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Volume 181 (1997)
- Issue 4 Pages 389-
- Issue 3 Pages 321-
- Issue 2 Pages 245-
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Volume 181, Issue 3
March
Displaying 1-7 of 7 articles from this issue
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Review
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Takao Saito1997 Volume 181 Issue 3 Pages 321-337
Published: 1997
Released on J-STAGE: March 09, 2006
JOURNAL FREE ACCESSAlthough renal diseases including nephrotic syndrome and chronic renal failure are associated with hyperlipidemia, significance of abnormal lipid metabolism has been thought to be limited in some inherited renal diseases. However, recent studies have postulated that glomerulosclerosis is induced by hyperlipidemia and is in common with atherosclerosis. This involvement is found in the progressive renal disorders, e.g., focal glomerular sclerosis, diabetic nephropathy and glycogen storage disease. Interaction between macrophages and mesangial cells may play an important role in such conditions. This evidence is supported by experimental models with hyperlipidemia. On the other hand, discovery of new hereditary metabolic disorders, such as type III hyperlipoproteinemia and lipoprotein glomerulopathy, shows that apolipoprotein (apo) E abnormalities are responsible for the glomerular lesions. Especially, lipoprotein glomerulopathy has specific features different from those of lipid-induced renal diseases. In this disease, apo E Sendai which results from new substitution (Arginine 145→Proline) may induce intraglomerular lipoprotein thrombi characteristic of lipoprotein glomerulopathy.View full abstractDownload PDF (5233K)
Regular Contributions
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Shinichiro Shimbo, Chan-Seok Moon, Zuo-Wen Zhang, Takao Watanabe, Yue- ...1997 Volume 181 Issue 3 Pages 339-352
Published: 1997
Released on J-STAGE: March 09, 2006
JOURNAL FREE ACCESSNutritional survey was conducted in 1994 in Tainan City, southern Taiwan. Total food duplicate samples were collected from 52 women volunteers. Clinical examinations, anthropometry, hematology and serum biochemistry were also conducted. The intakes of nutrients were estimated from the weights of food items in reference to the standard food composition tables for Taiwanese. On average, the participants took 1,973 kcal energy, 69 g protein, 73 g lipid and 269 g carbohydrate per day. Animal-based foods accounted for 49% and 36% of protein and lipid sources, respectively, but fish and shellfish contributed only 11% for protein and essentially nil for lipid. Lunch was the most substantial meal of the day. When classified by age (i.e., 22-29, 30-39 and 40-66 year-old groups), no age-related difference was detected among the three groups in all nutrients except for crude fiber. Comparison with recommended dietary allowance (RDA) for Taiwanese, the insufficiency ratios were more than 50% for minerals (i.e., Fe and Ca) and vitamins (except for vitamin C). Excess in the lipid energy ratio (>30%) was observed in 60% of the study population. In agreement with this high lipid intake, 17% of the participants had BMI of > 25, and triglyceride levels were elevated (>150 mg/100 ml) in 27%. There was no anemic case despite the low Fe intake (14 mg/day).View full abstractDownload PDF (819K) -
Makato Tominaga, Mamoru Kimura, Masahiko Igarashi, Hideyuki Eguchi, Ki ...1997 Volume 181 Issue 3 Pages 353-360
Published: 1997
Released on J-STAGE: March 09, 2006
JOURNAL FREE ACCESSTo know whether the insulin resistance is improved by delaying carbohydrate absorption from the small intestine, we studied the effect of a disaccharidase inhibitor, AO-128, on insulin resistance of Wistar fatty rats. Rats were kept on standard laboratory chow with and without 10 ppm of AO-128 for 4 weeks, and then subjected to the glucose clamp. At the end of the 4-week treatment, plasma glucose level at 14 : 00 to 16 : 00 of AO-128 treated rats was 121±14 mg/100 ml (mean±S.D.), significantly lower than 226±72 mg/100 ml of the rats without AO-128. During clamp steady state under 20 mU·kg−1 continuous insulin infusion, glucose uptake of AO-128 treated rats was only 7.62 ± 0.70 mg. kg−1. min−1, not different from 6.64±0.91 mg·kg−1·min−1 of rats without AO-128, but much lower than the lean littermates (20.81±3.11 mg·kg−1·min−1). However, the percent suppression of hepatic glucose output was 55.2±23.8%, which, though incomplete, was significantly higher than 17.4±11.2% of rats without AO-128. The present study suggested that there were at least two, components of insulin resistance, a genetically determined and a poor-glycemic control-related, and that the latter insulin resistance was ameliorated by AO-128.View full abstractDownload PDF (479K) -
