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Volume 201 (2003)
- Issue 4 Pages 201-
- Issue 3 Pages 131-
- Issue 2 Pages 67-
- Issue 1 Pages 1-
Volume 201, Issue 2
October
Displaying 1-8 of 8 articles from this issue
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Regular Contributions
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Salih Kavukçu, Alper Soylu, Mehmet Türkmen, Filiz Kuralay, ...2003 Volume 201 Issue 2 Pages 67-73
Published: 2003
Released on J-STAGE: August 20, 2004
JOURNAL FREE ACCESSMaintenance of serum albumin levels within normal limits is difficult to achieve in nephrotic children with normal renal functions who are unresponsive to specific treatment. One approach in such children is unilateral nephrectomy with rapid progression to renal failure. Peritoneal membrane is permeable to fluids, electrolytes and proteins, and peritoneal space has been used for total parenteral alimentation. Experimental ureteroperitoneostomy has been reported not to cause any significant side effect. The aim of this study was to evaluate the effects of unilateral ureteroperitoneostomy on serum and urine protein levels in rats with adriamycin-induced nephrosis. Adriamycin nephrosis was induced in 45 male Wistar rats. After two weeks, unilateral nephrectomy (Nx), unilateral ureteroperitoneostomy (Up) and sham operated (Sh) groups, each including 15 rats were formed. Serum creatine (SCr) and albumin (Salb), and daily urinary protein excretion (Upro) were determined before adriamycin injection (week 0), before operations (week 2) and at the end of 6th week in all rats. In addition, percent change in serum albumin (ΔSalb) and urine protein levels (ΔUpro) between weeks 0-2, 0-6 and 2-6 were calculated for each group (e.g.; ΔSalb 0−2=[Salb week 2−Salb week 0]/Salb week 0×100). Then, these parameters were compared within and between the groups. Furthermore, peritoneal tissue samples were obtained from the rats in Sh and Up groups to be examined for pathological changes. SCr did not change within and in between the groups during the study period. Salb decreased significantly at weeks 2 and 6 with respect to week 0 in all three groups. In addition, although Salb tended to decrease at week 6 with respect to week 2 in all groups, this was significant only in Sh group. Upro increased significantly at weeks 2 and 6 with respect to week 0, and at week 6 with respect to week 2 in all groups. However, Salb and Upro were not different between the three groups at weeks 0.2 and 6. On the other hand, ΔSalb and ΔUpro were not different between Sh vs. Nx and Nx vs. Up rats, but ΔSalb 0-6, ΔSalb 2-6 and ΔUpro 0-6 were significantly lower in Up group compared to Sh group. Histopathological examination of peritoneal samples revealed significantly higher fibrosis score in Up group compared to Sh group. In conclusion, unilateral ureteroperitoneostomy may one important therapeutic selection in the treatment of intractable nephrotic syndrome. However, peritoneal fibrosis could be a concern for further use of peritoneum in case of end stage renal failure.View full abstractDownload PDF (163K) -
Arif Bahar, Ufuk Sevgican, Ferhan Karademir, Ismail Gocmen2003 Volume 201 Issue 2 Pages 75-80
Published: 2003
Released on J-STAGE: August 20, 2004
JOURNAL FREE ACCESSThe aim of this study is to determine the normal values of serum cholesterol, triglyceride, VLDL-C, LDL-C, and HDL-C to obtain the reference values for diagnostic tests in healthy children. The study group included 420 healthy children (209 male, 211 female) ranging from 0 to 15 years. The cases were divided in 4 groups of age: 0-12 month (Group I), 13 month-6 year (Group II), 7-11 year (Group III), and 12-15 year (Group IV). Mean cholesterol, triglyceride, HDL-C, LDL-C and VLDL-C levels were 102.01±27.91, 96.32±37.57, 32.13±11.69, 46.64±21.97 and 24.19±10.56 in group I, 142.58±30.12, 91.57±37.27, 45.68±13.86, 78.41±32.23 and 21.55±10.75 in group II, 139.85±28.06, 95.42±43.12, 46.04±14.03, 71.44±27.05 and 21.69±12.51 in group III, and 153.98±26.71, 101.72±46.66, 45.84±13.06, 83.33±27.25 and 25.17±12.66 in group IV, respectively. There is no significant difference in serum lipid levels between males and females in any age groups. Mean values of cholesterol, HDL-C and LDL-C are significantly higher in older age group.View full abstractDownload PDF (93K) -
