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Volume 199 (2003)
- Issue 4 Pages 197-
- Issue 3 Pages 127-
- Issue 2 Pages 59-
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Volume 199, Issue 3
March
Displaying 1-9 of 9 articles from this issue
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Regular Contributions
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Gunhan Karakurum, Metin Karakok, Mehmet Tarakcioglu, N. Emrah Kocer, R ...2003 Volume 199 Issue 3 Pages 127-134
Published: 2003
Released on J-STAGE: October 15, 2004
JOURNAL FREE ACCESSHyaluronan and cortisone have controversial and an important role in the healing of degenerative osteoarthritis. The purpose of the research was to compare individual and combined effects of hyaluronan and cortisone on the healing of degenerative osteoarthritis and to determine the serum malondialdehyde level as a lipid peroxidation marker. A rabbit model was used in which a degenerative osteoarthritis was created in the articular cartilage by resection of anterior cruciate ligament. The rabbits divided into three groups namely were injected with hyaluronan (group A) and cortisone (group B) at days 31, 38 and 45. Cortisone at day 31 and hyaluronan at days 38 and 45 were injected to the third group (group C). We obtained blood samples from each rabbit to determine the malondialdehyde levels at days 1, 30, and 52. At day 52, 21 rabbits were sacrificed. In biopsies obtained from treated and untreated knees articular cartilage degeneration was examined by light microscopy. Histopathologically the healing rate was significantly higher in group C than the other groups. Degeneration decreased 72% in group A, 52% in group B and 88% in group C at day 22. Malondialdehyde levels were 2.05±0.37 in the control group, 1.94±0.54 in group A, 1.98±0.37 in group B and 1.55±0.41 in goup C. The malondialdehyde levels of group A and B were less than the control group (statistically insignificant, p>0.05). But, there were statistically significant values between control group and group C (p<0.05). The results showed that the combination of cortisone and hyaluronan is the most effective in the treatment of cartilage degeneration in the course of the ostearthritis and the malondialdehyde levels are correlated with the severity of degeneration.View full abstractDownload PDF (166K) -
Figen Narin, Nazmi Narin, Hatice Pasaoglu, Canan Halici, Duran Aslan2003 Volume 199 Issue 3 Pages 135-139
Published: 2003
Released on J-STAGE: October 15, 2004
JOURNAL FREE ACCESSAcute rheumatic fever (ARF), is a systemic inflammatory disease etiologically related to infection with group A β hemolytic streptococcus, characterized by a broad spectrum of disorders in cellular immunity. To estimate the activity of the immunopathological process in patients with ARF, plasma nitric oxide metabolities (NOx) concentrations, IL-1α and IL-2 levels were investigated in 22 patients with ARF at the time on admission, and after 3 months, in children with chronic rheumatic heart disease (CRHD). Plasma NOx concentrations, IL-1α and IL-2 levels in patients with ARF on admission were significantly higher than in the same patients 3 months later, and higher than in CRHD, or controls. Increased plasma NO may be a useful index for the quantitative assessment of the activity during immunological challange. This information may be useful for the prognosis and monitoring of ARF.View full abstractDownload PDF (89K) -
Onder Onguru, Bulent Celasun, Omer Gunhan2003 Volume 199 Issue 3 Pages 141-148
Published: 2003
Released on J-STAGE: October 15, 2004
JOURNAL FREE ACCESSCarcinomas of the bladder cause important problems of mortality and morbidity despite diagnostic and therapeutic improvements. A variety of grading systems has been developed to reflect the different biologic behavior and malignant potential of this heterogeneous neoplasm. However, these histologic grading systems are subjective and reproducibility is low. In this study, the nuclear morphometric features and DNA ploidy status of 86 cases of transitional cell bladder carcinomas have been studied using image analysis methods with different data selection methods in nucleus suspension to evaluate the relationship of these parameters with the conventional prognostic factors. The relationship between these parameters and likelihood of relapse has also been investigated. In conclusion, the mean nuclear area of the 10 largest nuclei and DNA ploidy status have been shown to be significantly correlated with conventional prognostic factors. Cytomorphometrically, a binary grading system seems more suitable for transitional cell carcinoma of the bladder. For superficial carcinomas, morphometric parameters and DNA ploidy analysis can be helpful in the separation of the patients into prognostically different groups.View full abstractDownload PDF (121K) -
