Vater. An Immunohistochemical Study. Tohoku J. Exp. Med., 1993, 170 (4), 235-244 - The origin and pathogenesis of the carcinoma of the Vater's papilla were estimated by immunohistochemically analysing the distribution of CA19-9 in the tumor tissue. The material comprised surgical specimens from 29 patients with carcinoma of the Vater's papilla, 15 with carcinoma of the pancreas, 24 with carcinoma of the bile duct and two with carcinoma of the duodenum. A non-invasive adenomatous component (NAC) was shown to coexist with carcinoma of the Vater's papilla in 14 patients. Besides, normal papilla of Vater from ten autopsy cases were added as control. The presence of CA19-9 in the tissue was demonstrated by ABC method using a monoclonal antibody. The epithelia of normal pancreatic and bile ducts showed diffuse distribution of CA19-9, while at the common channel and the orifice of the papilla it was partially distributed. CA19-9 was not demonstrated in the duodenum. The NAC-positive carcinoma of the papilla of Vater showed partially distributed CA19-9. In contrast, NAC-negative carcinoma of the the Vater's papilla and carcinomas of the pancreas and bile duct showed diffuse distribution of CA19-9. Moreover, the level of serum CA19-9 in most of the patients with NAC-positive carcinoma of Vater's papilla remained within the normal limit, while in patients with NAC-negative carcinoma, or with carcinoma of the pancreas or bile duct, the level was higher. Thus it was speculated that NAC-positive carcinoma of Vater's papilla may arise from the common channel, the orifice of the papilla, or the duodenum acquiring antigenicity against CA19-9 during the cancer development. On the other hand, NAC-negative carcinoma of the Vater's papilla may originate from the pancreatic or bile ducts.抄録全体を表示PDF形式でダウンロード (3047K) -
KUNIHIKO HOSHI, YASUHIKO HASHIMOTO, SHU MATSUKAWA1993 年 170 巻 4 号 p. 245-250
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーHOSHI, K., HASHIMOTO, Y. and MATSUKAWA, S. Pharmacokinetics of Succinylcholine in Man. Tohoku J. Exp. Med., 1993, 170(4), 245-250 - The pharmacokinetics of succinylcholine (SCh) 1 or 2mg/kg was studied in 14 anesthetized patients. Arterial blood concentrations of SCh were measured using a high-performance liquid chromatographic assay. The arterial concentration vs. time data were analyzed by log-linear regression and fitted to an one-compartment model. The pharmacokinetic parameters were (SCh 1, n=8 and 2mg/kg, n=6): apparent volume of distribution (16.4±14.7 and 5.6±6.8ml/kg, mean±S.D. ), total body clearance (40.5±38.7 and 15.0±14.8liter/min), area under the plasma concentration-time curve (124.3±163.2 and 695.3±1008.9min•μg/ml), and elimination half-life (16.6±4.8 and 11.7±4.5sec). The rapid disappearance of SCh from the blood may be due to diffusion out of the blood vessel.抄録全体を表示PDF形式でダウンロード (544K) -
OSAMU UKIMURA1993 年 170 巻 4 号 p. 251-260
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーUKIMURA, O. Effects of Intravesically Administered Anticholinergics, β-Adrenergic Stimulant and α-Adrenergic Blocker on Bladder Function in Unanesthetized Rats. Tohoku J. Exp. Med., 1993, 170 (4), 251-260 - Comparative analysis of the effects of intravesical instillation of drugs on urodynamic parameters (MVP, maximum intravesical pressure; RR, residual rate; BC, bladder capacity) was performed using an experimental model in unanesthetized rats. The drugs investigated in this study were atropine (7.2×10-4-7.2×10-2M), propantheline (7.2×10-3-2.2×10-2M), oxybutynin (2.5×10-3-2.5×10-2M), isoproterenol (5×10-2-10-1M) and prazosin (5×10-4M). Of the anticholinergics, propantheline and oxybutynin showed a remarkable suppression of MVP accompanied with a consistent increase of RR and BC in a dose-dependent manner. Atropine showed, however, no suppression of MVP in spite of a significant change of RR and BC. Isoproterenol suppressed MVP with an increase of RR and BC in a dose-dependent manner at a relatively high concentration. Prazosin increased BC and RR at a relatively low concentration. This study revealed that these intravesical drugs have the ability to suppress spontaneous bladder contraction in unanesthetized rats and to change the micturition function in the urinary filling and storage phases. It is expected that intravesical instillation therapy for detrusor hyperreflexia will be improved in the future based upon the data obtained.抄録全体を表示PDF形式でダウンロード (946K) -
KOJI ABE, KAZUO KOBAYASHI, KEIJI CHIDA, NORIKO KIMURA, KYUYA KOGURE1993 年 170 巻 4 号 p. 261-272
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーABE, K., KOBAYASHI, K., CHIDA, K., KIMURA, N. and KOGURE, K. Dominantly Inherited Cytoplasmic Body Myopathy in a Japanese Kindred. Tohoku J. Exp. Med., 1993, 170 (4), 261-272-An autosomal dominant progressive myopathy with diffuse cytoplasmic bodies (CBs) is described. In four successive generations, 12 patients suffered from weakness and atrophy of muscles in the distal extremities, neck, thorax and shoulder girdles. The mean age at onset was 42 years old, and the patients became disabled after 5 to 10 years due to chronic respiratory failure. The level of serum creatine kinase was normal or slightly elevated. An electromyogram showed a predominant myopathic change with a slight neurogenic change. Autopsy of 2 cases revealed numerous CBs in the skeletal muscles. Smooth and cardiac muscles were also affected. CBs were present predominantly in type I fibers in skeletal muscles. Males were more frequently affected than females (2:1). An electron microscopic examination showed dense central cores of myofilaments surrounded by radiating filaments. Characteristics of clinical course and histopathological findings in a new kindred are discussed in this rare disease.抄録全体を表示PDF形式でダウンロード (3581K) -
TOMOMASA IZUMIYAMA, WATARU HIDA, MASAKAZU ICHINOSE, HIROSHI INOUE, TAM ...1993 年 170 巻 4 号 p. 273-283
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーIZUMIYAMA, T., HIDA, W., ICHINOSE, M., INOUE, H., TAKISHIMA, T., OKAZAKI, T. and SHIRATO, K. Small Airway Involvement in Mixed Connective Tissue Disease. Tohoku J. Exp. Med., 1993, 170 (4), 273-283-We studied pulmonary functions in 17 female patients with mixed connective tissue disease (MCTD) to detect early pulmonary involvement in this disease; in 8 of the 17 patients follow-up studies were also performed at 1.2- to 5.9-year intervals. In the first pulmonary function tests, decreases in vital capacity (VC) and diffusing capacity (DLCO) were observed in 6 (35%) and 8 (47%) patients, respectively. The ratio of forced expiratory volume in one second to VC was normal in all the patients, but pulmonary resistance and static compliance were abnormal in 6 (35%) and 10 (59%) patients, respectively. However, frequency dependence of dynamic compliance was found in all 16 patients tested. Moreover, 4 (24%) of the 17 patients had normal DLCO and DLCO-to-alveolar volume ratio (DLCO/VA). Reductions in DLCO and DLCO/VA were significantly correlated with the disease duration. These results suggest that small airway obstruction is an early and frequent indication of functional pulmonary impairment, and that impairment of alveolar gas exchange is progressive in patients with MCTD.抄録全体を表示PDF形式でダウンロード (1108K)
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