Gönül Simsek, Hafize Uzun, Yesari Karter, Seval Aydin, G&uum ...2003 Volume 201 Issue 2 Pages 81-89
Published: 2003
Released on J-STAGE: August 20, 2004
JOURNAL FREE ACCESSThis experimental study was designed to examine the effects of hyperthyroidism on osteoporotic cytokines such as interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α in the physiological concentrations and in the deficiency of estrogen. We investigated the effects of thyroid hormones on cytokines and bone metabolism in L-thyroxine induced ovary-intact and ovariectomised rats, as levels of cytokines were increased in hyperthyroidism. The rats were divided into three groups. In the first group, L-thyroxine-induced hyperthyroid rats were ovariectomised (OVX), while the OVX rats were administered L-thyroxine in the second group. The third group received sham-operation. Blood samples taken from the tail vein of rats were analyzed for plasma T3, T4, TSH and serum IL-1β, IL-6, TNFα, calcium (Ca), phosphorous (P), parathyroid hormone (PTH), alkaline phosphatase (ALP), bone-specific alkaline phosphatase (b-ALP). L-thyroxine administration increased the cytokines, ALP and b-ALP and decreased PTH, while there was no change in Ca and P. However, the ovariectomy of these rats did not change the levels of cytokines, Ca, P, PTH, ALP, and b-ALP. In ovariectomised rats, the cytokines, ALP and b-ALP increased but not Ca and P conversely, PTH decreased. L-thyroxine administration to ovariectomised rats did not change the levels of cytokines, Ca, P, PTH, ALP and b-ALP. In sham-operated rats there was no change in any of the parameters compared with initial values. Thyroid hormones may not be effective on bone metabolism in estrogen deficiency.View full abstractDownload PDF (130K) -
Yoichi Shimada, Satoaki Chida, Toshiki Matsunaga, Akiko Misawa, Hiroki ...2003 Volume 201 Issue 2 Pages 91-96
Published: 2003
Released on J-STAGE: August 20, 2004
JOURNAL FREE ACCESSGrasping power (GP) by means of functional electrical stimulation (FES) was measured in a case of C6 complete tetraplegia. This was compared with GP by means of the dynamic tenodesis effect, the flexor hinge splint and the GP of normal female. Palmar grasp strength by means of FES was approximately 16% of the control group and 2.4 times greater than the flexor hinge splint. Lateral grasp strength by FES was approximately 13% of the control group. Our results suggest that FES is more effective than the flexor hinge splint in increasing the GP of tetraplegic patients, and that a stronger and stable GP, which is not affected by wrist position, makes FES practical for improving activities of daily living (ADL).View full abstractDownload PDF (145K) -
Yong Zhang, Kiyoshi Aoyagi, Sumihisa Honda, Yuichiro Yahata, Itsuro Yo ...2003 Volume 201 Issue 2 Pages 97-107
Published: 2003
Released on J-STAGE: August 20, 2004
JOURNAL FREE ACCESSTo explore how the stiffness index of the calcaneus is related to lifestyle factors, we examined the associations of lifestyle factors, age, and years since menopause, with stiffness index of the calcaneus among 573 community-dwelling Japanese women aged 40-89 years. Stiffness index of the calcaneus was obtained from quantitative ultrasound measurement. Body height and weight were measured, from which body mass index (BMI) was calculated. Physical activity index was calculated using a validated questionnaire. Dietary calcium intake and amount of ingested alcohol were estimated by a semiquantitative food frequency questionnaire. Current smoking status was obtained by questionnaire. In univariate analysis, stiffness index was positively related to physical activity index and BMI, and inversely to age and years since menopause, but not to dietary calcium intake. Stiffness index of drinkers