Huo Shen, Kazuya Kannari, Hiroshi Yamato, Akira Arai, Muneo Matsunaga2003 Volume 199 Issue 3 Pages 149-159
Published: 2003
Released on J-STAGE: October 15, 2004
JOURNAL FREE ACCESSBenserazide is commonly used for Parkinson’s disease in combination with L-DOPA as a peripheral aromatic L-amino acid decarboxylase (AADC) inhibitor. However, recent studies using intact animals indicate that benserazide acts also in the central nervous system. We determined the influence of benserazide on the central AADC activity in rats with dopaminergic denervation and observed changes in extracellular dopamine (DA) levels after benserazide and L-DOPA administration. First, using in vivo microdialysis technique, we measured extracellular DA levels in the striatum of 6-hydroxydopamine (6-OHDA)-lesioned rats treated with benserazide and L-DOPA. Second, we measured AADC activity in the striatal tissues after benserazide administration. Although administration of 5, 10 and 50 mg/kg benserazide to 6-OHDA-lesioned rats showed an identical increase in exogenous L-DOPA-derived extracellular DA levels, the time to reach the peak DA levels were significantly prolonged by benserazide dose-dependently. The AADC activity in the denervated striatal tissues showed a significant decrease by 10 mg/kg and 50 mg/kg benserazide. These results suggest that benserazide reduces the central AADC activity in the striatum of rats with nigrostriatal denervation, which leads to changes in the metabolism of exogenous L-DOPA. Central activity of AADC inhibitors should be taken into consideration when they are used both in experimental and clinical studies on Parkinson’s disease.View full abstractDownload PDF (168K) -
Akira Yasutake, Miyuki Matsumoto, Masako Yamaguchi, Noriyuki Hachiya2003 Volume 199 Issue 3 Pages 161-169
Published: 2003
Released on J-STAGE: October 15, 2004
JOURNAL FREE ACCESSTo understand the current Japanese hair mercury levels, we planned a survey of hair mercury among the general populations of different regions in Japan. The present paper, as the first report of the survey, summarized the results obtained in five districts, Minamata, Kumamoto, Tottori, Wakayama and Chiba. Hair samples were collected at beauty saloons, barbershops and primary schools in each district with questionnaires on age, sex, amount and species of fish usually consumed, hair-dyed and artificial hair waving “permanent wave.” The total mercury levels of 3686 hair samples collected were analyzed by an oxygen combustion-gold amalgamation method. The geometric mean of the total mercury concentration was significantly higher in males than in females, i.e., 2.55 μg/g and 1.43 μg/g, respectively. The sex difference was also observed on hair samples without artificial waving, i.e., 2.64 μg/g and 1.64 μg/g, respectively. The geometric mean in each district varied from 2.23 to 4.79 μg/g for males and from 1.23 to 2.50 μg/g for females. The average hair mercury levels were highest in Chiba among the five districts both in males and females. A multiple regression analysis revealed a significant correlation of the mercury level with age, sex, amount of daily fish consumption, tuna and bonito as usually consumed fish, artificial waving and Chiba as a residential area. In the laboratory experiment, we found that the treatment of hair samples with a lotion for artificial waving caused a 30%-reduction in the mercury content. Furthermore, longitudinal hair analysis showed a marked difference in the concentration between the hair root and the tip of the hair taken from artificially waved females; higher values were observed at the hair root. These results suggested that artificial waving significantly removes hair mercury and that hair analysis at the hair root should be necessary to estimate an accurate methylmercury exposure for waved persons.View full abstractDownload PDF (129K) -