Shunsuke Kobayashi, Shinichiro Okada, Hiroyuki Yoshida, Shigefumi Fuji ...1997 Volume 181 Issue 3 Pages 361-370
Published: 1997
Released on J-STAGE: March 09, 2006
JOURNAL FREE ACCESSThe ability of anti-inflammatory agents to modulate cellular sensitivity to anticancer drugs was investigated for pulmonary carcinoma cells in vitro. We examined the drug sensitivity of two pulmonary adenocarcinoma cell lines (76-2, 77-4) in the presence of two drugs, an anticancer drug and an anti-inflammatory agent, for 72 hr by the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay with 96 well plates. Anticancer drugs used for screening test were cyclophosphamide (CPM), mitomycin C (MMC), adriamycin (ADR), 5-fluorouracil (5FU), vindesine (VDS), cisplatin (CDDP), cytarabine (Ara C), methotrexate (MTX), etoposide (VP-16), and vincristine (VCR). Anti-inflammatory agents examined as modulators to anticancer drugs were aspirin, mefenamic acid, ibuprofen, sulindac, piroxicam, phenacetin, dicrofenac, ketoprofen, tolmetin and indomethacin. Screening tests showed indomethacin to be the most effective modulator, resulting in more than a 3-fold increase in cytotoxicity of VCR as compared with that produced by VCR alone. Study of each of the ten anticancer drugs in combination with indomethacin showed VCR to be the most effective anticancer drug in this combination. In 76-2 cells, the concentration of VCR producing 50% growth inhibition (IC50) for VCR alone and VCR in combination with 2 μg/ml indomethacin were 1.58±0.16 and 0.52±0.1 ng/ml respectively, which represents a 3-fold decrease. In 77-4 cells, the IC50 for VCR alone and VCR in combination with 2 μg/ml indomethacin were 2.86 ± 0.2 and 0.52 ± 0.11 ng/ml respectively, which represents a 3.8-fold decrease. Our studies indicate that clinically achievable concentrations of indomethacin may be useful in modulating VCR resistance in human pulmonary adenocarcinoma cells, so that combined use of VCR and indomethacin may be of potential clinical significance in the treatment of lung cancer.View full abstractDownload PDF (1352K)
Case Reports
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Satoshige Wagatsuma, Nobuo Yaegashi, Tsuneo Namiki, Shinji Sato, Akira ...1997 Volume 181 Issue 3 Pages 371-377
Published: 1997
Released on J-STAGE: March 09, 2006
JOURNAL FREE ACCESSWe report a 63-year-old woman with a female adnexal tumor of probable Wolffian origin, which arose within the leaves of the broad ligament, connected to the left ovary and the fallopian tube. She remains alive without evidence of disease 2 years after left salpingo-oophorectomy without subsequent adjuvant therapy. Microscopically, tumor cells were arranged in three different patterns; closely packed tubules, solid, and sieve-like. Cells had uniform round or oval nuclei and mitoses were rare. Although the majority of these tumors are benign, a few cases have shown malignant potential. Therefore, such tumors should receive careful follow-up for possible recurrence and/or metastasis.View full abstractDownload PDF (3910K) -
Hiroshi Suzuki, Mitsuru Nakasato, Satoshi Sato, Shinkichi Yokoyama, Mi ...1997 Volume 181 Issue 3 Pages 379-384
Published: 1997
Released on J-STAGE: March 09, 2006
JOURNAL FREE ACCESSMicroangiopathic hemolytic anemia and thrombocytopenia have been reported in patients with primary pulmonary hypertension, but not in patients with congenital heart disease even if accompanied with pulmonary hypertension. We present a 7-year-old boy with atrial septal defect and pulmonary hypertension who developed microangiopathic hemolysis and thrombocytopenia. Microangiopathic hemolytic anemia and thrombocytopenia should be remarked as a complication in patients with congenital heart disease.View full abstractDownload PDF (2610K) -
Kaichiro Yamamoto, Yohji Mitsuhashi, Tetsuji Takaike, Kikuya Takase, H ...1997 Volume 181 Issue 3 Pages 385-387
Published: 1997
Released on J-STAGE: March 09, 2006
JOURNAL FREE ACCESSA 13-year-old nulligravida girl, 158.5 cm in height and 76.0 kg in body weight, came to our department complaining of continuous right lower abdominal pain. One month earlier, an ovarian cyst in the right ovary, about 3 cm in diameter, was found when she underwent appendectomy at another hospital, but was left untreated. Menarche occurred at the age of 13 years and 1 month, which was after the appendectomy and 24 days before the present operation. Right hematosalpinx with peripheral obstruction and a para-ovarian serous cyst on the same side were diagnosed, and therefore right salpingectomy with para-ovarian cyst resection was performed. The bilateral ovaries and uterus were completely normal by inspection. The post operative histological examination confirmed hematosalpinx and revealed tubal endometriosis.View full abstractDownload PDF (783K)
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