and current smokers was not significantly different from that of non-drinkers and non-smokers, respectively. Among the natural menopausal women, multiple regression analysis showed that advancing age and years since menopause were associated with lower stiffness index, while higher physical activity index and greater BMI were associated with higher stiffness index. In conclusion, higher physical activity, in combination with adequate nutrition for weight maintenance, should be emphasized as a part of a healthy lifestyle in order to maintain bone health among middle-aged and elderly Japanese women.View full abstractDownload PDF (164K) -
Yasuteru Kondo, Koju Kobayashi, Tomoo Kobayashi, Masaaki Shiina, Yoshi ...2003 Volume 201 Issue 2 Pages 109-117
Published: 2003
Released on J-STAGE: August 20, 2004
JOURNAL FREE ACCESSAn essential process for resolution of viral infections is the efficient recognition and elimination of intracellular virus. Recognition of viral antigens in the form of short peptides associated with HLA class I molecule is a major task of CD8+ cytotoxic T lymphocytes. In this study, we have evaluated the frequency of the HLA class I alleles in patients with chronic hepatitis C. HLA-B51, -B52, -B55, -B56, -B61, B70, -Cw1, -Cw3, and -Cw4 are less frequent in patients with chronic hepatitis C than in Japanese individuals. The frequency of HLA-A2 is slightly lower in the patients but tends to be higher in patients with normal alanine aminotransferase (ALT) level than in those with elevated ALT level (p=0.07). Other HLA alleles are not significantly different between two groups. Comparison of HLA homozygosity at HLA-A and -B or -C or at two or three loci did not show a significant association with levels of serum ALT or with the clinical outcome of interferon therapy in patients with hepatitis C. These results suggest a possibility that the alterations of host response, which depends on genetic background, influence disease activities of HCV infection.View full abstractDownload PDF (119K)
Case Report
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Erol Egeli, Fatih Oghan, Murat Alper, Ugur Harputluoglu, Ismet Bulut2003 Volume 201 Issue 2 Pages 119-125
Published: 2003
Released on J-STAGE: August 20, 2004
JOURNAL FREE ACCESSIsolated epiglottic tuberculosis (TBC) is uncommon and has rarely been described. We report the case of a 40-year-old man with tuberculous involvement of the epiglottis and primary adrenal insufficiency. Endoscopic examination showed a severely swollen epiglottis with granulomatous and partially necrotic mucosa. The patient has been treated with glucocorticoids for four years due to primary adrenocortical insufficiency. We therefore assume that tuferculous involvement of epiglottis is due to the reactivation of pulmonary TBC. We also discuss differential diagnosis and management of epiglottic TBC and Addison’s disease.View full abstractDownload PDF (146K)
Short Report
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Shunji Suzuki, Yoshio Yoneyama2003 Volume 201 Issue 2 Pages 127-130
Published: 2003
Released on J-STAGE: August 20, 2004
JOURNAL FREE ACCESSWe evaluated the possible role of increased adenosine in the regulation of uteroplacental circulation during nonpreeclamptic twin gestations. We performed uterine artery Doppler velocimetry and maternal arterial blood sampling for measurement of plasma adenosine levels in 16 women with singleton gestation and 14 women with dichorionic twin gestation without preeclampsia at 11-12, 25-26 and 34-36 weeks. In singleton gestations, a negative correlation between maternal plasma adenosine levels and maternal uterine artery pulsatility index was observed. In twin gestations, there were no noticeable association between maternal plasma adenosine levels and maternal uterine artery pulsatility index. Our results suggest that the decrease in vascular resistance in twin gestations may be through the mechanisms that are independent of adenosine.View full abstractDownload PDF (73K)
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