Koh Sugawara, Go Miyata, Ryuzaburo Shineha, Susumu Satomi2003 Volume 199 Issue 3 Pages 171-179
Published: 2003
Released on J-STAGE: October 15, 2004
JOURNAL FREE ACCESSIn sepsis and endotoxemia, metabolism is characterized by accelerated catabolism. In the present study, lipolytic responsiveness of subcutaneous and mesenteric adipose tissue to the sub-lethal dose of endotoxin injection (5 mg/kg) was evaluated using microdialysis techniques in rats. All rats were urethane-anesthetized and implanted with microdialysis probes in their subcutaneous and mesenteric adipose tissue. Lipolysis in each adipose tissue was assessed by measuring the glycerol concentration (an index of lipolysis) in the dialysate from the microdialysis probe. Lipolysis was continuously monitored for 7-hours, prior to and following the injection of endotoxin. The control animals were injected with only saline. Lipolysis in subcutaneous adipose tissue began to increase by 1-hours after endotoxin injection, and reached a peak 60% higher than the basal level by 2-hours after injection. This activated lipolysis after endotoxin was markedly greater than that in the control animals and maintained for 5 hours. In mesenteric adipose tissue, lipolysis after endotoxin injection was greater than in the control animals, but not significant. The endotoxin-induced lipolysis in the subcutaneous adipose tissue was significantly greater than that in the mesenteric adipose tissue. We conclude that the sub-lethal dose of endotoxin injection cause active lipolysis in adipose tissues, and that the lipolytic responsiveness to endotoxin in subcutaneous adipose tissue is greater than in mesenteric adipose tissue.View full abstractDownload PDF (139K)
Case Reports
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M. Emin Sakarya, Hasan Irmak, Ömer Etlik, Ömer Evirgen, Osma ...2003 Volume 199 Issue 3 Pages 181-185
Published: 2003
Released on J-STAGE: October 15, 2004
JOURNAL FREE ACCESSPericardial hydatid cyst is rare. We present a 32-year-old man with a pericardial hydatid cyst. Chest x-ray film showed a spherical mass located left mediastinum. A pericardial cyst with low signal intensity was noted on T1 weighted magnetic resonance (MR) images. The cyst had high signal intensity, but signal intensity of folded parasitic membranes in the cyst were seen lower intensity on T2 weighted MR images. Based on these MR findings, pericardial hydatid cyst was diagnosed. The patient underwent surgical removal of the cyst. Histologic study of the cyst confirmed hydatid cyst diagnosis.View full abstractDownload PDF (117K) -
Hakan Çankaya, Özkan Ünal, Serdar Ugras, Koksal Yuca, ...2003 Volume 199 Issue 3 Pages 187-191
Published: 2003
Released on J-STAGE: October 15, 2004
JOURNAL FREE ACCESSHemangiomas are the most common lesions of the major salivary glands during infancy and early childhood. Changes in blood flow dynamic within hemangioma results in thrombus and phleboliths. There have been a number of reports of hemangiomas with phleboliths in parotid and submandibular glands. We present the first case of a hemangioma with multiple phleboliths in the subligual gland as a cause of submental opacity, and discussed the diagnosis of radiopaque masses in the sublingual and submental regions.View full abstractDownload PDF (201K) -
Takashi Orui, Hiroyasu Yasuda, Mutsuo Yamaya, Toshifumi Matsui, Hideta ...2003 Volume 199 Issue 3 Pages 193-196
Published: 2003
Released on J-STAGE: October 15, 2004
JOURNAL FREE ACCESSBilirubin arises from enzymatic reduction by biliverdin reductase of biliverdin, a product of heme oxygenase activity. Recent literature describes that bilirubin is a major physiologic antioxidant that can protect cells from chemical oxidants such as hydrogen peroxide. Recently, it has been reported that oxidative stress may play a crucial role in the pathogenesis of asthma. We report a case of complete resolution of persistent difficult-to-control asthma in accordance with increased levels of serum bilirubin due to acute hepatitis B. The present case suggests that anti-oxidative agents might be effective for the treatment of asthma.View full abstractDownload PDF (127K)
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